{"id":"https://openalex.org/W3085430416","doi":"https://doi.org/10.1093/bioinformatics/btaa778","title":"MR-Clust: clustering of genetic variants in Mendelian randomization with similar causal estimates","display_name":"MR-Clust: clustering of genetic variants in Mendelian randomization with similar causal estimates","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3085430416","doi":"https://doi.org/10.1093/bioinformatics/btaa778","mag":"3085430416","pmid":"https://pubmed.ncbi.nlm.nih.gov/32915962"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa778","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa778","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/4/531/37757588/btaa778.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/37/4/531/37757588/btaa778.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044626025","display_name":"Christopher N. Foley","orcid":"https://orcid.org/0000-0002-0970-2610"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher N Foley","raw_affiliation_strings":["MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge , Cambridge CB2 0SR, UK"],"raw_orcid":"https://orcid.org/0000-0002-0970-2610","affiliations":[{"raw_affiliation_string":"MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge , Cambridge CB2 0SR, UK","institution_ids":["https://openalex.org/I4210134973","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026495489","display_name":"Amy M. Mason","orcid":"https://orcid.org/0000-0002-8019-0777"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amy M Mason","raw_affiliation_strings":["Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge , Cambridge CB1 8RN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge , Cambridge CB1 8RN, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058209508","display_name":"Paul Kirk","orcid":"https://orcid.org/0000-0002-5931-7489"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul D W Kirk","raw_affiliation_strings":["Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge , Cambridge CB2 0AW, UK","MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge , Cambridge CB2 0SR, UK"],"raw_orcid":"https://orcid.org/0000-0002-5931-7489","affiliations":[{"raw_affiliation_string":"Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge , Cambridge CB2 0AW, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge , Cambridge CB2 0SR, UK","institution_ids":["https://openalex.org/I4210134973","https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087932701","display_name":"Stephen Burgess","orcid":"https://orcid.org/0000-0001-5365-8760"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephen Burgess","raw_affiliation_strings":["Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge , Cambridge CB1 8RN, UK","MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge , Cambridge CB2 0SR, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge , Cambridge CB1 8RN, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge , Cambridge CB2 0SR, UK","institution_ids":["https://openalex.org/I4210134973","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044626025","https://openalex.org/A5087932701"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210134973"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":8.0481,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.98027231,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"37","issue":"4","first_page":"531","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9556999802589417,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9556999802589417,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.9621052742004395},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.6702974438667297},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.623702347278595},{"id":"https://openalex.org/keywords/causal-inference","display_name":"Causal inference","score":0.5272452235221863},{"id":"https://openalex.org/keywords/cluster","display_name":"Cluster (spacecraft)","score":0.4561835825443268},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3637630045413971},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3488749861717224},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31157800555229187},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2839052677154541},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.2659236490726471},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23974302411079407},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20843654870986938},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17091885209083557},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.15798431634902954},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1551634967327118}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9621052742004395},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.6702974438667297},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.623702347278595},{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.5272452235221863},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.4561835825443268},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3637630045413971},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3488749861717224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31157800555229187},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2839052677154541},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.2659236490726471},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23974302411079407},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20843654870986938},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17091885209083557},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.15798431634902954},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1551634967327118},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaa778","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa778","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/4/531/37757588/btaa778.