{"id":"https://openalex.org/W3100884242","doi":"https://doi.org/10.1093/bioinformatics/btaa957","title":"MEScan: a powerful statistical framework for genome-scale mutual exclusivity analysis of cancer mutations","display_name":"MEScan: a powerful statistical framework for genome-scale mutual exclusivity analysis of cancer mutations","publication_year":2020,"publication_date":"2020-10-31","ids":{"openalex":"https://openalex.org/W3100884242","doi":"https://doi.org/10.1093/bioinformatics/btaa957","mag":"3100884242","pmid":"https://pubmed.ncbi.nlm.nih.gov/33165532"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa957","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa957","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8189684","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008945048","display_name":"Sisheng Liu","orcid":"https://orcid.org/0000-0001-7888-1387"},"institutions":[{"id":"https://openalex.org/I4210108985","display_name":"Bellevue Hospital Center","ror":"https://ror.org/01ky34z31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283621791","https://openalex.org/I4210086933","https://openalex.org/I4210108985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sisheng Liu","raw_affiliation_strings":["Adcolony Inc ., Bellevue, WA 98004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adcolony Inc ., Bellevue, WA 98004, USA","institution_ids":["https://openalex.org/I4210108985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619675","display_name":"Jinpeng Liu","orcid":"https://orcid.org/0000-0003-4100-0237"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinpeng Liu","raw_affiliation_strings":["Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I2802239656","https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052314053","display_name":"Yanqi Xie","orcid":"https://orcid.org/0000-0002-9887-0084"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanqi Xie","raw_affiliation_strings":["Molecular and Cellular Biochemistry, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biochemistry, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087327572","display_name":"Tingting Zhai","orcid":"https://orcid.org/0000-0001-5812-4055"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingting Zhai","raw_affiliation_strings":["Department of Statistics, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026865750","display_name":"Eugene W. Hinderer","orcid":"https://orcid.org/0000-0001-8045-7083"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene W Hinderer","raw_affiliation_strings":["Molecular and Cellular Biochemistry, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biochemistry, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067935460","display_name":"Arnold J. Stromberg","orcid":"https://orcid.org/0000-0003-0336-9789"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold J Stromberg","raw_affiliation_strings":["Department of Statistics, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013817922","display_name":"Nathan L. Vanderford","orcid":"https://orcid.org/0000-0002-0810-2701"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan L Vanderford","raw_affiliation_strings":["Department of Toxicology and Cancer Biology, University of Kentucky , Lexington, KY 40536, USA","Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology and Cancer Biology, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I2802239656","https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016348831","display_name":"Jill Kolesar","orcid":"https://orcid.org/0000-0003-1802-6439"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill M Kolesar","raw_affiliation_strings":["Department of Pharmacy Practice and Science, University of Kentucky , Lexington, KY 40536, USA","Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice and Science, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I2802239656","https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040212698","display_name":"Hunter Moseley","orcid":"https://orcid.org/0000-0003-3995-5368"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunter N B Moseley","raw_affiliation_strings":["Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","Molecular and Cellular Biochemistry, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":"https://orcid.org/0000-0003-3995-5368","affiliations":[{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I2802239656","https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular and Cellular Biochemistry, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379193","display_name":"Li Chen","orcid":"https://orcid.org/0000-0001-9303-4047"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Chen","raw_affiliation_strings":["Department of Internal Medicine, University of Kentucky , Lexington, KY 40536, USA","Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I2802239656","https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100623406","display_name":"Chunming Liu","orcid":"https://orcid.org/0000-0002-3913-4474"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunming Liu","raw_affiliation_strings":["Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","Molecular and Cellular Biochemistry, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I2802239656","https://openalex.org/I143302722"]},{"raw_affiliation_string":"Molecular and Cellular Biochemistry, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100342205","display_name":"Chi Wang","orcid":"https://orcid.org/0000-0001-8984-4995"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chi Wang","raw_affiliation_strings":["Department of Internal Medicine, University of Kentucky , Lexington, KY 40536, USA","Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA"],"raw_orcid":"https://orcid.org/0000-0001-8984-4995","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I2802239656","https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5100342205"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6425,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.63070776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"37","issue":"9","first_page":"1189","last_page":"1197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8586000204086304,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8586000204086304,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5981867909431458},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5946677923202515},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.528110146522522},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.5273070335388184},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4948405623435974},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.4929502010345459},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.48174265027046204},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.45525985956192017},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44758644700050354},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.4210788905620575},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37581074237823486},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3446443974971771},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.12088674306869507}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