{"id":"https://openalex.org/W3033597334","doi":"https://doi.org/10.1093/bioinformatics/btaa563","title":"Screening novel drug candidates for Alzheimer\u2019s disease by an integrated network and transcriptome analysis","display_name":"Screening novel drug candidates for Alzheimer\u2019s disease by an integrated network and transcriptome analysis","publication_year":2020,"publication_date":"2020-06-03","ids":{"openalex":"https://openalex.org/W3033597334","doi":"https://doi.org/10.1093/bioinformatics/btaa563","mag":"3033597334","pmid":"https://pubmed.ncbi.nlm.nih.gov/32516365"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa563","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa563","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043533818","display_name":"Yonglin Peng","orcid":"https://orcid.org/0000-0003-3446-3030"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonglin Peng","raw_affiliation_strings":["School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102710379","display_name":"Meng Yuan","orcid":"https://orcid.org/0000-0003-0087-6152"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Yuan","raw_affiliation_strings":["School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046080883","display_name":"Juncai Xin","orcid":null},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juncai Xin","raw_affiliation_strings":["School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100677153","display_name":"Xinhua Liu","orcid":"https://orcid.org/0000-0002-9972-8215"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhua Liu","raw_affiliation_strings":["School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100648233","display_name":"Ju Wang","orcid":"https://orcid.org/0000-0002-6514-0923"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ju Wang","raw_affiliation_strings":["School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Technology, Tianjin Medical University , Tianjin 300070 China","institution_ids":["https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100648233"],"corresponding_institution_ids":["https://openalex.org/I5740404"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.7642,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.94446294,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"36","issue":"17","first_page":"4626","last_page":"4632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6967008113861084},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5956910252571106},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5679522752761841},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5205098986625671},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47843626141548157},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29766330122947693},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24830806255340576},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2194201648235321},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.20103436708450317},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1391884982585907},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10778683423995972},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.0897836983203888}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6967008113861084},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5956910252571106},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5679522752761841},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5205098986625671},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47843626141548157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29766330122947693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24830806255340576},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2194201648235321},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20103436708450317},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1391884982585907},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10778683423995972},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0897836983203888}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btaa563","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa563","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32516365","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32516365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5600000023841858}],"awards":[{"id":"https://openalex.org/G552597168","display_name":null,"funder_award_id":"31271411 & 91746205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G829843395","display_name":null,"funder_award_id":"2016YFC0906300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1000383428","https://openalex.org/W1529339318","https://openalex.org/W1573834370","https://openalex.org/W1737223868","https://openalex.org/W1876892944","https://openalex.org/W1978116973","https://openalex.org/W1994397669","https://openalex.org/W2009405916","https://openalex.org/W2020859582","https://openalex.org/W2026970282","https://openalex.org/W2062533676","https://openalex.org/W2081051305","https://openalex.org/W2081375228","https://openalex.org/W2081484373","https://openalex.org/W2089350319","https://openalex.org/W2098999434","https://openalex.org/W2106301585","https://openalex.org/W2110065044","https://openalex.org/W2121604817","https://openalex.org/W2124575784","https://openalex.org/W2125065061","https://openalex.org/W2129267808","https://openalex.org/W2130410032","https://openalex.org/W2139036189","https://openalex.org/W2141262291","https://openalex.org/W2151357092","https://openalex.org/W2155462253","https://openalex.org/W2159675211","https://openalex.org/W2162151166","https://openalex.org/W2169589032","https://openalex.org/W2170146596","https://openalex.org/W2174011260","https://openalex.org/W2246104260","https://openalex.org/W2263739890","https://openalex.org/W2401678552","https://openalex.org/W2444690946","https://openalex.org/W2557231653","https://openalex.org/W2559028527","https://openalex.org/W2559588208","https://openalex.org/W2579520456","https://openalex.org/W2608472446","https://openalex.org/W2612467560","https://openalex.org/W2617072792","https://openalex.org/W2749491127","https://openalex.org/W2766376439","https://openalex.org/W2767891136","https://openalex.org/W2790974918","https://openalex.org/W2794128897","https://openalex.org/W2804267327","https://openalex.org/W2886368619","https://openalex.org/W2886819196","https://openalex.org/W2888299538","https://openalex.org/W2896002881","https://openalex.org/W2900569176","https://openalex.org/W2904431137","https://openalex.org/W2914334675","https://openalex.org/W2958397484","https://openalex.org/W2970537246","https://openalex.org/W2974222077","https://openalex.org/W2979677128","https://openalex.org/W2980147368","https://openalex.org/W2987102569","https://openalex.org/W3023013291","https://openalex.org/W4211189332","https://openalex.org/W4233678306","https://openalex.org/W4238843899","https://openalex.org/W6674916259","https://openalex.org/W6681120399"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2390279801","https://openalex.org/W2028462563","https://openalex.org/W2982720988","https://openalex.org/W4391913857","https://openalex.org/W2358668433"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7}],"updated_date":"2026-04-03T22:45:19.894376","created_date":"2025-10-10T00:00:00"}