{"id":"https://openalex.org/W3025725598","doi":"https://doi.org/10.1093/bioinformatics/btaa496","title":"iBioProVis: interactive visualization and analysis of compound bioactivity space","display_name":"iBioProVis: interactive visualization and analysis of compound bioactivity space","publication_year":2020,"publication_date":"2020-05-08","ids":{"openalex":"https://openalex.org/W3025725598","doi":"https://doi.org/10.1093/bioinformatics/btaa496","mag":"3025725598","pmid":"https://pubmed.ncbi.nlm.nih.gov/32407491"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa496","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa496","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11511/57127","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000915449","display_name":"Ataberk Donmez","orcid":"https://orcid.org/0000-0002-4817-0637"},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ataberk Donmez","raw_affiliation_strings":["Department of Computer Engineering , METU, Ankara 06800, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering , METU, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082878067","display_name":"Ahmet S\u00fcreyya Rifaio\u011flu","orcid":"https://orcid.org/0000-0001-6717-4767"},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]},{"id":"https://openalex.org/I4210155859","display_name":"\u0130skenderun Technical University","ror":"https://ror.org/052nzqz14","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210155859"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet Sureyya Rifaioglu","raw_affiliation_strings":["Department of Computer Engineering , METU, Ankara 06800, Turkey","Department of Computer Engineering , \u0130skenderun Technical University, Hatay 31200, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering , METU, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I201799495"]},{"raw_affiliation_string":"Department of Computer Engineering , \u0130skenderun Technical University, Hatay 31200, Turkey","institution_ids":["https://openalex.org/I4210155859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037079774","display_name":"Aybar C. Acar","orcid":"https://orcid.org/0000-0001-5694-8675"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aybar Acar","raw_affiliation_strings":["Department of Health Informatics , KanSiL, Graduate School of Informatics, METU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Informatics , KanSiL, Graduate School of Informatics, METU","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003981652","display_name":"Tunca Do\u011fan","orcid":"https://orcid.org/0000-0002-1298-9763"},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tunca Do\u011fan","raw_affiliation_strings":["Department of Computer Engineering , Hacettepe University, 06800 Ankara, Turkey","Institute of Informatics , Hacettepe University, 06800 Ankara, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1298-9763","affiliations":[{"raw_affiliation_string":"Department of Computer Engineering , Hacettepe University, 06800 Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Institute of Informatics , Hacettepe University, 06800 Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037440533","display_name":"Reng\u00fcl \u00c7etin-Atalay","orcid":"https://orcid.org/0000-0003-2408-6606"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rengul Cetin-Atalay","raw_affiliation_strings":["Department of Health Informatics , KanSiL, Graduate School of Informatics, METU","Department of Medicine , Section of Pulmonary and Critical Care Medicine, the University of Chicago, Chicago, IL 60637, USA"],"raw_orcid":"https://orcid.org/0000-0003-2408-6606","affiliations":[{"raw_affiliation_string":"Department of Health Informatics , KanSiL, Graduate School of Informatics, METU","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine , Section of Pulmonary and Critical Care Medicine, the University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042515589","display_name":"Volkan Atalay","orcid":"https://orcid.org/0000-0001-7850-0601"},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Volkan Atalay","raw_affiliation_strings":["Department of Computer Engineering , METU, Ankara 06800, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering , METU, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I201799495"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5042515589"],"corresponding_institution_ids":["https://openalex.org/I201799495"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.8743,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.79273248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"36","issue":"14","first_page":"4227","last_page":"4230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9316999912261963,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9316999912261963,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6866222620010376},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.5269777774810791},{"id":"https://openalex.org/keywords/projection","display_name":"Projection (relational algebra)","score":0.5123851895332336},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5079026818275452},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.5047835111618042},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47420552372932434},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4109559655189514},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2499012053012848},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23391926288604736},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.14367741346359253}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6866222620010376},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.5269777774810791},{"id":"https://openalex.org/C57493831","wikidata":"https://www.wikidata.org/wiki/Q3134666","display_name":"Projection (relational