{"id":"https://openalex.org/W3203311767","doi":"https://doi.org/10.1093/bioinformatics/btac047","title":"A mixture model for determining SARS-Cov-2 variant composition in pooled samples","display_name":"A mixture model for determining SARS-Cov-2 variant composition in pooled samples","publication_year":2022,"publication_date":"2022-01-26","ids":{"openalex":"https://openalex.org/W3203311767","doi":"https://doi.org/10.1093/bioinformatics/btac047","mag":"3203311767","pmid":"https://pubmed.ncbi.nlm.nih.gov/35104309"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac047","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/7/1809/49010438/btac047.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"preprint","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/38/7/1809/49010438/btac047.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048107289","display_name":"Renan Valieris","orcid":"https://orcid.org/0000-0002-8402-3175"},"institutions":[{"id":"https://openalex.org/I3019035496","display_name":"AC Camargo Hospital","ror":"https://ror.org/03025ga79","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I3019035496"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renan Valieris","raw_affiliation_strings":["Laboratory of Computational Biology and Bioinformatics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Biology and Bioinformatics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,","institution_ids":["https://openalex.org/I3019035496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087196517","display_name":"Rodrigo D. Drummond","orcid":"https://orcid.org/0000-0002-9000-8115"},"institutions":[{"id":"https://openalex.org/I3019035496","display_name":"AC Camargo Hospital","ror":"https://ror.org/03025ga79","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I3019035496"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo D Drummond","raw_affiliation_strings":["Laboratory of Computational Biology and Bioinformatics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Biology and Bioinformatics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,","institution_ids":["https://openalex.org/I3019035496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081114432","display_name":"Alexandre Defelicibus","orcid":"https://orcid.org/0000-0002-3484-6317"},"institutions":[{"id":"https://openalex.org/I3019035496","display_name":"AC Camargo Hospital","ror":"https://ror.org/03025ga79","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I3019035496"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alexandre Defelicibus","raw_affiliation_strings":["Laboratory of Computational Biology and Bioinformatics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Biology and Bioinformatics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,","institution_ids":["https://openalex.org/I3019035496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042936457","display_name":"Emannuel Dias-Neto","orcid":null},"institutions":[{"id":"https://openalex.org/I3019035496","display_name":"AC Camargo Hospital","ror":"https://ror.org/03025ga79","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I3019035496"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Emmanuel Dias-Neto","raw_affiliation_strings":["Laboratory of Medical Genomics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medical Genomics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,","institution_ids":["https://openalex.org/I3019035496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087670867","display_name":"Rafael Rosales","orcid":"https://orcid.org/0000-0002-7518-2975"},"institutions":[{"id":"https://openalex.org/I1331278255","display_name":"Universidade de Ribeir\u00e3o Preto","ror":"https://ror.org/00ey54k21","country_code":"BR","type":"education","lineage":["https://openalex.org/I1331278255"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael A Rosales","raw_affiliation_strings":["Departamento de Computa\u00e7\u00e3o e Matem\u00e1tica, Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo 14040-901,","University of S\u00e3o Paulo"],"raw_orcid":"https://orcid.org/0000-0002-7518-2975","affiliations":[{"raw_affiliation_string":"Departamento de Computa\u00e7\u00e3o e Matem\u00e1tica, Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo 14040-901,","institution_ids":["https://openalex.org/I1331278255","https://openalex.org/I17974374"]},{"raw_affiliation_string":"University of S\u00e3o Paulo","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036545708","display_name":"Israel Tojal da Silva","orcid":"https://orcid.org/0000-0002-4687-1499"},"institutions":[{"id":"https://openalex.org/I3019035496","display_name":"AC Camargo Hospital","ror":"https://ror.org/03025ga79","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I3019035496"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Israel Tojal da Silva","raw_affiliation_strings":["Laboratory of Computational Biology and Bioinformatics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,"],"raw_orcid":"https://orcid.org/0000-0002-4687-1499","affiliations":[{"raw_affiliation_string":"Laboratory of Computational Biology and Bioinformatics, CIPE/A.C. Camargo Cancer Center , S\u00e3o Paulo 01508-010,","institution_ids":["https://openalex.org/I3019035496"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.2016,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47783049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"38","issue":"7","first_page":"1809","last_page":"1815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6220941543579102},{"id":"https://openalex.org/keywords/pandemic","display_name":"Pandemic","score":0.5113286375999451},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49997472763061523},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4928281605243683},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.48173239827156067},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.46186596155166626},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.42208120226860046},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3083631098270416},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.2907688319683075},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2179970145225525},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.1264527142047882},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.09586650133132935}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6220941543579102},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.5113286375999451},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49997472763061523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4928281605243683},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.48173239827156067},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.46186596155166626},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.42208120226860046},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3083631098270416},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2907688319683075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2179970145225525},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.1264527142047882},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.09586650133132935},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btac047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac047","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/7/1809/49010438/btac047.