{"id":"https://openalex.org/W2999336918","doi":"https://doi.org/10.1093/bib/bbz159","title":"NCMCMDA: miRNA\u2013disease association prediction through neighborhood constraint matrix completion","display_name":"NCMCMDA: miRNA\u2013disease association prediction through neighborhood constraint matrix completion","publication_year":2019,"publication_date":"2019-11-12","ids":{"openalex":"https://openalex.org/W2999336918","doi":"https://doi.org/10.1093/bib/bbz159","mag":"2999336918","pmid":"https://pubmed.ncbi.nlm.nih.gov/31927572"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbz159","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbz159","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100371773","display_name":"Xing Chen","orcid":"https://orcid.org/0000-0001-9297-7174"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing Chen","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology"],"affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056593488","display_name":"Lian-Gang Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian-Gang Sun","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology"],"affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053490763","display_name":"Yan Zhao","orcid":"https://orcid.org/0000-0002-5319-0202"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology"],"affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology","institution_ids":["https://openalex.org/I25757504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100371773"],"corresponding_institution_ids":["https://openalex.org/I25757504"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":9.0099,"has_fulltext":false,"cited_by_count":218,"citation_normalized_percentile":{"value":0.98965116,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"22","issue":"1","first_page":"485","last_page":"496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6231757402420044},{"id":"https://openalex.org/keywords/cross-validation","display_name":"Cross-validation","score":0.5503307580947876},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.5406825542449951},{"id":"https://openalex.org/keywords/matrix-completion","display_name":"Matrix completion","score":0.5052259564399719},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.495552659034729},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4906555712223053},{"id":"https://openalex.org/keywords/thresholding","display_name":"Thresholding","score":0.46962904930114746},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.44630947709083557},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4107779860496521},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21761423349380493},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18248626589775085},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.0905914306640625}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6231757402420044},{"id":"https://openalex.org/C27181475","wikidata":"https://www.wikidata.org/wiki/Q541014","display_name":"Cross-validation","level":2,"score":0.5503307580947876},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.5406825542449951},{"id":"https://openalex.org/C2778459887","wikidata":"https://www.wikidata.org/wiki/Q6787865","display_name":"Matrix completion","level":3,"score":0.5052259564399719},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.495552659034729},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4906555712223053},{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.46962904930114746},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44630947709083557},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4107779860496521},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21761423349380493},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18248626589775085},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0905914306640625},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbz159","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbz159","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31927572","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31927572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G5742557939","display_name":null,"funder_award_id":"2019ZDPY01","funder_id":"https://openalex.org/F4320326503","funder_display_name":"General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320326503","display_name":"General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W14098964","https://openalex.org/W144423133","https://openalex.org/W1436642346","https://openalex.org/W1590311193","https://openalex.org/W1648301895","https://openalex.org/W1667789979","https://openalex.org/W1963906441","https://openalex.org/W1967087625","https://openalex.org/W1969350389","https://openalex.org/W2002995168","https://openalex.org/W2022732522","https://openalex.org/W2026120913","https://openalex.org/W2032630075","https://openalex.org/W2047529648","https://openalex.org/W2047967134","https://openalex.org/W2054210950","https://openalex.org/W2090678665","https://openalex.org/W2094532696","https://openalex.org/W2096433394","https://openalex.org/W2098318517","https://openalex.org/W2106029302","