{"id":"https://openalex.org/W3121194719","doi":"https://doi.org/10.1093/bioinformatics/btaa1083","title":"A two-step approach to testing overall effect of gene\u2013environment interaction for multiple phenotypes","display_name":"A two-step approach to testing overall effect of gene\u2013environment interaction for multiple phenotypes","publication_year":2020,"publication_date":"2020-12-15","ids":{"openalex":"https://openalex.org/W3121194719","doi":"https://doi.org/10.1093/bioinformatics/btaa1083","mag":"3121194719","pmid":"https://pubmed.ncbi.nlm.nih.gov/33453114"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa1083","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa1083","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033682154","display_name":"Arunabha Majumdar","orcid":"https://orcid.org/0000-0002-5609-075X"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arunabha Majumdar","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of California , San Francisco, CA 94158, USA","Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California , Los Angeles, Los Angeles, CA 90095, USA"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of California , San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California , Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013091003","display_name":"Kathryn S. Burch","orcid":"https://orcid.org/0000-0001-9624-2108"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn S Burch","raw_affiliation_strings":["Bioinformatics Interdepartmental Program, University of California, Los Angeles , Los Angeles, CA 90095, USA"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Interdepartmental Program, University of California, Los Angeles , Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035652446","display_name":"Tanushree Haldar","orcid":"https://orcid.org/0000-0002-5425-1230"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanushree Haldar","raw_affiliation_strings":["Institute for Human Genetics, University of California , San Francisco, CA 94158, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Human Genetics, University of California , San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049741676","display_name":"Sriram Sankararaman","orcid":"https://orcid.org/0000-0003-1586-9641"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriram Sankararaman","raw_affiliation_strings":["Department of Computer Science, University of California , Los Angeles, Los Angeles, CA 90095, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California , Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057630970","display_name":"Bogdan Pa\u015faniuc","orcid":"https://orcid.org/0000-0002-0227-2056"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bogdan Pasaniuc","raw_affiliation_strings":["Bioinformatics Interdepartmental Program, University of California, Los Angeles , Los Angeles, CA 90095, USA","Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California , Los Angeles, Los Angeles, CA 90095, USA"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Interdepartmental Program, University of California, Los Angeles , Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California , Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113865889","display_name":"W. James Gauderman","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W James Gauderman","raw_affiliation_strings":["Department of Preventive Medicine, Keck School of Medicine, University of Southern California , Los Angeles, CA 90007, USA"],"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California , Los Angeles, CA 90007, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035070420","display_name":"John S. Witte","orcid":"https://orcid.org/0000-0003-0146-1434"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John S Witte","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of California , San Francisco, CA 94158, USA"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of California , San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5035070420"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.3314,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58045291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"36","issue":"24","first_page":"5640","last_page":"5648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.7462993860244751},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5879989862442017},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5244941115379333},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"Pleiotropy","score":0.5162951350212097},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.49880266189575195},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4292387068271637},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.343137264251709},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30158859491348267},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2659357786178589},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25367701053619385},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2044498324394226},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.11804676055908203}],"concepts":[{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.7462993860244751},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5879989862442017},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5244941115379333},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.5162951350212097},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.49880266189575195},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4292387068271637},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.343137264251709},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30158859491348267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2659357786178589},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25367701053619385},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2044498324394226},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.11804676055908203}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btaa1083","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa1083","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33453114","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33453114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"awards":[{"id":"https://openalex.org/G5850737185","display_name":null,"funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W260994251","https://openalex.org/W1703482192","https://openalex.org/W1922569994","https://openalex.org/W1968228833","https://openalex.org/W1969151189","https://openalex.org/W1977636169","https://openalex.org/W1979358400","https://openalex.org/W1991739837","https://openalex.org/W2022815972","https://openalex.org/W2027399762","https://openalex.org/W2093453252","https://openalex.org/W2096095753","https://openalex.org/W2104504285","https://openalex.org/W2116363786","https://openalex.org/W2120364751","https://openalex.org/W2126086474","https://openalex.org/W2130701931","https://openalex.org/W2132039887","https://openalex.org/W2135103130","https://openalex.org/W2151752382","https://openalex.org/W2154532816","https://openalex.org/W2327849580","https://openalex.org/W2412117756","https://openalex.org/W2418811587","https://openalex.org/W2600693125","https://openalex.org/W2735856318","https://openalex.org/W2780560743","https://openalex.org/W2895486342","https://openalex.org/W2898585601","https://openalex.org/W2911294343","https://openalex.org/W2911684552","https://openalex.org/W2951490487","https://openalex.org/W2952635637","https://openalex.org/W2952892633","https://openalex.org/W2986602759","https://openalex.org/W2995579925","https://openalex.org/W2998425895","https://openalex.org/W3027216799","https://openalex.org/W6679706704"],"related_works":["https://openalex.org/W2049578243","https://openalex.org/W1828158523","https://openalex.org/W2122079181","https://openalex.org/W2000145235","https://openalex.org/W1985848810","https://openalex.org/W2889939530","https://openalex.org/W2399195672","https://openalex.org/W3121881699","https://openalex.org/W2748838164","https://openalex.org/W2066015000"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-23T05:10:03.516525","created_date":"2025-10-10T00:00:00"}
