{"id":"https://openalex.org/W4210639382","doi":"https://doi.org/10.1093/bioinformatics/btac052","title":"Noise-Transfer2Clean: denoising cryo-EM images based on noise modeling and transfer","display_name":"Noise-Transfer2Clean: denoising cryo-EM images based on noise modeling and transfer","publication_year":2022,"publication_date":"2022-01-28","ids":{"openalex":"https://openalex.org/W4210639382","doi":"https://doi.org/10.1093/bioinformatics/btac052","pmid":"https://pubmed.ncbi.nlm.nih.gov/35134862"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac052","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac052","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/7/2022/43113474/btac052.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/38/7/2022/43113474/btac052.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101911274","display_name":"Hongjia Li","orcid":"https://orcid.org/0000-0001-7016-421X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjia Li","raw_affiliation_strings":["High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China","University of Chinese Academy of Sciences , Beijing 100049, China"],"raw_orcid":"https://orcid.org/0000-0001-7016-421X","affiliations":[{"raw_affiliation_string":"High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323320","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0001-5014-8458"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China","University of Chinese Academy of Sciences , Beijing 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058683397","display_name":"Xiaohua Wan","orcid":"https://orcid.org/0000-0002-9340-878X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohua Wan","raw_affiliation_strings":["High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103011696","display_name":"Zhidong Yang","orcid":"https://orcid.org/0000-0002-9738-0227"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhidong Yang","raw_affiliation_strings":["High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China","University of Chinese Academy of Sciences , Beijing 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101688296","display_name":"Chengmin Li","orcid":"https://orcid.org/0000-0002-1949-9230"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengmin Li","raw_affiliation_strings":["National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334711","display_name":"Jintao Li","orcid":"https://orcid.org/0000-0002-7175-741X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jintao Li","raw_affiliation_strings":["High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690212","display_name":"Renmin Han","orcid":"https://orcid.org/0000-0003-4761-6526"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Renmin Han","raw_affiliation_strings":["Research Center for Mathematics and Interdisciplinary Sciences, Shandong University , Qingdao 266237, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Mathematics and Interdisciplinary Sciences, Shandong University , Qingdao 266237, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108239310","display_name":"Ping Zhu","orcid":"https://orcid.org/0000-0003-2648-3170"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Zhu","raw_affiliation_strings":["National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China","University of Chinese Academy of Sciences , Beijing 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100731978","display_name":"Fa Zhang","orcid":"https://orcid.org/0000-0002-2081-9369"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fa Zhang","raw_affiliation_strings":["High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Performance Computer Research Center, Institute of Computing Technology Chinese Academy of Sciences , Beijing 100190, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100690212","https://openalex.org/A5100731978","https://openalex.org/A5108239310"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I19820366","https://openalex.org/I4210090176","https://openalex.org/I4210112540","https://openalex.org/I4210165038"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":5.1405,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.94687654,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"38","issue":"7","first_page":"2022","last_page":"2029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9768999814987183,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9768999814987183,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11183","display_name":"Advanced X-ray Imaging Techniques","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noise-reduction","display_name":"Noise reduction","score":0.819695234298706},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.7781645059585571},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6671379208564758},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5729409456253052},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.47489920258522034},{"id":"https://openalex.org/keywords/noise-measurement","display_name":"Noise