{"id":"https://openalex.org/W3002043276","doi":"https://doi.org/10.1093/bib/bbz134","title":"CpG-island-based annotation and analysis of human housekeeping genes","display_name":"CpG-island-based annotation and analysis of human housekeeping genes","publication_year":2019,"publication_date":"2019-10-08","ids":{"openalex":"https://openalex.org/W3002043276","doi":"https://doi.org/10.1093/bib/bbz134","mag":"3002043276","pmid":"https://pubmed.ncbi.nlm.nih.gov/31982909"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbz134","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbz134","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/ws/files/139384917/Cpg-island-based-annotation-and-analysis-of-human-housekeeping-genes.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100350625","display_name":"Le Zhang","orcid":"https://orcid.org/0000-0002-3708-1727"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Zhang","raw_affiliation_strings":["College of Computer Science, Sichuan University, Chengdu, 610065, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science, Sichuan University, Chengdu, 610065, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003551314","display_name":"Zichun Dai","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zichun Dai","raw_affiliation_strings":["Medical Big Data Center of Sichuan University, Sichuan University, Chengdu, 610065, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Big Data Center of Sichuan University, Sichuan University, Chengdu, 610065, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728445","display_name":"Jun Yu","orcid":"https://orcid.org/0000-0002-2702-055X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Yu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, PR China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101717292","display_name":"Ming Xiao","orcid":"https://orcid.org/0000-0001-8608-5903"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Xiao","raw_affiliation_strings":["University of Chinese Academy of Sciences, Beijing 100049, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, PR China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101717292"],"corresponding_institution_ids":["https://openalex.org/I4210165038"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.8223,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.86142927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"515","last_page":"525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12640","display_name":"Environmental DNA in Biodiversity Studies","score":0.980400025844574,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/housekeeping-gene","display_name":"Housekeeping gene","score":0.8638814687728882},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.7713791131973267},{"id":"https://openalex.org/keywords/housekeeping","display_name":"Housekeeping","score":0.6947819590568542},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.6731666922569275},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5817412734031677},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.505108654499054},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.45434021949768066},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37161219120025635},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34033745527267456},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.13225668668746948},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.05620068311691284}],"concepts":[{"id":"https://openalex.org/C33922130","wikidata":"https://www.wikidata.org/wiki/Q419232","display_name":"Housekeeping gene","level":4,"score":0.8638814687728882},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.7713791131973267},{"id":"https://openalex.org/C90861158","wikidata":"https://www.wikidata.org/wiki/Q708514","display_name":"Housekeeping","level":3,"score":0.6947819590568542},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6731666922569275},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5817412734031677},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.505108654499054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45434021949768066},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37161219120025635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34033745527267456},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.13225668668746948},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.05620068311691284}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016385","descriptor_name":"TATA Box","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016385","descriptor_name":"TATA Box","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016385","descriptor_name":"TATA Box","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbz134","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbz134","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31982909","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31982909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/c1bee2ee-4fc7-4701-bb01-2f76f94e84dd","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/c1bee2ee-4fc7-4701-bb01-2f76f94e84dd","pdf_url":"https://pure.amsterdamumc.nl/ws/files/139384917/Cpg-island-based-annotation-and-analysis-of-human-housekeeping-genes.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, L, Dai, Z, Yu, J & Xiao, M 2021, 'CpG-island-based annotation and analysis of human housekeeping genes', Briefings in bioinformatics, vol. 22, no. 1, pp. 515-525. https://doi.org/10.1093/bib/bbz134","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/c15c8ded-50b4-4355-812a-354d0e3e1fcf","is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/cpgislandbased-annotation-and-analysis-of-human-housekeeping-genes(c15c8ded-50b4-4355-812a-354d0e3e1fcf).