{"id":"https://openalex.org/W3198879735","doi":"https://doi.org/10.1093/bioinformatics/btab651","title":"MVGCN: data integration through multi-view graph convolutional network for predicting links in biomedical bipartite networks","display_name":"MVGCN: data integration through multi-view graph convolutional network for predicting links in biomedical bipartite networks","publication_year":2021,"publication_date":"2021-09-08","ids":{"openalex":"https://openalex.org/W3198879735","doi":"https://doi.org/10.1093/bioinformatics/btab651","mag":"3198879735","pmid":"https://pubmed.ncbi.nlm.nih.gov/34499148"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab651","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab651","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101443469","display_name":"Haitao Fu","orcid":"https://orcid.org/0000-0001-9673-6845"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitao Fu","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University , Wuhan 430070, China"],"raw_orcid":"https://orcid.org/0000-0001-9673-6845","affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University , Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101659630","display_name":"Feng Huang","orcid":"https://orcid.org/0000-0001-5502-8105"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Huang","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University , Wuhan 430070, China"],"raw_orcid":"https://orcid.org/0000-0001-5502-8105","affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University , Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362324","display_name":"Xuan Liu","orcid":"https://orcid.org/0000-0002-7356-7898"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Liu","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University , Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University , Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379370","display_name":"Yang Qiu","orcid":"https://orcid.org/0000-0001-8022-0465"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Qiu","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University , Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University , Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100448121","display_name":"Wen Zhang","orcid":"https://orcid.org/0000-0001-5221-2628"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wen Zhang","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University , Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University , Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100448121"],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":6.4233,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.9785835,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"38","issue":"2","first_page":"426","last_page":"434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9562000036239624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9562000036239624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipartite-graph","display_name":"Bipartite graph","score":0.8719899654388428},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7233251333236694},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.6117072701454163},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.519099235534668},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.5061668753623962},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.4865552484989166},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4656670093536377},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.43290090560913086},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.43081605434417725},{"id":"https://openalex.org/keywords/network-science","display_name":"Network science","score":0.41063788533210754},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4002472162246704},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.39977824687957764},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.33942508697509766},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16949820518493652}],"concepts":[{"id":"https://openalex.org/C197657726","wikidata":"https://www.wikidata.org/wiki/Q174733","display_name":"Bipartite graph","level":3,"score":0.8719899654388428},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7233251333236694},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6117072701454163},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.519099235534668},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.5061668753623962},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.4865552484989166},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4656670093536377},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.43290090560913086},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.43081605434417725},{"id":"https://openalex.org/C137753397","wikidata":"https://www.wikidata.org/wiki/Q2434424","display_name":"Network