{"id":"https://openalex.org/W2991838765","doi":"https://doi.org/10.1093/bioinformatics/btaa690","title":"Discovering a sparse set of pairwise discriminating features in high-dimensional data","display_name":"Discovering a sparse set of pairwise discriminating features in high-dimensional data","publication_year":2020,"publication_date":"2020-07-23","ids":{"openalex":"https://openalex.org/W2991838765","doi":"https://doi.org/10.1093/bioinformatics/btaa690","mag":"2991838765","pmid":"https://pubmed.ncbi.nlm.nih.gov/32730566"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa690","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa690","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/2/202/41158105/btaa690.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"preprint","indexed_in":["arxiv","crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/37/2/202/41158105/btaa690.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103876492","display_name":"Samuel Melton","orcid":null},"institutions":[{"id":"https://openalex.org/I4210131439","display_name":"Applied Mathematics (United States)","ror":"https://ror.org/03seew607","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131439"]},{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samuel Melton","raw_affiliation_strings":["Applied Mathematics Harvard University , Cambridge, MA 02138, USA","Harvard University ,"],"affiliations":[{"raw_affiliation_string":"Applied Mathematics Harvard University , Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I4210131439","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University ,","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069314096","display_name":"Sharad Ramanathan","orcid":"https://orcid.org/0000-0001-9445-1248"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharad Ramanathan","raw_affiliation_strings":["Applied Physics, John A. Paulson School of Engineering and Applied Sciences, Harvard University , Cambridge, MA 02138, USA","Department of Molecular and Cellular Biology, Harvard University , Cambridge, MA 02138, USA","Department of Stem Cell and Regenerative Biology , Cambridge, MA 02138, USA","Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA"],"affiliations":[{"raw_affiliation_string":"Applied Physics, John A. Paulson School of Engineering and Applied Sciences, Harvard University , Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University , Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology , Cambridge, MA 02138, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103876492"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801851002","https://openalex.org/I4210131439"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00258383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"37","issue":"2","first_page":"202","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subspace-topology","display_name":"Subspace topology","score":0.6952987909317017},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6689962148666382},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6390986442565918},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6238089203834534},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.6130974292755127},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5117935538291931},{"id":"https://openalex.org/keywords/clustering-high-dimensional-data","display_name":"Clustering high-dimensional data","score":0.4701414704322815},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4399517774581909}],"concepts":[{"id":"https://openalex.org/C32834561","wikidata":"https://www.wikidata.org/wiki/Q660730","display_name":"Subspace topology","level":2,"score":0.6952987909317017},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6689962148666382},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6390986442565918},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6238089203834534},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.6130974292755127},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5117935538291931},{"id":"https://openalex.org/C184509293","wikidata":"https://www.wikidata.org/wiki/Q5136711","display_name":"Clustering high-dimensional data","level":3,"score":0.4701414704322815},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4399517774581909}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/btaa690","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa690","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/2/202/41158105/btaa690.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32730566","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32730566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:arXiv.org:1910.05814","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1910.05814","pdf_url":"https://arxiv.org/pdf/1910.05814","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8599814","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8599814","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"doi:10.48550/arxiv.1910.05814","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1910.05814","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"},{"id":"mag:2991838765","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaa690","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa690","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/2/202/41158105/btaa690.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.75,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G165823587","display_name":null,"funder_award_id":"R01HD100036","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G49026605","display_name":null,"funder_award_id":"W911NF-19-2-0018","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991838765.pdf","grobid_xml":"https://content.openalex.org/works/W2991838765.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W109865423","https://openalex.org/W1579271636","https://openalex.org/W1811961634","https://openalex.org/W1813068103","https://openalex.org/W1951882906","https://openalex.org/W1953604676","https://openalex.org/W1963780732","https://openalex.org/W1972983233","https://openalex.org/W1973387539","https://openalex.org/W1974368058","https://openalex.org/W1975900269","https://openalex.org/W1976632596","https://openalex.org/W1988397986","https://openalex.org/W1988403805","https://openalex.org/W1990009229","https://openalex.org/W1998370054","https://openalex.org/W2000667008","https://openalex.org/W2001848617","https://openalex.org/W2011832962","https://openalex.org/W2016985320","https://openalex.org/W2017818759","https://openalex.org/W2020936558","https://openalex.org/W2021593900","https://openalex.org/W2027703497","https://openalex.org/W2029587765","https://openalex.org/W2033709959","https://openalex.org/W2035566476","https://openalex.org/W2043980237","https://openalex.org/W2048178552","https://openalex.org/W2049633694","https://openalex.org/W2060440361","https://openalex.org/W2067076477","https://openalex.org/W2070700342","https://openalex.org/W2071949631","https://openalex.org/W2077478450","https://openalex.org/W2080342872","https://openalex.org/W2083403694","https://openalex.org/W2098290597","https://openalex.org/W2099851046","https://openalex.org/W2100681150","https://openalex.org/W2108435369","https://openalex.org/W2108946209","https://openalex.org/W2110555613","https://openalex.org/W2117768773","https://openalex.org/W2125987139","https://openalex.org/W2128665076","https://openalex.org/W2129835280","https://openalex.org/W2132820034","https://openalex.org/W2152504473","https://openalex.org/W2157651437","https://openalex.org/W2158931884","https://openalex.org/W2169529166","https://openalex.org/W2170185022","https://openalex.org/W2176310740","https://openalex.org/W2186118094","https://openalex.org/W2189351183","https://openalex.org/W2195615921","https://openalex.org/W2292791236","https://openalex.org/W2488678869","https://openalex.org/W2571241168","https://openalex.org/W2596707196","https://openalex.org/W2747297590","https://openalex.org/W2794429933","https://openalex.org/W2800028441","https://openalex.org/W2800912249","https://openalex.org/W2809204666","https://openalex.org/W2904280281","https://openalex.org/W2907783748","https://openalex.org/W2912272542","https://openalex.org/W2912276026","https://openalex.org/W2949200178","https://openalex.org/W2952650776","https://openalex.org/W2953059646","https://openalex.org/W2963371845","https://openalex.org/W3105178084","https://openalex.org/W6604452388","https://openalex.org/W6657043098","https://openalex.org/W6676358527","https://openalex.org/W6732873731","https://openalex.org/W6786263214"],"related_works":["https://openalex.org/W3022474557","https://openalex.org/W2116806401","https://openalex.org/W1599794708","https://openalex.org/W2961786220","https://openalex.org/W3028487860","https://openalex.org/W2751118311","https://openalex.org/W3026130375","https://openalex.org/W3101614233","https://openalex.org/W3189934245","https://openalex.org/W2056837054","https://openalex.org/W2106294446","https://openalex.org/W2343128467","https://openalex.org/W3089922441","https://openalex.org/W2098811021","https://openalex.org/W2057518933","https://openalex.org/W2940674270","https://openalex.org/W1980652169","https://openalex.org/W2105860794","https://openalex.org/W2114031356","https://openalex.org/W30846217"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
