{"id":"https://openalex.org/W3198971962","doi":"https://doi.org/10.1093/bioinformatics/btab650","title":"TGSA: protein\u2013protein association-based twin graph neural networks for drug response prediction with similarity augmentation","display_name":"TGSA: protein\u2013protein association-based twin graph neural networks for drug response prediction with similarity augmentation","publication_year":2021,"publication_date":"2021-09-17","ids":{"openalex":"https://openalex.org/W3198971962","doi":"https://doi.org/10.1093/bioinformatics/btab650","mag":"3198971962","pmid":"https://pubmed.ncbi.nlm.nih.gov/34559177"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab650","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab650","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013049479","display_name":"Yiheng Zhu","orcid":"https://orcid.org/0000-0001-8020-9979"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiheng Zhu","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University , Hangzhou 310000, China"],"raw_orcid":"https://orcid.org/0000-0001-8020-9979","affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University , Hangzhou 310000, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014243777","display_name":"Zhenqiu Ouyang","orcid":"https://orcid.org/0000-0002-4314-8692"},"institutions":[{"id":"https://openalex.org/I4210132079","display_name":"Hangzhou Wanxiang Polytechnic","ror":"https://ror.org/03sxnxp24","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210132079"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenqiu Ouyang","raw_affiliation_strings":["Polytechnic Institute, Zhejiang University , Hangzhou 310000, China"],"raw_orcid":"https://orcid.org/0000-0002-4314-8692","affiliations":[{"raw_affiliation_string":"Polytechnic Institute, Zhejiang University , Hangzhou 310000, China","institution_ids":["https://openalex.org/I4210132079","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362717","display_name":"Wenbo Chen","orcid":"https://orcid.org/0000-0002-5712-6101"},"institutions":[{"id":"https://openalex.org/I4210132079","display_name":"Hangzhou Wanxiang Polytechnic","ror":"https://ror.org/03sxnxp24","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210132079"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Chen","raw_affiliation_strings":["Polytechnic Institute, Zhejiang University , Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polytechnic Institute, Zhejiang University , Hangzhou 310000, China","institution_ids":["https://openalex.org/I4210132079","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003036972","display_name":"Ruiwei Feng","orcid":"https://orcid.org/0000-0003-3732-7595"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiwei Feng","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University , Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University , Hangzhou 310000, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060901632","display_name":"Danny Z. Chen","orcid":"https://orcid.org/0000-0001-6565-2884"},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danny Z Chen","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Notre Dame , Notre Dame, IN 46556, USA"],"raw_orcid":"https://orcid.org/0000-0001-6565-2884","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Notre Dame , Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065297872","display_name":"Ji Cao","orcid":"https://orcid.org/0000-0003-2813-6404"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ji Cao","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University , Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University , Hangzhou 310000, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071068569","display_name":"Jian Wu","orcid":"https://orcid.org/0000-0002-3230-6392"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Wu","raw_affiliation_strings":["Department of Ophthalmology of the Second Affiliated Hospital School of Medicine, and School of Public Health, Zhejiang University , Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology of the Second Affiliated Hospital School of Medicine, and School of Public Health, Zhejiang University , Hangzhou 310000, China","institution_ids":["https://openalex.org/I4210158318"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5065297872","https://openalex.org/A5071068569"],"corresponding_institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"],"apc_list":{"value":3478,"currency":"USD","value_usd":3478},"apc_paid":null,"fwci":2.2379,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.89238988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"38","issue":"2","first_page":"461","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.40369999408721924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.40369999408721924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.2632000148296356,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.73563551902771},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.5811942219734192},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5732682943344116},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5482627749443054},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5233913064002991},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5008084774017334},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.49130979180336},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.4855163097381592},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.4236065745353699},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.41235682368278503},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38492774963378906},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.23432588577270508}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.73563551902771},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.5811942219734192},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5732682943344116},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5482627749443054},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5233913064002991},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5008084774017334},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.49130979180336},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.4855163097381592},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4236065745353699},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.41235682368278503},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38492774963378906},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.23432588577270508},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btab650","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab650","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34559177","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34559177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4687910176","display_name":"AF: