{"id":"https://openalex.org/W4283513881","doi":"https://doi.org/10.1093/bioinformatics/btac417","title":"CancerCellTracker: a brightfield time-lapse microscopy framework for cancer drug sensitivity estimation","display_name":"CancerCellTracker: a brightfield time-lapse microscopy framework for cancer drug sensitivity estimation","publication_year":2022,"publication_date":"2022-06-25","ids":{"openalex":"https://openalex.org/W4283513881","doi":"https://doi.org/10.1093/bioinformatics/btac417","pmid":"https://pubmed.ncbi.nlm.nih.gov/35751591"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac417","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac417","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9991899","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083008488","display_name":"Qibing Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qibing Jiang","raw_affiliation_strings":["Department of Computer Science, University of Central Florida , Orlando, FL 32816, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Central Florida , Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012307401","display_name":"Praneeth Sudalagunta","orcid":"https://orcid.org/0000-0003-1283-9332"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Praneeth Sudalagunta","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729771","display_name":"Carolina Silva","orcid":"https://orcid.org/0000-0003-1603-9519"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria C Silva","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060845150","display_name":"Rafael Renatino Canevarolo","orcid":"https://orcid.org/0000-0002-8722-8512"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael R Canevarolo","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101464792","display_name":"Xiaohong Zhao","orcid":"https://orcid.org/0000-0003-4064-7426"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohong Zhao","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074491379","display_name":"Khandakar Tanvir Ahmed","orcid":null},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khandakar Tanvir Ahmed","raw_affiliation_strings":["Department of Computer Science, University of Central Florida , Orlando, FL 32816, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Central Florida , Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040771903","display_name":"Raghunandan Reddy Alugubelli","orcid":"https://orcid.org/0000-0002-4314-1204"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghunandan Reddy Alugubelli","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012980165","display_name":"Gabriel DeAvila","orcid":null},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel DeAvila","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076018965","display_name":"Alexandre Tungesvik","orcid":null},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre Tungesvik","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108298475","display_name":"Lia Perez","orcid":null},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lia Perez","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032533490","display_name":"Robert A. Gatenby","orcid":"https://orcid.org/0000-0002-1621-1510"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A Gatenby","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082346230","display_name":"Robert J. Gillies","orcid":"https://orcid.org/0000-0002-8888-7747"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J Gillies","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077110117","display_name":"Rachid Baz","orcid":"https://orcid.org/0000-0003-4538-4733"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachid Baz","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014350127","display_name":"Mark B. Meads","orcid":"https://orcid.org/0009-0008-0259-1875"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark B Meads","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053572690","display_name":"Kenneth H. Shain","orcid":"https://orcid.org/0000-0003-4178-8888"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth H Shain","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086011649","display_name":"Ariosto S. Silva","orcid":"https://orcid.org/0000-0003-3237-9986"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariosto S Silva","raw_affiliation_strings":["Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Malignant Hematology and Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center and Research Institute , Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100441789","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0003-3605-9373"},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Computer Science, University of Central Florida , Orlando, FL 32816, USA"],"raw_orcid":"https://orcid.org/0000-0003-3605-9373","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Central Florida , Orlando, FL 32816, USA","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5100441789"],"corresponding_institution_ids":["https://openalex.org/I106165777"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.8487,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.86901079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"38","issue":"16","first_page":"4002","last_page":"4010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.953499972820282,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.953499972820282,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-drugs","display_name":"Cancer