{"id":"https://openalex.org/W4400800727","doi":"https://doi.org/10.1093/bioinformatics/btae457","title":"Controlled noise: evidence of epigenetic regulation of single-cell expression variability","display_name":"Controlled noise: evidence of epigenetic regulation of single-cell expression variability","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4400800727","doi":"https://doi.org/10.1093/bioinformatics/btae457","pmid":"https://pubmed.ncbi.nlm.nih.gov/39018178"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btae457","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae457","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/7/btae457/58667756/btae457.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/40/7/btae457/58667756/btae457.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066519862","display_name":"Yan Zhong","orcid":"https://orcid.org/0000-0003-2412-043X"},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Zhong","raw_affiliation_strings":["School of Statistics, KLATASDS-MOE, East China Normal University , Shanghai, 200062, China"],"affiliations":[{"raw_affiliation_string":"School of Statistics, KLATASDS-MOE, East China Normal University , Shanghai, 200062, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111173178","display_name":"Shuaijun Cui","orcid":null},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siwei Cui","raw_affiliation_strings":["School of Statistics, KLATASDS-MOE, East China Normal University , Shanghai, 200062, China"],"affiliations":[{"raw_affiliation_string":"School of Statistics, KLATASDS-MOE, East China Normal University , Shanghai, 200062, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014958505","display_name":"Yongjian Yang","orcid":"https://orcid.org/0000-0002-4135-5014"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongjian Yang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&M University , College Station, TX 77843, United States"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University , College Station, TX 77843, United States","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059360459","display_name":"James J. Cai","orcid":"https://orcid.org/0000-0002-8081-6725"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J Cai","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&M University , College Station, TX 77843, United States","Department of Veterinary Integrative Biosciences, Texas A&M University , College Station, TX 77843, United States","Interdisciplinary Program of Genetics, Texas A&M University , College Station, TX 77843, United States"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University , College Station, TX 77843, United States","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University , College Station, TX 77843, United States","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Interdisciplinary Program of Genetics, Texas A&M University , College Station, TX 77843, United States","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066519862"],"corresponding_institution_ids":["https://openalex.org/I66867065"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.9159,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.7373321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"40","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9754999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.7692575454711914},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.6983212232589722},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6831662654876709},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5805092453956604},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4953102171421051},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.49451014399528503},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4791947305202484},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.43034467101097107},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.415108859539032},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.4116094410419464},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.34524089097976685},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.23687806725502014}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7692575454711914},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6983212232589722},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6831662654876709},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5805092453956604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4953102171421051},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49451014399528503},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4791947305202484},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.43034467101097107},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.415108859539032},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4116094410419464},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34524089097976685},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.23687806725502014}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btae457","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae457","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/7/btae457/58667756/btae457.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39018178","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39018178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11283284","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11283284","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11283284/pdf/btae457.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btae457","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae457","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/7/btae457/58667756/btae457.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1045535893","display_name":null,"funder_award_id":"2021YFA1000101","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1649416926","display_name":null,"funder_award_id":"2021YFA1000100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7009121769","display_name":null,"funder_award_id":"123013","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7320824963","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G768629655","display_name":null,"funder_award_id":"12301336","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8156429214","display_name":null,"funder_award_id":"RP230204","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G8316206084","display_name":null,"funder_award_id":"72331005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8624615794","display_name":null,"funder_award_id":"GW200026","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4400800727.pdf"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W19101126","https://openalex.org/W1575736368","https://openalex.org/W1602702667","https://openalex.org/W1738348680","https://openalex.org/W1983653170","https://openalex.org/W1996203485","https://openalex.org/W2013324041","https://openalex.org/W2040662877","https://openalex.org/W2045949302","https://openalex.org/W2069089843","https://openalex.org/W2095705004","https://openalex.org/W2121602932","https://openalex.org/W2135046866","https://openalex.org/W2181419079","https://openalex.org/W2345356016","https://openalex.org/W2768348081","https://openalex.org/W2794480084","https://openalex.org/W2805746333","https://openalex.org/W2889236955","https://openalex.org/W2889326414","https://openalex.org/W2945570991","https://openalex.org/W2949177718","https://openalex.org/W2983296376","https://openalex.org/W2995912489","https://openalex.org/W3082938683","https://openalex.org/W3131634425","https://openalex.org/W3144696998","https://openalex.org/W3164692211","https://openalex.org/W3186404867","https://openalex.org/W3189065844","https://openalex.org/W3210860076","https://openalex.org/W4213344226","https://openalex.org/W4225426244","https://openalex.org/W4289835859","https://openalex.org/W4320487182","https://openalex.org/W4385250061","https://openalex.org/W4387381514","https://openalex.org/W4387817861","https://openalex.org/W4387949868","https://openalex.org/W4393043593","https://openalex.org/W6674330103","https://openalex.org/W6745609711"],"related_works":["https://openalex.org/W4366603091","https://openalex.org/W4286930115","https://openalex.org/W2485141070","https://openalex.org/W2411374999","https://openalex.org/W2083798468","https://openalex.org/W3004891660","https://openalex.org/W2969540308","https://openalex.org/W3145419749","https://openalex.org/W3038565614","https://openalex.org/W2752005645"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}