{"id":"https://openalex.org/W4403335414","doi":"https://doi.org/10.1093/bioinformatics/btae598","title":"TarKG: a comprehensive biomedical knowledge graph for target discovery","display_name":"TarKG: a comprehensive biomedical knowledge graph for target discovery","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403335414","doi":"https://doi.org/10.1093/bioinformatics/btae598","pmid":"https://pubmed.ncbi.nlm.nih.gov/39392404"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btae598","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae598","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bioinformatics/btae598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100438375","display_name":"Cong Zhou","orcid":"https://orcid.org/0000-0002-1526-1452"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Zhou","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088963449","display_name":"Chuipu Cai","orcid":"https://orcid.org/0000-0002-6778-9697"},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chui-Pu Cai","raw_affiliation_strings":["Division of Data Intelligence, Department of Computer Science, Shantou University , Shantou 515063,","Division of Data Intelligence, Department of Computer Science, Shantou University, Shantou, 515063, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Data Intelligence, Department of Computer Science, Shantou University , Shantou 515063,","institution_ids":["https://openalex.org/I32574673"]},{"raw_affiliation_string":"Division of Data Intelligence, Department of Computer Science, Shantou University, Shantou, 515063, China","institution_ids":["https://openalex.org/I32574673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002987520","display_name":"Xiaotian Huang","orcid":"https://orcid.org/0000-0003-1145-8386"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Tian Huang","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101562878","display_name":"Song Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Wu","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110829680","display_name":"Junlin Yu","orcid":"https://orcid.org/0009-0007-3689-4367"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Lin Yu","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037983694","display_name":"Jingwei Wu","orcid":"https://orcid.org/0000-0002-0285-3619"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Wei Wu","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029470846","display_name":"Jiansong Fang","orcid":"https://orcid.org/0000-0002-6998-5384"},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Song Fang","raw_affiliation_strings":["Science and Technology Innovation Center, Guangzhou University of Chinese Medicine , Guangzhou 510405,","Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine , Guangzhou 510405,","institution_ids":["https://openalex.org/I117532281"]},{"raw_affiliation_string":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031861128","display_name":"Guo\u2010Bo Li","orcid":"https://orcid.org/0000-0002-4915-6677"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guo-Bo Li","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China"],"raw_orcid":"https://orcid.org/0000-0002-4915-6677","affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029470846","https://openalex.org/A5031861128"],"corresponding_institution_ids":["https://openalex.org/I117532281","https://openalex.org/I24185976"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":4.4264,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.95350642,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"40","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5555999875068665,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5555999875068665,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.28540000319480896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6958406567573547},{"id":"https://openalex.org/keywords/knowledge-graph","display_name":"Knowledge graph","score":0.6262438297271729},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.560380220413208},{"id":"https://openalex.org/keywords/relation","display_name":"Relation (database)","score":0.520220935344696},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5179416537284851},{"id":"https://openalex.org/keywords/knowledge-extraction","display_name":"Knowledge extraction","score":0.44439923763275146},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4160520136356354},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3717832565307617},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2583519518375397},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.22851309180259705},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.22239884734153748},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.11012992262840271},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09626105427742004}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6958406567573547},{"id":"https://openalex.org/C2987255567","wikidata":"https://www.wikidata.org/wiki/Q33002955","display_name":"Knowledge graph","level":2,"score":0.6262438297271729},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.560380220413208},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.520220935344696},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5179416537284851},{"id":"https://openalex.org/C120567893","wikidata":"https://www.wikidata.org/wiki/Q1582085","display_name":"Knowledge extraction","level":2,"score":0.44439923763275146},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4160520136356354},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3717832565307617},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2583519518375397},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.22851309180259705},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22239884734153748},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.11012992262840271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09626105427742004}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btae598","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae598","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39392404","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39392404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11513019","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11513019","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11513019/pdf/btae598.