algebra)","level":2,"score":0.5123851895332336},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5079026818275452},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.5047835111618042},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47420552372932434},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4109559655189514},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2499012053012848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23391926288604736},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.14367741346359253},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022702","descriptor_name":"Receptors, Adrenergic, beta-3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022702","descriptor_name":"Receptors, Adrenergic, beta-3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022702","descriptor_name":"Receptors, Adrenergic, beta-3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022702","descriptor_name":"Receptors, Adrenergic, beta-3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/bioinformatics/btaa496","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa496","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32407491","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32407491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmid:33094316","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33094316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:https://open.metu.edu.tr:11511/77281","is_oa":false,"landing_page_url":"https://hdl.handle.net/11511/77281","pdf_url":null,"source":{"id":"https://openalex.org/S4306402495","display_name":"OpenMETU (Middle East Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201799495","host_organization_name":"Middle East Technical University","host_organization_lineage":["https://openalex.org/I201799495"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Presentation"},{"id":"pmh:oai:open.metu.edu.tr:11511/57127","is_oa":true,"landing_page_url":"https://hdl.handle.net/11511/57127","pdf_url":null,"source":{"id":"https://openalex.org/S4306402495","display_name":"OpenMETU (Middle East Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201799495","host_organization_name":"Middle East Technical University","host_organization_lineage":["https://openalex.org/I201799495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7454317","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7454317","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7992908","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7992908","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:open.metu.edu.tr:11511/57127","is_oa":true,"landing_page_url":"https://hdl.handle.net/11511/57127","pdf_url":null,"source":{"id":"https://openalex.org/S4306402495","display_name":"OpenMETU (Middle East Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201799495","host_organization_name":"Middle East Technical University","host_organization_lineage":["https://openalex.org/I201799495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G504592714","display_name":null,"funder_award_id":"EEEAG-116E930","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1988037271","https://openalex.org/W2028988193","https://openalex.org/W2059032294","https://openalex.org/W2079502123","https://openalex.org/W2122513050","https://openalex.org/W2187089797","https://openalex.org/W2346982987","https://openalex.org/W2767891136","https://openalex.org/W2886544065","https://openalex.org/W2899450762","https://openalex.org/W2900090807","https://openalex.org/W2913076747","https://openalex.org/W3008047170","https://openalex.org/W3009912996","https://openalex.org/W3012379316","https://openalex.org/W4239308575"],"related_works":["https://openalex.org/W2579148721","https://openalex.org/W4387893611","https://openalex.org/W2347335694","https://openalex.org/W2091056927","https://openalex.org/W2067407580","https://openalex.org/W4317486777","https://openalex.org/W4389669152","https://openalex.org/W2038514069","https://openalex.org/W1967233468","https://openalex.org/W2009181529"],"abstract_inverted_index":{"SUMMARY:":[0],"iBioProVis":[1,25,99,183,262],"is":[2,155,174,223],"an":[3],"interactive":[4],"tool":[5,26],"for":[6,137,254,272],"visual":[7],"analysis":[8,148],"of":[9,17,54,65,68,74,109,140,151,170,205,247],"the":[10,15,39,52,63,72,87,92,106,118,128,152,159,164,203],"compound":[11,33,120,139,166],"bioactivity":[12],"space":[13],"in":[14,57,71,202,244],"context":[16,73],"target":[18,28,96,113],"proteins,":[19],"drugs":[20,189,240],"and":[21,37,70,122,179,190,199,237,263],"drug":[22,191],"candidate":[23,192],"compounds.":[24],"takes":[27],"protein":[29,221,232],"identifiers":[30],"and,":[31],"optionally,":[32],"SMILES":[34],"as":[35],"input,":[36],"uses":[38],"state-of-the-art":[40],"non-linear":[41],"dimensionality":[42],"reduction":[43],"method":[44],"t-Distributed":[45],"Stochastic":[46],"Neighbor":[47],"Embedding":[48],"(t-SNE)":[49],"to":[50,83,103,123,127,132,196],"plot":[51],"distribution":[53,108],"compounds":[55,69,154,172,193,236],"embedded":[56,82,180,243],"a":[58,138,168],"2D":[59,88,119],"map,":[60,89],"based":[61,142],"on":[62,86,117,143,216],"similarity":[64],"structural":[66,107],"properties":[67],"compounds'":[75],"cognate":[76],"targets.":[77],"Similar":[78],"compounds,":[79],"which":[80,173,222,245],"are":[81,268,281],"proximate":[84],"points":[85],"may":[90],"bind":[91],"same":[93,129,165],"or":[94,111,131,167],"similar":[95],"proteins.":[97],"Thus,":[98],"can":[100,161],"be":[101],"used":[102,198],"easily":[104],"observe":[105,163],"one":[110,214],"two":[112,246],"proteins'":[114],"known":[115],"ligands":[116],"space,":[121],"infer":[124,133],"new":[125,134],"binders":[126],"protein,":[130],"potential":[135],"target(s)":[136],"interest,":[141],"this":[144],"distribution.":[145],"Principal":[146],"component":[147],"(PCA)":[149],"projection":[150],"input":[153],"also":[156,184],"provided,":[157],"Hence":[158],"user":[160],"interactively":[162],"group":[169],"selected":[171],"projected":[175],"by":[176,181],"both":[177],"PCA":[178],"t-SNE.":[182],"provides":[185],"detailed":[186],"information":[187],"about":[188],"through":[194],"cross-references":[195],"widely":[197],"well-known":[200],"databases,":[201],"form":[204],"linked":[206],"table":[207],"views.":[208],"Two":[209],"use-case":[210],"studies":[211],"were":[212,241],"demonstrated,":[213],"being":[215],"angiotensin-converting":[217],"enzyme":[218],"2":[219,229],"(ACE2)":[220],"Severe":[224],"Acute":[225],"Respiratory":[226],"Syndrome":[227],"Coronavirus":[228,255],"(SARS-CoV-2)":[230],"Spike":[231],"receptor.":[233],"ACE2":[234],"binding":[235],"seven":[238],"antiviral":[239],"closely":[242],"them":[248],"have":[249],"been":[250],"under":[251],"clinical":[252],"trial":[253],"disease":[256],"19":[257],"(COVID-19).":[258],"AVAILABILITY":[259],"AND":[260],"IMPLEMENTATION:":[261],"its":[264],"carefully":[265],"filtered":[266],"dataset":[267],"available":[269,282],"at":[270,283],"https://ibpv.kansil.org/":[271],"public":[273],"use.":[274],"CONTACT:":[275],"vatalay@metu.edu.tr.":[276],"SUPPLEMENTARY":[277],"INFORMATION:":[278],"Supplementary":[279],"data":[280],"Bioinformatics":[284],"online.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}