science","level":3,"score":0.41063788533210754},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4002472162246704},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39977824687957764},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.33942508697509766},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16949820518493652},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btab651","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab651","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34499148","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34499148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G1311322377","display_name":"\u77e5\u8bc6\u56fe\u8c31\u9a71\u52a8\u7684\u836f\u7269-\u75be\u75c5\u5173\u8054\u9884\u6d4b\u65b9\u6cd5\u7814\u7a76","funder_award_id":"62072206","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5693357935","display_name":"\u57fa\u4e8e\u836f\u7269\u5927\u6570\u636e\u7684\u6f5c\u5728\u4e0d\u826f\u836f\u7269\u53cd\u5e94\u6316\u6398\u7814\u7a76","funder_award_id":"61772381","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1540426123","https://openalex.org/W1671480867","https://openalex.org/W1974645069","https://openalex.org/W1984335547","https://openalex.org/W1989619850","https://openalex.org/W1997048564","https://openalex.org/W1998898494","https://openalex.org/W2003397087","https://openalex.org/W2062768198","https://openalex.org/W2094159851","https://openalex.org/W2097308346","https://openalex.org/W2110881853","https://openalex.org/W2113072832","https://openalex.org/W2141222510","https://openalex.org/W2148145769","https://openalex.org/W2187089797","https://openalex.org/W2393319904","https://openalex.org/W2402674527","https://openalex.org/W2579434750","https://openalex.org/W2750900465","https://openalex.org/W2753953057","https://openalex.org/W2754595644","https://openalex.org/W2766498431","https://openalex.org/W2780777007","https://openalex.org/W2789564895","https://openalex.org/W2790385355","https://openalex.org/W2809156537","https://openalex.org/W2896725104","https://openalex.org/W2904828342","https://openalex.org/W2911932738","https://openalex.org/W2942820662","https://openalex.org/W2946099214","https://openalex.org/W2948035163","https://openalex.org/W2950834624","https://openalex.org/W2952522777","https://openalex.org/W2962909765","https://openalex.org/W2966349991","https://openalex.org/W2977707586","https://openalex.org/W3000082418","https://openalex.org/W3009246021","https://openalex.org/W3015296677","https://openalex.org/W3042221936","https://openalex.org/W3048858802","https://openalex.org/W3093030756","https://openalex.org/W3148130466","https://openalex.org/W3154221903","https://openalex.org/W3163706053","https://openalex.org/W6632360541","https://openalex.org/W6712081154","https://openalex.org/W6712987211","https://openalex.org/W6752129415","https://openalex.org/W6784088628","https://openalex.org/W6791119338"],"related_works":["https://openalex.org/W1982442837","https://openalex.org/W2912240081","https://openalex.org/W2950946391","https://openalex.org/W3007491431","https://openalex.org/W4384518057","https://openalex.org/W2999398081","https://openalex.org/W4210291460","https://openalex.org/W3157957316","https://openalex.org/W3121544743","https://openalex.org/W2082867051"],"abstract_inverted_index":{"MOTIVATION:":[0],"There":[1],"are":[2,208,262],"various":[3],"interaction/association":[4],"bipartite":[5,15,52,69,82,118,136,147],"networks":[6,16,132],"in":[7,13,50,66,116,180,194],"biomolecular":[8],"systems.":[9],"Identifying":[10],"unobserved":[11],"links":[12,49],"biomedical":[14,51,117,135],"helps":[17],"to":[18,47,80,92,149,201,214],"understand":[19],"the":[20,31,64,73,78,130,134,146,168,184,203,216,235],"underlying":[21],"molecular":[22],"mechanisms":[23],"of":[24,35,41,55,76,170,183,190,218],"human":[25],"complex":[26],"diseases":[27],"and":[28,33,61,90,138,177,197,233,251],"thus":[29],"benefits":[30],"diagnosis":[32],"treatment":[34],"diseases.":[36],"Although":[37],"a":[38,105,123,141,157,212],"great":[39],"number":[40],"computational":[42],"methods":[43,232],"have":[44,87],"been":[45,97],"proposed":[46],"predict":[48,215],"networks,":[53],"most":[54],"them":[56,94],"heavily":[57],"depend":[58],"on":[59,145,228,238],"features":[60],"structures":[62],"involving":[63,242],"bioentities":[65,85],"one":[67],"specific":[68],"network,":[70,137],"which":[71,207],"limits":[72],"generalization":[74,236],"capacity":[75,237],"applying":[77],"models":[79],"other":[81],"networks.":[83,119],"Meanwhile,":[84],"usually":[86],"multiple":[88,191,199],"features,":[89],"how":[91],"leverage":[93],"has":[95,234],"also":[96],"challenging.":[98],"RESULTS:":[99],"In":[100],"this":[101],"study,":[102],"we":[103,187],"propose":[104],"novel":[106],"multi-view":[107,124],"graph":[108],"convolution":[109],"network":[110,126,148],"(MVGCN)":[111],"framework":[112],"for":[113,165],"link":[114],"prediction":[115],"We":[120],"first":[121],"construct":[122],"heterogeneous":[125],"(MVHN)":[127],"by":[128,172],"combining":[129],"similarity":[131],"with":[133,230],"then":[139,209],"perform":[140],"self-supervised":[142],"learning":[143],"strategy":[144],"obtain":[150,202],"node":[151,205],"attributes":[152],"as":[153],"initial":[154],"embeddings.":[155],"Further,":[156],"neighborhood":[158],"information":[159,174],"aggregation":[160],"(NIA)":[161],"layer":[162],"is":[163],"designed":[164],"iteratively":[166],"updating":[167],"embeddings":[169,189],"nodes":[171],"aggregating":[173],"from":[175,256],"inter-":[176],"intra-domain":[178],"neighbors":[179],"every":[181],"view":[182],"MVHN.":[185],"Next,":[186],"combine":[188],"NIA":[192],"layers":[193],"each":[195],"view,":[196],"integrate":[198],"views":[200],"final":[204],"embeddings,":[206],"fed":[210],"into":[211],"discriminator":[213],"existence":[217],"links.":[219],"Extensive":[220],"experiments":[221],"show":[222],"MVGCN":[223],"performs":[224],"better":[225],"than":[226],"or":[227],"par":[229],"baseline":[231],"six":[239],"benchmark":[240],"datasets":[241],"three":[243],"typical":[244],"tasks.":[245],"AVAILABILITY":[246],"AND":[247],"IMPLEMENTATION:":[248],"Source":[249],"code":[250],"data":[252,261],"can":[253],"be":[254],"downloaded":[255],"https://github.com/fuhaitao95/MVGCN.":[257],"SUPPLEMENTARY":[258],"INFORMATION:":[259],"Supplementary":[260],"available":[263],"at":[264],"Bioinformatics":[265],"online.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
