{"id":"https://openalex.org/W4400184827","doi":"https://doi.org/10.1093/bioinformatics/btae431","title":"A multi-bin rarefying method for evaluating alpha diversities in TCR sequencing data","display_name":"A multi-bin rarefying method for evaluating alpha diversities in TCR sequencing data","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4400184827","doi":"https://doi.org/10.1093/bioinformatics/btae431","pmid":"https://pubmed.ncbi.nlm.nih.gov/38950175"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btae431","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae431","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/7/btae431/58536930/btae431.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/40/7/btae431/58536930/btae431.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100912242","display_name":"Mo Li","orcid":"https://orcid.org/0000-0001-5188-9346"},"institutions":[{"id":"https://openalex.org/I79516672","display_name":"University of Louisiana at Lafayette","ror":"https://ror.org/01x8rc503","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I79516672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mo Li","raw_affiliation_strings":["Department of Mathematics, University of Louisiana at Lafayette , Lafayette, LA, 70504, United States"],"raw_orcid":"https://orcid.org/0000-0001-5188-9346","affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Louisiana at Lafayette , Lafayette, LA, 70504, United States","institution_ids":["https://openalex.org/I79516672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026919585","display_name":"Xing Hua","orcid":"https://orcid.org/0000-0002-8346-5887"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Hua","raw_affiliation_strings":["Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA, 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA, 98109, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083428910","display_name":"Shuai Cheng Li","orcid":"https://orcid.org/0000-0001-6246-6349"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuai Li","raw_affiliation_strings":["Department of Biostatistics, Johns Hopkins University , Baltimore, MD, 21205, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Johns Hopkins University , Baltimore, MD, 21205, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000129649","display_name":"Michael C. Wu","orcid":"https://orcid.org/0000-0002-3357-6570"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C Wu","raw_affiliation_strings":["Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA, 98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA, 98109, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022433604","display_name":"Ni Zhao","orcid":"https://orcid.org/0000-0002-7762-3949"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ni Zhao","raw_affiliation_strings":["Department of Biostatistics, Johns Hopkins University , Baltimore, MD, 21205, United States"],"raw_orcid":"https://orcid.org/0000-0002-7762-3949","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Johns Hopkins University , Baltimore, MD, 21205, United States","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12240417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5871999859809875,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5871999859809875,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.23929999768733978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6742337942123413},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.6323907971382141},{"id":"https://openalex.org/keywords/bin","display_name":"Bin","score":0.6015276908874512},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.5383966565132141},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.4957810342311859},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.43332168459892273},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.40824222564697266},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.32174152135849},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.2494627833366394},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.24923592805862427},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.19519782066345215},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19094687700271606},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12320727109909058}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6742337942123413},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.6323907971382141},{"id":"https://openalex.org/C156273044","wikidata":"https://www.wikidata.org/wiki/Q4913766","display_name":"Bin","level":2,"score":0.6015276908874512},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.5383966565132141},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4957810342311859},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.43332168459892273},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.40824222564697266},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32174152135849},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.2494627833366394},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.24923592805862427},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.19519782066345215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19094687700271606},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12320727109909058},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btae431","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae431","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/7/btae431/58536930/btae431.