{"id":"https://openalex.org/W2985149427","doi":"https://doi.org/10.1093/bib/bbz059","title":"Sepsis in the era of data-driven medicine: personalizing risks, diagnoses, treatments and prognoses","display_name":"Sepsis in the era of data-driven medicine: personalizing risks, diagnoses, treatments and prognoses","publication_year":2019,"publication_date":"2019-04-27","ids":{"openalex":"https://openalex.org/W2985149427","doi":"https://doi.org/10.1093/bib/bbz059","mag":"2985149427","pmid":"https://pubmed.ncbi.nlm.nih.gov/31190075"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbz059","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbz059","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8179509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064711982","display_name":"Andrew C. Liu","orcid":"https://orcid.org/0000-0003-1927-0900"},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"funder","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210106353","display_name":"Donald & Barbara Zucker School of Medicine at Hofstra/Northwell","ror":"https://ror.org/01ff5td15","country_code":"US","type":"education","lineage":["https://openalex.org/I1302444339","https://openalex.org/I139290212","https://openalex.org/I4210106353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew C Liu","raw_affiliation_strings":["Department of Information Services, Northwell Health, New Hyde Park, NY, USA","Donald and Barbara School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4242-6873","affiliations":[{"raw_affiliation_string":"Department of Information Services, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"Donald and Barbara School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY, USA","institution_ids":["https://openalex.org/I4210106353","https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061633865","display_name":"Krishna Patel","orcid":"https://orcid.org/0000-0003-0512-8444"},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"funder","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210106353","display_name":"Donald & Barbara Zucker School of Medicine at Hofstra/Northwell","ror":"https://ror.org/01ff5td15","country_code":"US","type":"education","lineage":["https://openalex.org/I1302444339","https://openalex.org/I139290212","https://openalex.org/I4210106353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Patel","raw_affiliation_strings":["Department of Information Services, Northwell Health, New Hyde Park, NY, USA","Donald and Barbara School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Services, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"Donald and Barbara School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY, USA","institution_ids":["https://openalex.org/I4210106353","https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001123855","display_name":"Ramya Vunikili","orcid":null},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"funder","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I36672615","display_name":"Courant Institute of Mathematical Sciences","ror":"https://ror.org/037tm7f56","country_code":"US","type":"education","lineage":["https://openalex.org/I36672615","https://openalex.org/I57206974"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramya Dhatri Vunikili","raw_affiliation_strings":["Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","Courant Institute of Mathematical Sciences, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"Courant Institute of Mathematical Sciences, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I36672615","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085920644","display_name":"Kipp W. Johnson","orcid":"https://orcid.org/0000-0002-5102-741X"},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kipp W Johnson","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA","Institute for Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA","institution_ids":["https://openalex.org/I1320796813"]},{"raw_affiliation_string":"Institute for Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA","institution_ids":["https://openalex.org/I1320796813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036318780","display_name":"Fahad Abdu","orcid":null},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"funder","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fahad Abdu","raw_affiliation_strings":["Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","Stonybrook University, 100 Nicolls Rd, Stony Brook, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"Stonybrook University, 100 Nicolls Rd, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024335192","display_name":"Shivani Kamath Belman","orcid":null},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"funder","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivani Kamath Belman","raw_affiliation_strings":["Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030539003","display_name":"Benjamin S. Glicksberg","orcid":"https://orcid.org/0000-0003-4515-8090"},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin S Glicksberg","raw_affiliation_strings":["Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA","Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA","Institute for Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA","institution_ids":["https://openalex.org/I1320796813"]},{"raw_affiliation_string":"Institute for Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA","institution_ids":["https://openalex.org/I1320796813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079841412","display_name":"Pratyush Tandale","orcid":null},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"funder","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210153931","display_name":"D.Y. Patil University","ror":"https://ror.org/045qb5273","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210153931"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Pratyush Tandale","raw_affiliation_strings":["Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","School of Biotechnology and Bioinformatics, D Y Patil University, Navi Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"School of Biotechnology and Bioinformatics, D Y Patil University, Navi Mumbai, India","institution_ids":["https://openalex.org/I4210153931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060036222","display_name":"Roberto Fontanez","orcid":null},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"funder","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Fontanez","raw_affiliation_strings":["Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","Department of Information Services, Northwell Health, New Hyde Park, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"Department of Information Services, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029869558","display_name":"Oommen K. Mathew","orcid":"https://orcid.org/0000-0002-6312-3118"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oommen K Mathew","raw_affiliation_strings":["TBC, B3, JKR, Aluva, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TBC, B3, JKR, Aluva, Kerala, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032714338","display_name":"Andrew