{"id":"https://openalex.org/W4387113587","doi":"https://doi.org/10.1093/bioinformatics/btad585","title":"A cell-level discriminative neural network model for diagnosis of blood cancers","display_name":"A cell-level discriminative neural network model for diagnosis of blood cancers","publication_year":2023,"publication_date":"2023-09-25","ids":{"openalex":"https://openalex.org/W4387113587","doi":"https://doi.org/10.1093/bioinformatics/btad585","pmid":"https://pubmed.ncbi.nlm.nih.gov/37756695"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btad585","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad585","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad585/51770591/btad585.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad585/51770591/btad585.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001656704","display_name":"Edgar E. Robles","orcid":"https://orcid.org/0000-0001-6128-3268"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edgar E Robles","raw_affiliation_strings":["Department of Computer Science, University of California , Irvine, CA 92697, United States"],"raw_orcid":"https://orcid.org/0000-0001-6128-3268","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California , Irvine, CA 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447777","display_name":"Jin Ye","orcid":"https://orcid.org/0000-0001-9255-2547"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ye Jin","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School , Boston, MA 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School , Boston, MA 02115, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077460655","display_name":"Padhraic Smyth","orcid":"https://orcid.org/0000-0001-9971-8378"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Padhraic Smyth","raw_affiliation_strings":["Department of Computer Science, University of California , Irvine, CA 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California , Irvine, CA 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034262562","display_name":"Richard H. Scheuermann","orcid":"https://orcid.org/0000-0003-1355-892X"},"institutions":[{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]},{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard H Scheuermann","raw_affiliation_strings":["Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , La Jolla, CA 92037, United States","Department of Informatics, J. Craig Venter Institute , La Jolla, CA 92037, United States","Department of Pathology, University of California , San Diego, CA 92093, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , La Jolla, CA 92037, United States","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"Department of Informatics, J. Craig Venter Institute , La Jolla, CA 92037, United States","institution_ids":["https://openalex.org/I1301553790"]},{"raw_affiliation_string":"Department of Pathology, University of California , San Diego, CA 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079751653","display_name":"Jack D. Bui","orcid":"https://orcid.org/0000-0002-9324-368X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack D Bui","raw_affiliation_strings":["Department of Pathology, University of California , San Diego, CA 92093, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California , San Diego, CA 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087644608","display_name":"Huan\u2010You Wang","orcid":"https://orcid.org/0000-0002-6777-8963"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huan-You Wang","raw_affiliation_strings":["Department of Pathology, University of California , San Diego, CA 92093, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California , San Diego, CA 92093, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090836249","display_name":"Jean Oak","orcid":"https://orcid.org/0000-0001-5220-4628"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Oak","raw_affiliation_strings":["Department of Pathology, Stanford University , Stanford, CA 94305, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University , Stanford, CA 94305, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055944639","display_name":"Qian Yu","orcid":"https://orcid.org/0000-0002-6224-5607"},"institutions":[{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yu Qian","raw_affiliation_strings":["Department of Informatics, J. Craig Venter Institute , La Jolla, CA 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informatics, J. Craig Venter Institute , La Jolla, CA 92037, United States","institution_ids":["https://openalex.org/I1301553790"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5001656704","https://openalex.org/A5055944639"],"corresponding_institution_ids":["https://openalex.org/I1301553790","https://openalex.org/I204250578"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.9107,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.76904728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"39","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.6513000130653381,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.6513000130653381,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.13330000638961792,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6678385138511658},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5985986590385437},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.558679461479187},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5536994934082031},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.5436846017837524},{"id":"https://openalex.org/keywords/medical-diagnosis","display_name":"Medical diagnosis","score":0.48495057225227356},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.471895307302475},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.43369781970977783},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.42293867468833923},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.36762937903404236},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.36101245880126953},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23222187161445618},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.18557289242744446},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10520851612091064},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.088582843542099}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6678385138511658},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5985986590385437},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.558679461479187},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5536994934082031},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.5436846017837524},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.48495057225227356},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.471895307302475},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.43369781970977783},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.42293867468833923},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.36762937903404236},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.36101245880126953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23222187161445618},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18557289242744446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10520851612091064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.088582843542099},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btad585","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad585","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad585/51770591/btad585.