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btae598","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae598","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3441359491","display_name":null,"funder_award_id":"82073698","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6446954825","display_name":null,"funder_award_id":"2023YFF1204901","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G658642563","display_name":null,"funder_award_id":"82122065","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8225790866","display_name":null,"funder_award_id":"2024A1515030161","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G8243098916","display_name":null,"funder_award_id":"2023SCUH0073","funder_id":"https://openalex.org/F4320322990","funder_display_name":"Sichuan University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W90362830","https://openalex.org/W1837617056","https://openalex.org/W2037132500","https://openalex.org/W2060214041","https://openalex.org/W2103017472","https://openalex.org/W2123850443","https://openalex.org/W2148671784","https://openalex.org/W2790010524","https://openalex.org/W2899291554","https://openalex.org/W2912219565","https://openalex.org/W2949311246","https://openalex.org/W2980674730","https://openalex.org/W2986888203","https://openalex.org/W3017312058","https://openalex.org/W3020759564","https://openalex.org/W3046971123","https://openalex.org/W3092072640","https://openalex.org/W3108860514","https://openalex.org/W3116099552","https://openalex.org/W3134259328","https://openalex.org/W3135995749","https://openalex.org/W3137253127","https://openalex.org/W3137864305","https://openalex.org/W3177828909","https://openalex.org/W3210331473","https://openalex.org/W4205519906","https://openalex.org/W4206661596","https://openalex.org/W4211238337","https://openalex.org/W4220710576","https://openalex.org/W4285093609","https://openalex.org/W4306353169","https://openalex.org/W4308346198","https://openalex.org/W4318671044","https://openalex.org/W4318983406","https://openalex.org/W4366742733","https://openalex.org/W4378072282","https://openalex.org/W4380853828","https://openalex.org/W4385185876","https://openalex.org/W4387674194","https://openalex.org/W4388033637","https://openalex.org/W4388455891","https://openalex.org/W4388615774","https://openalex.org/W4388615775","https://openalex.org/W4388819432","https://openalex.org/W4390954434","https://openalex.org/W4393936594","https://openalex.org/W4399366004","https://openalex.org/W6603694148","https://openalex.org/W6638600212","https://openalex.org/W6787444470"],"related_works":["https://openalex.org/W2055243143","https://openalex.org/W2480711475","https://openalex.org/W4321636575","https://openalex.org/W1986418932","https://openalex.org/W2357796999","https://openalex.org/W2045526782","https://openalex.org/W4292070284","https://openalex.org/W4319071221","https://openalex.org/W4313174091","https://openalex.org/W4313219769"],"abstract_inverted_index":{"MOTIVATION:":[0],"Target":[1],"discovery":[2],"is":[3,211],"a":[4,50,64,190],"crucial":[5],"step":[6],"in":[7,26,52],"drug":[8,44],"development,":[9],"as":[10,43],"it":[11],"directly":[12],"affects":[13],"the":[14,53,125,144,179],"success":[15],"rate":[16],"of":[17,55,91,148],"clinical":[18],"trials.":[19],"Knowledge":[20],"graphs":[21],"(KGs)":[22],"offer":[23],"unique":[24],"advantages":[25],"processing":[27],"complex":[28],"biological":[29],"data":[30],"and":[31,46,83,96,105,118,172,202],"inferring":[32],"new":[33],"relationships.":[34],"Existing":[35],"biomedical":[36,66,78],"KGs":[37,56],"primarily":[38],"focus":[39],"on":[40,69],"tasks":[41],"such":[42],"repositioning":[45],"drug-target":[47],"interactions,":[48],"leaving":[49],"gap":[51],"construction":[54],"tailored":[57],"for":[58,124,151,168,185],"target":[59,70],"discovery.":[60],"RESULTS:":[61],"We":[62],"established":[63],"comprehensive":[65],"KG":[67,139],"focusing":[68],"discovery,":[71],"termed":[72],"TarKG,":[73,149],"by":[74],"integrating":[75],"seven":[76],"existing":[77],"KGs,":[79],"nine":[80],"public":[81],"databases,":[82],"traditional":[84],"Chinese":[85],"medicine":[86],"knowledge":[87,145,200],"databases.":[88],"TarKG":[89,120,210],"consists":[90],"1":[92],"143":[93],"313":[94],"entities":[95,127],"32":[97],"806":[98],"467":[99],"relations":[100],"across":[101],"15":[102],"entity":[103,114],"categories":[104],"171":[106],"relation":[107,203],"types,":[108],"all":[109],"centered":[110],"around":[111],"3":[112],"core":[113,126],"types:":[115],"Disease,":[116],"Gene,":[117],"Compound.":[119],"provides":[121],"specialized":[122],"knowledges":[123],"including":[128],"chemical":[129],"structures,":[130],"protein":[131,166],"sequences,":[132],"or":[133],"text":[134],"descriptions.":[135],"By":[136],"using":[137,182,205],"different":[138],"embedding":[140],"algorithms,":[141],"we":[142,158,188],"assessed":[143],"completion":[146],"capabilities":[147],"particularly":[150],"disease-target":[152],"link":[153],"prediction.":[154],"In":[155],"case":[156],"studies,":[157],"further":[159],"examined":[160],"TarKG's":[161],"ability":[162],"to":[163,173,198],"predict":[164],"potential":[165],"targets":[167],"Alzheimer's":[169],"disease":[170],"(AD)":[171],"identify":[174],"diseases":[175],"potentially":[176],"associated":[177],"with":[178],"metallo-deubiquitinase":[180],"CSN5,":[181],"literature":[183],"analysis":[184],"validation.":[186],"Furthermore,":[187],"provided":[189],"user-friendly":[191],"web":[192],"server":[193],"(https://tarkg.ddtmlab.org)":[194],"that":[195],"enables":[196],"users":[197],"perform":[199],"retrieval":[201],"inference":[204],"TarKG.":[206],"AVAILABILITY":[207],"AND":[208],"IMPLEMENTATION:":[209],"accessible":[212],"at":[213],"https://tarkg.ddtmlab.org.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":8}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}