{"id":"https://openalex.org/W2998938938","doi":"https://doi.org/10.1093/bioinformatics/btaa015","title":"MDEHT: a multivariate approach for detecting differential expression of microRNA isoform data in RNA-sequencing studies","display_name":"MDEHT: a multivariate approach for detecting differential expression of microRNA isoform data in RNA-sequencing studies","publication_year":2020,"publication_date":"2020-01-09","ids":{"openalex":"https://openalex.org/W2998938938","doi":"https://doi.org/10.1093/bioinformatics/btaa015","mag":"2998938938","pmid":"https://pubmed.ncbi.nlm.nih.gov/31930386"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa015","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/9/2657/33181013/btaa015.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/36/9/2657/33181013/btaa015.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101145757","display_name":"Md Amanullah","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Md Amanullah","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","institution_ids":["https://openalex.org/I4210137217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073362527","display_name":"Mengqian Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengqian Yu","raw_affiliation_strings":["Department of Respiratory Medicine , Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine , Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110382044","display_name":"Xiwei Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiwei Sun","raw_affiliation_strings":["Department of Respiratory Medicine , Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China","Institute for Advanced Research , Wenzhou Medical University, Wenzhou, Zhejiang 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine , Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute for Advanced Research , Wenzhou Medical University, Wenzhou, Zhejiang 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013349525","display_name":"Aoran Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aoran Luo","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","institution_ids":["https://openalex.org/I4210137217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604369","display_name":"Qing Zhou","orcid":"https://orcid.org/0000-0002-9900-3353"},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Zhou","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","institution_ids":["https://openalex.org/I4210137217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101622398","display_name":"Liyuan Zhou","orcid":"https://orcid.org/0000-0001-7485-8163"},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyuan Zhou","raw_affiliation_strings":["Department of Respiratory Medicine , Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine , Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023238050","display_name":"Ling Hou","orcid":"https://orcid.org/0000-0003-2596-9953"},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Hou","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","institution_ids":["https://openalex.org/I4210137217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100391890","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-1614-0759"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210148790","display_name":"Hangzhou First People's Hospital","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Department of Pathology , Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","Institute for Advanced Research , Wenzhou Medical University, Wenzhou, Zhejiang 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","institution_ids":["https://openalex.org/I4210148790","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute for Advanced Research , Wenzhou Medical University, Wenzhou, Zhejiang 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108089993","display_name":"Weiguo L\u00fc","orcid":"https://orcid.org/0000-0003-2062-7145"},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiguo Lu","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","institution_ids":["https://openalex.org/I4210137217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714943","display_name":"Pengyuan Liu","orcid":"https://orcid.org/0000-0002-8386-8416"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I4210148790","display_name":"Hangzhou First People's Hospital","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Pengyuan Liu","raw_affiliation_strings":["Department of Pathology , Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","Department of Physiology , Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA","Department of Respiratory Medicine , Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China"],"raw_orcid":"https://orcid.org/0000-0002-8386-8416","affiliations":[{"raw_affiliation_string":"Department of Pathology , Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","institution_ids":["https://openalex.org/I4210148790","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Physiology , Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Respiratory Medicine , Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100627527","display_name":"Yan L\u00fc","orcid":"https://orcid.org/0000-0002-5004-4656"},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Lu","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women\u2019s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women\u2019s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China","institution_ids":["https://openalex.org/I4210137217"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100627527","https://openalex.org/A5100714943"],"corresponding_institution_ids":["https://openalex.org/I204308271","https://openalex.org/I2802390878","https://openalex.org/I4210137217","https://openalex.org/I4210148790","https://openalex.org/I76130692"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.239,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.460658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"36","issue":"9","first_page":"2657","last_page":"2664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.968999981880188,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.968999981880188,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.6666979193687439},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6387604475021362},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5793297290802002},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.5506517291069031},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45416244864463806},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4400445818901062},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.4308403730392456},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.420045405626297},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3312830328941345},