{"id":"https://openalex.org/W4283581268","doi":"https://doi.org/10.1093/bioinformatics/btac423","title":"Single-cell generalized trend model (scGTM): a flexible and interpretable model of gene expression trend along cell pseudotime","display_name":"Single-cell generalized trend model (scGTM): a flexible and interpretable model of gene expression trend along cell pseudotime","publication_year":2022,"publication_date":"2022-06-27","ids":{"openalex":"https://openalex.org/W4283581268","doi":"https://doi.org/10.1093/bioinformatics/btac423","pmid":"https://pubmed.ncbi.nlm.nih.gov/35758616"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac423","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac423","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/16/3927/49889877/btac423.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/38/16/3927/49889877/btac423.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083630331","display_name":"Elvis Han Cui","orcid":"https://orcid.org/0000-0001-9030-3141"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elvis Han Cui","raw_affiliation_strings":["Department of Biostatistics, University of California , Los Angeles, CA 90095-1772, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of California , Los Angeles, CA 90095-1772, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012370609","display_name":"Dongyuan Song","orcid":"https://orcid.org/0000-0003-1114-1215"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dongyuan Song","raw_affiliation_strings":["Bioinformatics Interdepartmental Ph.D. Program, University of California , Los Angeles, CA 90095-7246, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Interdepartmental Ph.D. Program, University of California , Los Angeles, CA 90095-7246, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050143476","display_name":"Weng Kee Wong","orcid":"https://orcid.org/0000-0001-5568-3054"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weng Kee Wong","raw_affiliation_strings":["Department of Biostatistics, University of California , Los Angeles, CA 90095-1772, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of California , Los Angeles, CA 90095-1772, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045434495","display_name":"Jingyi Jessica Li","orcid":"https://orcid.org/0000-0002-9288-5648"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jingyi Jessica Li","raw_affiliation_strings":["Bioinformatics Interdepartmental Ph.D. Program, University of California , Los Angeles, CA 90095-7246, USA","Department of Biostatistics, University of California , Los Angeles, CA 90095-1772, USA","Department of Computational Medicine, University of California , Los Angeles, CA 90095-1766, USA","Department of Human Genetics, University of California , Los Angeles, CA 90095-7088, USA","Department of Statistics, University of California , Los Angeles, CA 90095-1554, USA"],"raw_orcid":"https://orcid.org/0000-0002-9288-5648","affiliations":[{"raw_affiliation_string":"Bioinformatics Interdepartmental Ph.D. Program, University of California , Los Angeles, CA 90095-7246, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Biostatistics, University of California , Los Angeles, CA 90095-1772, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Computational Medicine, University of California , Los Angeles, CA 90095-1766, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Human Genetics, University of California , Los Angeles, CA 90095-7088, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Statistics, University of California , Los Angeles, CA 90095-1554, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012370609","https://openalex.org/A5045434495"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.5481,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60110446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"38","issue":"16","first_page":"3927","last_page":"3934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.9109091758728027},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6808441877365112},{"id":"https://openalex.org/keywords/nonparametric-statistics","display_name":"Nonparametric statistics","score":0.6499373912811279},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.5727225542068481},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.5060338377952576},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4937766492366791},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4118027687072754},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3404603600502014},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.21947547793388367},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17335733771324158}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.9109091758728027},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6808441877365112},{"id":"https://openalex.org/C102366305","wikidata":"https://www.wikidata.org/wiki/Q1097688","display_name":"Nonparametric statistics","level":2,"score":0.6499373912811279},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5727225542068481},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.5060338377952576},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4937766492366791},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4118027687072754},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3404603600502014},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.21947547793388367},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17335733771324158},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btac423","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac423","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/16/3927/49889877/btac423.