{"id":"https://openalex.org/W3084864536","doi":"https://doi.org/10.1093/bioinformatics/btaa766","title":"PanGPCR: predictions for multiple targets, repurposing and side effects","display_name":"PanGPCR: predictions for multiple targets, repurposing and side effects","publication_year":2020,"publication_date":"2020-08-28","ids":{"openalex":"https://openalex.org/W3084864536","doi":"https://doi.org/10.1093/bioinformatics/btaa766","mag":"3084864536","pmid":"https://pubmed.ncbi.nlm.nih.gov/32915954"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa766","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa766","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071029830","display_name":"Lu-Chi Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lu-Chi Liu","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001681901","display_name":"Ming-Yang Ho","orcid":"https://orcid.org/0000-0002-1767-7494"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Yang Ho","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University , Taipei 106, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University , Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100801411","display_name":"Bo-Han Su","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bo-Han Su","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002945521","display_name":"San\u2010Yuan Wang","orcid":"https://orcid.org/0000-0002-8804-2226"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"San-Yuan Wang","raw_affiliation_strings":["Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, College of Pharmacy, Taipei Medical University , Taipei 106, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, College of Pharmacy, Taipei Medical University , Taipei 106, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055631081","display_name":"Ming-Tsung Hsu","orcid":"https://orcid.org/0000-0002-6940-1844"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Tsung Hsu","raw_affiliation_strings":["Genome and Systems Biology Degree Program, National Taiwan University , Taipei, 106, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome and Systems Biology Degree Program, National Taiwan University , Taipei, 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021255582","display_name":"Yufeng Jane Tseng","orcid":"https://orcid.org/0000-0002-8461-6181"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yufeng J Tseng","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan","Genome and Systems Biology Degree Program, National Taiwan University , Taipei, 106, Taiwan","Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University , Taipei 106, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-8461-6181","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University , Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Genome and Systems Biology Degree Program, National Taiwan University , Taipei, 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University , Taipei 106, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5021255582"],"corresponding_institution_ids":["https://openalex.org/I16733864"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.0834,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.45375081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"37","issue":"8","first_page":"1184","last_page":"1186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9666000008583069,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9666000008583069,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.8644822835922241},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.8349313735961914},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.6483815908432007},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.6178562641143799},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6041747331619263},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6029368042945862},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5059286952018738},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33883965015411377},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3269478678703308},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2973928153514862},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.19916057586669922},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1732686460018158},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09366720914840698},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08612304925918579}],"concepts":[{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.8644822835922241},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.8349313735961914},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6483815908432007},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6178562641143799},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6041747331619263},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6029368042945862},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5059286952018738},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33883965015411377},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3269478678703308},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2973928153514862},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19916057586669922},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1732686460018158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09366720914840698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08612304925918579},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btaa766","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa766","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32915954","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32915954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G469049380","display_name":null,"funder_award_id":"109-FDA-D-114-000611","funder_id":"https://openalex.org/F4320332813","funder_display_name":"Food and Drug Administration"},{"id":"https://openalex.org/G5734142645","display_name":null,"funder_award_id":"109-2926-I-002-506-","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6198163596","display_name":null,"funder_award_id":"108-2627-E-002-001-","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6591324324","display_name":null,"funder_award_id":"109-2320-B-002-040-","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320332813","display_name":"Food and Drug Administration","ror":"https://ror.org/0250say61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1682431075","https://openalex.org/W1979686694","https://openalex.org/W2011223793","https://openalex.org/W2041292257","https://openalex.org/W2050132252","https://openalex.org/W2063685911","https://openalex.org/W2073110681","https://openalex.org/W2084175807","https://openalex.org/W2113875031","https://openalex.org/W2134967712","https://openalex.org/W2145578524","https://openalex.org/W2149888039","https://openalex.org/W2170146596","https://openalex.org/W2342650696","https://openalex.org/W2620937603","https://openalex.org/W2774455409","https://openalex.org/W6607054263","https://openalex.org/W6676660176","https://openalex.org/W6680198531","https://openalex.org/W6739075417"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4396858017","https://openalex.org/W4400165188","https://openalex.org/W4206422705","https://openalex.org/W4320009247","https://openalex.org/W3186872001"],"abstract_inverted_index":{"SUMMARY:":[0],"Drug":[1],"discovery":[2,21],"targeting":[3],"G":[4],"protein-coupled":[5],"receptors":[6],"(GPCRs),":[7],"the":[8,19,43,55,85,115],"largest":[9],"known":[10],"class":[11],"of":[12,24,50,57,64,71],"therapeutic":[13],"targets,":[14,142],"is":[15,59,82,161],"challenging.":[16],"To":[17],"facilitate":[18],"rapid":[20],"and":[22,38,47,78,92,104,120,125,133,145],"development":[23],"GPCR":[25,36,51,102],"drugs,":[26],"we":[27],"built":[28],"a":[29,62,79,99,154],"system,":[30],"PanGPCR,":[31,54,140],"to":[32,61,88,122],"predict":[33],"multiple":[34,141],"potential":[35,107,110,144],"targets":[37,103],"their":[39,93,134],"expression":[40],"locations":[41],"in":[42],"tissues,":[44],"side":[45,111,146],"effects":[46,112,147],"possible":[48],"repurposing":[49,106,143],"drugs.":[52],"With":[53,139],"compound":[56],"interest":[58],"docked":[60],"library":[63],"36":[65],"experimentally":[66],"determined":[67,150],"crystal":[68],"structures":[69],"comprising":[70],"46":[72],"docking":[73,86],"sites":[74],"for":[75],"human":[76],"GPCRs,":[77],"ranked":[80],"list":[81],"generated":[83],"from":[84,114],"studies":[87],"assess":[89],"all":[90],"GPCRs":[91],"binding":[94],"affinities.":[95],"Users":[96],"can":[97,148],"determine":[98],"given":[100],"compound's":[101],"its":[105],"accordingly.":[108],"Moreover,":[109],"collected":[113],"SIDER":[116],"(Side-Effect":[117],"Resource)":[118],"database":[119],"mapped":[121],"45":[123],"tissues":[124],"organs":[126],"are":[127,170],"provided":[128],"by":[129,151],"linking":[130],"predicted":[131],"off-targets":[132],"expressed":[135],"sequence":[136],"tag":[137],"profiles.":[138],"be":[149],"simply":[152],"uploading":[153],"small":[155],"ligand.":[156],"AVAILABILITY":[157],"AND":[158],"IMPLEMENTATION:":[159],"PanGPCR":[160],"freely":[162],"accessible":[163],"at":[164,172],"https://gpcrpanel.cmdm.tw/index.html.":[165],"SUPPLEMENTARY":[166],"INFORMATION:":[167],"Supplementary":[168],"data":[169],"available":[171],"Bioinformatics":[173],"online.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
