{"id":"https://openalex.org/W4382631765","doi":"https://doi.org/10.1093/bioinformatics/btad220","title":"Deep statistical modelling of nanopore sequencing translocation times reveals latent non-B DNA structures","display_name":"Deep statistical modelling of nanopore sequencing translocation times reveals latent non-B DNA structures","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4382631765","doi":"https://doi.org/10.1093/bioinformatics/btad220"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btad220","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad220","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/Supplement_1/i242/50741480/btad220.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/39/Supplement_1/i242/50741480/btad220.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101887015","display_name":"Marjan Hosseini","orcid":"https://orcid.org/0000-0002-0927-6658"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marjan Hosseini","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032519981","display_name":"Aaron Zeff Palmer","orcid":"https://orcid.org/0000-0002-2731-6895"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Palmer","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092364007","display_name":"William Manka","orcid":null},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Manka","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088905168","display_name":"Patrick G. S. Grady","orcid":"https://orcid.org/0000-0003-0180-7810"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick G S Grady","raw_affiliation_strings":["Institute for Systems Genomics and Department of Molecular and Cell Biology, University of Connecticut , Storrs, CT 06269-3003, United States"],"affiliations":[{"raw_affiliation_string":"Institute for Systems Genomics and Department of Molecular and Cell Biology, University of Connecticut , Storrs, CT 06269-3003, United States","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011414434","display_name":"Venkata S. P. Patchigolla","orcid":"https://orcid.org/0000-0001-6441-9976"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkata Patchigolla","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051393532","display_name":"Jinbo Bi","orcid":"https://orcid.org/0000-0001-6996-4092"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinbo Bi","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015873205","display_name":"Rachel J. O\u2019Neill","orcid":"https://orcid.org/0000-0002-1525-6821"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel J O\u2019Neill","raw_affiliation_strings":["Institute for Systems Genomics and Department of Molecular and Cell Biology, University of Connecticut , Storrs, CT 06269-3003, United States"],"affiliations":[{"raw_affiliation_string":"Institute for Systems Genomics and Department of Molecular and Cell Biology, University of Connecticut , Storrs, CT 06269-3003, United States","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044791174","display_name":"Zhiyi Chi","orcid":null},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyi Chi","raw_affiliation_strings":["Department of Statistics, University of Connecticut , Storrs, CT 06269-4120, United States"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Connecticut , Storrs, CT 06269-4120, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083334761","display_name":"Derek Aguiar","orcid":"https://orcid.org/0000-0001-9166-8783"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Aguiar","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Connecticut , Storrs, CT 06269-4155, United States","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5101887015"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.9136,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75052693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"39","issue":"Supplement_1","first_page":"i242","last_page":"i251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanopore-sequencing","display_name":"Nanopore sequencing","score":0.7134220600128174},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6225124001502991},{"id":"https://openalex.org/keywords/nanopore","display_name":"Nanopore","score":0.61436527967453},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.5934447646141052},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.5345767140388489},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4829375147819519},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37870141863822937},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.35350361466407776},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29712867736816406},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.1251932680606842}],"concepts":[{"id":"https://openalex.org/C126513998","wikidata":"https://www.wikidata.org/wiki/Q8973627","display_name":"Nanopore sequencing","level":4,"score":0.7134220600128174},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6225124001502991},{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.61436527967453},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.5934447646141052},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5345767140388489},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4829375147819519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37870141863822937},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.35350361466407776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29712867736816406},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1251932680606842},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btad220","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad220","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/Supplement_1/i242/50741480/btad220.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10311326","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10311326","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10311326/pdf/btad220.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btad220","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad220","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/Supplement_1/i242/50741480/btad220.