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37756695","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37756695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10563151","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10563151","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10563151/pdf/btad585.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btad585","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad585","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btad585/51770591/btad585.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.7099999785423279}],"awards":[{"id":"https://openalex.org/G5537716563","display_name":null,"funder_award_id":"U01TR001801","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"}],"funders":[{"id":"https://openalex.org/F4320317364","display_name":"BD","ror":"https://ror.org/048vrgr14"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4387113587.pdf"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1516237833","https://openalex.org/W1631320694","https://openalex.org/W1712068381","https://openalex.org/W1976151361","https://openalex.org/W1980081406","https://openalex.org/W1982074959","https://openalex.org/W1982729887","https://openalex.org/W1989838792","https://openalex.org/W1993835819","https://openalex.org/W2036515432","https://openalex.org/W2041520207","https://openalex.org/W2042829929","https://openalex.org/W2047594345","https://openalex.org/W2048395646","https://openalex.org/W2060415116","https://openalex.org/W2060886231","https://openalex.org/W2067858168","https://openalex.org/W2073256527","https://openalex.org/W2082016821","https://openalex.org/W2087932775","https://openalex.org/W2095280237","https://openalex.org/W2095664313","https://openalex.org/W2097446839","https://openalex.org/W2099268808","https://openalex.org/W2099760648","https://openalex.org/W2101038583","https://openalex.org/W2114124472","https://openalex.org/W2120366344","https://openalex.org/W2124159210","https://openalex.org/W2138839185","https://openalex.org/W2143451223","https://openalex.org/W2155573955","https://openalex.org/W2156049613","https://openalex.org/W2157673856","https://openalex.org/W2158591658","https://openalex.org/W2159150982","https://openalex.org/W2159917050","https://openalex.org/W2337259373","https://openalex.org/W2346039638","https://openalex.org/W2358421111","https://openalex.org/W2461073387","https://openalex.org/W2612538354","https://openalex.org/W2761095749","https://openalex.org/W2761645446","https://openalex.org/W2767607422","https://openalex.org/W2788915007","https://openalex.org/W2801193972","https://openalex.org/W2886484539","https://openalex.org/W2889103878","https://openalex.org/W2896930435","https://openalex.org/W2950814274","https://openalex.org/W2952775948","https://openalex.org/W2953193207","https://openalex.org/W2986044976","https://openalex.org/W3049397729","https://openalex.org/W3080263813","https://openalex.org/W3201130650","https://openalex.org/W3205926610","https://openalex.org/W3210362879","https://openalex.org/W4205437613","https://openalex.org/W4248463836","https://openalex.org/W4280647382","https://openalex.org/W4386009263","https://openalex.org/W6647707980","https://openalex.org/W6660976593","https://openalex.org/W6683063028","https://openalex.org/W6683804565"],"related_works":["https://openalex.org/W4389116644","https://openalex.org/W2153315159","https://openalex.org/W3103844505","https://openalex.org/W259157601","https://openalex.org/W4205463238","https://openalex.org/W2761785940","https://openalex.org/W1482209366","https://openalex.org/W2110523656","https://openalex.org/W2521627374","https://openalex.org/W2981954115"],"abstract_inverted_index":{"MOTIVATION:":[0],"Precise":[1],"identification":[2],"of":[3,107,114,138,193,229],"cancer":[4,28,81,176,196,206,220],"cells":[5,73,117,140],"in":[6,23,118,210,234],"patient":[7,211],"samples":[8,110,127],"is":[9],"essential":[10],"for":[11,27,78,158,174,191],"accurate":[12],"diagnosis":[13,68,106,177],"and":[14,103,111,164,178,185,231],"clinical":[15,154],"monitoring":[16],"but":[17],"has":[18],"been":[19],"a":[20,87],"significant":[21],"challenge":[22],"machine":[24],"learning":[25],"approaches":[26,49,173],"precision":[29],"medicine.":[30],"In":[31,161],"most":[32],"scenarios,":[33],"training":[34,101],"data":[35,102,214],"are":[36,58,75,128,237],"only":[37],"available":[38,239],"with":[39],"disease":[40],"annotation":[41],"at":[42],"the":[43,51,92,105,108,112,115,119,131,136,194,200,205,218,235],"subject":[44],"or":[45,74],"sample":[46,132],"level.":[47],"Traditional":[48],"separate":[50],"classification":[52],"process":[53],"into":[54],"multiple":[55],"steps":[56],"that":[57,199],"optimized":[59],"independently.":[60],"Recent":[61],"methods":[62],"either":[63],"focus":[64],"on":[65,240],"predicting":[66],"sample-level":[67,100],"without":[69],"identifying":[70,79],"individual":[71,139],"pathologic":[72],"less":[76],"effective":[77],"heterogeneous":[80],"cell":[82,202,221],"phenotypes.":[83],"RESULTS:":[84],"We":[85,148],"developed":[86],"generalized":[88],"end-to-end":[89],"differentiable":[90],"model,":[91],"Cell":[93],"Scoring":[94],"Neural":[95],"Network":[96],"(CSNN),":[97],"which":[98,134],"takes":[99],"predicts":[104],"testing":[109],"identity":[113],"diagnostic":[116,142],"sample,":[120],"simultaneously.":[121],"The":[122,226],"cell-level":[123,179],"density":[124],"differences":[125],"between":[126],"linked":[129],"to":[130,143,151],"diagnosis,":[133],"allows":[135],"probabilities":[137],"being":[141],"be":[144,247],"calculated":[145],"using":[146],"backpropagation.":[147],"applied":[149],"CSNN":[150,167,230],"two":[152],"independent":[153],"flow":[155],"cytometry":[156],"datasets":[157,232],"leukemia":[159],"diagnosis.":[160],"both":[162,175],"qualitative":[163],"quantitative":[165],"assessments,":[166],"outperformed":[168],"preexisting":[169],"neural":[170],"network":[171],"modeling":[172],"classification.":[180],"Post":[181],"hoc":[182],"decision":[183],"trees":[184],"2D":[186],"dot":[187],"plots":[188],"were":[189],"generated":[190],"interpretation":[192],"identified":[195,201,219],"cells,":[197],"showing":[198],"phenotypes":[203],"match":[204],"endotypes":[207],"observed":[208],"clinically":[209],"cohorts.":[212],"Independent":[213],"clustering":[215],"analysis":[216],"confirmed":[217],"populations.":[222],"AVAILABILITY":[223],"AND":[224],"IMPLEMENTATION:":[225],"source":[227],"code":[228],"used":[233],"experiments":[236],"publicly":[238],"GitHub":[241],"(http://github.com/erobl/csnn).":[242],"Raw":[243],"FCS":[244],"files":[245],"can":[246],"downloaded":[248],"from":[249],"FlowRepository":[250],"(ID:":[251],"FR-FCM-Z6YK).":[252]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}