{"id":"https://openalex.org/W4402253302","doi":"https://doi.org/10.1093/bioinformatics/btae399","title":"Ouroboros: cross-linking protein expression perturbations and cancer histology imaging with generative-predictive modeling","display_name":"Ouroboros: cross-linking protein expression perturbations and cancer histology imaging with generative-predictive modeling","publication_year":2024,"publication_date":"2024-09-01","ids":{"openalex":"https://openalex.org/W4402253302","doi":"https://doi.org/10.1093/bioinformatics/btae399","pmid":"https://pubmed.ncbi.nlm.nih.gov/39230703"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btae399","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae399","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/Supplement_2/ii174/59017010/btae399.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/40/Supplement_2/ii174/59017010/btae399.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043745920","display_name":"Srijay Deshpande","orcid":"https://orcid.org/0000-0003-3923-2944"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Srijay Deshpande","raw_affiliation_strings":["Department of Computer Science, Tissue Image Analytics Centre, University of Warwick , Coventry, CV4 7AL, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Tissue Image Analytics Centre, University of Warwick , Coventry, CV4 7AL, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074890996","display_name":"Sokratia Georgaka","orcid":"https://orcid.org/0000-0002-0078-8083"},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sokratia Georgaka","raw_affiliation_strings":["Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085653682","display_name":"Michael Haley","orcid":"https://orcid.org/0000-0003-2485-8485"},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Haley","raw_affiliation_strings":["Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005164428","display_name":"Robert Sellers","orcid":null},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Sellers","raw_affiliation_strings":["Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083259471","display_name":"James Minshull","orcid":"https://orcid.org/0000-0001-9372-5163"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Minshull","raw_affiliation_strings":["Division of Neuroscience and Experimental Psychology, University of Manchester , Manchester, M13 9PL, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Division of Neuroscience and Experimental Psychology, University of Manchester , Manchester, M13 9PL, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006803565","display_name":"Jayakrupakar Nallala","orcid":"https://orcid.org/0000-0002-9473-5782"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jayakrupakar Nallala","raw_affiliation_strings":["School of Physics and Astronomy, University of Exeter , Exeter, EX4 4QL, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, University of Exeter , Exeter, EX4 4QL, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084939027","display_name":"Martin Fergie","orcid":"https://orcid.org/0000-0002-9531-6109"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Fergie","raw_affiliation_strings":["Division of Informatics, Imaging and Data Science, University of Manchester , Manchester, M13 9PT, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Division of Informatics, Imaging and Data Science, University of Manchester , Manchester, M13 9PT, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088796043","display_name":"Nicholas Stone","orcid":"https://orcid.org/0000-0001-5603-3731"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Stone","raw_affiliation_strings":["School of Physics and Astronomy, University of Exeter , Exeter, EX4 4QL, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, University of Exeter , Exeter, EX4 4QL, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069179055","display_name":"Nasir Rajpoot","orcid":"https://orcid.org/0000-0002-4706-1308"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nasir Rajpoot","raw_affiliation_strings":["Department of Computer Science, Tissue Image Analytics Centre, University of Warwick , Coventry, CV4 7AL, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Tissue Image Analytics Centre, University of Warwick , Coventry, CV4 7AL, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021710415","display_name":"Syed Murtuza Baker","orcid":"https://orcid.org/0000-0002-6633-333X"},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Syed Murtuza Baker","raw_affiliation_strings":["Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090543390","display_name":"Mudassar Iqbal","orcid":"https://orcid.org/0000-0002-5006-4331"},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mudassar Iqbal","raw_affiliation_strings":["Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052599084","display_name":"Kevin N. Couper","orcid":"https://orcid.org/0000-0003-4659-8960"},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Couper","raw_affiliation_strings":["Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester , M13 9PL, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066934299","display_name":"Federico Roncaroli","orcid":"https://orcid.org/0000-0003-3650-5572"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Federico Roncaroli","raw_affiliation_strings":["Division of Neuroscience and Experimental Psychology, University of Manchester , Manchester, M13 9PL, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Division of Neuroscience and Experimental Psychology, University of Manchester , Manchester, M13 9PL, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086173090","display_name":"Fayyaz Minhas","orcid":"https://orcid.org/0000-0001-9129-1189"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fayyaz Minhas","raw_affiliation_strings":["Department of Computer Science, Tissue Image Analytics Centre, University of Warwick , Coventry, CV4 7AL, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Tissue Image Analytics Centre, University of Warwick , Coventry, CV4 