{"id":"https://openalex.org/W3200131653","doi":"https://doi.org/10.1093/bioinformatics/btab566","title":"PATHOME-Drug: a subpathway-based polypharmacology drug-repositioning method","display_name":"PATHOME-Drug: a subpathway-based polypharmacology drug-repositioning method","publication_year":2021,"publication_date":"2021-09-10","ids":{"openalex":"https://openalex.org/W3200131653","doi":"https://doi.org/10.1093/bioinformatics/btab566","mag":"3200131653","pmid":"https://pubmed.ncbi.nlm.nih.gov/34515762"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab566","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab566","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081771012","display_name":"Seungyoon Nam","orcid":"https://orcid.org/0000-0002-0966-7915"},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]},{"id":"https://openalex.org/I4210088426","display_name":"Gachon University Gil Medical Center","ror":"https://ror.org/005nteb15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I12832649","https://openalex.org/I4210088426"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seungyoon Nam","raw_affiliation_strings":["Department of Genome Medicine and Science, College of Medicine, Gachon University , 21565 Incheon, Korea","Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology, Gachon University , 21999 Incheon, Korea","Department of Life Sciences, Gachon University , 13120 Seongnam, Korea","Gachon Institute of Genomic Medicine and Science, Gachon University Gil Medical Center , 21565 Incheon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Medicine and Science, College of Medicine, Gachon University , 21565 Incheon, Korea","institution_ids":["https://openalex.org/I12832649"]},{"raw_affiliation_string":"Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology, Gachon University , 21999 Incheon, Korea","institution_ids":["https://openalex.org/I12832649"]},{"raw_affiliation_string":"Department of Life Sciences, Gachon University , 13120 Seongnam, Korea","institution_ids":["https://openalex.org/I12832649"]},{"raw_affiliation_string":"Gachon Institute of Genomic Medicine and Science, Gachon University Gil Medical Center , 21565 Incheon, Korea","institution_ids":["https://openalex.org/I4210088426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076575654","display_name":"Sungyoung Lee","orcid":"https://orcid.org/0000-0003-3458-1440"},"institutions":[{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungyoung Lee","raw_affiliation_strings":["Center for Precision Medicine, Seoul National University Hospital , 03080 Seoul, Korea","Department of Genomic Medicine, Seoul National University Hospital , 03080 Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-3458-1440","affiliations":[{"raw_affiliation_string":"Center for Precision Medicine, Seoul National University Hospital , 03080 Seoul, Korea","institution_ids":["https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Department of Genomic Medicine, Seoul National University Hospital , 03080 Seoul, Korea","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323627","display_name":"Sungjin Park","orcid":"https://orcid.org/0000-0003-3663-9220"},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]},{"id":"https://openalex.org/I4210088426","display_name":"Gachon University Gil Medical Center","ror":"https://ror.org/005nteb15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I12832649","https://openalex.org/I4210088426"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungjin Park","raw_affiliation_strings":["Department of Genome Medicine and Science, College of Medicine, Gachon University , 21565 Incheon, Korea","Gachon Institute of Genomic Medicine and Science, Gachon University Gil Medical Center , 21565 Incheon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Medicine and Science, College of Medicine, Gachon University , 21565 Incheon, Korea","institution_ids":["https://openalex.org/I12832649"]},{"raw_affiliation_string":"Gachon Institute of Genomic Medicine and Science, Gachon University Gil Medical Center , 21565 Incheon, Korea","institution_ids":["https://openalex.org/I4210088426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101413439","display_name":"Jinhyuk Lee","orcid":"https://orcid.org/0000-0002-7437-1846"},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinhyuk Lee","raw_affiliation_strings":["Department of Bioinformatics, University of Sciences and Technology , 34113 Daejeon, Korea","Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology , 34141 Daejeon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, University of Sciences and Technology , 34113 Daejeon, Korea","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology , 34141 Daejeon, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058531980","display_name":"Aron Park","orcid":"https://orcid.org/0000-0003-0203-6069"},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Aron Park","raw_affiliation_strings":["Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology, Gachon University , 21999 Incheon, Korea"],"raw_orcid":"https://orcid.org/0000-0003-0203-6069","affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology, Gachon University , 21999 Incheon, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021860620","display_name":"Yon Hui Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yon Hui Kim","raw_affiliation_strings":["Department of Biomedical Science, Hanyang University , 04763 Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Hanyang University , 04763 Seoul, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100643662","display_name":"Taesung Park","orcid":"https://orcid.org/0000-0002-8294-590X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Taesung Park","raw_affiliation_strings":["Department of Statistics, Seoul National University , 08826 Seoul, Korea","Interdisciplinary Program in Bioinformatics, Seoul National University , 08826 Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-8294-590X","affiliations":[{"raw_affiliation_string":"Department of Statistics, Seoul National University , 08826 Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, Seoul National University , 08826 Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5021860620","https://openalex.org/A5100643662"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4575257"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0133,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80031143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"38","issue":"2","first_page":"444","last_page":"452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.49810001254081726,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.49810001254081726,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.8472305536270142},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7246236801147461},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6398571133613586},{"id":"https://openalex.org/keywords/economic-shortage","display_name":"Economic