{"id":"https://openalex.org/W4288068292","doi":"https://doi.org/10.1093/bioinformatics/btac515","title":"Best templates outperform homology models in predicting the impact of mutations on protein stability","display_name":"Best templates outperform homology models in predicting the impact of mutations on protein stability","publication_year":2022,"publication_date":"2022-07-27","ids":{"openalex":"https://openalex.org/W4288068292","doi":"https://doi.org/10.1093/bioinformatics/btac515","pmid":"https://pubmed.ncbi.nlm.nih.gov/35894930"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac515","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac515","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022074179","display_name":"Marina A. Pak","orcid":"https://orcid.org/0000-0003-1075-6509"},"institutions":[{"id":"https://openalex.org/I125989756","display_name":"Skolkovo Institute of Science and Technology","ror":"https://ror.org/03f9nc143","country_code":"RU","type":"education","lineage":["https://openalex.org/I125989756"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Marina A Pak","raw_affiliation_strings":["Center of Life Sciences, Skolkovo Institute of Science and Technology , Moscow 121205, Russia"],"affiliations":[{"raw_affiliation_string":"Center of Life Sciences, Skolkovo Institute of Science and Technology , Moscow 121205, Russia","institution_ids":["https://openalex.org/I125989756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028642432","display_name":"Dmitry N. Ivankov","orcid":"https://orcid.org/0000-0002-8224-4118"},"institutions":[{"id":"https://openalex.org/I125989756","display_name":"Skolkovo Institute of Science and Technology","ror":"https://ror.org/03f9nc143","country_code":"RU","type":"education","lineage":["https://openalex.org/I125989756"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry N Ivankov","raw_affiliation_strings":["Center of Life Sciences, Skolkovo Institute of Science and Technology , Moscow 121205, Russia"],"affiliations":[{"raw_affiliation_string":"Center of Life Sciences, Skolkovo Institute of Science and Technology , Moscow 121205, Russia","institution_ids":["https://openalex.org/I125989756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022074179"],"corresponding_institution_ids":["https://openalex.org/I125989756"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.8013,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8546139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"38","issue":"18","first_page":"4312","last_page":"4320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/template","display_name":"Template","score":0.7118818163871765},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.5841916799545288},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5160474181175232},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48451441526412964},{"id":"https://openalex.org/keywords/protein-stability","display_name":"Protein stability","score":0.4350394606590271},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.43134114146232605},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.4186152219772339},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38682904839515686},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3815303146839142},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.14173081517219543},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.14012983441352844},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.125531405210495},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.07465419173240662}],"concepts":[{"id":"https://openalex.org/C82714645","wikidata":"https://www.wikidata.org/wiki/Q438331","display_name":"Template","level":2,"score":0.7118818163871765},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.5841916799545288},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5160474181175232},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48451441526412964},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.4350394606590271},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.43134114146232605},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.4186152219772339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38682904839515686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3815303146839142},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.14173081517219543},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.14012983441352844},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.125531405210495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07465419173240662},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btac515","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac515","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35894930","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35894930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1803102843","https://openalex.org/W1985006546","https://openalex.org/W1987134040","https://openalex.org/W2008708467","https://openalex.org/W2055043387","https://openalex.org/W2065283382","https://openalex.org/W2068265376","https://openalex.org/W2081556853","https://openalex.org/W2092387745","https://openalex.org/W2094458603","https://openalex.org/W2097137621","https://openalex.org/W2097632784","https://openalex.org/W2110065044","https://openalex.org/W2130479394","https://openalex.org/W2153457180","https://openalex.org/W2154792548","https://openalex.org/W2168749685","https://openalex.org/W2414282720","https://openalex.org/W2580643247","https://openalex.org/W2799513065","https://openalex.org/W2801491392","https://openalex.org/W2936956377","https://openalex.org/W2937251344","https://openalex.org/W2953906682","https://openalex.org/W2972411752","https://openalex.org/W3012929814","https://openalex.org/W3029583129","https://openalex.org/W3092785324","https://openalex.org/W3109312535","https://openalex.org/W3128959431","https://openalex.org/W3133259203","https://openalex.org/W3136963718","https://openalex.org/W3137341729","https://openalex.org/W3173575423","https://openalex.org/W3177828909","https://openalex.org/W3195021868","https://openalex.org/W4308463927","https://openalex.org/W6800915063","https://openalex.org/W6802074738"],"related_works":["https://openalex.org/W2121300814","https://openalex.org/W4231091074","https://openalex.org/W1886613375","https://openalex.org/W4236081792","https://openalex.org/W4250583430","https://openalex.org/W4234406076","https://openalex.org/W2010731026","https://openalex.org/W3130075881","https://openalex.org/W4387581414","https://openalex.org/W3104156022"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3}],"updated_date":"2025-11-23T05:10:03.516525","created_date":"2025-10-10T00:00:00"}