{"id":"https://openalex.org/W4225596141","doi":"https://doi.org/10.1093/bioinformatics/btac293","title":"KIMGENS: a novel method to estimate kinship in organisms with mixed haploid diploid genetic systems robust to population structure","display_name":"KIMGENS: a novel method to estimate kinship in organisms with mixed haploid diploid genetic systems robust to population structure","publication_year":2022,"publication_date":"2022-04-21","ids":{"openalex":"https://openalex.org/W4225596141","doi":"https://doi.org/10.1093/bioinformatics/btac293","pmid":"https://pubmed.ncbi.nlm.nih.gov/35482481"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac293","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac293","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053280248","display_name":"Yen\u2010Wen Wang","orcid":"https://orcid.org/0000-0002-6851-1646"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yen-Wen Wang","raw_affiliation_strings":["Department of Botany, University of Wisconsin-Madison , Madison, WI 53706, USA"],"raw_orcid":"https://orcid.org/0000-0002-6851-1646","affiliations":[{"raw_affiliation_string":"Department of Botany, University of Wisconsin-Madison , Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031584591","display_name":"C\u00e9cile An\u00e9","orcid":"https://orcid.org/0000-0002-4702-8217"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C\u00e9cile An\u00e9","raw_affiliation_strings":["Department of Botany, University of Wisconsin-Madison , Madison, WI 53706, USA","Department of Statistics, University of Wisconsin-Madison , Madison, WI 53706, USA"],"raw_orcid":"https://orcid.org/0000-0002-4702-8217","affiliations":[{"raw_affiliation_string":"Department of Botany, University of Wisconsin-Madison , Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Statistics, University of Wisconsin-Madison , Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053280248"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0812,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.78394896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"38","issue":"11","first_page":"3044","last_page":"3050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.5486999750137329,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.5486999750137329,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.23170000314712524,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.07590000331401825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ploidy","display_name":"Ploidy","score":0.8666321039199829},{"id":"https://openalex.org/keywords/kinship","display_name":"Kinship","score":0.8068047761917114},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5232057571411133},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5156744718551636},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4759542644023895},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.36100590229034424},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.10082319378852844},{"id":"https://openalex.org/keywords/sociology","display_name":"Sociology","score":0.08868235349655151},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.060085028409957886}],"concepts":[{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.8666321039199829},{"id":"https://openalex.org/C144348335","wikidata":"https://www.wikidata.org/wiki/Q171318","display_name":"Kinship","level":2,"score":0.8068047761917114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5232057571411133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5156744718551636},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4759542644023895},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36100590229034424},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.10082319378852844},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.08868235349655151},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.060085028409957886},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004171","descriptor_name":"Diploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004171","descriptor_name":"Diploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004171","descriptor_name":"Diploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006238","descriptor_name":"Haploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006238","descriptor_name":"Haploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006238","descriptor_name":"Haploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btac293","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac293","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35482481","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35482481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312802","display_name":"Mycological Society of America","ror":"https://ror.org/00nzx7971"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1935210448","https://openalex.org/W2001111470","https://openalex.org/W2007630815","https://openalex.org/W2025621308","https://openalex.org/W2076658681","https://openalex.org/W2102213696","https://openalex.org/W2107089590","https://openalex.org/W2119580331","https://openalex.org/W2147464346","https://openalex.org/W2157184850","https://openalex.org/W2160195487","https://openalex.org/W2231185426","https://openalex.org/W2314792383","https://openalex.org/W2736438465","https://openalex.org/W2964006510","https://openalex.org/W3080223158","https://openalex.org/W4248047293","https://openalex.org/W4294554434"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W1579373186","https://openalex.org/W4312685612","https://openalex.org/W2046291598","https://openalex.org/W4317827232","https://openalex.org/W2890085216","https://openalex.org/W2504703202","https://openalex.org/W4252628068","https://openalex.org/W1708418756","https://openalex.org/W2976679446"],"abstract_inverted_index":{"MOTIVATION:":[0],"Kinship":[1],"estimation":[2,69],"is":[3,76,83,142,155],"necessary":[4],"for":[5,25,43,61,67],"evaluating":[6],"violations":[7],"of":[8,49,72,94,97,101,112,140],"assumptions":[9],"or":[10],"testing":[11],"certain":[12],"hypotheses":[13],"in":[14,32,126,149],"many":[15],"population":[16,50,79,161],"genomic":[17],"studies.":[18],"However,":[19],"kinship":[20,68,119],"estimators":[21,42,125,148],"are":[22,173,184],"usually":[23],"designed":[24],"diploid":[26,37,92],"systems":[27],"and":[28,103,109,130,168,175],"cannot":[29],"be":[30],"used":[31],"populations":[33],"with":[34],"mixed":[35],"haploid":[36,110],"genetic":[38],"systems.":[39],"The":[40],"only":[41],"different":[44],"ploidies":[45],"require":[46],"datasets":[47],"free":[48],"structure,":[51],"limiting":[52],"their":[53],"usage.":[54],"RESULTS:":[55],"We":[56,114],"present":[57],"KIMGENS":[58,117,144,154,167],"(Kinship":[59],"Inference":[60],"Mixed":[62],"GENetic":[63],"Systems),":[64],"an":[65],"estimator":[66,82,89],"among":[70],"individuals":[71,96],"various":[73],"ploidies,":[74],"that":[75,116],"robust":[77],"to":[78,107,159],"structure.":[80],"This":[81],"based":[84],"on":[85],"the":[86,95,138],"popular":[87],"KING-robust":[88],"but":[90,133],"uses":[91],"relatives":[93],"interest":[98,141],"as":[99],"references":[100],"heterozygosity":[102],"extends":[104],"its":[105,169],"use":[106],"haploid-diploid":[108],"pairs":[111],"individuals.":[113],"demonstrate":[115],"estimates":[118],"more":[120],"accurately":[121],"than":[122],"previously":[123],"developed":[124],"simulated":[127],"panmictic,":[128],"structured":[129],"admixed":[131],"populations,":[132],"has":[134],"lower":[135],"accuracy":[136],"when":[137],"individual":[139],"inbred.":[143],"also":[145],"outperforms":[146],"other":[147],"a":[150,156,160],"honeybee":[151],"dataset.":[152],"Therefore,":[153],"valuable":[157],"addition":[158],"geneticist's":[162],"toolbox.":[163],"AVAILABILITY":[164],"AND":[165],"IMPLEMENTATION:":[166],"association":[170],"simulation":[171],"tool":[172],"implemented":[174],"available":[176,185],"open-source":[177],"at":[178,186],"https://github.com/YenWenWang/HapDipKinship.":[179],"SUPPLEMENTARY":[180],"INFORMATION:":[181],"Supplementary":[182],"data":[183],"Bioinformatics":[187],"online.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}