shortage","score":0.5531432628631592},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5272535085678101},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4807529151439667},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4613613486289978},{"id":"https://openalex.org/keywords/approved-drug","display_name":"Approved drug","score":0.44749802350997925},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.44077861309051514},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36780476570129395},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.35550761222839355},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3109099268913269},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22281503677368164}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.8472305536270142},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7246236801147461},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6398571133613586},{"id":"https://openalex.org/C194051981","wikidata":"https://www.wikidata.org/wiki/Q1337691","display_name":"Economic shortage","level":3,"score":0.5531432628631592},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5272535085678101},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4807529151439667},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4613613486289978},{"id":"https://openalex.org/C2777494893","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Approved drug","level":3,"score":0.44749802350997925},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.44077861309051514},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36780476570129395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35550761222839355},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3109099268913269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22281503677368164},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C2778137410","wikidata":"https://www.wikidata.org/wiki/Q2732820","display_name":"Government (linguistics)","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btab566","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab566","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34515762","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34515762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1962607015","https://openalex.org/W1972898190","https://openalex.org/W1974918249","https://openalex.org/W1981737096","https://openalex.org/W1985504842","https://openalex.org/W1987979808","https://openalex.org/W1998898494","https://openalex.org/W1999086631","https://openalex.org/W2004840870","https://openalex.org/W2024381669","https://openalex.org/W2031954078","https://openalex.org/W2033591223","https://openalex.org/W2033599624","https://openalex.org/W2035618305","https://openalex.org/W2038122249","https://openalex.org/W2038385234","https://openalex.org/W2062533676","https://openalex.org/W2096173332","https://openalex.org/W2100463963","https://openalex.org/W2110684048","https://openalex.org/W2111213181","https://openalex.org/W2113951828","https://openalex.org/W2121604817","https://openalex.org/W2128088446","https://openalex.org/W2137052779","https://openalex.org/W2142879323","https://openalex.org/W2157997136","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2166574880","https://openalex.org/W2168764383","https://openalex.org/W2319060767","https://openalex.org/W2341504574","https://openalex.org/W2489003193","https://openalex.org/W2555023220","https://openalex.org/W2593436234","https://openalex.org/W2607935009","https://openalex.org/W2611696724","https://openalex.org/W2612467560","https://openalex.org/W2744262088","https://openalex.org/W2761346730","https://openalex.org/W2791544564","https://openalex.org/W2804582507","https://openalex.org/W2905506251","https://openalex.org/W2911848688","https://openalex.org/W2965506096","https://openalex.org/W3038543817","https://openalex.org/W4294216483","https://openalex.org/W6757506816"],"related_works":["https://openalex.org/W2886266969","https://openalex.org/W3044296243","https://openalex.org/W4292112179","https://openalex.org/W4280584065","https://openalex.org/W2083826446","https://openalex.org/W3134564766","https://openalex.org/W4285506882","https://openalex.org/W2561827752","https://openalex.org/W2299074827","https://openalex.org/W4387074703"],"abstract_inverted_index":{"MOTIVATION:":[0],"Drug":[1],"repositioning":[2,20,87],"reveals":[3],"novel":[4],"indications":[5],"for":[6,133,145],"existing":[7,112],"drugs":[8,56,114],"and":[9,38,60,110,137,143,149,179],"in":[10,42,72,122],"particular,":[11],"diseases":[12],"with":[13],"no":[14],"available":[15,173,182,190],"drugs.":[16],"Diverse":[17],"computational":[18],"drug":[19,36,86],"methods":[21,47],"have":[22],"been":[23],"proposed":[24],"by":[25],"measuring":[26],"either":[27],"drug-treated":[28],"gene":[29],"expression":[30],"signatures":[31],"or":[32],"the":[33,79,123,160],"proximity":[34],"of":[35,68,99,163],"targets":[37,67,119],"disease":[39,107],"proteins":[40],"found":[41],"prior":[43],"networks.":[44],"However,":[45],"these":[46],"do":[48,61],"not":[49,62],"explain":[50],"which":[51],"signaling":[52,100,135],"subparts":[53,98],"allow":[54],"potential":[55],"to":[57,77,103,141],"be":[58],"selected,":[59],"consider":[63],"polypharmacology,":[64],"i.e.":[65],"multiple":[66,118],"a":[69,83],"known":[70],"drug,":[71],"specific":[73,138],"subparts.":[74,124],"RESULTS:":[75],"Here,":[76],"address":[78,159],"limitations,":[80],"we":[81],"developed":[82],"subpathway-based":[84],"polypharmacology":[85],"method,":[88],"PATHOME-Drug,":[89],"based":[90],"on":[91],"drug-associated":[92],"transcriptomes.":[93],"Specifically,":[94],"this":[95],"tool":[96,156],"locates":[97],"cascading":[101],"related":[102],"phenotype":[104],"changes":[105],"(e.g.":[106],"status":[108],"changes),":[109],"identifies":[111],"approved":[113],"such":[115],"that":[116,127,154],"their":[117],"are":[120,181,189],"enriched":[121],"We":[125,152],"show":[126],"our":[128,155],"method":[129],"demonstrated":[130],"better":[131],"performance":[132],"detecting":[134],"context":[136],"drugs/compounds,":[139],"compared":[140],"WebGestalt":[142],"clusterProfiler,":[144],"both":[146],"real":[147],"biological":[148],"simulated":[150],"datasets.":[151],"believe":[153],"can":[157],"successfully":[158],"current":[161],"shortage":[162],"targeted":[164],"therapy":[165],"agents.":[166],"AVAILABILITY":[167],"AND":[168],"IMPLEMENTATION:":[169],"The":[170,176],"web-service":[171],"is":[172],"at":[174,183,191],"http://statgen.snu.ac.kr/software/pathome.":[175],"source":[177],"codes":[178],"data":[180,188],"https://github.com/labnams/pathome-drug.":[184],"SUPPLEMENTARY":[185],"INFORMATION:":[186],"Supplementary":[187],"Bioinformatics":[192],"online.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}