{"id":"https://openalex.org/W4312094511","doi":"https://doi.org/10.1093/bioinformatics/btac815","title":"konnect2prot: a web application to explore the protein properties in a functional protein\u2013protein interaction network","display_name":"konnect2prot: a web application to explore the protein properties in a functional protein\u2013protein interaction network","publication_year":2022,"publication_date":"2022-12-20","ids":{"openalex":"https://openalex.org/W4312094511","doi":"https://doi.org/10.1093/bioinformatics/btac815","pmid":"https://pubmed.ncbi.nlm.nih.gov/36545703"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac815","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac815","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btac815/48763716/btac815.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btac815/48763716/btac815.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067404507","display_name":"Shivam Kumar","orcid":null},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shivam Kumar","raw_affiliation_strings":["Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076905376","display_name":"Dipanka Tanu Sarmah","orcid":null},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dipanka Tanu Sarmah","raw_affiliation_strings":["Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035806483","display_name":"Shailendra Asthana","orcid":"https://orcid.org/0000-0002-6143-7500"},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shailendra Asthana","raw_affiliation_strings":["Non-communicable Disease Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Non-communicable Disease Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082491317","display_name":"Samrat Chatterjee","orcid":"https://orcid.org/0000-0002-5010-2799"},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Samrat Chatterjee","raw_affiliation_strings":["Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India"],"raw_orcid":"https://orcid.org/0000-0002-5010-2799","affiliations":[{"raw_affiliation_string":"Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India","institution_ids":["https://openalex.org/I2801880299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082491317"],"corresponding_institution_ids":["https://openalex.org/I2801880299"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.8394,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.71040267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"39","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9767000079154968,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9767000079154968,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6845917105674744},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.5952262878417969},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.5715683698654175},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5351022481918335},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5276614427566528},{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.48674821853637695},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4604663550853729},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.4190611243247986},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32168200612068176},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.24439489841461182},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.22930842638015747},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.19620868563652039},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13657048344612122},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11922040581703186},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.11764088273048401}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6845917105674744},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.5952262878417969},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.5715683698654175},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5351022481918335},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5276614427566528},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.48674821853637695},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4604663550853729},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.4190611243247986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32168200612068176},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.24439489841461182},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.22930842638015747},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.19620868563652039},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13657048344612122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11922040581703186},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.11764088273048401},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btac815","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac815","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btac815/48763716/btac815.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36545703","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36545703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9848060","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9848060","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btac815","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac815","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/1/btac815/48763716/btac815.