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35758616","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35758616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9991897","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9991897","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9dr1v31q","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9dr1v31q","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, vol 38, iss 16","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btac423","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac423","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/16/3927/49889877/btac423.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G164391527","display_name":"Statistical methods for elucidating regulatory mechanisms and functional impacts of transcriptome variation at population and single-cell scales","funder_award_id":"5r35gm140888-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G184584700","display_name":"Collaborative Research: Development of Classification Theory and Methods for Objective Asymmetry, Sample Size Limitation, Labeling Ambiguity, and Feature Importance","funder_award_id":"2113754","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2108729386","display_name":null,"funder_award_id":"R35GM140888","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3105137680","display_name":"CAREER: Advancing the Bioinformatic Infrastructure and Methodology for Single-cell RNA Sequencing","funder_award_id":"1846216","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4211017516","display_name":null,"funder_award_id":"R01 GM120507","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G960741868","display_name":"Robust Identification and accurate quantification of RNA transcripts on a system wide scale","funder_award_id":"5r01gm120507-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337666","display_name":"David Geffen School of Medicine, University of California, Los Angeles","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283581268.pdf","grobid_xml":"https://content.openalex.org/works/W4283581268.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1874466506","https://openalex.org/W1984883254","https://openalex.org/W1993287310","https://openalex.org/W2012186479","https://openalex.org/W2019312328","https://openalex.org/W2059594564","https://openalex.org/W2085316301","https://openalex.org/W2108414494","https://openalex.org/W2119160928","https://openalex.org/W2140258573","https://openalex.org/W2149566602","https://openalex.org/W2373831850","https://openalex.org/W2532141416","https://openalex.org/W2562850749","https://openalex.org/W2747877289","https://openalex.org/W2764302022","https://openalex.org/W2916020270","https://openalex.org/W2951093541","https://openalex.org/W2951799803","https://openalex.org/W2951818953","https://openalex.org/W3009370296","https://openalex.org/W3022482370","https://openalex.org/W3086909323","https://openalex.org/W3091376159","https://openalex.org/W3112717819","https://openalex.org/W3121673678","https://openalex.org/W3159652022","https://openalex.org/W3178601061","https://openalex.org/W3192162026","https://openalex.org/W4225981439","https://openalex.org/W6734069042"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W4390569940","https://openalex.org/W2888392564","https://openalex.org/W4361193272","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W2806259446","https://openalex.org/W2963326959","https://openalex.org/W1986582023","https://openalex.org/W2966829450"],"abstract_inverted_index":{"MOTIVATION:":[0],"Modeling":[1],"single-cell":[2,59,82,171],"gene":[3,138,172,185],"expression":[4,91,139,173,186],"trends":[5,33,113,187],"along":[6,100,188],"cell":[7,101,189],"pseudotime":[8,190],"is":[9,205],"a":[10,62,89],"crucial":[11],"analysis":[12],"for":[13,25,54,87,136,161],"exploring":[14],"biological":[15,56,196],"processes.":[16,197],"Most":[17],"existing":[18,39],"methods":[19,40],"rely":[20],"on":[21],"nonparametric":[22,29,74],"regression":[23,75],"models":[24,30],"their":[26],"flexibility;":[27],"however,":[28],"often":[31],"provide":[32],"too":[34],"complex":[35,144],"to":[36,117,154],"interpret.":[37],"Other":[38],"use":[41,148],"interpretable":[42,124,184],"but":[43],"restrictive":[44],"models.":[45,76],"Since":[46],"model":[47,63,85],"interpretability":[48,67],"and":[49,68,125,128,178,191,207],"flexibility":[50,72],"are":[51,115,122,215],"both":[52],"indispensable":[53],"understanding":[55],"processes,":[57],"the":[58,66,71,81,143,149,156,162,176],"field":[60],"needs":[61],"that":[64,114,180],"improves":[65],"largely":[69],"maintains":[70],"of":[73],"RESULTS:":[77],"Here,":[78],"we":[79,147,168],"propose":[80],"generalized":[83],"trend":[84,126],"(scGTM)":[86],"capturing":[88],"gene's":[90],"trend,":[92],"which":[93],"may":[94],"be":[95],"monotone,":[96],"hill-shaped":[97],"or":[98],"valley-shaped,":[99],"pseudotime.":[102],"The":[103,201],"scGTM":[104,163,177,181,204],"has":[105],"three":[106],"advantages:":[107],"(i)":[108],"it":[109,130],"can":[110,131,182],"capture":[111,183],"non-monotonic":[112],"easy":[116],"interpret,":[118],"(ii)":[119],"its":[120],"parameters":[121],"biologically":[123],"informative,":[127],"(iii)":[129],"flexibly":[132],"accommodate":[133],"common":[134],"distributions":[135],"modeling":[137],"counts.":[140],"To":[141],"tackle":[142],"optimization":[145,152],"problems,":[146],"particle":[150],"swarm":[151],"algorithm":[153],"find":[155],"constrained":[157],"maximum":[158],"likelihood":[159],"estimates":[160],"parameters.":[164],"As":[165],"an":[166],"application,":[167],"analyze":[169],"several":[170],"datasets":[174],"using":[175],"show":[179],"reveal":[192],"molecular":[193],"insights":[194],"underlying":[195],"AVAILABILITY":[198],"AND":[199],"IMPLEMENTATION:":[200],"Python":[202],"package":[203],"open-access":[206],"available":[208,216],"at":[209,217],"https://github.com/ElvisCuiHan/scGTM.":[210],"SUPPLEMENTARY":[211],"INFORMATION:":[212],"Supplementary":[213],"data":[214],"Bioinformatics":[218],"online.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}