{"id":"https://openalex.org/W4404185145","doi":"https://doi.org/10.1093/bioinformatics/btae666","title":"MR Corge: sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures","display_name":"MR Corge: sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures","publication_year":2024,"publication_date":"2024-11-01","ids":{"openalex":"https://openalex.org/W4404185145","doi":"https://doi.org/10.1093/bioinformatics/btae666","pmid":"https://pubmed.ncbi.nlm.nih.gov/39513749"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btae666","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae666","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bioinformatics/btae666","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101782352","display_name":"Wenmin Zhang","orcid":"https://orcid.org/0000-0002-4472-8859"},"institutions":[{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"funder","lineage":["https://openalex.org/I2800290161"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wenmin Zhang","raw_affiliation_strings":["Montreal Heart Institute , Montreal, QC, H1T 1C8,"],"raw_orcid":"https://orcid.org/0000-0002-4472-8859","affiliations":[{"raw_affiliation_string":"Montreal Heart Institute , Montreal, QC, H1T 1C8,","institution_ids":["https://openalex.org/I2800290161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033627178","display_name":"Chen\u2010Yang Su","orcid":"https://orcid.org/0000-0001-6071-4660"},"institutions":[{"id":"https://openalex.org/I3018882396","display_name":"Victor (Japan)","ror":"https://ror.org/04b0q3m21","country_code":"JP","type":"company","lineage":["https://openalex.org/I3018882396"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Chen-Yang Su","raw_affiliation_strings":["Quantitative Life Sciences Program, McGill University , Montreal, QC, H3A 0G4,","Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University , Montreal, QC, H3A 0G1,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Life Sciences Program, McGill University , Montreal, QC, H3A 0G4,","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University , Montreal, QC, H3A 0G1,","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I3018882396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016490953","display_name":"Satoshi Yoshiji","orcid":"https://orcid.org/0000-0001-8863-2413"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I3018882396","display_name":"Victor (Japan)","ror":"https://ror.org/04b0q3m21","country_code":"JP","type":"company","lineage":["https://openalex.org/I3018882396"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Satoshi Yoshiji","raw_affiliation_strings":["Department of Human Genetics, McGill University , Montreal, QC, H3A 0G1,","Harvard Medical School , Boston, MA, 02115,","Lady Davis Institute for Medical Research , Montreal, QC, H3T 1E2,","Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard , Cambridge, MA, 02142,","Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University , Montreal, QC, H3A 0G1,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, McGill University , Montreal, QC, H3A 0G1,","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA, 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research , Montreal, QC, H3T 1E2,","institution_ids":[]},{"raw_affiliation_string":"Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard , Cambridge, MA, 02142,","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University , Montreal, QC, H3A 0G1,","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I3018882396"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002177152","display_name":"Tianyuan Lu","orcid":"https://orcid.org/0000-0002-5664-5698"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tianyuan Lu","raw_affiliation_strings":["Center for Demography of Health and Aging, University of Wisconsin-Madison , Madison, WI, 53706,","Center for Genomic Science Innovation, University of Wisconsin-Madison , Madison, WI, 53706,","Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison , Madison, WI, 53705,","Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison , Madison, WI, 53726,","Department of Population Health Sciences, University of Wisconsin-Madison , Madison, WI, 53726,"],"raw_orcid":"https://orcid.org/0000-0002-5664-5698","affiliations":[{"raw_affiliation_string":"Center for Demography of Health and Aging, University of Wisconsin-Madison , Madison, WI, 53706,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Center for Genomic Science Innovation, University of Wisconsin-Madison , Madison, WI, 53706,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison , Madison, WI, 53705,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison , Madison, WI, 53726,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Population Health Sciences, University of Wisconsin-Madison , Madison, WI, 53726,","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002177152"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.8237,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.9103657,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"40","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5031999945640564,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5031999945640564,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.9049023985862732},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.6609861850738525},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5164806842803955},{"id":"https://openalex.org/keywords/mendelian-inheritance","display_name":"Mendelian inheritance","score":0.46248918771743774},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4338570833206177},{"id":"https://openalex.org/keywords/core","display_name":"Core (optical