Small: Algorithms in Computational Geometry and Medical Applications","funder_award_id":"1617735","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8327927261","display_name":"\u79fb\u52a8\u4e92\u8054\u7f51\u73af\u5883\u4e0b\u7684API\u53d1\u73b0\u4e0e\u805a\u5408\u7814\u7a76","funder_award_id":"61672453","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1757990252","https://openalex.org/W1872239493","https://openalex.org/W1988037271","https://openalex.org/W2043398720","https://openalex.org/W2064037082","https://openalex.org/W2072944938","https://openalex.org/W2083501474","https://openalex.org/W2096541451","https://openalex.org/W2108068107","https://openalex.org/W2108235071","https://openalex.org/W2112796928","https://openalex.org/W2135957668","https://openalex.org/W2146274229","https://openalex.org/W2176372762","https://openalex.org/W2187089797","https://openalex.org/W2189911347","https://openalex.org/W2197241765","https://openalex.org/W2432718434","https://openalex.org/W2461427403","https://openalex.org/W2516657620","https://openalex.org/W2606780347","https://openalex.org/W2742007096","https://openalex.org/W2767593474","https://openalex.org/W2803122042","https://openalex.org/W2804284974","https://openalex.org/W2807463161","https://openalex.org/W2898789672","https://openalex.org/W2900569176","https://openalex.org/W2901794234","https://openalex.org/W2948035163","https://openalex.org/W2948897453","https://openalex.org/W2950063908","https://openalex.org/W2953265656","https://openalex.org/W2955502047","https://openalex.org/W2962858109","https://openalex.org/W2965750004","https://openalex.org/W2969085937","https://openalex.org/W3000469142","https://openalex.org/W3101319109","https://openalex.org/W3116278528","https://openalex.org/W3130891725","https://openalex.org/W4237979515","https://openalex.org/W4241669766","https://openalex.org/W6736685754","https://openalex.org/W6766263406","https://openalex.org/W6775553191","https://openalex.org/W6793127252"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4224009465","https://openalex.org/W4286629047","https://openalex.org/W2885094885","https://openalex.org/W4306321456","https://openalex.org/W4285260836","https://openalex.org/W3046775127","https://openalex.org/W2950141738","https://openalex.org/W2492384539"],"abstract_inverted_index":{"MOTIVATION:":[0],"Drug":[1,80],"response":[2],"prediction":[3],"(DRP)":[4],"plays":[5],"an":[6,122,144],"important":[7],"role":[8],"in":[9,20,206],"precision":[10,207],"medicine":[11],"(e.g.":[12],"for":[13,79,115,203],"cancer":[14],"analysis":[15],"and":[16,84,93,109,130,156,185],"treatment).":[17],"Recent":[18],"advances":[19],"deep":[21],"learning":[22],"algorithms":[23],"make":[24,65],"it":[25],"possible":[26],"to":[27,64,90,133,148],"predict":[28],"drug":[29],"responses":[30],"accurately":[31],"based":[32,103],"on":[33,104,126,162],"genetic":[34],"profiles.":[35],"However,":[36],"existing":[37],"methods":[38],"ignore":[39],"the":[40,135,150,163,173,183],"potential":[41,202],"relationships":[42],"among":[43,48],"genes.":[44],"In":[45],"addition,":[46],"similarity":[47],"cell":[49,99,139],"lines/drugs":[50],"was":[51],"rarely":[52],"considered":[53],"explicitly.":[54],"RESULTS:":[55],"We":[56,180],"propose":[57],"a":[58,85,127],"novel":[59],"DRP":[60,120],"framework,":[61],"called":[62],"TGSA,":[63],"better":[66],"use":[67],"of":[68,74,137,153,187,190,198],"prior":[69],"domain":[70],"knowledge.":[71],"TGSA":[72,169,191,199],"consists":[73],"Twin":[75],"Graph":[76,111],"neural":[77],"networks":[78,108],"Response":[81],"Prediction":[82],"(TGDRP)":[83],"Similarity":[86],"Augmentation":[87],"(SA)":[88],"module":[89],"fuse":[91],"fine-grained":[92],"coarse-grained":[94],"information.":[95],"Specifically,":[96],"TGDRP":[97],"abstracts":[98],"lines":[100],"as":[101,121],"graphs":[102],"STRING":[105],"protein-protein":[106],"association":[107],"uses":[110],"Neural":[112],"Networks":[113],"(GNNs)":[114],"representation":[116],"learning.":[117],"SA":[118],"views":[119],"edge":[123],"regression":[124],"problem":[125],"heterogeneous":[128],"graph":[129],"utilizes":[131],"GNNs":[132],"smooth":[134],"representations":[136],"similar":[138],"lines/drugs.":[140],"Besides,":[141],"we":[142],"introduce":[143],"auxiliary":[145],"pre-training":[146],"strategy":[147],"remedy":[149],"identified":[151],"limitations":[152],"scarce":[154],"data":[155,222],"poor":[157],"out-of-distribution":[158],"generalization.":[159],"Extensive":[160],"experiments":[161],"GDSC2":[164],"dataset":[165],"demonstrate":[166],"that":[167],"our":[168],"consistently":[170],"outperforms":[171],"all":[172],"state-of-the-art":[174],"baselines":[175],"under":[176],"various":[177],"experimental":[178],"settings.":[179],"further":[181],"evaluate":[182],"effectiveness":[184],"contributions":[186],"each":[188],"component":[189],"via":[192],"ablation":[193],"experiments.":[194],"The":[195,212],"promising":[196],"performance":[197],"shows":[200],"enormous":[201],"clinical":[204],"applications":[205],"medicine.":[208],"AVAILABILITY":[209],"AND":[210],"IMPLEMENTATION:":[211],"source":[213],"code":[214],"is":[215],"available":[216,224],"at":[217,225],"https://github.com/violet-sto/TGSA.":[218],"SUPPLEMENTARY":[219],"INFORMATION:":[220],"Supplementary":[221],"are":[223],"Bioinformatics":[226],"online.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":3}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}
