{"id":"https://openalex.org/W4205591602","doi":"https://doi.org/10.1093/bioinformatics/btab816","title":"HolistIC: leveraging Hi\u2013C and whole genome shotgun sequencing for double minute chromosome discovery","display_name":"HolistIC: leveraging Hi\u2013C and whole genome shotgun sequencing for double minute chromosome discovery","publication_year":2021,"publication_date":"2021-12-04","ids":{"openalex":"https://openalex.org/W4205591602","doi":"https://doi.org/10.1093/bioinformatics/btab816","pmid":"https://pubmed.ncbi.nlm.nih.gov/34888626"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab816","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab816","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9991898","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101595969","display_name":"Matthew Hayes","orcid":"https://orcid.org/0000-0002-0457-8550"},"institutions":[{"id":"https://openalex.org/I169251466","display_name":"Xavier University of Louisiana","ror":"https://ror.org/0085d9t86","country_code":"US","type":"education","lineage":["https://openalex.org/I169251466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew Hayes","raw_affiliation_strings":["Department of Physics and Computer Science, Xavier University of Louisiana , New Orleans, LA 70125, USA"],"raw_orcid":"https://orcid.org/0000-0002-0457-8550","affiliations":[{"raw_affiliation_string":"Department of Physics and Computer Science, Xavier University of Louisiana , New Orleans, LA 70125, USA","institution_ids":["https://openalex.org/I169251466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108775586","display_name":"Angela Nguyen","orcid":null},"institutions":[{"id":"https://openalex.org/I169251466","display_name":"Xavier University of Louisiana","ror":"https://ror.org/0085d9t86","country_code":"US","type":"education","lineage":["https://openalex.org/I169251466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Nguyen","raw_affiliation_strings":["Department of Biology, Xavier University of Louisiana , New Orleans, LA 70125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Xavier University of Louisiana , New Orleans, LA 70125, USA","institution_ids":["https://openalex.org/I169251466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085318150","display_name":"Rahib Islam","orcid":null},"institutions":[{"id":"https://openalex.org/I169251466","display_name":"Xavier University of Louisiana","ror":"https://ror.org/0085d9t86","country_code":"US","type":"education","lineage":["https://openalex.org/I169251466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahib Islam","raw_affiliation_strings":["Department of Biology, Xavier University of Louisiana , New Orleans, LA 70125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Xavier University of Louisiana , New Orleans, LA 70125, USA","institution_ids":["https://openalex.org/I169251466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006670722","display_name":"Caryn Butler","orcid":null},"institutions":[{"id":"https://openalex.org/I169251466","display_name":"Xavier University of Louisiana","ror":"https://ror.org/0085d9t86","country_code":"US","type":"education","lineage":["https://openalex.org/I169251466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caryn Butler","raw_affiliation_strings":["Department of Public Health Sciences, Xavier University of Louisiana , New Orleans, LA 70125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Xavier University of Louisiana , New Orleans, LA 70125, USA","institution_ids":["https://openalex.org/I169251466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ethan Tran","orcid":null},"institutions":[{"id":"https://openalex.org/I169251466","display_name":"Xavier University of Louisiana","ror":"https://ror.org/0085d9t86","country_code":"US","type":"education","lineage":["https://openalex.org/I169251466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Tran","raw_affiliation_strings":["Department of Biology, Xavier University of Louisiana , New Orleans, LA 70125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Xavier University of Louisiana , New Orleans, LA 70125, USA","institution_ids":["https://openalex.org/I169251466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076374808","display_name":"Derrick Mullins","orcid":null},"institutions":[{"id":"https://openalex.org/I169251466","display_name":"Xavier University of Louisiana","ror":"https://ror.org/0085d9t86","country_code":"US","type":"education","lineage":["https://openalex.org/I169251466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derrick Mullins","raw_affiliation_strings":["Department of Physics and Computer Science, Xavier University of Louisiana , New Orleans, LA 70125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Computer Science, Xavier University of Louisiana , New Orleans, LA 70125, USA","institution_ids":["https://openalex.org/I169251466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023610125","display_name":"Chindo Hicks","orcid":"https://orcid.org/0000-0002-1876-299X"},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chindo Hicks","raw_affiliation_strings":["Department of Genetics, Louisiana State University Health Sciences Center New Orleans , New Orleans, LA 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Louisiana State University Health Sciences Center New Orleans , New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101595969"],"corresponding_institution_ids":["https://openalex.org/I169251466"],"apc_list":{"value":3478,"currency":"USD","value_usd":3478},"apc_paid":null,"fwci":2.9088,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.91995128,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"38","issue":"5","first_page":"1208","last_page":"1215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.1492999941110611,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6094310879707336},{"id":"https://openalex.org/keywords/amplicon","display_name":"Amplicon","score":0.5834791660308838},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5780243873596191},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5447484254837036},{"id":"https://openalex.org/keywords/shotgun-sequencing","display_name":"Shotgun sequencing","score":0.46244198083877563},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"Whole genome