{"id":"https://openalex.org/W3182693720","doi":"https://doi.org/10.1093/bioinformatics/btab498","title":"D-MANOVA: fast distance-based multivariate analysis of variance for large-scale microbiome association studies","display_name":"D-MANOVA: fast distance-based multivariate analysis of variance for large-scale microbiome association studies","publication_year":2021,"publication_date":"2021-07-07","ids":{"openalex":"https://openalex.org/W3182693720","doi":"https://doi.org/10.1093/bioinformatics/btab498","mag":"3182693720","pmid":"https://pubmed.ncbi.nlm.nih.gov/34255026"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab498","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab498","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8696110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100450167","display_name":"Jun Chen","orcid":"https://orcid.org/0000-0002-1273-5624"},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Chen","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN 55901, USA"],"raw_orcid":"https://orcid.org/0000-0002-1273-5624","affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN 55901, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102873564","display_name":"Xianyang Zhang","orcid":"https://orcid.org/0000-0002-2512-1816"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xianyang Zhang","raw_affiliation_strings":["Department of Statistics, Texas A&M University , College Station, TX 77840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Texas A&M University , College Station, TX 77840, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100450167","https://openalex.org/A5102873564"],"corresponding_institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I91045830"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.791,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.85558621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"38","issue":"1","first_page":"286","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivariate-analysis-of-variance","display_name":"Multivariate analysis of variance","score":0.7942532896995544},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.6754780411720276},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.6451417207717896},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.5881200432777405},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.5654032826423645},{"id":"https://openalex.org/keywords/statistic","display_name":"Statistic","score":0.5404582619667053},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.5260094404220581},{"id":"https://openalex.org/keywords/covariate","display_name":"Covariate","score":0.517169177532196},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.5128574371337891},{"id":"https://openalex.org/keywords/variance","display_name":"Variance (accounting)","score":0.4847854971885681},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.4713525176048279},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4319581091403961},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.39407843351364136},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2569550573825836},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.22780436277389526},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.1034034788608551},{"id":"https://openalex.org/keywords/cartography","display_name":"Cartography","score":0.0764140784740448}],"concepts":[{"id":"https://openalex.org/C192424360","wikidata":"https://www.wikidata.org/wiki/Q929408","display_name":"Multivariate analysis of variance","level":2,"score":0.7942532896995544},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.6754780411720276},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.6451417207717896},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5881200432777405},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5654032826423645},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.5404582619667053},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5260094404220581},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.517169177532196},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5128574371337891},{"id":"https://openalex.org/C196083921","wikidata":"https://www.wikidata.org/wiki/Q7915758","display_name":"Variance (accounting)","level":2,"score":0.4847854971885681},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4713525176048279},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4319581091403961},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.39407843351364136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2569550573825836},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22780436277389526},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.1034034788608551},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.0764140784740448},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C121955636","wikidata":"https://www.wikidata.org/wiki/Q4116214","display_name":"Accounting","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btab498","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab498","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34255026","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34255026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8696110","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8696110","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8696110","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8696110","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1458540498","display_name":null,"funder_award_id":"R21 HG011662","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2105937617","https://openalex.org/W2144751786","https://openalex.org/W2149421543","https://openalex.org/W2531272587","https://openalex.org/W2771485505","https://openalex.org/W2794407684"],"related_works":["https://openalex.org/W2899206237","https://openalex.org/W2371153315","https://openalex.org/W2985746494","https://openalex.org/W3178534496","https://openalex.org/W4206042385","https://openalex.org/W2511384863","https://openalex.org/W2096089271","https://openalex.org/W1537632507","https://openalex.org/W2923628599","https://openalex.org/W2014100433"],"abstract_inverted_index":{"SUMMARY:":[0],"PERMANOVA":[1,58,73,95],"(permutational":[2],"multivariate":[3],"analysis":[4],"of":[5,24,57,71,121],"variance":[6],"based":[7,81],"on":[8,82,125],"distances)":[9],"has":[10],"been":[11],"widely":[12],"used":[13],"for":[14,36],"testing":[15],"the":[16,19,68,72,88,94,113,119,126,136,140],"association":[17],"between":[18],"microbiome":[20,42],"and":[21,76,108],"a":[22,53,99],"covariate":[23],"interest.":[25],"Statistical":[26],"significance":[27],"is":[28,33,59,91,105,133],"established":[29],"by":[30,135],"permutation,":[31],"which":[32],"computationally":[34,54],"intensive":[35],"large":[37],"sample":[38,101],"sizes.":[39],"As":[40],"large-scale":[41],"studies,":[43],"such":[44],"as":[45],"American":[46],"Gut":[47],"Project":[48],"(AGP),":[49],"become":[50],"increasingly":[51],"popular,":[52],"efficient":[55],"version":[56],"much":[60],"needed.":[61],"To":[62],"achieve":[63],"this":[64],"end,":[65],"we":[66],"derive":[67],"asymptotic":[69,89],"distribution":[70],"pseudo-F":[74],"statistic":[75],"provide":[77],"analytical":[78],"P-value":[79,90,96],"calculation":[80],"chi-square":[83],"approximation.":[84],"We":[85,117],"show":[86],"that":[87],"close":[92],"to":[93],"even":[97],"under":[98],"moderate":[100],"size.":[102],"Moreover,":[103],"it":[104],"more":[106],"accurate":[107],"an":[109],"order-of-magnitude":[110],"faster":[111],"than":[112],"permutation-free":[114],"method":[115],"MDMR.":[116],"demonstrated":[118],"use":[120],"our":[122],"procedure":[123],"D-MANOVA":[124,132],"AGP":[127],"dataset.":[128],"AVAILABILITY":[129],"AND":[130],"IMPLEMENTATION:":[131],"implemented":[134],"dmanova":[137],"function":[138],"in":[139],"CRAN":[141],"package":[142],"GUniFrac.":[143],"SUPPLEMENTARY":[144],"INFORMATION:":[145],"Supplementary":[146],"data":[147],"are":[148],"available":[149],"at":[150],"Bioinformatics":[151],"online.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
