{"id":"https://openalex.org/W4312095267","doi":"https://doi.org/10.1093/bioinformatics/btac818","title":"NetSHy: network summarization via a hybrid approach leveraging topological properties","display_name":"NetSHy: network summarization via a hybrid approach leveraging topological properties","publication_year":2022,"publication_date":"2022-12-20","ids":{"openalex":"https://openalex.org/W4312095267","doi":"https://doi.org/10.1093/bioinformatics/btac818","pmid":"https://pubmed.ncbi.nlm.nih.gov/36548341"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac818","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac818","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btac818/48599788/btac818.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btac818/48599788/btac818.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037463126","display_name":"Thao Vu","orcid":"https://orcid.org/0000-0001-5252-0006"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thao Vu","raw_affiliation_strings":["Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA"],"raw_orcid":"https://orcid.org/0000-0001-5252-0006","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049059003","display_name":"Elizabeth Litkowski","orcid":"https://orcid.org/0000-0002-7079-696X"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth M Litkowski","raw_affiliation_strings":["Department of Epidemiology, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA","Division of Biomedical Informatics & Personalized Medicine, School of Medicine, Colorado University Anschutz Medical Campus , Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Division of Biomedical Informatics & Personalized Medicine, School of Medicine, Colorado University Anschutz Medical Campus , Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101689438","display_name":"Weixuan Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weixuan Liu","raw_affiliation_strings":["Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019860007","display_name":"Katherine Pratte","orcid":"https://orcid.org/0000-0003-3358-8907"},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A Pratte","raw_affiliation_strings":["Department of Biostatistics, National Jewish Health , Denver, CO 80206, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, National Jewish Health , Denver, CO 80206, USA","institution_ids":["https://openalex.org/I3019586173","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114012012","display_name":"Leslie A. Lange","orcid":null},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Lange","raw_affiliation_strings":["Division of Biomedical Informatics & Personalized Medicine, School of Medicine, Colorado University Anschutz Medical Campus , Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Informatics & Personalized Medicine, School of Medicine, Colorado University Anschutz Medical Campus , Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017665414","display_name":"Russell P. Bowler","orcid":"https://orcid.org/0000-0003-4651-363X"},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell P Bowler","raw_affiliation_strings":["Division of Pulmonary Medicine, Department of Medicine, National Jewish Health , Denver, CO 80206, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, Department of Medicine, National Jewish Health , Denver, CO 80206, USA","institution_ids":["https://openalex.org/I3019586173","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007232242","display_name":"Farnoush Banaei\u2010Kashani","orcid":"https://orcid.org/0000-0003-4102-9873"},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farnoush Banaei-Kashani","raw_affiliation_strings":["Department of Computer Science and Engineering, College of Engineering, Design and Computing, University of Colorado Denver , Denver, CO 80204, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, College of Engineering, Design and Computing, University of Colorado Denver , Denver, CO 80204, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022404035","display_name":"Katerina Kechris","orcid":"https://orcid.org/0000-0002-3725-5459"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katerina J Kechris","raw_affiliation_strings":["Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA"],"raw_orcid":"https://orcid.org/0000-0002-3725-5459","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022404035","https://openalex.org/A5037463126"],"corresponding_institution_ids":["https://openalex.org/I51713134"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.5036,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6145439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"39","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8436999917030334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8436999917030334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/automatic-summarization","display_name":"Automatic