{"id":"https://openalex.org/W3134419254","doi":"https://doi.org/10.1093/bioinformatics/btab139","title":"CCmed: cross-condition mediation analysis for identifying replicable trans-associations mediated by cis-gene expression","display_name":"CCmed: cross-condition mediation analysis for identifying replicable trans-associations mediated by cis-gene expression","publication_year":2021,"publication_date":"2021-02-25","ids":{"openalex":"https://openalex.org/W3134419254","doi":"https://doi.org/10.1093/bioinformatics/btab139","mag":"3134419254","pmid":"https://pubmed.ncbi.nlm.nih.gov/33647928"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab139","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab139","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8428610","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113881767","display_name":"Fan Yang","orcid":"https://orcid.org/0009-0005-9671-0991"},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fan Yang","raw_affiliation_strings":["Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus , Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033873134","display_name":"Kevin J. Gleason","orcid":"https://orcid.org/0000-0002-3850-5093"},"institutions":[{"id":"https://openalex.org/I169222155","display_name":"Chicago Department of Public Health","ror":"https://ror.org/045v7ay82","country_code":"US","type":"government","lineage":["https://openalex.org/I169222155"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Gleason","raw_affiliation_strings":["Department of Public Health Sciences, University of Chicago , Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, University of Chicago , Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I169222155","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042915991","display_name":"Jiebiao Wang","orcid":"https://orcid.org/0000-0003-3828-4400"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiebiao Wang","raw_affiliation_strings":["Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15261, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Pittsburgh , Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020329452","display_name":"Jubao Duan","orcid":"https://orcid.org/0000-0002-7215-3220"},"institutions":[{"id":"https://openalex.org/I1339509835","display_name":"NorthShore University HealthSystem","ror":"https://ror.org/04tpp9d61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339509835"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jubao Duan","raw_affiliation_strings":["Department of Psychiatry and Behavioral Neuroscience , Chicago, IL 60637, USA","Unit of Functional Genomics in Psychiatry, Center for Psychiatric Genetics, NorthShore University HealthSystem , Evanston, IL 60201, USA"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Neuroscience , Chicago, IL 60637, USA","institution_ids":[]},{"raw_affiliation_string":"Unit of Functional Genomics in Psychiatry, Center for Psychiatric Genetics, NorthShore University HealthSystem , Evanston, IL 60201, USA","institution_ids":["https://openalex.org/I1339509835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064795764","display_name":"Xin He","orcid":"https://orcid.org/0000-0001-9011-5212"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin He","raw_affiliation_strings":["Department of Human Genetics, University of Chicago , Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Chicago , Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065566745","display_name":"Brandon L. Pierce","orcid":"https://orcid.org/0000-0002-7829-952X"},"institutions":[{"id":"https://openalex.org/I169222155","display_name":"Chicago Department of Public Health","ror":"https://ror.org/045v7ay82","country_code":"US","type":"government","lineage":["https://openalex.org/I169222155"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon L. Pierce","raw_affiliation_strings":["Department of Human Genetics, University of Chicago , Chicago, IL 60637, USA","Department of Public Health Sciences, University of Chicago , Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Chicago , Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Public Health Sciences, University of Chicago , Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I169222155","https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015182161","display_name":"Lin Chen","orcid":"https://orcid.org/0000-0002-6645-5708"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I169222155","display_name":"Chicago Department of Public Health","ror":"https://ror.org/045v7ay82","country_code":"US","type":"government","lineage":["https://openalex.org/I169222155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lin S. Chen","raw_affiliation_strings":["Department of Public Health Sciences, University of Chicago , Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, University of Chicago , Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I169222155","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5015182161","https://openalex.org/A5113881767"],"corresponding_institution_ids":["https://openalex.org/I151808059","https://openalex.org/I169222155","https://openalex.org/I40347166","https://openalex.org/I51713134"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6858,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.72624717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"37","issue":"17","first_page":"2513","last_page":"2520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.8699119091033936},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7164251804351807},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6505255699157715},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6450762152671814},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5695503354072571},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.5656296014785767},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.5264273881912231},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5070552825927734},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.48919156193733215},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.4845229983329773},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.4161078631877899},{"id":"https://openalex.org/keywords/trans-acting","display_name":"Trans-acting","score":0.41095829010009766},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.3635540008544922}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.8699119091033936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7164251804351807},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6505255699157715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6450762152671814},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5695503354072571},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5656296014785767},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.5264273881912231},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5070552825927734},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.48919156193733215},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4845229983329773},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4161078631877899},{"id":"https://openalex.org/C53479859","wikidata":"https://www.wikidata.org/wiki/Q3064200","display_name":"Trans-acting","level":4,"score":0.41095829010009766},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3635540008544922},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btab139","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab139","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33647928","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33647928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8428610","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8428610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8428610","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8428610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1377134883","display_name":null,"funder_award_id":"SUB-U24 CA2109993","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G372721019","display_name":null,"funder_award_id":"F31CA239557","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6660088476","display_name":null,"funder_award_id":"2R01GM108711","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1964895626","https://openalex.org/W1969936364","https://openalex.org/W1976876708","https://openalex.org/W2067245109","https://openalex.org/W2073836327","https://openalex.org/W2101357408","https://openalex.org/W2129758889","https://openalex.org/W2144961623","https://openalex.org/W2154998360","https://openalex.org/W2171137184","https://openalex.org/W2241686927","https://openalex.org/W2336520232","https://openalex.org/W2526546796","https://openalex.org/W2761275051","https://openalex.org/W2811205482","https://openalex.org/W2896352133","https://openalex.org/W2949244245","https://openalex.org/W2951159567","https://openalex.org/W2951962793","https://openalex.org/W2952835495","https://openalex.org/W3084019684","https://openalex.org/W3084033366","https://openalex.org/W3133859624","https://openalex.org/W3143073563"],"related_works":["https://openalex.org/W104925310","https://openalex.org/W2464196154","https://openalex.org/W1995613491","https://openalex.org/W2951751247","https://openalex.org/W2143143063","https://openalex.org/W2112543488","https://openalex.org/W4323567910","https://openalex.org/W3098850595","https://openalex.org/W4384126845","https://openalex.org/W2071852132"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}