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in bioinformatics, 22(1), 515 - 525. Oxford University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/c1bee2ee-4fc7-4701-bb01-2f76f94e84dd","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/c1bee2ee-4fc7-4701-bb01-2f76f94e84dd","pdf_url":"https://pure.amsterdamumc.nl/ws/files/139384917/Cpg-island-based-annotation-and-analysis-of-human-housekeeping-genes.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, L, Dai, Z, Yu, J & Xiao, M 2021, 'CpG-island-based annotation and analysis of human housekeeping genes', Briefings in bioinformatics, vol. 22, no. 1, pp. 515-525. https://doi.org/10.1093/bib/bbz134","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"awards":[{"id":"https://openalex.org/G1868565335","display_name":"\u57fa\u4e8e\u751f\u7269\u5f71\u50cf\u5206\u6790\u548c\u591a\u5c42\u6b21\u4ee3\u7406\u6a21\u578b\u7684\u8111\u764c\u53d1\u80b2\u6a21\u62df\u53ca\u4f18\u5316\u65b9\u6cd5\u7684\u7814\u7a76\u4e0e\u5e94\u7528","funder_award_id":"61372138","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6851554750","display_name":null,"funder_award_id":"2018ZX10201002","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3002043276.pdf","grobid_xml":"https://content.openalex.org/works/W3002043276.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1538643690","https://openalex.org/W1964184081","https://openalex.org/W1967841068","https://openalex.org/W1971258934","https://openalex.org/W1987111014","https://openalex.org/W1993848554","https://openalex.org/W2018838463","https://openalex.org/W2022636167","https://openalex.org/W2033174805","https://openalex.org/W2035251881","https://openalex.org/W2035618305","https://openalex.org/W2036848594","https://openalex.org/W2037545834","https://openalex.org/W2043586699","https://openalex.org/W2084748297","https://openalex.org/W2099343472","https://openalex.org/W2102405388","https://openalex.org/W2107903949","https://openalex.org/W2107995607","https://openalex.org/W2108984616","https://openalex.org/W2146849272","https://openalex.org/W2163669353","https://openalex.org/W2164813466","https://openalex.org/W2164883151","https://openalex.org/W2186768585","https://openalex.org/W2263726729","https://openalex.org/W2276030348","https://openalex.org/W2414206081","https://openalex.org/W2474989629","https://openalex.org/W2485928572","https://openalex.org/W2557886758","https://openalex.org/W2563857680","https://openalex.org/W2573737646","https://openalex.org/W2594533529","https://openalex.org/W2610451137","https://openalex.org/W2761275051","https://openalex.org/W2765494761","https://openalex.org/W2777047301","https://openalex.org/W2787788280","https://openalex.org/W2804097979","https://openalex.org/W2886223143","https://openalex.org/W2921473648","https://openalex.org/W2942824232","https://openalex.org/W2947684550","https://openalex.org/W2964343099","https://openalex.org/W2969571588","https://openalex.org/W4230932396","https://openalex.org/W4243251406","https://openalex.org/W4255659575","https://openalex.org/W6666658774","https://openalex.org/W6687185898","https://openalex.org/W6715483336","https://openalex.org/W6731234078","https://openalex.org/W6745631737","https://openalex.org/W6763815618"],"related_works":["https://openalex.org/W2028359308","https://openalex.org/W2512481868","https://openalex.org/W2782714379","https://openalex.org/W2016751415","https://openalex.org/W2594201224","https://openalex.org/W2056273006","https://openalex.org/W2145442384","https://openalex.org/W4394558289","https://openalex.org/W1573192450","https://openalex.org/W4200304300"],"abstract_inverted_index":{"By":[0],"reviewing":[1],"previous":[2,74],"CpG-related":[3],"studies,":[4],"we":[5,144,183],"consider":[6],"that":[7,185],"the":[8,15,36,94,161,171,194],"transcription":[9],"regulation":[10],"of":[11,14,42,68,106,135],"about":[12],"half":[13],"human":[16],"genes,":[17,21,113],"mostly":[18],"housekeeping":[19],"(HK)":[20],"involves":[22],"CpG":[23,29,91],"islands":[24],"(CGIs),":[25],"their":[26],"methylation":[27],"states,":[28],"spacing":[30],"and":[31,40,62,70,85,99,108,138,155,163,200],"other":[32],"chromosomal":[33],"parameters.":[34],"However,":[35],"precise":[37],"CGI":[38,97],"definition":[39],"positioning":[41],"CGIs":[43,79,107],"within":[44],"gene":[45,61,100,202],"structures,":[46],"as":[47,49,104],"well":[48],"specific":[50],"CGI-associated":[51,147,201],"regulatory":[52],"mechanisms,":[53],"all":[54],"remain":[55],"to":[56,115,157],"be":[57,116,158],"explained":[58],"at":[59],"individual":[60],"gene-family":[63],"levels,":[64],"together":[65],"with":[66],"consideration":[67],"species":[69],"lineage":[71],"specificity.":[72],"Although":[73],"studies":[75],"have":[76],"already":[77],"classified":[78],"into":[80],"high-CpG":[81],"(HCGI),":[82],"intermediate-CpG":[83],"(ICGI)":[84],"low-CpG":[86],"(LCGI)":[87],"densities":[88],"based":[89,131,177],"on":[90,111,132,178],"density":[92,98],"variation,":[93],"correlation":[95],"between":[96],"expression":[101],"regulation,":[102],"such":[103,122],"co-regulation":[105],"TATA":[109],"box":[110],"HK":[112,159],"remains":[114],"elucidated.":[117],"First,":[118],"this":[119],"study":[120],"introduces":[121],"a":[123,133],"problem-solving":[124],"protocol":[125],"for":[126],"human-genome":[127],"annotation,":[128],"which":[129],"is":[130,174,190],"combination":[134,173],"GTEx,":[136],"JBLA":[137,196],"Gene":[139],"Ontology":[140],"(GO)":[141],"analysis.":[142,181,203],"Next,":[143],"discuss":[145],"why":[146],"genes":[148],"are":[149],"most":[150],"likely":[151],"regulated":[152],"by":[153],"HCGI":[154],"tend":[156],"genes;":[160],"HCGI/TATA\u00b1":[162],"LCGI/TATA\u00b1":[164],"combinations":[165],"show":[166],"different":[167],"GO":[168,179],"enrichment,":[169],"whereas":[170],"ICGI/TATA\u00b1":[172],"less":[175],"characteristic":[176],"enrichment":[180],"Finally,":[182],"demonstrate":[184],"Hadoop":[186],"MapReduce-based":[187],"MR-JBLA":[188],"algorithm":[189],"more":[191],"efficient":[192],"than":[193],"original":[195],"in":[197],"k-mer":[198],"counting":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}