measurement","score":0.46596434712409973},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"Signal-to-noise ratio (imaging)","score":0.4498884677886963},{"id":"https://openalex.org/keywords/multiplicative-noise","display_name":"Multiplicative noise","score":0.4146847128868103},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.32041728496551514},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.21285724639892578},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.12967467308044434},{"id":"https://openalex.org/keywords/signal-transfer-function","display_name":"Signal transfer function","score":0.11804249882698059}],"concepts":[{"id":"https://openalex.org/C163294075","wikidata":"https://www.wikidata.org/wiki/Q581861","display_name":"Noise reduction","level":2,"score":0.819695234298706},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.7781645059585571},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6671379208564758},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5729409456253052},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.47489920258522034},{"id":"https://openalex.org/C29265498","wikidata":"https://www.wikidata.org/wiki/Q7047719","display_name":"Noise measurement","level":3,"score":0.46596434712409973},{"id":"https://openalex.org/C13944312","wikidata":"https://www.wikidata.org/wiki/Q7512748","display_name":"Signal-to-noise ratio (imaging)","level":2,"score":0.4498884677886963},{"id":"https://openalex.org/C18015164","wikidata":"https://www.wikidata.org/wiki/Q6935000","display_name":"Multiplicative noise","level":5,"score":0.4146847128868103},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.32041728496551514},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.21285724639892578},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.12967467308044434},{"id":"https://openalex.org/C131021393","wikidata":"https://www.wikidata.org/wiki/Q7512759","display_name":"Signal transfer function","level":4,"score":0.11804249882698059},{"id":"https://openalex.org/C13412647","wikidata":"https://www.wikidata.org/wiki/Q174948","display_name":"Analog signal","level":3,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btac052","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac052","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/7/2022/43113474/btac052.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35134862","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35134862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8963287","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8963287","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btac052","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac052","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/7/2022/43113474/btac052.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1045301406","display_name":null,"funder_award_id":"62072441","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G189991007","display_name":"\u67d3\u8272\u8d28\u7ed3\u6784\u86cb\u767d\u53ca\u5176\u81f4\u75c5\u7a81\u53d8\u4f53\u5bf9\u67d3\u8272\u8d28\u9ad8\u7ea7\u7ed3\u6784\u8c03\u63a7\u7684\u51b7\u51bb\u7535\u955c\u7814\u7a76","funder_award_id":"31730023","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G207892162","display_name":null,"funder_award_id":"2021 YFF0704300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2379517498","display_name":"\u9ad8\u5206\u8fa8\u51b7\u51bb\u7535\u955c\u65ad\u5c42\u4e09\u7ef4\u91cd\u6784\u7684\u53c2\u6570\u6807\u5b9a\u7b97\u6cd5\u7814\u7a76","funder_award_id":"62072280","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5536530938","display_name":null,"funder_award_id":"2017YFA0504700","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5988517324","display_name":null,"funder_award_id":"2019KF07","funder_id":"https://openalex.org/F4320338022","funder_display_name":"National Laboratory of Biomacromolecules"},{"id":"https://openalex.org/G6338270068","display_name":null,"funder_award_id":"2017YFA0504700","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6401138543","display_name":null,"funder_award_id":"31521002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6753228197","display_name":null,"funder_award_id":"XDB37010100","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G7015795882","display_name":null,"funder_award_id":"2020YFA0712401","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7043150659","display_name":null,"funder_award_id":"XDB37010100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7195034529","display_name":null,"funder_award_id":"XDB37010100","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7602616423","display_name":"\u751f\u7269\u5927\u5206\u5b50\u51b7\u51bb\u7535\u955c\u6570\u636e\u9ad8\u6548\u80fd\u5904\u7406\u7684\u5173\u952e\u6280\u672f","funder_award_id":"61932018","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8313872943","display_name":null,"funder_award_id":"31521002","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8548991612","display_name":null,"funder_award_id":"2017YFA0504700","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8714724616","display_name":null,"funder_award_id":"31521002","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320338022","display_name":"National Laboratory of Biomacromolecules","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210639382.pdf","grobid_xml":"https://content.openalex.org/works/W4210639382.