{"id":"https://openalex.org/W4388706662","doi":"https://doi.org/10.1093/bioinformatics/btad679","title":"ReGeNNe: genetic pathway-based deep neural network using canonical correlation regularizer for disease prediction","display_name":"ReGeNNe: genetic pathway-based deep neural network using canonical correlation regularizer for disease prediction","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4388706662","doi":"https://doi.org/10.1093/bioinformatics/btad679","pmid":"https://pubmed.ncbi.nlm.nih.gov/37963055"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btad679","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad679","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad679/53403484/btad679.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad679/53403484/btad679.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100724599","display_name":"Divya Sharma","orcid":"https://orcid.org/0000-0003-4777-8090"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Divya Sharma","raw_affiliation_strings":["Biostatistics Department, Princess Margaret Cancer Center, University Health Network , Toronto, ON M5G2C4, Canada","Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto , Toronto, ON M5T 3M7, Canada"],"affiliations":[{"raw_affiliation_string":"Biostatistics Department, Princess Margaret Cancer Center, University Health Network , Toronto, ON M5G2C4, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto , Toronto, ON M5T 3M7, Canada","institution_ids":["https://openalex.org/I4210125326","https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007217781","display_name":"Wei Xu","orcid":"https://orcid.org/0000-0002-1287-4552"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Wei Xu","raw_affiliation_strings":["Biostatistics Department, Princess Margaret Cancer Center, University Health Network , Toronto, ON M5G2C4, Canada","Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto , Toronto, ON M5T 3M7, Canada"],"affiliations":[{"raw_affiliation_string":"Biostatistics Department, Princess Margaret Cancer Center, University Health Network , Toronto, ON M5G2C4, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto , Toronto, ON M5T 3M7, Canada","institution_ids":["https://openalex.org/I4210125326","https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007217781"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2802654988","https://openalex.org/I4210125326"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.5337,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.83178137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"39","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.8716434240341187},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6990195512771606},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6392967700958252},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.5804612040519714},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.553225040435791},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5353216528892517},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5335505604743958},{"id":"https://openalex.org/keywords/canonical-correlation","display_name":"Canonical correlation","score":0.5007381439208984},{"id":"https://openalex.org/keywords/generalizability-theory","display_name":"Generalizability theory","score":0.49938082695007324},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.4952527582645416},{"id":"https://openalex.org/keywords/novelty","display_name":"Novelty","score":0.4106300473213196},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2074792981147766},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19803795218467712},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10111430287361145},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07981359958648682},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.07925540208816528}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8716434240341187},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6990195512771606},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6392967700958252},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.5804612040519714},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.553225040435791},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5353216528892517},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5335505604743958},{"id":"https://openalex.org/C153874254","wikidata":"https://www.wikidata.org/wiki/Q115542","display_name":"Canonical correlation","level":2,"score":0.5007381439208984},{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.49938082695007324},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.4952527582645416},{"id":"https://openalex.org/C2778738651","wikidata":"https://www.wikidata.org/wiki/Q16546687","display_name":"Novelty","level":2,"score":0.4106300473213196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2074792981147766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19803795218467712},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10111430287361145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07981359958648682},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.07925540208816528},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089342","descriptor_name":"Canonical Correlation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000089342","descriptor_name":"Canonical Correlation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000089342","descriptor_name":"Canonical Correlation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000089342","descriptor_name":"Canonical Correlation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btad679","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad679","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad679/53403484/btad679.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37963055","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37963055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10666205","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10666205","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10666205/pdf/btad679.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btad679","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad679","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad679/53403484/btad679.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388706662.pdf"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1759375471","https://openalex.org/W1909915578","https://openalex.org/W2024036382","https://openalex.org/W2070444434","https://openalex.org/W2074066657","https://openalex.org/W2079210771","https://openalex.org/W2090808827","https://openalex.org/W2092218554","https://openalex.org/W2104664243","https://openalex.org/W2108172198","https://openalex.org/W2114907267","https://openalex.org/W2117004913","https://openalex.org/W2123688186","https://openalex.org/W2126632735","https://openalex.org/W2135046866","https://openalex.org/W2146519949","https://openalex.org/W2163605009","https://openalex.org/W2327399544","https://openalex.org/W2610717825","https://openalex.org/W2739333501","https://openalex.org/W2789619620","https://openalex.org/W2795989238","https://openalex.org/W2800388620","https://openalex.org/W2808014987","https://openalex.org/W2890964550","https://openalex.org/W2892587974","https://openalex.org/W2901568326","https://openalex.org/W2955557725","https://openalex.org/W2963819344","https://openalex.org/W2999574254","https://openalex.org/W3008957256","https://openalex.org/W3015666767","https://openalex.org/W3028383715","https://openalex.org/W3044822573","https://openalex.org/W3045143113","https://openalex.org/W3090926208","https://openalex.org/W3108155943","https://openalex.org/W3199772305","https://openalex.org/W3208787103","https://openalex.org/W4234698323","https://openalex.org/W4249992252","https://openalex.org/W6610017368","https://openalex.org/W6684191040","https://openalex.org/W6752163247"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W4361193272","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W2806259446","https://openalex.org/W2963326959","https://openalex.org/W2118717649","https://openalex.org/W4247136043","https://openalex.org/W4378220270","https://openalex.org/W4389522849"],"abstract_inverted_index":{"https://github.com/divya031090/ReGeNNe.":[0]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8}],"updated_date":"2026-04-02T15:55:50.835912","created_date":"2025-10-10T00:00:00"}
