{"id":"https://openalex.org/W4316926578","doi":"https://doi.org/10.1093/bioinformatics/btad023","title":"A unified mediation analysis framework for integrative cancer proteogenomics with clinical outcomes","display_name":"A unified mediation analysis framework for integrative cancer proteogenomics with clinical outcomes","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4316926578","doi":"https://doi.org/10.1093/bioinformatics/btad023","pmid":"https://pubmed.ncbi.nlm.nih.gov/36648331"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btad023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad023","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btad023/48909281/btad023.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btad023/48909281/btad023.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048280160","display_name":"Licai Huang","orcid":"https://orcid.org/0000-0002-5087-9661"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Licai Huang","raw_affiliation_strings":["Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069261710","display_name":"James P. Long","orcid":"https://orcid.org/0000-0001-5853-5938"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P Long","raw_affiliation_strings":["Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013889074","display_name":"Ehsan Irajizad","orcid":"https://orcid.org/0000-0001-7510-4849"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ehsan Irajizad","raw_affiliation_strings":["Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017855145","display_name":"James D. Doecke","orcid":"https://orcid.org/0000-0003-2863-0293"},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James D Doecke","raw_affiliation_strings":["CSIRO, Royal Brisbane and Women\u2019s Hospital , Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIRO, Royal Brisbane and Women\u2019s Hospital , Brisbane, Australia","institution_ids":["https://openalex.org/I1292875679","https://openalex.org/I2799393793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110946485","display_name":"Kim\u2010Anh Do","orcid":null},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim-Anh Do","raw_affiliation_strings":["Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039812679","display_name":"Min Jin Ha","orcid":"https://orcid.org/0000-0002-5165-1642"},"institutions":[{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Min Jin Ha","raw_affiliation_strings":["Department of Health Informatics and Biostatistics, Graduate School of Public Health, Yonsei University , Seoul, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-5165-1642","affiliations":[{"raw_affiliation_string":"Department of Health Informatics and Biostatistics, Graduate School of Public Health, Yonsei University , Seoul, South Korea","institution_ids":["https://openalex.org/I4210160791"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039812679"],"corresponding_institution_ids":["https://openalex.org/I4210160791"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.4615,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.56269721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"39","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.45249998569488525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.45249998569488525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.0925000011920929,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6507018208503723},{"id":"https://openalex.org/keywords/proteogenomics","display_name":"Proteogenomics","score":0.5840927958488464},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.527249276638031},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.5146151781082153},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41594403982162476},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35851359367370605},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3561542332172394},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.32180771231651306},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.23002466559410095},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19877025485038757},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.14723899960517883},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11123761534690857}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6507018208503723},{"id":"https://openalex.org/C145741570","wikidata":"https://www.wikidata.org/wiki/Q7251534","display_name":"Proteogenomics","level":5,"score":0.5840927958488464},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.527249276638031},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5146151781082153},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41594403982162476},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35851359367370605},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3561542332172394},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.32180771231651306},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.23002466559410095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19877025485038757},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.14723899960517883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11123761534690857},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071696","descriptor_name":"Proteogenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071696","descriptor_name":"Proteogenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071696","descriptor_name":"Proteogenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btad023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad023","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btad023/48909281/btad023.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36648331","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36648331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/194252","is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/194252","pdf_url":"https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/194252/1/T202302781.pdf","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9879726","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9879726","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9879726/pdf/btad023.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-1604","is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/612","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btad023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad023","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btad023/48909281/btad023.