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1483313280","https://openalex.org/W2017508876","https://openalex.org/W2021703585","https://openalex.org/W2056370875","https://openalex.org/W2067191022","https://openalex.org/W2069112956","https://openalex.org/W2072404529","https://openalex.org/W2133665775","https://openalex.org/W2138390185","https://openalex.org/W2142158597","https://openalex.org/W2143205611","https://openalex.org/W2144627501","https://openalex.org/W2332367469","https://openalex.org/W2550234534","https://openalex.org/W2620998958","https://openalex.org/W2793402357","https://openalex.org/W2911634634","https://openalex.org/W3009153763","https://openalex.org/W3093295276","https://openalex.org/W3096831136","https://openalex.org/W3103292928","https://openalex.org/W6758520943"],"related_works":["https://openalex.org/W3034789145","https://openalex.org/W2171117985","https://openalex.org/W1526760723","https://openalex.org/W2126659863","https://openalex.org/W2012356576","https://openalex.org/W4385545089","https://openalex.org/W3108403339","https://openalex.org/W2102487628","https://openalex.org/W383418545","https://openalex.org/W4367628250"],"abstract_inverted_index":{"MOTIVATION:":[0],"Cryo-electron":[1],"microscopy":[2],"(cryo-EM)":[3],"is":[4,62,115,262],"a":[5,23,96,152,212,230],"widely":[6],"used":[7,227],"technology":[8],"for":[9,102],"ultrastructure":[10],"determination,":[11],"which":[12,48],"constructs":[13],"the":[14,31,35,42,50,58,76,83,93,118,124,132,138,144,182,189,196,225,234,243,247,254],"3D":[15],"structures":[16],"of":[17,25,54,85,127,135,184,256],"protein":[18],"and":[19,52,108,130,155,164,205,252],"macromolecular":[20],"complex":[21,145,190],"from":[22,41,75,195],"set":[24],"2D":[26],"micrographs.":[27],"However,":[28],"limited":[29],"by":[30,121,246],"electron":[32],"beam":[33],"dose,":[34],"micrographs":[36],"in":[37,60,78,148,215,219],"cryo-EM":[38,61,103,128,191],"generally":[39],"suffer":[40],"extremely":[43,81],"low":[44],"signal-to-noise":[45],"ratio":[46],"(SNR),":[47],"hampers":[49],"efficiency":[51],"effectiveness":[53],"downstream":[55],"analysis.":[56],"Especially,":[57,140],"noise":[59,68,125,136,146,154,192,197,221],"not":[63],"simple":[64],"additive":[65],"or":[66],"multiplicative":[67],"whose":[69,112],"statistical":[70,133],"characteristics":[71],"are":[72,270],"quite":[73],"different":[74],"ones":[77],"natural":[79],"image,":[80],"shackling":[82],"performance":[84,120],"conventional":[86],"denoising":[87,97,119,185],"methods.":[88,228],"RESULTS:":[89],"Here,":[90],"we":[91,150],"introduce":[92],"Noise-Transfer2Clean":[94],"(NT2C),":[95],"deep":[98],"neural":[99],"network":[100],"(DNN)":[101],"to":[104,116,141,159,249],"enhance":[105],"image":[106,216],"contrast":[107],"restore":[109],"specimen":[110],"signal,":[111],"main":[113],"idea":[114],"improve":[117],"correctly":[122],"learning":[123],"distribution":[126],"images":[129],"transferring":[131],"nature":[134],"into":[137],"denoiser.":[139],"cope":[142],"with":[143,224],"model":[147],"cryo-EM,":[149],"design":[151],"contrast-guided":[153],"signal":[156,172],"re-weighted":[157],"algorithm":[158],"achieve":[160,171],"clean-noisy":[161],"data":[162,165,269],"synthesis":[163],"augmentation,":[166],"making":[167],"our":[168],"method":[169],"authentically":[170],"restoration":[173],"based":[174,186],"on":[175,187,202,233],"noise's":[176],"true":[177],"properties.":[178],"Our":[179],"work":[180],"verifies":[181],"feasibility":[183],"mining":[188],"patterns":[193],"directly":[194],"patches.":[198],"Comprehensive":[199],"experimental":[200],"results":[201],"simulated":[203],"datasets":[204,207],"real":[206,235],"show":[208],"that":[209,238],"NT2C":[210,239],"achieved":[211],"notable":[213],"improvement":[214],"denoising,":[217],"especially":[218],"background":[220],"removal,":[222],"compared":[223],"commonly":[226],"Moreover,":[229],"case":[231],"study":[232],"dataset":[236],"demonstrates":[237],"can":[240],"greatly":[241],"alleviate":[242],"obstacles":[244],"caused":[245],"SNR":[248],"particle":[250],"picking":[251],"simplify":[253],"identifying":[255],"particles.":[257],"AVAILABILITYAND":[258],"IMPLEMENTATION:":[259],"The":[260],"code":[261],"available":[263,271],"at":[264,272],"https://github.com/Lihongjia-ict/NoiseTransfer2Clean/.":[265],"SUPPLEMENTARY":[266],"INFORMATION:":[267],"Supplementary":[268],"Bioinformatics":[273],"online.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4}],"updated_date":"2026-08-09T07:27:16.801131","created_date":"2025-10-10T00:00:00"}