sequencing","score":0.44907668232917786},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38047072291374207},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36634862422943115},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2448962926864624},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1649397909641266}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6094310879707336},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.5834791660308838},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5780243873596191},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5447484254837036},{"id":"https://openalex.org/C101985253","wikidata":"https://www.wikidata.org/wiki/Q1073526","display_name":"Shotgun sequencing","level":4,"score":0.46244198083877563},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.44907668232917786},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38047072291374207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36634862422943115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2448962926864624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1649397909641266},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btab816","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab816","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34888626","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34888626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9991898","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9991898","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9991898","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9991898","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6200000047683716}],"awards":[{"id":"https://openalex.org/G3935617875","display_name":null,"funder_award_id":"5G12MD007595","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G493699698","display_name":null,"funder_award_id":"8UL1GM118967","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5903141975","display_name":"Research Initiation Award: Computational Inference of Mechanisms Underlying Double Minute Chromosome Formation","funder_award_id":"1901258","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7695900067","display_name":null,"funder_award_id":"TL4 GM118968","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334538","display_name":"Louisiana Cancer Research Consortium, Xavier University of Louisiana","ror":"https://ror.org/0034k2773"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1513515886","https://openalex.org/W1557209515","https://openalex.org/W1600873259","https://openalex.org/W1968588133","https://openalex.org/W1974959172","https://openalex.org/W2010048621","https://openalex.org/W2020912279","https://openalex.org/W2097920585","https://openalex.org/W2103441770","https://openalex.org/W2109948920","https://openalex.org/W2134907628","https://openalex.org/W2142270559","https://openalex.org/W2146005104","https://openalex.org/W2159862605","https://openalex.org/W2170551349","https://openalex.org/W2555719318","https://openalex.org/W2729264945","https://openalex.org/W2765865112","https://openalex.org/W2893930235","https://openalex.org/W2912484801","https://openalex.org/W2951458958","https://openalex.org/W2952744897","https://openalex.org/W2991552764","https://openalex.org/W3146078726","https://openalex.org/W4247053599","https://openalex.org/W4255665337","https://openalex.org/W6630856392"],"related_works":["https://openalex.org/W2995118009","https://openalex.org/W2786748503","https://openalex.org/W2011298649","https://openalex.org/W1966203981","https://openalex.org/W1919212819","https://openalex.org/W1997128949","https://openalex.org/W1841715584","https://openalex.org/W2143649997","https://openalex.org/W2175240434","https://openalex.org/W1972674712"],"abstract_inverted_index":{"MOTIVATION:":[0],"Double":[1],"minute":[2],"(DM)":[3],"chromosomes":[4],"are":[5,11,21,231],"acentric":[6],"extrachromosomal":[7,209],"DNA":[8],"artifacts":[9],"that":[10,57,63,94,108,135,198,207],"frequently":[12],"observed":[13],"in":[14,86,112,131,137,144,183,214],"the":[15,153,169,188,192],"cells":[16],"of":[17,41,124,127,159],"numerous":[18],"cancers.":[19],"They":[20],"highly":[22],"amplified":[23],"and":[24,27,118,148,156,163,180],"contain":[25],"oncogenes":[26],"drug-resistance":[28],"genes,":[29],"making":[30],"their":[31],"presence":[32],"a":[33,164],"challenge":[34],"for":[35,48],"effective":[36],"cancer":[37,49,161,170],"treatment.":[38,50],"Algorithmic":[39],"discovery":[40,78],"DM":[42,77,132,138],"can":[43,89,109,194],"potentially":[44,90],"improve":[45],"bench-derived":[46],"therapies":[47],"A":[51],"hindrance":[52],"to":[53,175],"this":[54,100],"task":[55],"is":[56,223],"DMs":[58,71,93,111,177,197],"evolve,":[59],"yielding":[60],"circular":[61],"chromatin":[62],"shares":[64],"segments":[65],"from":[66,178],"progenitor":[67],"DMs.":[68],"This":[69],"creates":[70],"with":[72,140],"overlapping":[73,96,200],"amplicon":[74,133,201],"coordinates.":[75,97],"Existing":[76],"algorithms":[79],"use":[80],"whole":[81],"genome":[82],"shotgun":[83],"sequencing":[84,120],"(WGS)":[85],"isolation,":[87],"which":[88],"incorrectly":[91],"classify":[92],"share":[95],"RESULTS:":[98],"In":[99],"study,":[101],"we":[102],"describe":[103],"an":[104,203],"algorithm":[105,151],"called":[106],"'HolistIC'":[107],"predict":[110,176,208],"tumor":[113],"genomes":[114],"by":[115],"integrating":[116],"WGS":[117,141,157,181,212],"Hi-C":[119,155,179],"data.":[121],"The":[122,185],"consolidation":[123],"these":[125],"sources":[126],"information":[128],"resolves":[129],"ambiguity":[130],"prediction":[134,139],"exists":[136],"data":[142,182,190,213,230],"used":[143],"isolation.":[145,215],"We":[146],"implemented":[147],"tested":[149],"our":[150],"on":[152,168,187],"tandem":[154],"datasets":[158,162,171],"three":[160],"simulated":[165,189],"dataset.":[166],"Results":[167],"demonstrated":[172],"HolistIC's":[173],"ability":[174],"tandem.":[184],"results":[186],"showed":[191],"HolistIC":[193],"accurately":[195],"distinguish":[196],"have":[199],"coordinates,":[202],"advance":[204],"over":[205],"methods":[206],"amplification":[210],"using":[211],"AVAILABILITY":[216],"AND":[217],"IMPLEMENTATION:":[218],"Our":[219],"software,":[220],"named":[221],"'HolistIC',":[222],"available":[224,232],"at":[225,233],"http://www.github.com/mhayes20/HolistIC.":[226],"SUPPLEMENTARY":[227],"INFORMATION:":[228],"Supplementary":[229],"Bioinformatics":[234],"online.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2025-10-10T00:00:00"}