5981867909431458},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5946677923202515},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.528110146522522},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.5273070335388184},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4948405623435974},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.4929502010345459},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48174265027046204},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45525985956192017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44758644700050354},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.4210788905620575},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37581074237823486},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3446443974971771},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.12088674306869507},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaa957","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa957","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33165532","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33165532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8189684","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8189684","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8189684","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8189684","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2526390019","display_name":null,"funder_award_id":"P30 CA177558","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2652762446","display_name":null,"funder_award_id":"UL1TR001998","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4773534043","display_name":null,"funder_award_id":"P20 GM103436","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5039681710","display_name":null,"funder_award_id":"R21CA205778","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5255565809","display_name":null,"funder_award_id":"P20GM103436-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1582541231","https://openalex.org/W1824047490","https://openalex.org/W1911343030","https://openalex.org/W1950829641","https://openalex.org/W1963592091","https://openalex.org/W2001866617","https://openalex.org/W2006305979","https://openalex.org/W2009572981","https://openalex.org/W2009720434","https://openalex.org/W2014096417","https://openalex.org/W2022495797","https://openalex.org/W2042851051","https://openalex.org/W2044702943","https://openalex.org/W2062009657","https://openalex.org/W2070871778","https://openalex.org/W2096283457","https://openalex.org/W2096460732","https://openalex.org/W2099454327","https://openalex.org/W2099702016","https://openalex.org/W2109816625","https://openalex.org/W2121443461","https://openalex.org/W2123696077","https://openalex.org/W2130388938","https://openalex.org/W2132630169","https://openalex.org/W2141911176","https://openalex.org/W2152130620","https://openalex.org/W2154444902","https://openalex.org/W2157795344","https://openalex.org/W2158485828","https://openalex.org/W2166771322","https://openalex.org/W2275877493","https://openalex.org/W2287386959","https://openalex.org/W2296095373","https://openalex.org/W2344657883","https://openalex.org/W2375577403","https://openalex.org/W2520340383","https://openalex.org/W2560367415","https://openalex.org/W2586629973","https://openalex.org/W2588969809","https://openalex.org/W2592761229","https://openalex.org/W2597175664","https://openalex.org/W2601000897","https://openalex.org/W2611387862","https://openalex.org/W2618992230","https://openalex.org/W2741253009","https://openalex.org/W2763815927","https://openalex.org/W2766401090","https://openalex.org/W2792459030","https://openalex.org/W2795940548","https://openalex.org/W2795941120","https://openalex.org/W2800589452","https://openalex.org/W2801958156","https://openalex.org/W2888569026","https://openalex.org/W2913421577","https://openalex.org/W2942508667","https://openalex.org/W2963382551","https://openalex.org/W2966169904","https://openalex.org/W3006500278","https://openalex.org/W3013884756","https://openalex.org/W3099438925","https://openalex.org/W4294107304","https://openalex.org/W6709498030","https://openalex.org/W6766928112"],"related_works":["https://openalex.org/W2189374991","https://openalex.org/W2787695989","https://openalex.org/W2146397496","https://openalex.org/W2076383445","https://openalex.org/W2592888218","https://openalex.org/W2171537806","https://openalex.org/W2136281516","https://openalex.org/W2025340064","https://openalex.org/W4384665577","https://openalex.org/W4231831369"],"abstract_inverted_index":{"MOTIVATION:":[0],"Cancer":[1],"somatic":[2],"driver":[3,33,42],"mutations":[4,36],"associated":[5],"with":[6,134,154],"genes":[7,74,92],"within":[8],"a":[9,13,18,87,107,125,148],"pathway":[10],"often":[11],"show":[12],"mutually":[14,23,51,168,205],"exclusive":[15,24,52,169,206],"pattern":[16],"across":[17],"cohort":[19],"of":[20,50,71,90,136,143,157,181],"patients.":[21],"This":[22],"mutational":[25,53,66],"signal":[26],"has":[27],"been":[28],"frequently":[29],"used":[30],"to":[31,38,77,96,101,190],"distinguish":[32],"from":[34,192],"passenger":[35],"and":[37,68,93,113,127,141,147,175,197],"investigate":[39],"relationships":[40],"among":[41],"mutations.":[43],"Current":[44],"methods":[45,83,174],"for":[46,111,131,151],"de":[47],"novo":[48],"discovery":[49,159],"patterns":[54],"are":[55,94,225],"limited":[56,88],"because":[57],"the":[58,69,119,137,155],"heterogeneity":[59],"in":[60],"background":[61,138],"mutation":[62,139],"rate":[63,140],"can":[64,75],"confound":[65],"patterns,":[67],"presence":[70],"highly":[72,144],"mutated":[73,145],"lead":[76],"spurious":[78],"patterns.":[79],"In":[80],"addition,":[81],"most":[82,185],"only":[84],"focus":[85],"on":[86],"number":[89],"pre-selected":[91],"unable":[95],"perform":[97],"genome-wide":[98,152],"analysis":[99,117],"due":[100],"computational":[102],"inefficiency.":[103],"RESULTS:":[104],"We":[105,161],"introduce":[106],"statistical":[108,129],"framework,":[109],"MEScan,":[110],"accurate":[112],"efficient":[114],"mutual":[115,132],"exclusivity":[116,133],"at":[118,177,219,227],"genomic":[120],"scale.":[121],"Our":[122],"framework":[123],"contains":[124],"fast":[126],"powerful":[128],"test":[130],"adjustment":[135],"impact":[142],"genes,":[146],"multi-step":[149],"procedure":[150],"screening":[153],"control":[156],"false":[158],"rate.":[160],"demonstrate":[162],"that":[163],"MEScan":[164,189,212],"more":[165],"accurately":[166],"identifies":[167],"gene":[170,207],"sets":[171],"than":[172,184],"existing":[173],"is":[176,213],"least":[178],"two":[179],"orders":[180],"magnitude":[182],"faster":[183],"methods.":[186],"By":[187],"applying":[188],"data":[191,224],"four":[193],"different":[194],"cancer":[195],"types":[196],"pan-cancer,":[198],"we":[199],"have":[200],"identified":[201],"several":[202],"biologically":[203],"meaningful":[204],"sets.":[208],"AVAILABILITY":[209],"AND":[210],"IMPLEMENTATION:":[211],"available":[214,226],"as":[215],"an":[216],"R":[217],"package":[218],"https://github.com/MarkeyBBSRF/MEScan.":[220],"SUPPLEMENTARY":[221],"INFORMATION:":[222],"Supplementary":[223],"Bioinformatics":[228],"online.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
