{"id":"https://openalex.org/W3133006703","doi":"https://doi.org/10.1093/bioinformatics/btab112","title":"Accurate deep learning off-target prediction with novel sgRNA-DNA sequence encoding in CRISPR-Cas9 gene editing","display_name":"Accurate deep learning off-target prediction with novel sgRNA-DNA sequence encoding in CRISPR-Cas9 gene editing","publication_year":2021,"publication_date":"2021-02-18","ids":{"openalex":"https://openalex.org/W3133006703","doi":"https://doi.org/10.1093/bioinformatics/btab112","mag":"3133006703","pmid":"https://pubmed.ncbi.nlm.nih.gov/33599251"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab112","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab112","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072525453","display_name":"J\u00e9r\u00e9my Charlier","orcid":null},"institutions":[{"id":"https://openalex.org/I159129438","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al","ror":"https://ror.org/002rjbv21","country_code":"CA","type":"education","lineage":["https://openalex.org/I159129438","https://openalex.org/I49663120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeremy Charlier","raw_affiliation_strings":["D\u00e9partement d\u2019Informatique, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al , Montr\u00e9al, QC H2X 3Y7, Canada"],"affiliations":[{"raw_affiliation_string":"D\u00e9partement d\u2019Informatique, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al , Montr\u00e9al, QC H2X 3Y7, Canada","institution_ids":["https://openalex.org/I159129438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039347446","display_name":"Robert Nadon","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148969","display_name":"McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre","ror":"https://ror.org/0589bxs97","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210148969"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert Nadon","raw_affiliation_strings":["Department of Human Genetics, McGill University , Montreal, QC H3A 0C7, Canada","McGill University and Genome Quebec Innovation Centre , Montreal, QC H3A 0C7, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, McGill University , Montreal, QC H3A 0C7, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"McGill University and Genome Quebec Innovation Centre , Montreal, QC H3A 0C7, Canada","institution_ids":["https://openalex.org/I4210148969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004592090","display_name":"Vladimir Makarenkov","orcid":"https://orcid.org/0000-0003-3753-5925"},"institutions":[{"id":"https://openalex.org/I159129438","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al","ror":"https://ror.org/002rjbv21","country_code":"CA","type":"education","lineage":["https://openalex.org/I159129438","https://openalex.org/I49663120"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Vladimir Makarenkov","raw_affiliation_strings":["D\u00e9partement d\u2019Informatique, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al , Montr\u00e9al, QC H2X 3Y7, Canada"],"affiliations":[{"raw_affiliation_string":"D\u00e9partement d\u2019Informatique, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al , Montr\u00e9al, QC H2X 3Y7, Canada","institution_ids":["https://openalex.org/I159129438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004592090"],"corresponding_institution_ids":["https://openalex.org/I159129438"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.0095,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.92522232,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"37","issue":"16","first_page":"2299","last_page":"2307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.760622501373291},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6622728109359741},{"id":"https://openalex.org/keywords/encoding","display_name":"Encoding (memory)","score":0.610166072845459},{"id":"https://openalex.org/keywords/recurrent-neural-network","display_name":"Recurrent neural network","score":0.6101177930831909},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5748894214630127},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.505985677242279},{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.4690471291542053},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.46346819400787354},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.36067265272140503},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21863189339637756},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1430334448814392},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12877106666564941}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.760622501373291},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6622728109359741},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.610166072845459},{"id":"https://openalex.org/C147168706","wikidata":"https://www.wikidata.org/wiki/Q1457734","display_name":"Recurrent neural network","level":3,"score":0.6101177930831909},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5748894214630127},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.505985677242279},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.4690471291542053},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.46346819400787354},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.36067265272140503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21863189339637756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1430334448814392},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12877106666564941}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btab112","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab112","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33599251","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33599251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.5899999737739563}],"awards":[{"id":"https://openalex.org/G1987157480","display_name":null,"funder_award_id":"173878","funder_id":"https://openalex.org/F4320321747","funder_display_name":"Fonds Qu\u00e9b\u00e9cois de la Recherche sur la Nature et les Technologies"},{"id":"https://openalex.org/G4926246454","display_name":null,"funder_award_id":"249644","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320321747","display_name":"Fonds Qu\u00e9b\u00e9cois de la Recherche sur la Nature et les Technologies","ror":"https://ror.org/00b9f9778"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1968385806","https://openalex.org/W1990149668","https://openalex.org/W1997281938","https://openalex.org/W2001962483","https://openalex.org/W2003797386","https://openalex.org/W2006617902","https://openalex.org/W2036176224","https://openalex.org/W2039705224","https://openalex.org/W2048060899","https://openalex.org/W2064675550","https://openalex.org/W2070614858","https://openalex.org/W2085993152","https://openalex.org/W2086860427","https://openalex.org/W2095705004","https://openalex.org/W2096261947","https://openalex.org/W2101234009","https://openalex.org/W2105464583","https://openalex.org/W2139314409","https://openalex.org/W2141825721","https://openalex.org/W2170302354","https://openalex.org/W2173737475","https://openalex.org/W2176028050","https://openalex.org/W2252568502","https://openalex.org/W2256679588","https://openalex.org/W2273244674","https://openalex.org/W2461013690","https://openalex.org/W2557181747","https://openalex.org/W2557283755","https://openalex.org/W2591777705","https://openalex.org/W2726053863","https://openalex.org/W2740810575","https://openalex.org/W2763854598","https://openalex.org/W2798909945","https://openalex.org/W2891210592","https://openalex.org/W2891826130","https://openalex.org/W2913340405","https://openalex.org/W3006093092","https://openalex.org/W3026606344","https://openalex.org/W6674330103","https://openalex.org/W6675354045","https://openalex.org/W6733941315"],"related_works":["https://openalex.org/W4293199045","https://openalex.org/W2405656580","https://openalex.org/W4226493464","https://openalex.org/W4312417841","https://openalex.org/W3193565141","https://openalex.org/W3133861977","https://openalex.org/W3008584592","https://openalex.org/W3167935049","https://openalex.org/W3029198973","https://openalex.org/W3031223029"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}