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G111615301","display_name":null,"funder_award_id":"P30 CA-016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1299990199","display_name":"Cancer Center Support Grant","funder_award_id":"3p30ca016672-48s2","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1620252213","display_name":"Center for Clinical and Translational Sciences (CCTS)","funder_award_id":"4ul1tr000371-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1792693341","display_name":null,"funder_award_id":"2022R1A2C1091488","funder_id":"https://openalex.org/F4320309788","funder_display_name":"Neurosciences Research Foundation"},{"id":"https://openalex.org/G21757800","display_name":null,"funder_award_id":"R01CA244845","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G281054136","display_name":"Administrative Core","funder_award_id":"3p50ca140388-10s1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G293715275","display_name":null,"funder_award_id":"P30-CA-016672","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G313027747","display_name":null,"funder_award_id":"5R21CA220299","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G339710222","display_name":null,"funder_award_id":"(P50-CA140388","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3555276392","display_name":"Bayesian Network-Based Integrative Genomics Methods for Precision Medicine","funder_award_id":"5r01ca244845-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3929693838","display_name":null,"funder_award_id":"P50CA140388","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G4276892241","display_name":null,"funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G5058533386","display_name":"Acute Myeloid Leukemia in the Immunosuppressed Microenvironment","funder_award_id":"RP160693","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G5801258847","display_name":"Biostatistics and Bioinformatics Core (Core C)","funder_award_id":"2p50ca127001-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G580208524","display_name":null,"funder_award_id":"UL1-TR000371","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G600474485","display_name":null,"funder_award_id":"P50-CA127001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6117660909","display_name":null,"funder_award_id":"R01CA244845-03","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7178484890","display_name":null,"funder_award_id":"2022R1A2C1091488","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G7489013827","display_name":null,"funder_award_id":"R01CA244845-01A1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8931720913","display_name":null,"funder_award_id":"TR000371","funder_id":"https://openalex.org/F4320332990","funder_display_name":"Center for Clinical and Translational Science, University of Utah"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320309788","display_name":"Neurosciences Research Foundation","ror":"https://ror.org/05exfab56"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321314","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320332990","display_name":"Center for Clinical and Translational Science, University of Utah","ror":"https://ror.org/03r0ha626"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4316926578.pdf"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W45518098","https://openalex.org/W169627897","https://openalex.org/W1606650805","https://openalex.org/W1929501557","https://openalex.org/W1971440513","https://openalex.org/W1973285887","https://openalex.org/W1974906010","https://openalex.org/W1979340580","https://openalex.org/W1979676475","https://openalex.org/W1987493079","https://openalex.org/W1995945562","https://openalex.org/W1998203489","https://openalex.org/W2001820152","https://openalex.org/W2005299121","https://openalex.org/W2010143351","https://openalex.org/W2010522003","https://openalex.org/W2011284201","https://openalex.org/W2014096417","https://openalex.org/W2020299969","https://openalex.org/W2026433130","https://openalex.org/W2046253393","https://openalex.org/W2046434400","https://openalex.org/W2057802075","https://openalex.org/W2078205316","https://openalex.org/W2084701241","https://openalex.org/W2097360283","https://openalex.org/W2108754368","https://openalex.org/W2130448611","https://openalex.org/W2132617827","https://openalex.org/W2138044466","https://openalex.org/W2143891888","https://openalex.org/W2157076315","https://openalex.org/W2157983986","https://openalex.org/W2159482845","https://openalex.org/W2160680909","https://openalex.org/W2259708582","https://openalex.org/W2335012284","https://openalex.org/W2463887981","https://openalex.org/W2531563875","https://openalex.org/W2607129810","https://openalex.org/W2626606138","https://openalex.org/W2738632062","https://openalex.org/W2765219164","https://openalex.org/W2766173132","https://openalex.org/W2795989238","https://openalex.org/W2807747040","https://openalex.org/W2890737229","https://openalex.org/W2895138060","https://openalex.org/W2898932164","https://openalex.org/W2913808025","https://openalex.org/W2939357350","https://openalex.org/W2973742719","https://openalex.org/W3021499551","https://openalex.org/W3098193298","https://openalex.org/W3098536600","https://openalex.org/W3107527779","https://openalex.org/W3151381390","https://openalex.org/W3191177528","https://openalex.org/W3210373320","https://openalex.org/W4200399550","https://openalex.org/W4292811746","https://openalex.org/W4294216483","https://openalex.org/W4294541781","https://openalex.org/W6601833752","https://openalex.org/W6683300772","https://openalex.org/W6754616560","https://openalex.org/W6784821266","https://openalex.org/W6805423377"],"related_works":["https://openalex.org/W2968156700","https://openalex.org/W2291098850","https://openalex.org/W2061992841","https://openalex.org/W2916022525","https://openalex.org/W4386856376","https://openalex.org/W2026433130","https://openalex.org/W3113006606","https://openalex.org/W4307776416","https://openalex.org/W2091921928","https://openalex.org/W2144791567"],"abstract_inverted_index":{"MOTIVATION:":[0],"Multilevel":[1],"molecular":[2,63],"profiling":[3,64],"of":[4,18,55,90,136,143],"tumors":[5],"and":[6,32,97,119,141,162,173],"the":[7,34,111,163],"integrative":[8],"analysis":[9,22,76],"with":[10,66],"clinical":[11,176],"outcomes":[12,169],"have":[13],"enabled":[14],"a":[15,26,39,48,73,134],"deeper":[16],"characterization":[17],"cancer":[19],"treatment.":[20],"Mediation":[21],"has":[23],"emerged":[24],"as":[25,92,110],"promising":[27],"statistical":[28],"tool":[29],"to":[30,51,126],"identify":[31,155],"quantify":[33],"intermediate":[35],"mechanisms":[36,165],"by":[37,160],"which":[38],"gene":[40],"affects":[41],"an":[42,186],"outcome.":[43],"However,":[44],"existing":[45],"methods":[46,128],"lack":[47],"unified":[49],"approach":[50,125],"handle":[52],"various":[53,88,167],"types":[54],"outcome":[56],"variables,":[57],"making":[58],"them":[59],"unsuitable":[60],"for":[61,78,94],"high-throughput":[62],"data":[65,80,193],"highly":[67],"interconnected":[68],"variables.":[69],"RESULTS:":[70],"We":[71,122],"develop":[72],"general":[74],"mediation":[75],"framework":[77],"proteogenomic":[79,152],"that":[81,157,170],"include":[82],"multiple":[83,117],"exposures,":[84],"multivariate":[85],"mediators":[86],"on":[87,106,166],"scales":[89],"effects":[91],"appropriate":[93],"continuous,":[95],"binary":[96],"survival":[98,168],"outcomes.":[99],"Our":[100],"estimation":[101],"method":[102],"avoids":[103],"imposing":[104],"constraints":[105],"model":[107],"parameters":[108],"such":[109],"rare":[112],"disease":[113,139],"assumption,":[114],"while":[115],"accommodating":[116],"exposures":[118],"high-dimensional":[120],"mediators.":[121,145],"compare":[123],"our":[124],"other":[127],"in":[129,185],"extensive":[130],"simulation":[131],"studies":[132],"at":[133,196],"range":[135],"sample":[137],"sizes,":[138],"prevalence":[140],"number":[142],"false":[144],"Using":[146],"kidney":[147],"renal":[148],"clear":[149],"cell":[150],"carcinoma":[151],"data,":[153],"we":[154],"genes":[156],"are":[158,194],"mediated":[159],"proteins":[161],"underlying":[164],"capture":[171],"short-":[172],"long-term":[174],"disease-specific":[175],"characteristics.":[177],"AVAILABILITY":[178],"AND":[179],"IMPLEMENTATION:":[180],"Software":[181],"is":[182],"made":[183],"available":[184,195],"R":[187],"package":[188],"(https://github.com/longjp/mediateR).":[189],"SUPPLEMENTARY":[190],"INFORMATION:":[191],"Supplementary":[192],"Bioinformatics":[197],"online.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}