{"id":"https://openalex.org/W4404377730","doi":"https://doi.org/10.1093/bioinformatics/btae678","title":"DeepRSMA: a cross-fusion-based deep learning method for RNA\u2013small molecule binding affinity prediction","display_name":"DeepRSMA: a cross-fusion-based deep learning method for RNA\u2013small molecule binding affinity prediction","publication_year":2024,"publication_date":"2024-11-14","ids":{"openalex":"https://openalex.org/W4404377730","doi":"https://doi.org/10.1093/bioinformatics/btae678","pmid":"https://pubmed.ncbi.nlm.nih.gov/39540702"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btae678","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae678","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btae678/60675507/btae678.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btae678/60675507/btae678.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhijian Huang","orcid":"https://orcid.org/0009-0000-1949-167X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijian Huang","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","School of Computer Science and Engineering, Central South University, Changsha, 410083, China"],"raw_orcid":"https://orcid.org/0009-0000-1949-167X","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410462","display_name":"Yucheng Wang","orcid":"https://orcid.org/0000-0002-8679-3851"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yucheng Wang","raw_affiliation_strings":["Machine Intellection Department, Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR) , Singapore 138632,","Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR), 138632, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Machine Intellection Department, Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR) , Singapore 138632,","institution_ids":["https://openalex.org/I3005327000","https://openalex.org/I115228651"]},{"raw_affiliation_string":"Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR), 138632, Singapore","institution_ids":["https://openalex.org/I3005327000","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423587","display_name":"Song Chen","orcid":"https://orcid.org/0000-0001-6412-5740"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Chen","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","School of Computer Science and Engineering, Central South University, Changsha, 410083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074799611","display_name":"Yaw Sing Tan","orcid":"https://orcid.org/0000-0002-2522-9421"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yaw Sing Tan","raw_affiliation_strings":["Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR) , Singapore 138671,","Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), 138671, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR) , Singapore 138671,","institution_ids":["https://openalex.org/I115228651"]},{"raw_affiliation_string":"Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), 138671, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085608332","display_name":"Lei Deng","orcid":"https://orcid.org/0000-0003-2869-1619"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Deng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","School of Computer Science and Engineering, Central South University, Changsha, 410083, China"],"raw_orcid":"https://orcid.org/0000-0003-2869-1619","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100340964","display_name":"Min Wu","orcid":"https://orcid.org/0000-0003-0977-3600"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Min Wu","raw_affiliation_strings":["Machine Intellection Department, Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR) , Singapore 138632,","Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR), 138632, Singapore"],"raw_orcid":"https://orcid.org/0000-0003-0977-3600","affiliations":[{"raw_affiliation_string":"Machine Intellection Department, Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR) , Singapore 138632,","institution_ids":["https://openalex.org/I3005327000","https://openalex.org/I115228651"]},{"raw_affiliation_string":"Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR), 138632, Singapore","institution_ids":["https://openalex.org/I3005327000","https://openalex.org/I115228651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.8576,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.91488394,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"40","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.49779999256134033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.49779999256134033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.29649999737739563,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.7524228096008301},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6768256425857544},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.6128442883491516},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5573512315750122},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5117704272270203},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44638678431510925},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.43311607837677},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17295292019844055}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.7524228096008301},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6768256425857544},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6128442883491516},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5573512315750122},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5117704272270203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44638678431510925},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.43311607837677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17295292019844055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btae678","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae678","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btae678/60675507/btae678.