{"id":"https://openalex.org/W4401794004","doi":"https://doi.org/10.1093/bioinformatics/btae518","title":"scDiffusion: conditional generation of high-quality single-cell data using diffusion model","display_name":"scDiffusion: conditional generation of high-quality single-cell data using diffusion model","publication_year":2024,"publication_date":"2024-08-22","ids":{"openalex":"https://openalex.org/W4401794004","doi":"https://doi.org/10.1093/bioinformatics/btae518","pmid":"https://pubmed.ncbi.nlm.nih.gov/39171840"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btae518","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae518","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btae518/58889831/btae518.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btae518/58889831/btae518.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105346134","display_name":"Erpai Luo","orcid":"https://orcid.org/0009-0009-4087-6027"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erpai Luo","raw_affiliation_strings":["MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University , Beijing 100084, China","Department of Automation, Tsinghua University, MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Beijing, 100084, China"],"raw_orcid":"https://orcid.org/0009-0009-4087-6027","affiliations":[{"raw_affiliation_string":"MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011263468","display_name":"Minsheng Hao","orcid":"https://orcid.org/0000-0001-6749-5659"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minsheng Hao","raw_affiliation_strings":["MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University , Beijing 100084, China","Department of Automation, Tsinghua University, MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Beijing, 100084, China"],"raw_orcid":"https://orcid.org/0000-0001-6749-5659","affiliations":[{"raw_affiliation_string":"MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634707","display_name":"Lei Wei","orcid":"https://orcid.org/0000-0002-1546-6458"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wei","raw_affiliation_strings":["MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University , Beijing 100084, China","Department of Automation, Tsinghua University, MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Beijing, 100084, China"],"raw_orcid":"https://orcid.org/0000-0002-1546-6458","affiliations":[{"raw_affiliation_string":"MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081242795","display_name":"Xuegong Zhang","orcid":"https://orcid.org/0000-0002-9684-5643"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuegong Zhang","raw_affiliation_strings":["MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University , Beijing 100084, China","School of Life Sciences and School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University , Beijing 100084, China","Department of Automation, Tsinghua University, MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Beijing, 100084, China"],"raw_orcid":"https://orcid.org/0000-0002-9684-5643","affiliations":[{"raw_affiliation_string":"MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"School of Life Sciences and School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University, MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":7.0756,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.9798365,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"40","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6429046392440796},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.5726345777511597},{"id":"https://openalex.org/keywords/quality","display_name":"Quality (philosophy)","score":0.5578949451446533},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.40959274768829346},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.3259924650192261},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.163180410861969}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6429046392440796},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5726345777511597},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.5578949451446533},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.40959274768829346},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.3259924650192261},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.163180410861969},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btae518","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae518","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btae518/58889831/btae518.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39171840","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39171840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11368386","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11368386","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11368386/pdf/btae518.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btae518","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae518","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btae518/58889831/btae518.