summarization","score":0.7629309892654419},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7138257026672363},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5724251866340637},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.47992926836013794},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4706116318702698},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.4463987946510315},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.4397299587726593},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.43336617946624756},{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.4260886013507843},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.4153112471103668},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.41256970167160034},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.3765803873538971},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3648056387901306},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2580465078353882},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20584067702293396}],"concepts":[{"id":"https://openalex.org/C170858558","wikidata":"https://www.wikidata.org/wiki/Q1394144","display_name":"Automatic summarization","level":2,"score":0.7629309892654419},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7138257026672363},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5724251866340637},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.47992926836013794},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4706116318702698},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.4463987946510315},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.4397299587726593},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.43336617946624756},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.4260886013507843},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4153112471103668},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.41256970167160034},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3765803873538971},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3648056387901306},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2580465078353882},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20584067702293396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btac818","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac818","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btac818/48599788/btac818.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36548341","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36548341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9831052","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9831052","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btac818","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac818","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btac818/48599788/btac818.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1650503535","display_name":null,"funder_award_id":"R01 HL137995","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2644038179","display_name":null,"funder_award_id":"U01 HL089897","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3039683629","display_name":null,"funder_award_id":"R01 HL152735","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4662854118","display_name":null,"funder_award_id":"U01 HL089897 and U01 HL089856","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5180013511","display_name":null,"funder_award_id":"R01 HL137995","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5258357286","display_name":null,"funder_award_id":"HL089897","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5400420060","display_name":null,"funder_award_id":"HL089897","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5419488334","display_name":null,"funder_award_id":"R01 HL152735","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5861375725","display_name":null,"funder_award_id":"U01 HL089856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6257285610","display_name":null,"funder_award_id":"U01 HL089856","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6470844488","display_name":null,"funder_award_id":"U01 HL089897","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7948161897","display_name":null,"funder_award_id":"HL089856","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G820522361","display_name":null,"funder_award_id":"U01 HL089897 and U01 HL089856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8354759825","display_name":null,"funder_award_id":"HL089856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320310320","display_name":"COPD Foundation","ror":"https://ror.org/02qfkky73"},{"id":"https://openalex.org/F4320311407","display_name":"Sunovion","ror":"https://ror.org/030zc7t66"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312095267.pdf","grobid_xml":"https://content.openalex.org/works/W4312095267.