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39540702","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39540702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11646567","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11646567","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11646567/pdf/btae678.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btae678","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae678","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btae678/60675507/btae678.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2008773563","display_name":null,"funder_award_id":"62272490","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5299854802","display_name":null,"funder_award_id":"U23A20321","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404377730.pdf","grobid_xml":"https://content.openalex.org/works/W4404377730.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1555644224","https://openalex.org/W1971049801","https://openalex.org/W2008056655","https://openalex.org/W2021688648","https://openalex.org/W2048792281","https://openalex.org/W2412446857","https://openalex.org/W2618530766","https://openalex.org/W2671097371","https://openalex.org/W2820941669","https://openalex.org/W2947497907","https://openalex.org/W3013781651","https://openalex.org/W3029836473","https://openalex.org/W3084513853","https://openalex.org/W3096561213","https://openalex.org/W3112748348","https://openalex.org/W3151148247","https://openalex.org/W4210357271","https://openalex.org/W4229058666","https://openalex.org/W4283523580","https://openalex.org/W4290672950","https://openalex.org/W4309362395","https://openalex.org/W4311860580","https://openalex.org/W4313315369","https://openalex.org/W4377093183","https://openalex.org/W4378782647","https://openalex.org/W4385774226","https://openalex.org/W4391132552","https://openalex.org/W4393339805","https://openalex.org/W6739901393"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W1986582023","https://openalex.org/W4380075502"],"abstract_inverted_index":{"MOTIVATION:":[0],"RNA":[1,103,116,165],"is":[2,27,143],"implicated":[3],"in":[4,185],"numerous":[5],"aberrant":[6],"cellular":[7],"functions":[8],"and":[9,73,104,110,117,126,154,166,174,192,216],"disease":[10],"progressions,":[11],"highlighting":[12],"the":[13,21,57,66,147,164,171,193,204],"crucial":[14],"importance":[15],"of":[16,23,59,69,150],"RNA-targeted":[17,208],"drugs.":[18],"To":[19,97,157],"accelerate":[20],"discovery":[22],"such":[24],"drugs,":[25],"it":[26],"essential":[28],"to":[29,50,64,132,145,206],"develop":[30],"an":[31,88],"effective":[32,159],"computational":[33,44],"method":[34,93],"for":[35,94,115],"predicting":[36],"RNA-small":[37],"molecule":[38,168],"affinity":[39],"(RSMA).":[40],"Recently,":[41],"deep":[42,61,91],"learning-based":[43],"methods":[45,63,184],"have":[46],"been":[47],"promising":[48],"due":[49],"their":[51,74],"powerful":[52],"nonlinear":[53],"modeling":[54],"ability.":[55],"However,":[56],"leveraging":[58],"advanced":[60],"learning":[62,92],"mine":[65],"diverse":[67],"information":[68],"RNAs,":[70],"small":[71,105,118,155,167],"molecules,":[72,106,119],"interaction":[75],"still":[76],"remains":[77],"a":[78,139],"great":[79],"challenge.":[80],"RESULTS:":[81],"In":[82],"this":[83],"study,":[84],"we":[85,107,122,162],"present":[86],"DeepRSMA,":[87],"innovative":[89],"cross-attention-based":[90],"RSMA":[95,160],"prediction.":[96],"effectively":[98],"capture":[99,133],"fine-grained":[100],"features":[101,134],"from":[102,135,170],"developed":[108],"nucleotide-level":[109],"atomic-level":[111],"feature":[112,172],"extraction":[113,173],"modules":[114,131],"respectively.":[120],"Additionally,":[121],"incorporated":[123],"both":[124],"sequence":[125],"graph":[127],"views":[128],"into":[129],"these":[130],"multiple":[136,186],"perspectives.":[137],"Moreover,":[138],"transformer-based":[140],"cross-fusion":[141,175],"module":[142],"introduced":[144],"learn":[146],"general":[148],"patterns":[149],"interactions":[151],"between":[152],"RNAs":[153],"molecules.":[156],"achieve":[158],"prediction,":[161],"integrated":[163],"representations":[169],"modules.":[176],"Our":[177],"results":[178],"show":[179],"that":[180,201],"DeepRSMA":[181,202],"outperforms":[182],"baseline":[183],"test":[187],"settings.":[188],"The":[189,214],"interpretability":[190],"analysis":[191],"case":[194],"study":[195],"on":[196],"spinal":[197],"muscular":[198],"atrophy":[199],"demonstrate":[200],"has":[203],"potential":[205],"guide":[207],"drug":[209],"design.":[210],"AVAILABILITY":[211],"AND":[212],"IMPLEMENTATION:":[213],"codes":[215],"data":[217],"are":[218],"publicly":[219],"available":[220],"at":[221],"https://github.com/Hhhzj-7/DeepRSMA.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