fiber)","score":0.4319295287132263},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4240078330039978},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3990180492401123},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39222338795661926},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3797902762889862},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2465900480747223},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.1561373472213745},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.08557525277137756}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9049023985862732},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6609861850738525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5164806842803955},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.46248918771743774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4338570833206177},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.4319295287132263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4240078330039978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3990180492401123},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39222338795661926},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3797902762889862},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2465900480747223},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.1561373472213745},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08557525277137756},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btae666","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae666","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39513749","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39513749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11578597","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11578597","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11578597/pdf/btae666.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btae666","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae666","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320314000","display_name":"Compute Canada","ror":"https://ror.org/03ty8yr27"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1496795801","https://openalex.org/W1905058580","https://openalex.org/W1973355122","https://openalex.org/W2039153962","https://openalex.org/W2064366700","https://openalex.org/W2102011776","https://openalex.org/W2103916483","https://openalex.org/W2106036991","https://openalex.org/W2127768736","https://openalex.org/W2139852278","https://openalex.org/W2147452548","https://openalex.org/W2153118028","https://openalex.org/W2153860431","https://openalex.org/W2164089346","https://openalex.org/W2195783463","https://openalex.org/W2216355665","https://openalex.org/W2272106152","https://openalex.org/W2324862792","https://openalex.org/W2417483443","https://openalex.org/W2527993022","https://openalex.org/W2528302205","https://openalex.org/W2600092046","https://openalex.org/W2604629929","https://openalex.org/W2613603864","https://openalex.org/W2614566443","https://openalex.org/W2616536890","https://openalex.org/W2626606138","https://openalex.org/W2725988230","https://openalex.org/W2795601394","https://openalex.org/W2803072880","https://openalex.org/W2805983714","https://openalex.org/W2883573930","https://openalex.org/W2894170300","https://openalex.org/W2895486342","https://openalex.org/W2899572198","https://openalex.org/W2901670341","https://openalex.org/W2909598358","https://openalex.org/W2952835495","https://openalex.org/W2963404097","https://openalex.org/W2969996045","https://openalex.org/W2996249643","https://openalex.org/W3006330340","https://openalex.org/W3042936392","https://openalex.org/W3121239749","https://openalex.org/W3123863341","https://openalex.org/W3129339917","https://openalex.org/W3132221372","https://openalex.org/W3152758353","https://openalex.org/W3210406414","https://openalex.org/W3210570897","https://openalex.org/W4220854628","https://openalex.org/W4229455035","https://openalex.org/W4231686634","https://openalex.org/W4292634140","https://openalex.org/W4310766578","https://openalex.org/W4315644439","https://openalex.org/W4315779240","https://openalex.org/W4321369732","https://openalex.org/W4382318822","https://openalex.org/W4396609669","https://openalex.org/W4400980361","https://openalex.org/W7009918872"],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W2169283889","https://openalex.org/W4210703904","https://openalex.org/W2052821216","https://openalex.org/W2036527494","https://openalex.org/W2610080820","https://openalex.org/W4294125588","https://openalex.org/W2416849719","https://openalex.org/W2015148400","https://openalex.org/W1604069670"],"abstract_inverted_index":{"SUMMARY:":[0],"Mendelian":[1,54],"randomization":[2],"is":[3,138],"being":[4],"utilized":[5],"to":[6,19,70,126],"assess":[7],"causal":[8,83],"effects":[9],"of":[10,53,62,94,116],"polygenic":[11,128],"exposures,":[12],"where":[13],"many":[14],"genetic":[15],"instruments":[16,65],"are":[17,67],"subject":[18],"horizontal":[20,29,95],"pleiotropy.":[21,96],"Existing":[22],"methods":[23],"for":[24,28,49],"detecting":[25],"and":[26,81,99,113],"correcting":[27],"pleiotropy":[30],"have":[31],"important":[32],"assumptions":[33],"that":[34,66,104],"may":[35,122],"not":[36],"be":[37,123],"fulfilled.":[38],"Built":[39],"upon":[40],"the":[41,92,114],"core":[42,64],"gene":[43],"hypothesis,":[44],"we":[45,102],"developed":[46],"MR":[47,56,105,120],"Corge":[48,57,106,121],"performing":[50],"sensitivity":[51],"analysis":[52],"randomization.":[55],"identifies":[58],"a":[59,74],"small":[60],"number":[61],"putative":[63],"more":[68],"likely":[69],"affect":[71],"genes":[72],"with":[73,109],"direct":[75],"biological":[76],"role":[77],"in":[78],"an":[79],"exposure":[80],"obtains":[82],"effect":[84],"estimates":[85,107],"based":[86],"on":[87],"these":[88],"instruments,":[89],"thereby":[90],"reducing":[91],"risk":[93],"Using":[97],"positive":[98],"negative":[100],"controls,":[101],"demonstrated":[103],"aligned":[108],"established":[110],"biomedical":[111],"knowledge":[112],"results":[115],"randomized":[117],"controlled":[118],"trials.":[119],"widely":[124],"applied":[125],"investigate":[127],"exposure-outcome":[129],"relationships.":[130],"AVAILABILITY":[131],"AND":[132],"IMPLEMENTATION:":[133],"An":[134],"open-sourced":[135],"R":[136],"package":[137],"available":[139],"at":[140],"https://github.com/zhwm/MRCorge.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}