drugs","score":0.6870403289794922},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.6532923579216003},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.49656563997268677},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.49649959802627563},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45815953612327576},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4538501501083374},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43887466192245483},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.33240628242492676},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32352662086486816},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.32103872299194336},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.23403185606002808},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1517905592918396}],"concepts":[{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.6870403289794922},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6532923579216003},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.49656563997268677},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.49649959802627563},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45815953612327576},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4538501501083374},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43887466192245483},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33240628242492676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32352662086486816},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.32103872299194336},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23403185606002808},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1517905592918396},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btac417","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac417","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35751591","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35751591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9991899","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9991899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9991899","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9991899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G634390504","display_name":null,"funder_award_id":"P30 CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W48935466","https://openalex.org/W904214523","https://openalex.org/W1901255537","https://openalex.org/W2002783575","https://openalex.org/W2031048835","https://openalex.org/W2039490988","https://openalex.org/W2054821087","https://openalex.org/W2090440060","https://openalex.org/W2100138660","https://openalex.org/W2102872573","https://openalex.org/W2105916176","https://openalex.org/W2111679504","https://openalex.org/W2129223507","https://openalex.org/W2138825607","https://openalex.org/W2140930481","https://openalex.org/W2141273399","https://openalex.org/W2159960204","https://openalex.org/W2162245111","https://openalex.org/W2165848594","https://openalex.org/W2195297470","https://openalex.org/W2222512263","https://openalex.org/W2418225355","https://openalex.org/W2562612963","https://openalex.org/W2605974076","https://openalex.org/W2772796218","https://openalex.org/W2910993836","https://openalex.org/W2937687211","https://openalex.org/W3014344094","https://openalex.org/W3089142927","https://openalex.org/W3117393006","https://openalex.org/W4233110100","https://openalex.org/W4302070335","https://openalex.org/W6624486038","https://openalex.org/W6758934918"],"related_works":["https://openalex.org/W2378757965","https://openalex.org/W4224903346","https://openalex.org/W2576994247","https://openalex.org/W2608353378","https://openalex.org/W1593262897","https://openalex.org/W2372869593","https://openalex.org/W2384194537","https://openalex.org/W4249206767","https://openalex.org/W2563559453","https://openalex.org/W2031011156"],"abstract_inverted_index":{"MOTIVATION:":[0],"Time-lapse":[1],"microscopy":[2,116],"is":[3],"a":[4,65,90,110,118,144,189,200],"powerful":[5],"technique":[6],"that":[7,17,93,150],"relies":[8],"on":[9],"images":[10,77,117,187],"of":[11,23,45,52,121,129,179,220,226],"live":[12,221],"cells":[13,54,81,96,123,152,157,222],"cultured":[14],"ex":[15,126],"vivo":[16,127],"are":[18,239],"captured":[19],"at":[20,241],"regular":[21],"intervals":[22],"time":[24,159],"to":[25,55,97,105,139],"describe":[26],"and":[27,58,101,146,160,188,206],"quantify":[28,102],"their":[29,99],"behavior":[30,100],"under":[31],"certain":[32],"experimental":[33],"conditions.":[34],"This":[35],"imaging":[36],"method":[37],"has":[38],"great":[39],"potential":[40],"in":[41,109,124,153,167,204,209,216,223],"advancing":[42],"the":[43,50,60,130,177,210,218,224],"field":[44],"precision":[46],"oncology":[47],"by":[48,175,183],"quantifying":[49],"response":[51],"cancer":[53,95],"various":[56],"therapies":[57],"identifying":[59],"most":[61],"efficacious":[62],"treatment":[63],"for":[64,137],"given":[66],"patient.":[67],"Digital":[68],"image":[69],"processing":[70],"algorithms":[71],"developed":[72,143],"so":[73],"far":[74],"require":[75],"high-resolution":[76],"involving":[78],"very":[79],"few":[80],"originating":[82],"from":[83,185],"homogeneous":[84],"cell":[85,103,162,168,180],"line":[86],"populations.":[87],"We":[88,142,170,195,212],"propose":[89],"novel":[91],"framework":[92],"tracks":[94,155],"capture":[98],"viability":[104],"inform":[106],"clinical":[107],"decisions":[108],"high-throughput":[111],"manner.":[112],"RESULTS:":[113],"The":[114],"brightfield":[115,186],"large":[119],"number":[120],"patient-derived":[122],"an":[125],"reconstruction":[128],"tumor":[131],"microenvironment":[132],"treated":[133],"with":[134],"31":[135],"drugs":[136],"up":[138],"6":[140],"days.":[141],"robust":[145],"user-friendly":[147],"pipeline":[148,174],"CancerCellTracker":[149,184],"detects":[151],"co-culture,":[154],"these":[156],"across":[158],"identifies":[161],"death":[163,181],"events":[164],"using":[165,199],"changes":[166],"attributes.":[169],"validated":[171],"our":[172,197],"computational":[173],"comparing":[176],"timing":[178],"estimates":[182],"fluorescent":[190],"channel":[191],"featuring":[192],"ethidium":[193],"homodimer.":[194],"benchmarked":[196],"results":[198],"state-of-the-art":[201],"algorithm":[202],"implemented":[203],"ImageJ":[205],"previously":[207],"published":[208],"literature.":[211],"highlighted":[213],"CancerCellTracker's":[214],"efficiency":[215],"estimating":[217],"percentage":[219],"presence":[225],"bone":[227],"marrow":[228],"stromal":[229],"cells.":[230],"AVAILABILITY":[231],"AND":[232],"IMPLEMENTATION:":[233],"https://github.com/compbiolabucf/CancerCellTracker.":[234],"SUPPLEMENTARY":[235],"INFORMATION:":[236],"Supplementary":[237],"data":[238],"available":[240],"Bioinformatics":[242],"online.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
