{"id":"https://openalex.org/W4313857235","doi":"https://doi.org/10.1093/bioinformatics/btad005","title":"A multi-view latent variable model reveals cellular heterogeneity in complex tissues for paired multimodal single-cell data","display_name":"A multi-view latent variable model reveals cellular heterogeneity in complex tissues for paired multimodal single-cell data","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4313857235","doi":"https://doi.org/10.1093/bioinformatics/btad005","pmid":"https://pubmed.ncbi.nlm.nih.gov/36622018"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btad005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad005","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btad005/48805301/btad005.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btad005/48805301/btad005.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100402317","display_name":"Yuwei Wang","orcid":"https://orcid.org/0000-0001-5782-1107"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuwei Wang","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070467379","display_name":"Bin Lian","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Lian","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102993465","display_name":"Haohui Zhang","orcid":"https://orcid.org/0009-0007-7394-8555"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haohui Zhang","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014008160","display_name":"Yuanke Zhong","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanke Zhong","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081773147","display_name":"Jie He","orcid":"https://orcid.org/0000-0002-7136-4181"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie He","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Peking University Health Science Center , Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Peking University Health Science Center , Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086114121","display_name":"Fashuai Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I1318643470","display_name":"Union Hospital","ror":"https://ror.org/01j7r2734","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1318643470"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fashuai Wu","raw_affiliation_strings":["Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China","institution_ids":["https://openalex.org/I1318643470","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078948324","display_name":"Knut Reinert","orcid":"https://orcid.org/0000-0003-3078-8129"},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Knut Reinert","raw_affiliation_strings":["Institut f\u00fcr Informatik, Freie Universit\u00e4t Berlin , 14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Informatik, Freie Universit\u00e4t Berlin , 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009944817","display_name":"Xuequn Shang","orcid":"https://orcid.org/0000-0002-7249-8210"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuequn Shang","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086704736","display_name":"Hui Yang","orcid":"https://orcid.org/0000-0001-7567-3048"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Yang","raw_affiliation_strings":["School of Life Science, Northwestern Polytechnical University , Shaanxi 710072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, Northwestern Polytechnical University , Shaanxi 710072, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018634374","display_name":"Jialu Hu","orcid":"https://orcid.org/0000-0002-3351-8020"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jialu Hu","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China"],"raw_orcid":"https://orcid.org/0000-0002-3351-8020","affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University , Shaanxi 710129, China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018634374"],"corresponding_institution_ids":["https://openalex.org/I17145004"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.96,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.91143749,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"39","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7982838153839111},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.666254460811615},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5991296768188477},{"id":"https://openalex.org/keywords/latent-variable","display_name":"Latent variable","score":0.5725799202919006},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.5467369556427002},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5374155044555664},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.5230542421340942},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.46972477436065674},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.42752766609191895},{"id":"https://openalex.org/keywords/canonical-correlation","display_name":"Canonical correlation","score":0.4148361086845398},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3509184718132019}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7982838153839111},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.666254460811615},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5991296768188477},{"id":"https://openalex.org/C51167844","wikidata":"https://www.wikidata.org/wiki/Q4422623","display_name":"Latent variable","level":2,"score":0.5725799202919006},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.5467369556427002},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5374155044555664},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.5230542421340942},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46972477436065674},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.42752766609191895},{"id":"https://openalex.org/C153874254","wikidata":"https://www.wikidata.org/wiki/Q115542","display_name":"Canonical correlation","level":2,"score":0.4148361086845398},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3509184718132019},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btad005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad005","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btad005/48805301/btad005.