{"id":"https://openalex.org/W3188659381","doi":"https://doi.org/10.1093/bioinformatics/btab576","title":"Predicting correlated outcomes from molecular data","display_name":"Predicting correlated outcomes from molecular data","publication_year":2021,"publication_date":"2021-08-05","ids":{"openalex":"https://openalex.org/W3188659381","doi":"https://doi.org/10.1093/bioinformatics/btab576","mag":"3188659381","pmid":"https://pubmed.ncbi.nlm.nih.gov/34358294"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab576","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab576","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/21/3889/41091787/btab576.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/37/21/3889/41091787/btab576.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001302914","display_name":"Armin Rauschenberger","orcid":"https://orcid.org/0000-0001-6498-4801"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":true,"raw_author_name":"Armin Rauschenberger","raw_affiliation_strings":["Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg , 4362 Esch-sur-Alzette, Luxembourg"],"raw_orcid":"https://orcid.org/0000-0001-6498-4801","affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg , 4362 Esch-sur-Alzette, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059437341","display_name":"Enrico Glaab","orcid":"https://orcid.org/0000-0003-3977-7469"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Enrico Glaab","raw_affiliation_strings":["Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg , 4362 Esch-sur-Alzette, Luxembourg"],"raw_orcid":"https://orcid.org/0000-0003-3977-7469","affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg , 4362 Esch-sur-Alzette, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001302914"],"corresponding_institution_ids":["https://openalex.org/I186903577"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.6337,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.66097748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"37","issue":"21","first_page":"3889","last_page":"3895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.16689999401569366,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.12020000070333481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5487329959869385},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.36091348528862},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.35453084111213684},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33863651752471924},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.142980694770813}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5487329959869385},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.36091348528862},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.35453084111213684},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33863651752471924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.142980694770813}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btab576","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab576","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/21/3889/41091787/btab576.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34358294","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34358294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:orbilu.uni.lu:10993/47788","is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/47788","pdf_url":"http://orbilu.uni.lu/handle/10993/47788","source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 37 (21), 3889\u20133895 (2021-08-06)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:pubmedcentral.nih.gov:10186156","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10186156","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10186156/pdf/btab576.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btab576","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab576","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/21/3889/41091787/btab576.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.49000000953674316}],"awards":[{"id":"https://openalex.org/G1222705056","display_name":"Multi-dimensional stratification of Parkinson\u2019s disease patients for personalised interventions","funder_award_id":"ANR-17-SYME-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8625210696","display_name":null,"funder_award_id":"I1R-BIC-PFN-15NCER","funder_id":"https://openalex.org/F4320321038","funder_display_name":"Fonds National de la Recherche Luxembourg"}],"funders":[{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3188659381.pdf","grobid_xml":"https://content.openalex.org/works/W3188659381.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W28412257","https://openalex.org/W1549928691","https://openalex.org/W1988494453","https://openalex.org/W1990378711","https://openalex.org/W2022565404","https://openalex.org/W2025983204","https://openalex.org/W2038381734","https://openalex.org/W2054359607","https://openalex.org/W2054561252","https://openalex.org/W2081531193","https://openalex.org/W2084714454","https://openalex.org/W2097360283","https://openalex.org/W2102201073","https://openalex.org/W2115098571","https://openalex.org/W2122825543","https://openalex.org/W2169577279","https://openalex.org/W2278601099","https://openalex.org/W2604470482","https://openalex.org/W2775363893","https://openalex.org/W2779618392","https://openalex.org/W2795568124","https://openalex.org/W2891165828","https://openalex.org/W2893021323","https://openalex.org/W2910934151","https://openalex.org/W2912368193","https://openalex.org/W2914369697","https://openalex.org/W2939516305","https://openalex.org/W2949427672","https://openalex.org/W2950266077","https://openalex.org/W3000128926","https://openalex.org/W3001025613","https://openalex.org/W3026087809","https://openalex.org/W3037936998","https://openalex.org/W3093932292","https://openalex.org/W3095049225","https://openalex.org/W3098865414","https://openalex.org/W3178862140","https://openalex.org/W4240294902","https://openalex.org/W4294541781","https://openalex.org/W4298826872","https://openalex.org/W6675321329","https://openalex.org/W6684849892","https://openalex.org/W6750028727"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W2350741829","https://openalex.org/W2530322880","https://openalex.org/W1596801655"],"abstract_inverted_index":{"MOTIVATION:":[0],"Multivariate":[1],"(multi-target)":[2],"regression":[3,11,31],"has":[4],"the":[5,57,61,72],"potential":[6],"to":[7,40,80],"outperform":[8],"univariate":[9],"(single-target)":[10],"at":[12,129],"predicting":[13,105],"correlated":[14,106],"outcomes,":[15],"which":[16],"frequently":[17],"occur":[18],"in":[19,45,87],"biomedical":[20],"and":[21,29,42,77,84,120],"clinical":[22,76],"research.":[23],"Here":[24],"we":[25,59,74],"implement":[26],"multivariate":[27,69,95],"lasso":[28],"ridge":[30],"using":[32],"stacked":[33,94],"generalization.":[34],"RESULTS:":[35],"Our":[36],"flexible":[37],"approach":[38],"leads":[39],"predictive":[41,62],"interpretable":[43],"models":[44],"high-dimensional":[46],"settings,":[47],"with":[48,97],"a":[49,101],"single":[50],"estimate":[51],"for":[52,68,104],"each":[53],"input-output":[54],"effect.":[55],"In":[56,71],"simulation,":[58],"compare":[60],"performance":[63],"of":[64],"several":[65],"state-of-the-art":[66],"methods":[67],"regression.":[70],"application,":[73],"use":[75],"genomic":[78],"data":[79,126],"predict":[81],"multiple":[82],"motor":[83],"non-motor":[85],"symptoms":[86],"Parkinson's":[88],"disease":[89],"patients.":[90],"We":[91],"conclude":[92],"that":[93],"regression,":[96],"our":[98],"adaptations,":[99],"is":[100,115],"competitive":[102],"method":[103],"outcomes.":[107],"AVAILABILITY":[108],"AND":[109],"IMPLEMENTATION:":[110],"The":[111],"R":[112],"package":[113],"joinet":[114],"available":[116,128],"on":[117],"GitHub":[118],"(https://github.com/rauschenberger/joinet)":[119],"cran":[121],"(https://cran.r-project.org/package=joinet).":[122],"SUPPLEMENTARY":[123],"INFORMATION:":[124],"Supplementary":[125],"are":[127],"Bioinformatics":[130],"online.":[131]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