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1928118392","display_name":null,"funder_award_id":"2021YFF1200901","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5814160623","display_name":null,"funder_award_id":"61721003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6722913013","display_name":null,"funder_award_id":"62373210","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G97774448","display_name":null,"funder_award_id":"62250005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401794004.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W13634249","https://openalex.org/W1970774603","https://openalex.org/W2412491875","https://openalex.org/W2509957998","https://openalex.org/W2794521141","https://openalex.org/W2894687190","https://openalex.org/W2901677030","https://openalex.org/W2911279170","https://openalex.org/W2949067670","https://openalex.org/W2951506174","https://openalex.org/W2960029024","https://openalex.org/W2962031564","https://openalex.org/W2979835214","https://openalex.org/W2990981753","https://openalex.org/W3000350302","https://openalex.org/W3019068524","https://openalex.org/W3036167779","https://openalex.org/W3037216933","https://openalex.org/W3040876684","https://openalex.org/W3082292479","https://openalex.org/W3088354555","https://openalex.org/W3092982430","https://openalex.org/W3107635367","https://openalex.org/W3111941790","https://openalex.org/W3158284947","https://openalex.org/W3161810785","https://openalex.org/W3162926177","https://openalex.org/W3196650609","https://openalex.org/W3200303312","https://openalex.org/W3204937802","https://openalex.org/W4200312086","https://openalex.org/W4220837089","https://openalex.org/W4225598893","https://openalex.org/W4225727976","https://openalex.org/W4280596398","https://openalex.org/W4280598116","https://openalex.org/W4281759935","https://openalex.org/W4294636450","https://openalex.org/W4294916331","https://openalex.org/W4307432965","https://openalex.org/W4360884927","https://openalex.org/W4376134478","https://openalex.org/W4378838672","https://openalex.org/W4392168151","https://openalex.org/W4399387478","https://openalex.org/W6600569132","https://openalex.org/W6688325169","https://openalex.org/W6779823529","https://openalex.org/W6795288823"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032"],"abstract_inverted_index":{"MOTIVATION:":[0],"Single-cell":[1],"RNA":[2],"sequencing":[3],"(scRNA-seq)":[4],"data":[5,48,64,79,111,129,170,181,239],"are":[6,53],"important":[7],"for":[8,87,234],"studying":[9],"the":[10,30,47,69,101,121,147,194,207,211,236,256],"laws":[11],"of":[12,33,153,197,206,221],"life":[13],"at":[14,255],"single-cell":[15,167],"level.":[16],"However,":[17],"it":[18],"is":[19,230,252],"still":[20],"challenging":[21],"to":[22,40,62,107,119,127,149,199],"obtain":[23],"enough":[24],"high-quality":[25,109],"scRNA-seq":[26,44,88,110,174,238],"data.":[27,45,175,209],"To":[28],"mitigate":[29],"limited":[31],"availability":[32],"data,":[34],"generative":[35,98],"models":[36,52,72],"have":[37,73],"been":[38],"proposed":[39,136],"computationally":[41],"generate":[42,63,108,128,150,166,200],"synthetic":[43],"Nevertheless,":[46],"generated":[49,216],"with":[50,65,80,112],"current":[51],"not":[54],"very":[55],"realistic":[56],"yet,":[57],"especially":[58],"when":[59],"we":[60,94,191,215],"need":[61],"controlled":[66,113],"conditions.":[67,114],"In":[68,91],"meantime,":[70],"diffusion":[71,102,122],"shown":[74],"their":[75],"power":[76],"in":[77],"generating":[78],"high":[81],"fidelity,":[82],"providing":[83],"a":[84,97,137,157,217,231],"new":[85,138],"opportunity":[86],"generation.":[89],"RESULTS:":[90],"this":[92],"study,":[93],"developed":[95],"scDiffusion,":[96],"model":[99,103,106,148],"combining":[100],"and":[104,240],"foundation":[105],"We":[115,134],"designed":[116],"multiple":[117,131],"classifiers":[118],"guide":[120],"process":[123],"simultaneously,":[124],"enabling":[125],"scDiffusion":[126,164,177,198,229,251],"under":[130],"condition":[132],"combinations.":[133],"also":[135],"control":[139],"strategy":[140,145],"called":[141],"Gradient":[142,212],"Interpolation.":[143],"This":[144],"allows":[146],"continuous":[151,218],"trajectories":[152],"cell":[154,159,184,188,201,245],"development":[155],"from":[156],"given":[158],"state.":[160],"Experiments":[161],"showed":[162],"that":[163,203,228],"could":[165,192],"gene":[168],"expression":[169],"closely":[171],"resembling":[172],"real":[173,237],"Also,":[176],"can":[178,241],"conditionally":[179],"produce":[180],"on":[182],"specific":[183],"types":[185],"including":[186],"rare":[187],"types.":[189],"Furthermore,":[190],"use":[193],"multiple-condition":[195],"generation":[196],"type":[202],"was":[204],"out":[205],"training":[208],"Leveraging":[210],"Interpolation":[213],"strategy,":[214],"developmental":[219],"trajectory":[220],"mouse":[222],"embryonic":[223],"cells.":[224],"These":[225],"experiments":[226],"demonstrate":[227],"powerful":[232],"tool":[233],"augmenting":[235],"provide":[242],"insights":[243],"into":[244],"fate":[246],"research.":[247],"AVAILABILITY":[248],"AND":[249],"IMPLEMENTATION:":[250],"openly":[253],"available":[254],"GitHub":[257],"repository":[258],"https://github.com/EperLuo/scDiffusion":[259],"or":[260],"Zenodo":[261],"https://zenodo.org/doi/10.5281/zenodo.13268742.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":3}],"updated_date":"2026-07-14T08:27:34.040176","created_date":"2025-10-10T00:00:00"}