{"id":"https://openalex.org/W4389934199","doi":"https://doi.org/10.1093/bioinformatics/btad764","title":"ELISL: early\u2013late integrated synthetic lethality prediction in cancer","display_name":"ELISL: early\u2013late integrated synthetic lethality prediction in cancer","publication_year":2023,"publication_date":"2023-12-18","ids":{"openalex":"https://openalex.org/W4389934199","doi":"https://doi.org/10.1093/bioinformatics/btad764","pmid":"https://pubmed.ncbi.nlm.nih.gov/38113447"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btad764","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad764","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad764/54642226/btad764.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad764/54642226/btad764.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040915179","display_name":"Yasin I. Tepeli","orcid":"https://orcid.org/0000-0002-3375-6678"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Yasin I Tepeli","raw_affiliation_strings":["Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088659656","display_name":"Colm Seale","orcid":"https://orcid.org/0000-0003-1716-8419"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Colm Seale","raw_affiliation_strings":["Holland Proton Therapy Center (HollandPTC) , Delft, The Netherlands","Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Holland Proton Therapy Center (HollandPTC) , Delft, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017104430","display_name":"Joana P. Gon\u00e7alves","orcid":"https://orcid.org/0000-0001-6072-9627"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joana P Gon\u00e7alves","raw_affiliation_strings":["Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040915179"],"corresponding_institution_ids":["https://openalex.org/I98358874"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.2181,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.80097215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"40","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lethality","display_name":"Lethality","score":0.8257460594177246},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"Synthetic lethality","score":0.7430064678192139},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.51859450340271},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4229661226272583},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2781237065792084},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1896325647830963},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07917311787605286}],"concepts":[{"id":"https://openalex.org/C20379349","wikidata":"https://www.wikidata.org/wiki/Q1720706","display_name":"Lethality","level":2,"score":0.8257460594177246},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.7430064678192139},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.51859450340271},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4229661226272583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2781237065792084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1896325647830963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07917311787605286},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btad764","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad764","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad764/54642226/btad764.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38113447","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38113447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11616771","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11616771","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11616771/pdf/btad764.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btad764","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad764","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad764/54642226/btad764.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.7300000190734863}],"awards":[{"id":"https://openalex.org/G2239976265","display_name":null,"funder_award_id":"U01DK133766","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4163069322","display_name":null,"funder_award_id":"R01AG078803","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5060240110","display_name":null,"funder_award_id":"U54DK134302","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6345853531","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7617662717","display_name":null,"funder_award_id":"U54EY032442","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389934199.pdf"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1532326900","https://openalex.org/W1678356000","https://openalex.org/W1968136597","https://openalex.org/W1968295028","https://openalex.org/W2003079893","https://openalex.org/W2010457001","https://openalex.org/W2011159055","https://openalex.org/W2018838463","https://openalex.org/W2027239974","https://openalex.org/W2028497134","https://openalex.org/W2035809306","https://openalex.org/W2036856098","https://openalex.org/W2043398720","https://openalex.org/W2043600151","https://openalex.org/W2045953361","https://openalex.org/W2056994384","https://openalex.org/W2071478061","https://openalex.org/W2103386635","https://openalex.org/W2105532921","https://openalex.org/W2108707301","https://openalex.org/W2113613985","https://openalex.org/W2120806256","https://openalex.org/W2122769974","https://openalex.org/W2131786456","https://openalex.org/W2149441684","https://openalex.org/W2160584334","https://openalex.org/W2161743129","https://openalex.org/W2169966223","https://openalex.org/W2171972386","https://openalex.org/W2190856209","https://openalex.org/W2271395282","https://openalex.org/W2615066396","https://openalex.org/W2734441862","https://openalex.org/W2735132087","https://openalex.org/W2735914287","https://openalex.org/W2770445484","https://openalex.org/W2809699427","https://openalex.org/W2810280645","https://openalex.org/W2810986024","https://openalex.org/W2883529879","https://openalex.org/W2911710737","https://openalex.org/W2944727022","https://openalex.org/W2963277165","https://openalex.org/W2990747402","https://openalex.org/W2994706149","https://openalex.org/W2995178483","https://openalex.org/W2995514860","https://openalex.org/W2996709325","https://openalex.org/W3007710549","https://openalex.org/W3013279271","https://openalex.org/W3102943483","https://openalex.org/W3112376646","https://openalex.org/W3131175301","https://openalex.org/W3132019936","https://openalex.org/W3134624884","https://openalex.org/W3146811394","https://openalex.org/W3149420618","https://openalex.org/W4200332430","https://openalex.org/W4200563399","https://openalex.org/W4287446891","https://openalex.org/W6642166753","https://openalex.org/W6766846328"],"related_works":["https://openalex.org/W2116506288","https://openalex.org/W3093199425","https://openalex.org/W4391952194","https://openalex.org/W1508071893","https://openalex.org/W3097247875","https://openalex.org/W4280520494","https://openalex.org/W2161566038","https://openalex.org/W4400224178","https://openalex.org/W2950148520","https://openalex.org/W2518938096"],"abstract_inverted_index":{"Data:":[0],"10.6084/m9.figshare.23607558":[1],"&":[2],"Code:":[3],"github.com/joanagoncalveslab/ELISL.":[4]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}