{"id":"https://openalex.org/W3113826677","doi":"https://doi.org/10.1093/bioinformatics/btaa1071","title":"PROSS 2: a new server for the design of stable and highly expressed protein variants","display_name":"PROSS 2: a new server for the design of stable and highly expressed protein variants","publication_year":2020,"publication_date":"2020-12-15","ids":{"openalex":"https://openalex.org/W3113826677","doi":"https://doi.org/10.1093/bioinformatics/btaa1071","mag":"3113826677","pmid":"https://pubmed.ncbi.nlm.nih.gov/33367682"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa1071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa1071","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/1/123/37005895/btaa1071.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/37/1/123/37005895/btaa1071.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079698360","display_name":"Jonathan J. Weinstein","orcid":"https://orcid.org/0000-0001-7581-965X"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jonathan Jacob Weinstein","raw_affiliation_strings":["Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025341781","display_name":"Adi Goldenzweig","orcid":null},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Adi Goldenzweig","raw_affiliation_strings":["Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022582060","display_name":"Shlomo Yakir Hoch","orcid":"https://orcid.org/0000-0003-3991-1533"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"ShlomoYakir Hoch","raw_affiliation_strings":["Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031768744","display_name":"Sarel J. Fleishman","orcid":"https://orcid.org/0000-0003-3177-7560"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Sarel Jacob Fleishman","raw_affiliation_strings":["Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031768744"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.9259,"has_fulltext":true,"cited_by_count":103,"citation_normalized_percentile":{"value":0.92181894,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"37","issue":"1","first_page":"123","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.7559927105903625},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7241932153701782},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.6219856142997742},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.5863519310951233},{"id":"https://openalex.org/keywords/protein-design","display_name":"Protein design","score":0.5157333016395569},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5024998188018799},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.4993574619293213},{"id":"https://openalex.org/keywords/protein-stability","display_name":"Protein stability","score":0.4853764772415161},{"id":"https://openalex.org/keywords/heterologous","display_name":"Heterologous","score":0.4291987419128418},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.42799919843673706},{"id":"https://openalex.org/keywords/sequence-analysis","display_name":"Sequence analysis","score":0.41506996750831604},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3868231773376465},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.2885168194770813},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24514922499656677},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.1752375066280365},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1393166184425354},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.11395975947380066},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.0872310996055603}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7559927105903625},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7241932153701782},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.6219856142997742},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.5863519310951233},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.5157333016395569},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5024998188018799},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4993574619293213},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.4853764772415161},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.4291987419128418},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.42799919843673706},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.41506996750831604},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3868231773376465},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2885168194770813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24514922499656677},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.1752375066280365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1393166184425354},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.11395975947380066},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0872310996055603},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaa1071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa1071","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/1/123/37005895/btaa1071.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33367682","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33367682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7611707","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7611707","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaa1071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa1071","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/37/1/123/37005895/btaa1071.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5954531416","display_name":null,"funder_award_id":"815379","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320318436","display_name":"Milner Foundation","ror":null},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3113826677.pdf","grobid_xml":"https://content.openalex.org/works/W3113826677.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2069152576","https://openalex.org/W2118265845","https://openalex.org/W2162870223","https://openalex.org/W2323927982","https://openalex.org/W2461384588","https://openalex.org/W2473135273","https://openalex.org/W2538176089","https://openalex.org/W2577723078","https://openalex.org/W2584678630","https://openalex.org/W2766687765","https://openalex.org/W2785250581","https://openalex.org/W2901812771","https://openalex.org/W2902084228","https://openalex.org/W2963515335","https://openalex.org/W2984919929","https://openalex.org/W3000378476","https://openalex.org/W3020993548","https://openalex.org/W3021975097"],"related_works":["https://openalex.org/W2116266427","https://openalex.org/W2991041010","https://openalex.org/W2003675367","https://openalex.org/W2991203454","https://openalex.org/W2113794949","https://openalex.org/W2512252615","https://openalex.org/W2888815005","https://openalex.org/W2409023191","https://openalex.org/W2069066899","https://openalex.org/W1983090887"],"abstract_inverted_index":{"PROSS2":[0],"is":[1],"freely":[2],"available":[3],"for":[4],"academic":[5],"use":[6],"at":[7],"https://pross.weizmann.ac.il.":[8]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}