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32915962","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32915962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8088327","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8088327","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaa778","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa778","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/4/531/37757588/btaa778.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"awards":[{"id":"https://openalex.org/G10155507","display_name":null,"funder_award_id":"204623/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3085430416.pdf","grobid_xml":"https://content.openalex.org/works/W3085430416.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1847771980","https://openalex.org/W1905058580","https://openalex.org/W1972696558","https://openalex.org/W2033403400","https://openalex.org/W2047607348","https://openalex.org/W2101031176","https://openalex.org/W2101605059","https://openalex.org/W2104780889","https://openalex.org/W2106036991","https://openalex.org/W2129465958","https://openalex.org/W2138290169","https://openalex.org/W2143282831","https://openalex.org/W2145813488","https://openalex.org/W2146050890","https://openalex.org/W2151355802","https://openalex.org/W2198755677","https://openalex.org/W2330290021","https://openalex.org/W2398690791","https://openalex.org/W2519132385","https://openalex.org/W2520048741","https://openalex.org/W2735339162","https://openalex.org/W2775393828","https://openalex.org/W2803072880","https://openalex.org/W2883415719","https://openalex.org/W2884028796","https://openalex.org/W2890555481","https://openalex.org/W2941271956","https://openalex.org/W2949540592","https://openalex.org/W2950044218","https://openalex.org/W2971431550","https://openalex.org/W2996249643","https://openalex.org/W3004892753","https://openalex.org/W3007536163","https://openalex.org/W3105265400","https://openalex.org/W3121556564","https://openalex.org/W3124658416","https://openalex.org/W3133236490","https://openalex.org/W4230866720","https://openalex.org/W4299515571"],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W3113091479","https://openalex.org/W2169283889","https://openalex.org/W941090075","https://openalex.org/W2162899405","https://openalex.org/W4210703904","https://openalex.org/W2044987316","https://openalex.org/W2237480245","https://openalex.org/W4306658544","https://openalex.org/W4283263913"],"abstract_inverted_index":{"MOTIVATION:":[0],"Mendelian":[1],"randomization":[2],"is":[3,70],"an":[4,24,87,98,181],"epidemiological":[5],"technique":[6],"that":[7,58,101,112,124,165,209],"uses":[8],"genetic":[9,201],"variants":[10,50,60,111,210,239],"as":[11],"instrumental":[12],"variables":[13],"to":[14,72,141,230],"estimate":[15],"the":[16,49,62,131,145,155,185,195,212],"causal":[17,32,66,79,93,115,132],"effect":[18,186,217],"of":[19,92,105,119,147,157,187,200,218],"a":[20,28,83,160,215],"risk":[21,84,225],"factor":[22,85],"on":[23,35,190,221],"outcome.":[25],"We":[26,95],"consider":[27],"scenario":[29,69],"in":[30,38,61,130,159,211,241],"which":[31,82],"estimates":[33],"based":[34],"each":[36],"variant":[37],"turn":[39],"differ":[40],"more":[41,227],"strongly":[42,228],"than":[43,238],"expected":[44],"by":[45,81],"chance":[46],"alone,":[47],"but":[48],"can":[51,109,248],"be":[52,249],"divided":[53],"into":[54],"distinct":[55,78,114],"clusters,":[56,140],"such":[57,103],"all":[59],"cluster":[63,213],"have":[64,96],"similar":[65],"estimates.":[67],"This":[68],"likely":[71],"occur":[73],"when":[74],"there":[75],"are":[76,123,257],"several":[77],"mechanisms":[80],"influences":[86],"outcome":[88],"with":[89,214],"different":[90],"magnitudes":[91],"effect.":[94],"developed":[97],"algorithm":[99,122,152],"MR-Clust":[100,247],"finds":[102],"clusters":[104,158,199],"variants,":[106],"and":[107,134,138,177,234],"so":[108],"identify":[110],"reflect":[113],"mechanisms.":[116],"Two":[117],"features":[118],"our":[120],"clustering":[121],"it":[125,135],"accounts":[126],"for":[127,170],"differential":[128],"uncertainty":[129,171],"estimates,":[133],"includes":[136],"'null'":[137],"'junk'":[139],"provide":[142],"protection":[143],"against":[144],"detection":[146],"spurious":[148],"clusters.":[149,179],"RESULTS:":[150],"Our":[151],"correctly":[153],"detected":[154,197],"number":[156],"simulation":[161],"analysis,":[162],"outperforming":[163],"methods":[164],"either":[166],"do":[167,173],"not":[168,174,240],"account":[169],"or":[172],"include":[175],"null":[176],"junk":[178],"In":[180],"applied":[182],"example":[183],"considering":[184],"blood":[188,219],"pressure":[189,220],"coronary":[191,222],"artery":[192,223],"disease":[193,224],"risk,":[194],"method":[196],"four":[198],"variants.":[202],"A":[203],"post":[204],"hoc":[205],"hypothesis-generating":[206],"search":[207],"suggested":[208],"negative":[216],"were":[226],"related":[229],"trunk":[231],"fat":[232],"percentage":[233],"other":[235],"adiposity":[236],"measures":[237],"this":[242],"cluster.":[243],"AVAILABILITY":[244],"AND":[245],"IMPLEMENTATION:":[246],"downloaded":[250],"from":[251],"https://github.com/cnfoley/mrclust.":[252],"SUPPLEMENTARY":[253],"INFORMATION:":[254],"Supplementary":[255],"data":[256],"available":[258],"at":[259],"Bioinformatics":[260],"online.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-09T07:52:08.696243","created_date":"2025-10-10T00:00:00"}