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7099999785423279}],"awards":[{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4917737078","display_name":null,"funder_award_id":"R01DA051922","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5427577994","display_name":null,"funder_award_id":"R01MH119678","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6080185816","display_name":null,"funder_award_id":"U19AI171421","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7917273172","display_name":null,"funder_award_id":"DA051922","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G840930335","display_name":null,"funder_award_id":"R01GM123312","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310017","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382631765.pdf","grobid_xml":"https://content.openalex.org/works/W4382631765.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1450574606","https://openalex.org/W1519765314","https://openalex.org/W1573708901","https://openalex.org/W1593675552","https://openalex.org/W1605738254","https://openalex.org/W1795473064","https://openalex.org/W1963658914","https://openalex.org/W1973503110","https://openalex.org/W1974450462","https://openalex.org/W1979204453","https://openalex.org/W1980480427","https://openalex.org/W1981106668","https://openalex.org/W1984783889","https://openalex.org/W1999364887","https://openalex.org/W2016491299","https://openalex.org/W2024366778","https://openalex.org/W2034815580","https://openalex.org/W2050913592","https://openalex.org/W2051058497","https://openalex.org/W2073722866","https://openalex.org/W2073921172","https://openalex.org/W2082408200","https://openalex.org/W2083703501","https://openalex.org/W2110065044","https://openalex.org/W2111705979","https://openalex.org/W2119360625","https://openalex.org/W2122646361","https://openalex.org/W2126466006","https://openalex.org/W2132341951","https://openalex.org/W2135542964","https://openalex.org/W2146470833","https://openalex.org/W2156094594","https://openalex.org/W2160336344","https://openalex.org/W2169745877","https://openalex.org/W2173267258","https://openalex.org/W2197471232","https://openalex.org/W2290989326","https://openalex.org/W2346680365","https://openalex.org/W2410310292","https://openalex.org/W2520749639","https://openalex.org/W2521004200","https://openalex.org/W2590835604","https://openalex.org/W2605455299","https://openalex.org/W2730926509","https://openalex.org/W2757169940","https://openalex.org/W2766679495","https://openalex.org/W2787900975","https://openalex.org/W2790527784","https://openalex.org/W2791375414","https://openalex.org/W2792536738","https://openalex.org/W2899614295","https://openalex.org/W2914466374","https://openalex.org/W2946262652","https://openalex.org/W2949071111","https://openalex.org/W2951434717","https://openalex.org/W2981145358","https://openalex.org/W3103797389","https://openalex.org/W3126007358","https://openalex.org/W3133091493","https://openalex.org/W3190118369","https://openalex.org/W3207867081","https://openalex.org/W3210810625","https://openalex.org/W3213101281","https://openalex.org/W4205752547","https://openalex.org/W4214811766","https://openalex.org/W4220850832","https://openalex.org/W4220999759","https://openalex.org/W4221083838","https://openalex.org/W4303438003","https://openalex.org/W6635447235","https://openalex.org/W6749232200"],"related_works":["https://openalex.org/W2774675543","https://openalex.org/W2119052929","https://openalex.org/W2326282944","https://openalex.org/W2330402197","https://openalex.org/W3197006535","https://openalex.org/W3201371206","https://openalex.org/W2420153309","https://openalex.org/W2107323267","https://openalex.org/W2589591413","https://openalex.org/W2096970964"],"abstract_inverted_index":{"Abstract":[0],"Motivation":[1],"Non-canonical":[2],"(or":[3],"non-B)":[4],"DNA":[5,19,51,59,106,139,178,182,220],"are":[6,29,40,63],"genomic":[7,32],"regions":[8],"whose":[9],"three-dimensional":[10],"conformation":[11],"deviates":[12],"from":[13,108,206,221],"the":[14,99,122,151,175,189],"canonical":[15],"double":[16],"helix.":[17],"Non-B":[18],"play":[20],"an":[21,76,124],"important":[22],"role":[23],"in":[24],"basic":[25],"cellular":[26],"processes":[27],"and":[28,36,42,78,120,144,203,227],"associated":[30],"with":[31,185,196],"instability,":[33],"gene":[34],"regulation,":[35],"oncogenesis.":[37],"Experimental":[38,212],"methods":[39,55,199],"low-throughput":[41],"can":[43,89],"detect":[44],"only":[45],"a":[46,116,132,207],"limited":[47],"set":[48],"of":[49,69,153,165,177,191,218],"non-B":[50,58,70,94,105,113,138,157,181,219],"structures,":[52],"while":[53],"computational":[54,101],"rely":[56],"on":[57,160],"base":[60],"motifs,":[61],"which":[62],"necessary":[64],"but":[65,81],"not":[66],"sufficient":[67],"indicators":[68],"structures.":[71,95,158],"Oxford":[72],"Nanopore":[73],"sequencing":[74,164,223],"is":[75,83,224,231],"efficient":[77],"low-cost":[79],"platform,":[80],"it":[82],"currently":[84],"unknown":[85],"whether":[86],"nanopore":[87,109,163,222],"reads":[88],"be":[90,141],"used":[91],"for":[92,150,180],"identifying":[93],"Results":[96],"We":[97,111,187],"build":[98],"first":[100],"pipeline":[102],"to":[103,140],"predict":[104],"structures":[107],"sequencing.":[110],"formalize":[112],"detection":[114,118,198,217],"as":[115,131],"novelty":[117,197],"problem":[119],"develop":[121],"GoFAE-DND,":[123],"autoencoder":[125],"that":[126,155,169,215],"uses":[127],"goodness-of-fit":[128],"(GoF)":[129],"tests":[130,148],"regularizer.":[133],"A":[134],"discriminative":[135],"loss":[136],"encourages":[137],"poorly":[142],"reconstructed":[143],"optimizing":[145],"Gaussian":[146],"GoF":[147],"allows":[149],"computation":[152],"P-values":[154],"indicate":[156],"Based":[159],"whole":[161],"genome":[162],"NA12878,":[166],"we":[167],"show":[168],"there":[170],"exist":[171],"significant":[172],"differences":[173],"between":[174],"timing":[176],"translocation":[179,209],"bases":[183],"compared":[184],"B-DNA.":[186],"demonstrate":[188],"efficacy":[190],"our":[192],"approach":[193],"through":[194],"comparisons":[195],"using":[200],"experimental":[201],"data":[202,204],"synthesized":[205],"new":[208],"time":[210],"simulator.":[211],"validations":[213],"suggest":[214],"reliable":[216],"achievable.":[225],"Availability":[226],"implementation":[228],"Source":[229],"code":[230],"available":[232],"at":[233],"https://github.com/bayesomicslab/ONT-nonb-GoFAE-DND.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
