{"id":"https://openalex.org/W3162415967","doi":"https://doi.org/10.1093/bioinformatics/btab395","title":"Bistability in cell signalling and its significance in identifying potential drug-targets","display_name":"Bistability in cell signalling and its significance in identifying potential drug-targets","publication_year":2021,"publication_date":"2021-05-20","ids":{"openalex":"https://openalex.org/W3162415967","doi":"https://doi.org/10.1093/bioinformatics/btab395","mag":"3162415967","pmid":"https://pubmed.ncbi.nlm.nih.gov/34021761"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab395","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab395","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014422002","display_name":"Suvankar Halder","orcid":"https://orcid.org/0009-0006-3070-4756"},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suvankar Halder","raw_affiliation_strings":["Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India"],"affiliations":[{"raw_affiliation_string":"Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103215684","display_name":"Sumana Ghosh","orcid":"https://orcid.org/0000-0002-4004-6869"},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumana Ghosh","raw_affiliation_strings":["Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India"],"affiliations":[{"raw_affiliation_string":"Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085738321","display_name":"Joydev Chattopadhyay","orcid":"https://orcid.org/0000-0003-0466-3066"},"institutions":[{"id":"https://openalex.org/I6498739","display_name":"Indian Statistical Institute","ror":"https://ror.org/00q2w1j53","country_code":"IN","type":"education","lineage":["https://openalex.org/I6498739"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Joydev Chattopadhyay","raw_affiliation_strings":["Agricultural and Ecological Research Unit, Indian Statistical Institute , Kolkata 700108, India"],"affiliations":[{"raw_affiliation_string":"Agricultural and Ecological Research Unit, Indian Statistical Institute , Kolkata 700108, India","institution_ids":["https://openalex.org/I6498739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082491317","display_name":"Samrat Chatterjee","orcid":"https://orcid.org/0000-0002-5010-2799"},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Samrat Chatterjee","raw_affiliation_strings":["Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India"],"affiliations":[{"raw_affiliation_string":"Complex Analysis Group, Translational Health Science and Technology Institute, NCR Biotech Science Cluster , Faridabad 121001, India","institution_ids":["https://openalex.org/I2801880299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082491317"],"corresponding_institution_ids":["https://openalex.org/I2801880299"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.4827,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61089861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"37","issue":"22","first_page":"4156","last_page":"4163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.9659433364868164},{"id":"https://openalex.org/keywords/signalling","display_name":"Signalling","score":0.586394727230072},{"id":"https://openalex.org/keywords/salient","display_name":"Salient","score":0.5853835344314575},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5784121155738831},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.503354012966156},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.48976898193359375},{"id":"https://openalex.org/keywords/relation","display_name":"Relation (database)","score":0.4373651146888733},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3632199764251709},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.314769446849823},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23152223229408264},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22082895040512085},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.19768226146697998},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.19240429997444153}],"concepts":[{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.9659433364868164},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.586394727230072},{"id":"https://openalex.org/C2780719617","wikidata":"https://www.wikidata.org/wiki/Q1030752","display_name":"Salient","level":2,"score":0.5853835344314575},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5784121155738831},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.503354012966156},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.48976898193359375},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.4373651146888733},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3632199764251709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314769446849823},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23152223229408264},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22082895040512085},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.19768226146697998},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19240429997444153},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btab395","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab395","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34021761","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34021761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G5859760341","display_name":null,"funder_award_id":"09/1049(0032)/2018-EMR-I","funder_id":"https://openalex.org/F4320320721","funder_display_name":"Council of Scientific and Industrial Research, India"},{"id":"https://openalex.org/G6804712193","display_name":null,"funder_award_id":"BT/PR13086/BRB/10/1380/2015","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1561954310","https://openalex.org/W1865855039","https://openalex.org/W1911421926","https://openalex.org/W1966638085","https://openalex.org/W1970070519","https://openalex.org/W1978217382","https://openalex.org/W1978319180","https://openalex.org/W1994032485","https://openalex.org/W1996842671","https://openalex.org/W2008855387","https://openalex.org/W2009313526","https://openalex.org/W2016546231","https://openalex.org/W2021058886","https://openalex.org/W2027733508","https://openalex.org/W2031206420","https://openalex.org/W2032759622","https://openalex.org/W2032838460","https://openalex.org/W2037992356","https://openalex.org/W2047365291","https://openalex.org/W2049336663","https://openalex.org/W2055945512","https://openalex.org/W2061425021","https://openalex.org/W2062116003","https://openalex.org/W2065611025","https://openalex.org/W2066995617","https://openalex.org/W2067895024","https://openalex.org/W2071495240","https://openalex.org/W2073487727","https://openalex.org/W2073697169","https://openalex.org/W2078119846","https://openalex.org/W2079722759","https://openalex.org/W2092509730","https://openalex.org/W2094204987","https://openalex.org/W2098344103","https://openalex.org/W2101647844","https://openalex.org/W2104525378","https://openalex.org/W2109110326","https://openalex.org/W2121567796","https://openalex.org/W2122587265","https://openalex.org/W2123880844","https://openalex.org/W2123973944","https://openalex.org/W2125808663","https://openalex.org/W2132488174","https://openalex.org/W2132980978","https://openalex.org/W2134759932","https://openalex.org/W2135535700","https://openalex.org/W2153624566","https://openalex.org/W2157989234","https://openalex.org/W2164925597","https://openalex.org/W2166132142","https://openalex.org/W2169628645","https://openalex.org/W2171228793","https://openalex.org/W2171280873","https://openalex.org/W2202647051","https://openalex.org/W2262060930","https://openalex.org/W2361838659","https://openalex.org/W2473732499","https://openalex.org/W2538555370","https://openalex.org/W2707747899","https://openalex.org/W2750588931","https://openalex.org/W2797970676","https://openalex.org/W2808577370","https://openalex.org/W2904016386","https://openalex.org/W2945797616","https://openalex.org/W2979957578","https://openalex.org/W2982368177","https://openalex.org/W3088110174","https://openalex.org/W3099251374","https://openalex.org/W3203011645","https://openalex.org/W6752533259","https://openalex.org/W6770440696"],"related_works":["https://openalex.org/W4224217224","https://openalex.org/W3118640947","https://openalex.org/W4388308731","https://openalex.org/W2042003698","https://openalex.org/W1964519618","https://openalex.org/W1969697984","https://openalex.org/W3048730783","https://openalex.org/W1992416820","https://openalex.org/W3094197880","https://openalex.org/W2183786486"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}