{"id":"https://openalex.org/W3098962209","doi":"https://doi.org/10.1093/bioinformatics/btab162","title":"MixTwice: large-scale hypothesis testing for peptide arrays by variance mixing","display_name":"MixTwice: large-scale hypothesis testing for peptide arrays by variance mixing","publication_year":2021,"publication_date":"2021-03-05","ids":{"openalex":"https://openalex.org/W3098962209","doi":"https://doi.org/10.1093/bioinformatics/btab162","mag":"3098962209","pmid":"https://pubmed.ncbi.nlm.nih.gov/33693483"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab162","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab162","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/17/2637/40342711/btab162.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/37/17/2637/40342711/btab162.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107987282","display_name":"Zihao Zheng","orcid":"https://orcid.org/0000-0001-8166-0649"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zihao Zheng","raw_affiliation_strings":["Department of Medicine, University of Wisconsin-Madison , Madison, WI 53705, USA","Department of Statistics, University of Wisconsin-Madison , Madison, WI 53706, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin-Madison , Madison, WI 53705, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Statistics, University of Wisconsin-Madison , Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027415194","display_name":"Aisha M. Mergaert","orcid":"https://orcid.org/0000-0002-8177-9161"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aisha M. Mergaert","raw_affiliation_strings":["Department of Medicine, University of Wisconsin-Madison , Madison, WI 53705, USA","Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, WI 53705-2281, USA","Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705-2281, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin-Madison , Madison, WI 53705, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, WI 53705-2281, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705-2281, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019665472","display_name":"Irene M. Ong","orcid":"https://orcid.org/0000-0002-9353-6941"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene M. Ong","raw_affiliation_strings":["Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison , Madison, WI 53726, USA","Department of Obstetrics and Gynecology, University of Wisconsin-Madison , Madison, WI 53792, USA","University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin-Madison , Madison, WI 53792, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison , Madison, WI 53726, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison , Madison, WI 53792, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin-Madison , Madison, WI 53792, USA","institution_ids":["https://openalex.org/I4210103341","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087464909","display_name":"Miriam A. Shelef","orcid":"https://orcid.org/0000-0002-8842-0303"},"institutions":[{"id":"https://openalex.org/I4210141342","display_name":"William S. Middleton Memorial Veterans Hospital","ror":"https://ror.org/037xafn82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210141342"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam A. Shelef","raw_affiliation_strings":["Department of Medicine, University of Wisconsin-Madison , Madison, WI 53705, USA","William S. Middleton Memorial Veterans Hospital , Madison, WI 53705, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin-Madison , Madison, WI 53705, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"William S. Middleton Memorial Veterans Hospital , Madison, WI 53705, USA","institution_ids":["https://openalex.org/I4210141342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072759658","display_name":"Michael A. Newton","orcid":"https://orcid.org/0000-0001-9038-878X"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Newton","raw_affiliation_strings":["Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison , Madison, WI 53726, USA","Department of Statistics, University of Wisconsin-Madison , Madison, WI 53706, USA","University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin-Madison , Madison, WI 53792, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison , Madison, WI 53726, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Statistics, University of Wisconsin-Madison , Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin-Madison , Madison, WI 53792, USA","institution_ids":["https://openalex.org/I4210103341","https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5072759658"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.7304,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67965177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"37","issue":"17","first_page":"2637","last_page":"2643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.80366051197052},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5264761447906494},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5260291695594788},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.4741227924823761},{"id":"https://openalex.org/keywords/variance","display_name":"Variance (accounting)","score":0.46056610345840454},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4359760880470276},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.43166983127593994},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.41225746273994446},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41025274991989136},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.39745092391967773},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.38838446140289307},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3475976884365082},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12351590394973755}],"concepts":[{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.80366051197052},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5264761447906494},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5260291695594788},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.4741227924823761},{"id":"https://openalex.org/C196083921","wikidata":"https://www.wikidata.org/wiki/Q7915758","display_name":"Variance (accounting)","level":2,"score":0.46056610345840454},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4359760880470276},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.43166983127593994},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.41225746273994446},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41025274991989136},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.39745092391967773},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.38838446140289307},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3475976884365082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12351590394973755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121955636","wikidata":"https://www.wikidata.org/wiki/Q4116214","display_name":"Accounting","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btab162","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab162","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/17/2637/40342711/btab162.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33693483","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33693483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:arXiv.org:2011.07420","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2011.07420","pdf_url":"https://arxiv.org/pdf/2011.07420","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:europepmc.org:7322594","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8428605","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8428605","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8428605","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btab162","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab162","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/17/2637/40342711/btab162.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3080512194","display_name":null,"funder_award_id":"1740707","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G764145429","display_name":null,"funder_award_id":"P50 DE026787","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3098962209.pdf","grobid_xml":"https://content.openalex.org/works/W3098962209.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1510659740","https://openalex.org/W2032247503","https://openalex.org/W2041729262","https://openalex.org/W2054622040","https://openalex.org/W2058358568","https://openalex.org/W2074089196","https://openalex.org/W2103991421","https://openalex.org/W2104669609","https://openalex.org/W2109578241","https://openalex.org/W2109938573","https://openalex.org/W2110065044","https://openalex.org/W2125905177","https://openalex.org/W2128952811","https://openalex.org/W2157009395","https://openalex.org/W2164539618","https://openalex.org/W2171537806","https://openalex.org/W2418024629","https://openalex.org/W2475874684","https://openalex.org/W2735846911","https://openalex.org/W2781808282","https://openalex.org/W2789967317","https://openalex.org/W2889362907","https://openalex.org/W2911277418","https://openalex.org/W2944481292","https://openalex.org/W2949555575","https://openalex.org/W2949830473","https://openalex.org/W2951144892","https://openalex.org/W2967411352","https://openalex.org/W2981003035","https://openalex.org/W3009965004","https://openalex.org/W3034221632","https://openalex.org/W3049635785","https://openalex.org/W3096605445","https://openalex.org/W3123457094","https://openalex.org/W4288617070","https://openalex.org/W4313368429","https://openalex.org/W4399582599","https://openalex.org/W6692239864","https://openalex.org/W6762611988","https://openalex.org/W6779368331","https://openalex.org/W6848400821"],"related_works":["https://openalex.org/W2389124870","https://openalex.org/W1921844237","https://openalex.org/W2168149717","https://openalex.org/W200978175","https://openalex.org/W2055552685","https://openalex.org/W2318436337","https://openalex.org/W2067135330","https://openalex.org/W2156178399","https://openalex.org/W2221502901","https://openalex.org/W1915362844"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