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35104309","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35104309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"mag:3203311767","is_oa":true,"landing_page_url":"http://export.arxiv.org/pdf/2110.01117","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"arXiv (Cornell University)","raw_type":null},{"id":"doi:10.48550/arxiv.2110.01117","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2110.01117","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btac047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac047","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/7/1809/49010438/btac047.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2900237062","display_name":null,"funder_award_id":"2021/05316-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W2025161234","https://openalex.org/W2065256070","https://openalex.org/W2103441770","https://openalex.org/W2168133698","https://openalex.org/W2597797541","https://openalex.org/W2605343262","https://openalex.org/W2765745983","https://openalex.org/W2767318416","https://openalex.org/W2789843538","https://openalex.org/W2808035849","https://openalex.org/W2949979136","https://openalex.org/W3003217347","https://openalex.org/W3043124965","https://openalex.org/W3084086363","https://openalex.org/W3091097417","https://openalex.org/W3092776600","https://openalex.org/W3106889297","https://openalex.org/W3118287678","https://openalex.org/W3118879984","https://openalex.org/W3156220950","https://openalex.org/W3160568774","https://openalex.org/W3163970933","https://openalex.org/W3164360779","https://openalex.org/W3164726319","https://openalex.org/W3175915728","https://openalex.org/W3185521398","https://openalex.org/W3186843229","https://openalex.org/W3187721828","https://openalex.org/W3204104449","https://openalex.org/W4255738661","https://openalex.org/W4285719527","https://openalex.org/W6696497002"],"related_works":["https://openalex.org/W3207024846","https://openalex.org/W3209047475","https://openalex.org/W3201146313","https://openalex.org/W3082088546","https://openalex.org/W3046304094","https://openalex.org/W2804866118","https://openalex.org/W2305509242","https://openalex.org/W3103364622","https://openalex.org/W3175431207","https://openalex.org/W3191422085","https://openalex.org/W3113503382","https://openalex.org/W2795030612","https://openalex.org/W2953301805","https://openalex.org/W2036252816","https://openalex.org/W3114748467","https://openalex.org/W2100882140","https://openalex.org/W2146384439","https://openalex.org/W2949575799","https://openalex.org/W2038749457"],"abstract_inverted_index":{"MOTIVATION:":[0],"Despite":[1],"of":[2,6,21,28,39,48,72,78,87,100,106,134,143,154,158,174,230,243,249,268],"the":[3,12,16,26,32,36,70,73,76,79,104,115,131,139,152,155,198,216,240,256,266],"fast":[4,132],"development":[5],"highly":[7],"effective":[8,213],"vaccines":[9,23],"to":[10,35,68,92,110,137],"control":[11],"current":[13,93],"COVID-19":[14,244],"pandemics,":[15],"unequal":[17],"distribution":[18],"and":[19,25,75,112,141,194,278],"availability":[20],"these":[22,250],"worldwide":[24],"number":[27],"people":[29],"infected":[30],"in":[31,118,161,197,214,233,246,271],"world":[33],"lead":[34],"continuous":[37],"emergence":[38],"Severe":[40],"Acute":[41],"Respiratory":[42],"Syndrome":[43],"coronavirus":[44],"2":[45],"(SARS-CoV-2)":[46],"variants":[47,86,90,160,245,270],"concern.":[49],"Therefore,":[50],"it":[51],"is":[52,166,211],"likely":[53],"that":[54,128,177,208,255],"real-time":[55],"genomic":[56,85,96,175],"surveillance":[57,97],"will":[58],"be":[59,260],"continuously":[60],"needed":[61],"as":[62,275],"an":[63],"unceasing":[64],"monitoring":[65],"tool,":[66],"necessary":[67],"follow":[69],"spread":[71,140],"disease":[74],"evolution":[77,242],"virus.":[80],"In":[81],"this":[82,135],"context,":[83],"new":[84],"SARS-CoV-2,":[88],"including":[89,122],"refractory":[91],"vaccines,":[94],"makes":[95],"programs":[98],"tools":[99,109],"utmost":[101],"importance.":[102],"Nevertheless,":[103],"lack":[105],"appropriate":[107],"analytical":[108],"quickly":[111],"effectively":[113],"access":[114],"viral":[116],"composition":[117],"meta-transcriptomic":[119],"sequencing":[120,188],"data,":[121],"environmental":[123,279],"surveillance,":[124],"represent":[125],"possible":[126],"challenges":[127],"may":[129],"impact":[130],"adoption":[133],"approach":[136],"mitigate":[138],"transmission":[142],"viruses.":[144],"RESULTS:":[145],"We":[146],"propose":[147],"a":[148,170,261],"statistical":[149],"model":[150,165],"for":[151,190,264],"estimation":[153],"relative":[156],"frequencies":[157],"SARS-CoV-2":[159,179,269],"pooled":[162],"samples.":[163,280],"This":[164],"built":[167],"by":[168,223],"considering":[169,224],"previously":[171],"defined":[172],"selection":[173],"polymorphisms":[176],"characterize":[178],"variants.":[180],"The":[181],"methods":[182],"described":[183,257],"here":[184],"support":[185],"both":[186],"raw":[187],"reads":[189],"polymorphisms-based":[191],"markers":[192,196],"calling":[193],"predefined":[195],"variant":[199,218],"call":[200],"format.":[201],"Results":[202],"obtained":[203,222],"using":[204],"simulated":[205],"data":[206,226,288],"show":[207,254],"our":[209],"method":[210,258],"quite":[212],"recovering":[215],"correct":[217],"proportions.":[219],"Further,":[220],"results":[221,253],"longitudinal":[225],"from":[227],"wastewater":[228],"samples":[229,248],"two":[231],"locations":[232],"Switzerland":[234],"agree":[235],"well":[236],"with":[237],"those":[238],"describing":[239],"epidemiological":[241],"clinical":[247],"locations.":[251],"Our":[252],"can":[259],"valuable":[262],"tool":[263],"tracking":[265],"proportions":[267],"complex":[272],"mixtures":[273],"such":[274],"waste":[276],"water":[277],"AVAILABILITY":[281],"AND":[282],"IMPLEMENTATION:":[283],"http://github.com/rvalieris/LCS.":[284],"SUPPLEMENTARY":[285],"INFORMATION:":[286],"Supplementary":[287],"are":[289],"available":[290],"at":[291],"Bioinformatics":[292],"online.":[293]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