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2521640658378601},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1850813329219818},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.12027314305305481}],"concepts":[{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.6666979193687439},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6387604475021362},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5793297290802002},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5506517291069031},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45416244864463806},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4400445818901062},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.4308403730392456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.420045405626297},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3312830328941345},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2521640658378601},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1850813329219818},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.12027314305305481}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaa015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa015","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/9/2657/33181013/btaa015.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31930386","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31930386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7203753","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7203753","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaa015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa015","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/9/2657/33181013/btaa015.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1261806821","display_name":null,"funder_award_id":"2016YFA0501800","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2047880500","display_name":null,"funder_award_id":"2019YFC1315700","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3138489451","display_name":null,"funder_award_id":"81772766","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4699867024","display_name":null,"funder_award_id":"81871864","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4708576552","display_name":null,"funder_award_id":"LZ20H160001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G5009294150","display_name":null,"funder_award_id":"81572256","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5628516111","display_name":null,"funder_award_id":"2016YFA0501800","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998938938.pdf","grobid_xml":"https://content.openalex.org/works/W2998938938.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1485542661","https://openalex.org/W1609044025","https://openalex.org/W1957438118","https://openalex.org/W1974511160","https://openalex.org/W1996963134","https://openalex.org/W2004791359","https://openalex.org/W2006247279","https://openalex.org/W2026570544","https://openalex.org/W2064771454","https://openalex.org/W2081098333","https://openalex.org/W2086320398","https://openalex.org/W2089055162","https://openalex.org/W2103441770","https://openalex.org/W2110065044","https://openalex.org/W2114104545","https://openalex.org/W2127293185","https://openalex.org/W2141549067","https://openalex.org/W2151922790","https://openalex.org/W2152239989","https://openalex.org/W2168352935","https://openalex.org/W2179438025","https://openalex.org/W2588840062","https://openalex.org/W2748577514","https://openalex.org/W2811212358","https://openalex.org/W2913073753","https://openalex.org/W2946714259","https://openalex.org/W2952130397","https://openalex.org/W3010685992","https://openalex.org/W4230065791"],"related_works":["https://openalex.org/W1828158523","https://openalex.org/W2049578243","https://openalex.org/W2000145235","https://openalex.org/W2122079181","https://openalex.org/W1985848810","https://openalex.org/W2889939530","https://openalex.org/W2399195672","https://openalex.org/W3121881699","https://openalex.org/W2748838164","https://openalex.org/W2066015000"],"abstract_inverted_index":{"MOTIVATION:":[0],"miRNA":[1,13,37,55,79,212],"isoforms":[2],"(isomiRs)":[3],"are":[4,27,137,224],"produced":[5],"from":[6,102,163],"the":[7,11,34,51,76,96,103,120,129,173],"same":[8,104],"arm":[9],"as":[10,107],"archetype":[12],"with":[14,153],"a":[15,57,89,108],"few":[16,68],"nucleotides":[17],"different":[18],"at":[19,218,226],"5":[20],"and/or":[21],"3":[22],"termini.":[23],"These":[24],"well-conserved":[25],"isomiRs":[26,124,209],"functionally":[28],"important":[29],"and":[30,56,63,148,160,181,197,207,210],"have":[31],"contributed":[32],"to":[33,92,127],"evolution":[35],"of":[36,41,44,54,78,95,99,119,131,151,189],"genes.":[38],"Accurate":[39],"detection":[40],"differential":[42,80,110,213],"expression":[43,111,214],"miRNAs":[45,135],"can":[46],"bring":[47],"new":[48],"insights":[49],"into":[50,73],"cellular":[52],"function":[53],"further":[58],"improvement":[59],"in":[60,75,123,141,158,187],"miRNA-based":[61],"diagnostic":[62],"prognostic":[64],"applications.":[65],"However,":[66],"very":[67],"methods":[69],"take":[70,93],"isomiR":[71,100],"variations":[72],"account":[74],"analysis":[77,215],"expression.":[81],"RESULTS:":[82],"To":[83],"overcome":[84],"this":[85],"challenge,":[86],"we":[87],"developed":[88],"novel":[90],"approach":[91],"advantage":[94],"multidimensional":[97],"structure":[98],"data":[101,223],"miRNAs,":[105],"termed":[106],"multivariate":[109],"by":[112],"Hotelling's":[113],"T2":[114],"test":[115],"(MDEHT).":[116],"The":[117,164,202],"utilization":[118],"information":[121],"hidden":[122],"enables":[125],"MDEHT":[126,152,174],"increase":[128],"power":[130],"identifying":[132,206],"differentially":[133],"expressed":[134],"that":[136,172],"not":[138],"marginally":[139],"detectable":[140],"univariate":[142],"testing":[143],"methods.":[144],"We":[145],"conducted":[146],"rigorous":[147],"unbiased":[149],"comparisons":[150],"seven":[154],"commonly":[155,184],"used":[156,185],"tools":[157,186],"simulated":[159],"real":[161],"datasets":[162,180],"Cancer":[165],"Genome":[166],"Atlas.":[167],"Our":[168],"comprehensive":[169],"evaluations":[170],"demonstrated":[171],"method":[175],"was":[176],"robust":[177],"among":[178],"various":[179],"outperformed":[182],"other":[183],"terms":[188],"Type":[190],"I":[191],"error":[192],"rate,":[193],"true":[194],"positive":[195],"rate":[196],"reproducibility.":[198],"AVAILABILITY":[199],"AND":[200],"IMPLEMENTATION:":[201],"source":[203],"code":[204],"for":[205],"quantifying":[208],"performing":[211],"is":[216],"available":[217,225],"https://github.com/amanzju/MDEHT.":[219],"SUPPLEMENTARY":[220],"INFORMATION:":[221],"Supplementary":[222],"Bioinformatics":[227],"online.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2020-01-23T00:00:00"}