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38950175","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38950175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11246167","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11246167","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11246167/pdf/btae431.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btae431","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae431","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/7/btae431/58536930/btae431.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46000000834465027,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G1903169257","display_name":null,"funder_award_id":"U10 CA180819","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2709593909","display_name":null,"funder_award_id":"U10CA180819","funder_id":"https://openalex.org/F4320314494","funder_display_name":"Hope Foundation"}],"funders":[{"id":"https://openalex.org/F4320314494","display_name":"Hope Foundation","ror":"https://ror.org/05wf1w785"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400184827.pdf","grobid_xml":"https://content.openalex.org/works/W4400184827.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1511920456","https://openalex.org/W1995373064","https://openalex.org/W2001542236","https://openalex.org/W2004014148","https://openalex.org/W2007362831","https://openalex.org/W2018330851","https://openalex.org/W2031011895","https://openalex.org/W2042421957","https://openalex.org/W2043071551","https://openalex.org/W2067564219","https://openalex.org/W2104767862","https://openalex.org/W2105381977","https://openalex.org/W2107328434","https://openalex.org/W2127242728","https://openalex.org/W2173617309","https://openalex.org/W2179823504","https://openalex.org/W2318871708","https://openalex.org/W2347998626","https://openalex.org/W2605177850","https://openalex.org/W2728919089","https://openalex.org/W2791370358","https://openalex.org/W2810097927","https://openalex.org/W2894661298","https://openalex.org/W2981394430","https://openalex.org/W3003556485","https://openalex.org/W3106236944","https://openalex.org/W3139007161","https://openalex.org/W3212450750","https://openalex.org/W4206441308","https://openalex.org/W4213440643","https://openalex.org/W4226224536","https://openalex.org/W4283159436"],"related_works":["https://openalex.org/W2107701374","https://openalex.org/W1616588898","https://openalex.org/W4249504934","https://openalex.org/W2183416055","https://openalex.org/W2568867011","https://openalex.org/W1994114538","https://openalex.org/W2413205705","https://openalex.org/W2735644334","https://openalex.org/W138879321","https://openalex.org/W3081644756"],"abstract_inverted_index":{"MOTIVATION:":[0],"T":[1],"cell":[2],"receptors":[3],"(TCRs)":[4],"constitute":[5],"a":[6,34],"major":[7],"component":[8],"of":[9,37,51,129,139],"our":[10],"adaptive":[11],"immune":[12,38],"system,":[13],"governing":[14],"the":[15,25,48,127,130,136],"recognition":[16],"and":[17,21,116,161,184],"response":[18],"to":[19,70,103],"internal":[20],"external":[22],"antigens.":[23],"Studying":[24],"TCR":[26],"diversity":[27,114],"via":[28],"sequencing":[29],"technology":[30],"is":[31,173],"critical":[32],"for":[33,112],"deeper":[35],"understanding":[36],"dynamics.":[39],"However,":[40],"library":[41,105,140,148],"sizes":[42],"differ":[43],"substantially":[44],"across":[45,119],"samples,":[46],"hindering":[47],"accurate":[49],"estimation/comparisons":[50],"alpha":[52,113],"diversities.":[53],"To":[54],"address":[55],"this,":[56],"researchers":[57],"frequently":[58],"use":[59],"an":[60,71,91],"overall":[61,131],"rarefying":[62,94,108,132],"approach":[63,95,133],"in":[64,134,146,165],"which":[65],"all":[66],"samples":[67,98],"are":[68,179],"sub-sampled":[69],"even":[72],"depth.":[73],"Despite":[74],"its":[75,78],"pervasive":[76],"application,":[77],"efficacy":[79],"has":[80],"never":[81],"been":[82],"rigorously":[83],"assessed.":[84],"RESULTS:":[85],"In":[86],"this":[87],"paper,":[88],"we":[89],"develop":[90],"innovative":[92],"\"multi-bin\"":[93],"that":[96],"partitions":[97],"into":[99],"multiple":[100],"bins":[101],"according":[102],"their":[104],"sizes,":[106],"conducts":[107],"within":[109],"each":[110],"bin":[111],"calculations,":[115],"performs":[117],"meta-analysis":[118],"bins.":[120],"Extensive":[121],"simulations":[122],"using":[123],"real-world":[124],"data":[125],"highlight":[126],"inadequacy":[128],"controlling":[135],"confounding":[137],"effect":[138],"size.":[141],"Our":[142],"method":[143],"proves":[144],"robust":[145],"addressing":[147],"size":[149],"confounding,":[150],"outperforming":[151],"competing":[152],"normalization":[153],"strategies":[154],"by":[155],"achieving":[156],"better-controlled":[157],"type-I":[158],"error":[159],"rates":[160],"enhanced":[162],"statistical":[163],"power":[164],"association":[166],"tests.":[167],"AVAILABILITY":[168],"AND":[169],"IMPLEMENTATION:":[170],"The":[171,177],"code":[172],"available":[174,181],"at":[175,182],"https://github.com/mli171/MultibinAlpha.":[176],"datasets":[178],"freely":[180],"https://doi.org/10.21417/B7001Z":[183],"https://doi.org/10.21417/AR2019NC.":[185]},"counts_by_year":[],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}