{"id":"https://openalex.org/W3115669579","doi":"https://doi.org/10.1093/bioinformatics/btaa798","title":"An efficient framework to identify key miRNA\u2013mRNA regulatory modules in cancer","display_name":"An efficient framework to identify key miRNA\u2013mRNA regulatory modules in cancer","publication_year":2020,"publication_date":"2020-09-07","ids":{"openalex":"https://openalex.org/W3115669579","doi":"https://doi.org/10.1093/bioinformatics/btaa798","mag":"3115669579","pmid":"https://pubmed.ncbi.nlm.nih.gov/33381822"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa798","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa798","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067240258","display_name":"Milad Mokhtaridoost","orcid":"https://orcid.org/0000-0001-6185-4251"},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Milad Mokhtaridoost","raw_affiliation_strings":["Graduate School of Science and Engineering , \u0130stanbul 34450, Turkey","Graduate School of Science and Engineering, _ Istanbul 34450, Turkey,"],"affiliations":[{"raw_affiliation_string":"Graduate School of Science and Engineering , \u0130stanbul 34450, Turkey","institution_ids":["https://openalex.org/I67581229"]},{"raw_affiliation_string":"Graduate School of Science and Engineering, _ Istanbul 34450, Turkey,","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019778058","display_name":"Mehmet G\u00f6nen","orcid":"https://orcid.org/0000-0002-2483-075X"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4210105167","display_name":"College of Industrial Engineering","ror":"https://ror.org/01j157486","country_code":"SI","type":"education","lineage":["https://openalex.org/I4210105167"]}],"countries":["SI","TR","US"],"is_corresponding":true,"raw_author_name":"Mehmet G\u00f6nen","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, OR 97239, USA","Department of Industrial Engineering, College of Engineering , \u0130stanbul 34450, Turkey","School of Medicine, Ko\u00e7 University , \u0130stanbul 34450, Turkey","Department of Industrial Engineering, College of Engineering, _ Istanbul 34450, Turkey,","Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Industrial Engineering, College of Engineering , \u0130stanbul 34450, Turkey","institution_ids":["https://openalex.org/I4210105167"]},{"raw_affiliation_string":"School of Medicine, Ko\u00e7 University , \u0130stanbul 34450, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Department of Industrial Engineering, College of Engineering, _ Istanbul 34450, Turkey,","institution_ids":["https://openalex.org/I4210105167"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019778058"],"corresponding_institution_ids":["https://openalex.org/I1351752","https://openalex.org/I165690674","https://openalex.org/I4210105167"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6387,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.62780934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"36","issue":"Supplement_2","first_page":"i592","last_page":"i600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.740361750125885},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"Gene silencing","score":0.6740108728408813},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6461126804351807},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6087105870246887},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.527337908744812},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4688592553138733},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.43710020184516907},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.39637482166290283},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3258328437805176},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24148151278495789}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.740361750125885},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6740108728408813},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6461126804351807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6087105870246887},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.527337908744812},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4688592553138733},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.43710020184516907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39637482166290283},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3258328437805176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24148151278495789}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaa798","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa798","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33381822","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33381822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:cdm21054.contentdm.oclc.org:IR/9198","is_oa":false,"landing_page_url":"http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9198","pdf_url":null,"source":{"id":"https://openalex.org/S4306401341","display_name":"Digital Collections portal (Ko\u00e7 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1351752","host_organization_name":"Ko\u00e7 University","host_organization_lineage":["https://openalex.org/I1351752"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics\\n","raw_type":"Journal article\\n"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.44999998807907104,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G5539662776","display_name":null,"funder_award_id":"BAGEP","funder_id":"https://openalex.org/F4320322628","funder_display_name":"T\u00fcrkiye Bilimler Akademisi"}],"funders":[{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320322628","display_name":"T\u00fcrkiye Bilimler Akademisi","ror":"https://ror.org/00aqt9352"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1589848011","https://openalex.org/W1975900269","https://openalex.org/W1992918752","https://openalex.org/W2002995168","https://openalex.org/W2015528928","https://openalex.org/W2020925091","https://openalex.org/W2025983204","https://openalex.org/W2063978378","https://openalex.org/W2065180801","https://openalex.org/W2070993269","https://openalex.org/W2095129237","https://openalex.org/W2109761160","https://openalex.org/W2117391818","https://openalex.org/W2122825543","https://openalex.org/W2126999940","https://openalex.org/W2131230871","https://openalex.org/W2141366416","https://openalex.org/W2147631685","https://openalex.org/W2149276587","https://openalex.org/W2153195747","https://openalex.org/W2168443777","https://openalex.org/W2342386646","https://openalex.org/W2578040947","https://openalex.org/W2735438349","https://openalex.org/W2752829361","https://openalex.org/W2767546566","https://openalex.org/W2769715796","https://openalex.org/W2919378721","https://openalex.org/W2925675330","https://openalex.org/W2949427672","https://openalex.org/W2982609542","https://openalex.org/W2995926697","https://openalex.org/W3030286867","https://openalex.org/W3100041486"],"related_works":["https://openalex.org/W2026936876","https://openalex.org/W2128583238","https://openalex.org/W2049907435","https://openalex.org/W2010571965","https://openalex.org/W2057742104","https://openalex.org/W2034377088","https://openalex.org/W4283692078","https://openalex.org/W2002709996","https://openalex.org/W3128451840","https://openalex.org/W4387092964"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}