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.4300000071525574,"id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G1185306214","display_name":null,"funder_award_id":"BT/PR15426/BRB/10/1459/2015","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312094511.pdf","grobid_xml":"https://content.openalex.org/works/W4312094511.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1611787727","https://openalex.org/W1791453308","https://openalex.org/W2009274826","https://openalex.org/W2052685738","https://openalex.org/W2070050178","https://openalex.org/W2095867585","https://openalex.org/W2122863289","https://openalex.org/W2129793061","https://openalex.org/W2130479394","https://openalex.org/W2132820240","https://openalex.org/W2140141454","https://openalex.org/W2155320925","https://openalex.org/W2155723007","https://openalex.org/W2159482845","https://openalex.org/W2180749449","https://openalex.org/W2228293239","https://openalex.org/W2406531951","https://openalex.org/W2526413677","https://openalex.org/W2604078450","https://openalex.org/W2751476102","https://openalex.org/W2761023110","https://openalex.org/W2772848669","https://openalex.org/W2884922228","https://openalex.org/W2910111050","https://openalex.org/W2949159188","https://openalex.org/W2950458545","https://openalex.org/W2962890993","https://openalex.org/W2969166296","https://openalex.org/W2982368177","https://openalex.org/W2983166786","https://openalex.org/W3034181846","https://openalex.org/W3038811628","https://openalex.org/W3081923621","https://openalex.org/W3093053585","https://openalex.org/W3098280565","https://openalex.org/W3100129010","https://openalex.org/W3101161631","https://openalex.org/W3107527779","https://openalex.org/W3107626709","https://openalex.org/W3111820675","https://openalex.org/W3113405673","https://openalex.org/W3120405310","https://openalex.org/W3138055079","https://openalex.org/W3160779055","https://openalex.org/W3184729641","https://openalex.org/W3205489811","https://openalex.org/W3206137635","https://openalex.org/W4250461336","https://openalex.org/W4294216483","https://openalex.org/W4397029089","https://openalex.org/W6691344902","https://openalex.org/W6746269460","https://openalex.org/W6770440696","https://openalex.org/W7073870358"],"related_works":["https://openalex.org/W2168157678","https://openalex.org/W2343879804","https://openalex.org/W2075963387","https://openalex.org/W2147566730","https://openalex.org/W34260016","https://openalex.org/W2023465156","https://openalex.org/W2810151076","https://openalex.org/W2095780712","https://openalex.org/W2127864418","https://openalex.org/W2049735364"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,211],"regulation":[2],"of":[3,66,113,130],"proteins":[4,29,95],"governs":[5],"the":[6,13,28,45,63,73,93,104,127,131,173,181,195,208],"biological":[7,99],"processes":[8,163],"and":[9,49,96,100,123,146,159,164,168,170,183],"functions":[10],"and,":[11],"therefore,":[12],"organisms'":[14],"phenotype.":[15],"So":[16],"there":[17],"is":[18,204,214],"an":[19,57],"unmet":[20],"need":[21],"for":[22,26,139],"a":[23,32,39,67,80,110,120,136,150],"systematic":[24],"tool":[25],"identifying":[27],"that":[30,60],"play":[31],"crucial":[33],"role":[34],"in":[35,38,103,172,180],"information":[36,148],"processing":[37],"protein-protein":[40],"interaction":[41],"(PPI)":[42],"network.":[43,105,175],"However,":[44],"current":[46],"protein":[47,154],"databases":[48],"web":[50,81],"servers":[51],"still":[52],"lag":[53],"behind":[54],"to":[55,71,186,189],"provide":[56],"end-to-end":[58],"pipeline":[59],"can":[61,86,193],"leverage":[62],"topological":[64,101],"understanding":[65],"context-specific":[68,88],"PPI":[69,90,140],"network":[70,91,182],"identify":[72],"influential":[74],"spreaders.":[75],"Addressing":[76],"this,":[77],"we":[78],"developed":[79],"application,":[82],"'konnect2prot'":[83],"(k2p),":[84],"which":[85],"generate":[87],"directional":[89,174],"from":[92],"input":[94],"detect":[97],"their":[98],"importance":[102],"RESULTS:":[106],"We":[107],"pooled":[108],"together":[109],"large":[111],"amount":[112],"ontological":[114],"knowledge,":[115],"parsed":[116],"it":[117],"down":[118],"into":[119,126],"functional":[121],"network,":[122],"gained":[124],"insight":[125],"molecular":[128],"underpinnings":[129],"disease":[132,156,187,196],"development":[133],"by":[134],"creating":[135],"one-stop":[137],"junction":[138],"data.":[141],"k2p":[142],"contains":[143],"both":[144],"local":[145],"global":[147],"about":[149],"protein,":[151],"such":[152],"as":[153],"class,":[155],"mutations,":[157],"ligands":[158],"PDB":[160],"structure,":[161],"enriched":[162],"pathways,":[165],"multi-disease":[166],"interactome":[167],"hubs":[169],"bottlenecks":[171],"It":[176],"also":[177],"identifies":[178],"spreaders":[179],"maps":[184],"them":[185],"hallmarks":[188],"determine":[190],"whether":[191],"they":[192],"affect":[194],"state":[197],"or":[198],"not.":[199],"AVAILABILITY":[200],"AND":[201],"IMPLEMENTATION:":[202],"konnect2prot":[203],"freely":[205],"accessible":[206],"using":[207],"link":[209],"https://konnect2prot.thsti.in.":[210],"code":[212],"repository":[213],"https://github.com/samrat-lab/k2p_bioinfo-2022.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-18T08:10:14.011955","created_date":"2025-10-10T00:00:00"}