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W229097380","https://openalex.org/W642687531","https://openalex.org/W1966327575","https://openalex.org/W1994761691","https://openalex.org/W2001141328","https://openalex.org/W2005623173","https://openalex.org/W2016474243","https://openalex.org/W2018045523","https://openalex.org/W2048697400","https://openalex.org/W2057626690","https://openalex.org/W2060705109","https://openalex.org/W2066531004","https://openalex.org/W2084373725","https://openalex.org/W2088891952","https://openalex.org/W2097308346","https://openalex.org/W2104783138","https://openalex.org/W2108678383","https://openalex.org/W2109652029","https://openalex.org/W2153768000","https://openalex.org/W2165009258","https://openalex.org/W2254563062","https://openalex.org/W2493614923","https://openalex.org/W2510773831","https://openalex.org/W2759319697","https://openalex.org/W2790295707","https://openalex.org/W2888838927","https://openalex.org/W2938032333","https://openalex.org/W2950434449","https://openalex.org/W2962756421","https://openalex.org/W2963224980","https://openalex.org/W2970771711","https://openalex.org/W2971862671","https://openalex.org/W2980263986","https://openalex.org/W2997574889","https://openalex.org/W2998800236","https://openalex.org/W3014057592","https://openalex.org/W3142570770","https://openalex.org/W4210298886","https://openalex.org/W4212774754","https://openalex.org/W4241598686","https://openalex.org/W6608852248","https://openalex.org/W6671650193","https://openalex.org/W6681096077","https://openalex.org/W6793127252"],"related_works":["https://openalex.org/W1995622179","https://openalex.org/W1484111231","https://openalex.org/W4391160746","https://openalex.org/W1552543208","https://openalex.org/W2074396517","https://openalex.org/W2166963679","https://openalex.org/W2187269125","https://openalex.org/W1641615907","https://openalex.org/W3089231081","https://openalex.org/W2093956241"],"abstract_inverted_index":{"MOTIVATION:":[0],"Biological":[1],"networks":[2,14,176,221,267],"can":[3],"provide":[4],"a":[5,16,58,62,109,120,143,163,166,205,211,233,247,257],"system-level":[6],"understanding":[7],"of":[8,19,24,26,60,89,115,119,130,145,199,207,214,227,256,285],"underlying":[9],"processes.":[10],"In":[11,43,103,134],"many":[12],"contexts,":[13],"have":[15],"high":[17],"degree":[18],"modularity,":[20],"i.e.":[21],"they":[22],"consist":[23],"subsets":[25],"nodes,":[27],"often":[28,75],"known":[29],"as":[30,241,253],"subnetworks":[31],"or":[32],"modules,":[33],"which":[34,112],"are":[35,222,295],"highly":[36],"interconnected":[37],"and":[38,57,71,149,174,181,209],"may":[39],"perform":[40,46],"separate":[41],"functions.":[42],"order":[44],"to":[45,49,126,161],"subsequent":[47],"analyses":[48],"investigate":[50],"the":[51,54,68,87,90,93,97,117,128,131,146,150,157,188,201,218,238,242,265,275],"association":[52,249],"between":[53],"identified":[55],"module":[56,63],"variable":[59],"interest,":[61],"summarization,":[64],"that":[65,185],"best":[66],"explains":[67],"module's":[69],"information":[70],"reduces":[72],"dimensionality":[73],"is":[74,113,229,251,287],"needed.":[76],"Conventional":[77],"approaches":[78],"for":[79],"obtaining":[80],"network":[81,94,99,121,158,179,277],"representation":[82],"typically":[83],"rely":[84],"only":[85],"on":[86,142,172,194,264],"profiles":[88,148],"nodes":[91],"within":[92],"while":[95,122],"disregarding":[96],"inherent":[98],"topological":[100,124],"information.":[101],"RESULTS:":[102],"this":[104],"article,":[105],"we":[106],"propose":[107],"NetSHy,":[108],"hybrid":[110],"approach":[111,191],"capable":[114],"reducing":[116],"dimension":[118],"incorporating":[123],"properties":[125],"aid":[127],"interpretation":[129],"downstream":[132,258],"analyses.":[133],"particular,":[135],"NetSHy":[136,186,228,261,286],"applies":[137],"principal":[138],"component":[139],"analysis":[140],"(PCA)":[141],"combination":[144],"node":[147,195],"well-known":[151],"Laplacian":[152],"matrix":[153,160],"derived":[154],"directly":[155,193],"from":[156],"similarity":[159],"extract":[162],"summarization":[164,262],"at":[165,177,289,297],"subject":[167],"level.":[168],"Simulation":[169],"scenarios":[170],"based":[171],"random":[173],"empirical":[175],"varying":[178],"sizes":[180],"sparsity":[182],"levels":[183],"show":[184],"outperforms":[187],"conventional":[189,276],"PCA":[190],"applied":[192],"profiles,":[196],"in":[197,217],"terms":[198],"recovering":[200],"true":[202],"correlation":[203,236],"with":[204,237],"phenotype":[206,240],"interest":[208],"maintaining":[210],"higher":[212],"amount":[213],"explained":[215],"variation":[216],"data":[219,294],"when":[220],"relatively":[223],"sparse.":[224],"The":[225],"robustness":[226],"also":[230],"demonstrated":[231],"by":[232],"more":[234,269],"consistent":[235],"observed":[239],"sample":[243],"size":[244],"decreases.":[245],"Lastly,":[246],"genome-wide":[248],"study":[250],"performed":[252],"an":[254],"application":[255],"analysis,":[259],"where":[260],"scores":[263],"biological":[266],"identify":[268],"significant":[270],"single":[271],"nucleotide":[272],"polymorphisms":[273],"than":[274],"representation.":[278],"AVAILABILITY":[279],"AND":[280],"IMPLEMENTATION:":[281],"R":[282],"code":[283],"implementation":[284],"available":[288,296],"https://github.com/thaovu1/NetSHy.":[290],"SUPPLEMENTARY":[291],"INFORMATION:":[292],"Supplementary":[293],"Bioinformatics":[298],"online.":[299]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}