https://openalex.org/W2118814218","https://openalex.org/W2123688186","https://openalex.org/W2126619650","https://openalex.org/W2128768066","https://openalex.org/W2129158737","https://openalex.org/W2132694427","https://openalex.org/W2141222510","https://openalex.org/W2142937131","https://openalex.org/W2146292498","https://openalex.org/W2158135353","https://openalex.org/W2162674813","https://openalex.org/W2171232191","https://openalex.org/W2172116465","https://openalex.org/W2410390867","https://openalex.org/W2416873003","https://openalex.org/W2473724422","https://openalex.org/W2511620854","https://openalex.org/W2542315333","https://openalex.org/W2557765022","https://openalex.org/W2567465856","https://openalex.org/W2584926544","https://openalex.org/W2605111099","https://openalex.org/W2607159126","https://openalex.org/W2611820672","https://openalex.org/W2624752195","https://openalex.org/W2687743292","https://openalex.org/W2747147629","https://openalex.org/W2765950793","https://openalex.org/W2801501532","https://openalex.org/W2807827186","https://openalex.org/W2808799430","https://openalex.org/W2809363952","https://openalex.org/W2810276774","https://openalex.org/W2888358121","https://openalex.org/W2911188335","https://openalex.org/W2936738922","https://openalex.org/W2971435330","https://openalex.org/W3099000562","https://openalex.org/W4211069901","https://openalex.org/W4211090034","https://openalex.org/W6678900281","https://openalex.org/W6743069378","https://openalex.org/W6761385901","https://openalex.org/W6845668274"],"related_works":["https://openalex.org/W1542224353","https://openalex.org/W1661087619","https://openalex.org/W2116854923","https://openalex.org/W2750730210","https://openalex.org/W2236974868","https://openalex.org/W4312766348","https://openalex.org/W4233939244","https://openalex.org/W2730764323","https://openalex.org/W3123806511","https://openalex.org/W1976727107"],"abstract_inverted_index":{"Emerging":[0],"evidence":[1],"shows":[2],"that":[3,50],"microRNAs":[4],"(miRNAs)":[5],"play":[6],"a":[7,76,131,156,162,226],"critical":[8],"role":[9],"in":[10,168],"diverse":[11],"fundamental":[12],"and":[13,26,41,57,113,170,177,191,223,234],"important":[14],"biological":[15,52],"processes":[16],"associated":[17],"with":[18,126,155],"human":[19,45],"diseases.":[20,46],"Inferring":[21],"potential":[22,68,92],"disease":[23,115],"related":[24],"miRNAs":[25,243],"employing":[27],"them":[28],"as":[29,63],"the":[30,38,103,109,140,143,164,239],"biomarkers":[31],"or":[32],"drug":[33],"targets":[34],"could":[35],"contribute":[36],"to":[37,66,90,101,138,210,217],"prevention,":[39],"diagnosis":[40],"treatment":[42],"of":[43,49,98,134,166,189,194,214,238],"complex":[44],"In":[47,71,118,180],"view":[48],"traditional":[51],"experiments":[53],"cost":[54],"much":[55],"time":[56],"resources,":[58],"computational":[59,78,204],"models":[60],"would":[61],"serve":[62],"complementary":[64],"means":[65],"uncover":[67],"miRNA-disease":[69,93,105,111],"associations.":[70,94],"this":[72,119],"study,":[73],"we":[74,121,152],"proposed":[75],"new":[77],"model":[79],"named":[80],"Neighborhood":[81],"Constraint":[82],"Matrix":[83],"Completion":[84],"for":[85],"MiRNA-Disease":[86],"Association":[87],"prediction":[88,221],"(NCMCMDA)":[89],"predict":[91],"The":[95],"main":[96],"task":[97,145],"NCMCMDA":[99,167,184,207],"was":[100,146,208],"recover":[102],"missing":[104],"associations":[106,112],"based":[107],"on":[108],"known":[110],"integrated":[114,123],"(miRNA)":[116],"similarity.":[117],"model,":[120],"innovatively":[122],"neighborhood":[124],"constraint":[125],"matrix":[127],"completion,":[128],"which":[129,196],"provided":[130],"novel":[132],"idea":[133],"utilizing":[135],"similarity":[136],"information":[137],"assist":[139],"prediction.":[141],"After":[142],"recovery":[144],"transformed":[147],"into":[148],"an":[149,186],"optimization":[150],"problem,":[151],"solved":[153],"it":[154],"fast":[157],"iterative":[158],"shrinkage-thresholding":[159],"algorithm.":[160],"As":[161,225],"result,":[163,227],"AUCs":[165],"global":[169],"local":[171],"leave-one-out":[172],"cross":[173,182],"validation":[174],"were":[175,244],"0.9086":[176],"0.8453,":[178],"respectively.":[179],"5-fold":[181],"validation,":[183],"achieved":[185],"average":[187],"AUC":[188],"0.8942":[190],"standard":[192],"deviation":[193],"0.0015,":[195],"demonstrated":[197],"NCMCMDA's":[198],"superior":[199],"performance":[200],"than":[201],"many":[202],"previous":[203],"methods.":[205],"Furthermore,":[206],"applied":[209],"three":[211],"different":[212],"types":[213],"case":[215],"studies":[216],"further":[218],"evaluate":[219],"its":[220],"reliability":[222],"accuracy.":[224],"84%":[228],"(colon":[229],"neoplasms),":[230],"98%":[231,235],"(esophageal":[232],"neoplasms)":[233,237],"(breast":[236],"top":[240],"50":[241],"predicted":[242],"verified":[245],"by":[246],"recent":[247],"literature.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":56},{"year":2022,"cited_by_count":67},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":12},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-14T08:43:22.919905","created_date":"2025-10-10T00:00:00"}