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36622018","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36622018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9857983","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9857983","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btad005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad005","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btad005/48805301/btad005.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G8581271137","display_name":"\u57fa\u4e8e\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u8bc6\u522b\u8111\u75be\u75c5\u76f8\u5173\u7ec4\u7ec7\u7684\u65b9\u6cd5\u7814\u7a76","funder_award_id":"62072374","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8881024869","display_name":"\u53ef\u53d8\u526a\u63a5\u7f51\u7edc\u6784\u5efa\u4e0e\u5206\u6790\u7814\u7a76","funder_award_id":"61772426","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1602702667","https://openalex.org/W1965863160","https://openalex.org/W2023108658","https://openalex.org/W2029121477","https://openalex.org/W2068881679","https://openalex.org/W2084848470","https://openalex.org/W2103464907","https://openalex.org/W2116474775","https://openalex.org/W2149573463","https://openalex.org/W2259229417","https://openalex.org/W2343821765","https://openalex.org/W2550247089","https://openalex.org/W2605810679","https://openalex.org/W2610509384","https://openalex.org/W2612519453","https://openalex.org/W2613629789","https://openalex.org/W2739492614","https://openalex.org/W2788348358","https://openalex.org/W2793965282","https://openalex.org/W2800392236","https://openalex.org/W2885716250","https://openalex.org/W2887326710","https://openalex.org/W2887910040","https://openalex.org/W2889236955","https://openalex.org/W2898460257","https://openalex.org/W2901677030","https://openalex.org/W2902652978","https://openalex.org/W2907783748","https://openalex.org/W2942678593","https://openalex.org/W2946232537","https://openalex.org/W2948469692","https://openalex.org/W2949177718","https://openalex.org/W2950758817","https://openalex.org/W2950909085","https://openalex.org/W2951799803","https://openalex.org/W2952148401","https://openalex.org/W2979911343","https://openalex.org/W2985765936","https://openalex.org/W2996045117","https://openalex.org/W3023456235","https://openalex.org/W3024013192","https://openalex.org/W3027051073","https://openalex.org/W3046099861","https://openalex.org/W3047392293","https://openalex.org/W3102434595","https://openalex.org/W3129866267","https://openalex.org/W3144696998","https://openalex.org/W3154039181","https://openalex.org/W3164692211","https://openalex.org/W3165484394","https://openalex.org/W3195317458","https://openalex.org/W3201518044","https://openalex.org/W3202112943","https://openalex.org/W3214158901","https://openalex.org/W4200473661","https://openalex.org/W4200581587","https://openalex.org/W4213108508","https://openalex.org/W4220680295","https://openalex.org/W4292722723","https://openalex.org/W4297257598","https://openalex.org/W6677227202","https://openalex.org/W6785192039","https://openalex.org/W6793866186"],"related_works":["https://openalex.org/W1565185441","https://openalex.org/W1968846550","https://openalex.org/W302711736","https://openalex.org/W2313359725","https://openalex.org/W2375550484","https://openalex.org/W3134705486","https://openalex.org/W2121524531","https://openalex.org/W2619932150","https://openalex.org/W2623587241","https://openalex.org/W2156897583"],"abstract_inverted_index":{"MOTIVATION:":[0],"Single-cell":[1],"multimodal":[2,67],"assays":[3],"allow":[4],"us":[5],"to":[6,64,78,142,153,161],"simultaneously":[7],"measure":[8],"two":[9,86,98],"different":[10,87,127],"molecular":[11],"features":[12],"of":[13,43,83,137],"the":[14,37,80],"same":[15],"cell,":[16],"enabling":[17],"new":[18],"insights":[19],"into":[20],"cellular":[21],"heterogeneity,":[22],"cell":[23,47,158,172],"development":[24],"and":[25,97,106,112,145,193],"diseases.":[26],"However,":[27],"most":[28],"existing":[29,117,162],"methods":[30],"suffer":[31],"from":[32],"inaccurate":[33],"dimensionality":[34],"reduction":[35],"for":[36],"joint-modality":[38,138,176],"data,":[39,139],"hindering":[40],"their":[41],"discovery":[42],"novel":[44,155],"or":[45,156],"rare":[46,157],"subpopulations.":[48],"RESULTS:":[49],"Here,":[50],"we":[51],"present":[52],"VIMCCA,":[53],"a":[54,74],"computational":[55],"framework":[56],"based":[57,174],"on":[58,120,175],"variational-assisted":[59],"multi-view":[60],"canonical":[61],"correlation":[62],"analysis":[63],"integrate":[65],"paired":[66,122],"single-cell":[68],"data.":[69],"Our":[70,90],"statistical":[71],"model":[72,96],"uses":[73],"common":[75,81],"latent":[76],"variable":[77],"interpret":[79],"source":[82],"variances":[84],"in":[85,187],"data":[88,207],"modalities.":[89],"approach":[91],"jointly":[92],"learns":[93],"an":[94],"inference":[95,105],"modality-specific":[99],"non-linear":[100],"models":[101],"by":[102,126],"leveraging":[103],"variational":[104],"deep":[107],"learning.":[108],"We":[109],"perform":[110],"VIMCCA":[111,132,149,182],"compare":[113],"it":[114,167],"with":[115],"10":[116],"state-of-the-art":[118],"algorithms":[119],"four":[121],"multi-modal":[123],"datasets":[124],"sequenced":[125],"protocols.":[128],"Results":[129],"demonstrate":[130],"that":[131],"facilitates":[133],"integrating":[134],"various":[135],"types":[136],"thus":[140],"leading":[141],"more":[143],"reliable":[144],"accurate":[146],"downstream":[147],"analysis.":[148],"improves":[150],"our":[151,188],"ability":[152],"identify":[154],"subtypes":[159],"compared":[160],"widely":[163],"used":[164],"methods.":[165],"Besides,":[166],"can":[168],"also":[169],"facilitate":[170],"inferring":[171],"lineage":[173],"profiles.":[177],"AVAILABILITY":[178],"AND":[179],"IMPLEMENTATION:":[180],"The":[181],"algorithm":[183],"has":[184,196],"been":[185,197],"implemented":[186],"toolkit":[189],"package":[190],"scbean":[191],"(\u22650.5.0),":[192],"its":[194],"code":[195],"archived":[198],"at":[199,210],"https://github.com/jhu99/scbean":[200],"under":[201],"MIT":[202],"license.":[203],"SUPPLEMENTARY":[204],"INFORMATION:":[205],"Supplementary":[206],"are":[208],"available":[209],"Bioinformatics":[211],"online.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}