7AL, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5043745920"],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09360021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"Supplement_2","first_page":"ii174","last_page":"ii181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9876999855041504,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-expression","display_name":"Protein expression","score":0.6765716671943665},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5848807096481323},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5584455132484436},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.5431075096130371},{"id":"https://openalex.org/keywords/generative-model","display_name":"Generative model","score":0.5080230236053467},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4984135627746582},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.44771283864974976},{"id":"https://openalex.org/keywords/h-e-stain","display_name":"H&E stain","score":0.4346693754196167},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.41888168454170227},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3969597816467285},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.36789214611053467},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.29804906249046326},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24006697535514832},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18323951959609985},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17553970217704773}],"concepts":[{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.6765716671943665},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5848807096481323},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5584455132484436},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.5431075096130371},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.5080230236053467},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4984135627746582},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.44771283864974976},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.4346693754196167},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.41888168454170227},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3969597816467285},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36789214611053467},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.29804906249046326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24006697535514832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18323951959609985},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17553970217704773},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/btae399","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae399","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/Supplement_2/ii174/59017010/btae399.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39230703","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39230703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/d62fb1d8-c128-4302-8650-a7e47eb66d08","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/d62fb1d8-c128-4302-8650-a7e47eb66d08","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deshpande, S, Georgaka, S, Haley, M, Sellers, R, Minshull, J, Nallala, J, Fergie, M, Stone, N, Rajpoot, N, Baker, S M, Iqbal, M, Couper, K, Roncaroli, F & Minhas, F 2024, 'Ouroboros : cross-linking protein expression perturbations and cancer histology imaging with generative-predictive modeling', Bioinformatics (Oxford, England), vol. 40, no. Supplement_2, pp. ii174-ii181. https://doi.org/10.1093/bioinformatics/btae399","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:11373318","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11373318","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11373318/pdf/btae399.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:wrap.warwick.ac.uk:186506","is_oa":true,"landing_page_url":"https://wrap.warwick.ac.uk/id/eprint/186506/1/dcs-150624-wrap--iscb_protein_generative_predictive_19_1.pdf","pdf_url":"https://wrap.warwick.ac.uk/id/eprint/186506/7/btae399.pdf","source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"NonPeerReviewed"},{"id":"pmh:oai:figshare.com:article/29814164","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal contribution"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btae399","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btae399","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/40/Supplement_2/ii174/59017010/btae399.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2461521968","display_name":null,"funder_award_id":"BB/S019324/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8452545418","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8808548929","display_name":null,"funder_award_id":"EP/W02909X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402253302.pdf","grobid_xml":"https://content.openalex.org/works/W4402253302.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2001867190","https://openalex.org/W2053129129","https://openalex.org/W2058911076","https://openalex.org/W2952481429","https://openalex.org/W3036882247","https://openalex.org/W3038310877","https://openalex.org/W3044996171","https://openalex.org/W3196139316","https://openalex.org/W3205605830","https://openalex.org/W3214280461","https://openalex.org/W4220765701","https://openalex.org/W4220978817","https://openalex.org/W4311350141","https://openalex.org/W4320013936","https://openalex.org/W4360618733","https://openalex.org/W4385367716","https://openalex.org/W4385760593"],"related_works":["https://openalex.org/W4365211920","https://openalex.org/W3014948380","https://openalex.org/W4380551139","https://openalex.org/W4317695495","https://openalex.org/W4287117424","https://openalex.org/W4387506531","https://openalex.org/W4238433571","https://openalex.org/W3174044702","https://openalex.org/W2967848559","https://openalex.org/W4299831724"],"abstract_inverted_index":{"Implementation":[0],"and":[1],"associated":[2],"data":[3],"for":[4],"the":[5,11],"proposed":[6],"approach":[7],"are":[8],"available":[9],"at":[10],"URL:":[12],"https://github.com/Srijay/Ouroboros.":[13]},"counts_by_year":[],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}