{"id":"https://openalex.org/W3092825552","doi":"https://doi.org/10.1093/bioinformatics/btaa894","title":"A novel estimator of the interaction matrix in Graphical Gaussian Model of omics data using the entropy of non-equilibrium systems","display_name":"A novel estimator of the interaction matrix in Graphical Gaussian Model of omics data using the entropy of non-equilibrium systems","publication_year":2020,"publication_date":"2020-10-02","ids":{"openalex":"https://openalex.org/W3092825552","doi":"https://doi.org/10.1093/bioinformatics/btaa894","mag":"3092825552","pmid":"https://pubmed.ncbi.nlm.nih.gov/33067612"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa894","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa894","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8098027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ahmad Borzou","orcid":"https://orcid.org/0000-0001-7630-9248"},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad Borzou","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , Galveston, TX 77555, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060210855","display_name":"Rovshan G. Sadygov","orcid":"https://orcid.org/0000-0003-1590-155X"},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rovshan G Sadygov","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , Galveston, TX 77555, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060210855"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.1672,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.50986491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"37","issue":"6","first_page":"837","last_page":"844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graphical-model","display_name":"Graphical model","score":0.6728248000144958},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.6164734363555908},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5892797112464905},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.5746712684631348},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.514995813369751},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.4617031216621399},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43801575899124146},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.4346112608909607},{"id":"https://openalex.org/keywords/mixture-model","display_name":"Mixture model","score":0.4329126179218292},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3931003510951996},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3370124101638794},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23919746279716492},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.23636266589164734},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2073773741722107},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19124460220336914},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17790791392326355},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.16345170140266418},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1631043255329132},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10287564992904663},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.08173909783363342}],"concepts":[{"id":"https://openalex.org/C155846161","wikidata":"https://www.wikidata.org/wiki/Q1143367","display_name":"Graphical model","level":2,"score":0.6728248000144958},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.6164734363555908},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5892797112464905},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.5746712684631348},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.514995813369751},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.4617031216621399},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43801575899124146},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4346112608909607},{"id":"https://openalex.org/C61224824","wikidata":"https://www.wikidata.org/wiki/Q2260434","display_name":"Mixture model","level":2,"score":0.4329126179218292},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3931003510951996},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3370124101638794},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23919746279716492},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23636266589164734},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2073773741722107},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19124460220336914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17790791392326355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16345170140266418},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1631043255329132},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10287564992904663},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.08173909783363342},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaa894","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa894","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33067612","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33067612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8098027","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8098027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8098027","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8098027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5226740208","display_name":null,"funder_award_id":"R01GM112044","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1520619721","https://openalex.org/W1983202741","https://openalex.org/W1992192674","https://openalex.org/W1995877017","https://openalex.org/W2006333907","https://openalex.org/W2009888774","https://openalex.org/W2010890545","https://openalex.org/W2023396760","https://openalex.org/W2062125287","https://openalex.org/W2063650222","https://openalex.org/W2065304353","https://openalex.org/W2078149659","https://openalex.org/W2101234009","https://openalex.org/W2112364930","https://openalex.org/W2117994680","https://openalex.org/W2119963163","https://openalex.org/W2125631472","https://openalex.org/W2132555912","https://openalex.org/W2145590522","https://openalex.org/W2147566730","https://openalex.org/W2148541040","https://openalex.org/W2151128232","https://openalex.org/W2151708044","https://openalex.org/W2152379610","https://openalex.org/W2156737316","https://openalex.org/W2163296115","https://openalex.org/W2163480486","https://openalex.org/W2167826316","https://openalex.org/W2176599823","https://openalex.org/W2537679995","https://openalex.org/W2611370172","https://openalex.org/W2777884179","https://openalex.org/W2801608667","https://openalex.org/W2855812653","https://openalex.org/W2887757903","https://openalex.org/W2919811956","https://openalex.org/W2950860419","https://openalex.org/W2964444983","https://openalex.org/W2972521539","https://openalex.org/W3099289621","https://openalex.org/W6675354045","https://openalex.org/W6676440343","https://openalex.org/W6682227116"],"related_works":["https://openalex.org/W1973959357","https://openalex.org/W2360158017","https://openalex.org/W2159604840","https://openalex.org/W2126785046","https://openalex.org/W1982829397","https://openalex.org/W2114802749","https://openalex.org/W2140673944","https://openalex.org/W4290803287","https://openalex.org/W1578916557","https://openalex.org/W2279165687"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}