Kasarskis","orcid":"https://orcid.org/0000-0001-6454-9076"},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Kasarskis","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA","institution_ids":["https://openalex.org/I1320796813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023272117","display_name":"Priyabrata Mukherjee","orcid":"https://orcid.org/0000-0002-0557-0833"},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyabrata Mukherjee","raw_affiliation_strings":["University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072232894","display_name":"Lakshminarayanan Subramanian","orcid":"https://orcid.org/0000-0001-8101-1243"},"institutions":[{"id":"https://openalex.org/I36672615","display_name":"Courant Institute of Mathematical Sciences","ror":"https://ror.org/037tm7f56","country_code":"US","type":"education","lineage":["https://openalex.org/I36672615","https://openalex.org/I57206974"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lakshminarayanan Subramanian","raw_affiliation_strings":["Courant Institute of Mathematical Sciences, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Courant Institute of Mathematical Sciences, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I36672615","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043599202","display_name":"Joel T. Dudley","orcid":"https://orcid.org/0000-0002-7036-6492"},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel T Dudley","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA","Institute for Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA","institution_ids":["https://openalex.org/I1320796813"]},{"raw_affiliation_string":"Institute for Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA","institution_ids":["https://openalex.org/I1320796813"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016416266","display_name":"Khader Shameer","orcid":"https://orcid.org/0000-0002-9982-1911"},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"funder","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Khader Shameer","raw_affiliation_strings":["Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","Department of Information Services, Northwell Health, New Hyde Park, NY, USA","Institute for Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics and Innovation, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"Department of Information Services, Northwell Health, New Hyde Park, NY, USA","institution_ids":["https://openalex.org/I1302444339"]},{"raw_affiliation_string":"Institute for Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA","institution_ids":["https://openalex.org/I1320796813"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5016416266"],"corresponding_institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I1320796813"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.5975,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.83784848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"21","issue":"4","first_page":"1182","last_page":"1195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9664999842643738,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medical-diagnosis","display_name":"Medical diagnosis","score":0.778937816619873},{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.7323720455169678},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5832898020744324},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.5628312826156616},{"id":"https://openalex.org/keywords/medline","display_name":"MEDLINE","score":0.4688820540904999},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.46415314078330994},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3733031749725342},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14652830362319946},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08229643106460571}],"concepts":[{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.778937816619873},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7323720455169678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5832898020744324},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5628312826156616},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4688820540904999},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.46415314078330994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3733031749725342},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14652830362319946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08229643106460571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbz059","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbz059","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31190075","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31190075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8179509","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8179509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8179509","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8179509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6800000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W748993927","https://openalex.org/W960051915","https://openalex.org/W1537188191","https://openalex.org/W1806043130","https://openalex.org/W1882905539","https://openalex.org/W1909429521","https://openalex.org/W1918323994","https://openalex.org/W1942377719","https://openalex.org/W1943063538","https://openalex.org/W1969208427","https://openalex.org/W1973111584","https://openalex.org/W1973468590","https://openalex.org/W1979421770","https://openalex.org/W1981243375","https://openalex.org/W1989245429","https://openalex.org/W1994451131","https://openalex.org/W1997072127","https://openalex.org/W1998427452","https://openalex.org/W2000642414","https://openalex.org/W2003171404","https://openalex.org/W2003964843","https://openalex.org/W2004106621","https://openalex.org/W2004910511","https://openalex.org/W2010270225","https://openalex.org/W2014629571","https://openalex.org/W2016061566","https://openalex.org/W2016908588","https://openalex.org/W2019952254","https://openalex.org/W2021967857","https://openalex.org/W2026170842","https://openalex.org/W2032150072","https://openalex.org/W2032599155","https://openalex.org/W2042438672","https://openalex.org/W2049927822","https://openalex.org/W2050449050","https://openalex.org/W2057913811","https://openalex.org/W2083513831","https://openalex.org/W2085137385","https://openalex.org/W2085452577","https://openalex.org/W2088835682","https://openalex.org/W2092576934","https://openalex.org/W2094924608","https://openalex.org/W2098744085","https://openalex.org/W2101245137","https://openalex.org/W2114325274","https://openalex.org/W2114536396","https://openalex.org/W2115614263","https://openalex.org/W2117196810","https://openalex.org/W2128682457","https://openalex.org/W2138784029","https://openalex.org/W2140658947","https://openalex.org/W2147307467","https://openalex.org/W2147622298","https://openalex.org/W2149133507","https://openalex.org/W2151390091","https://openalex.org/W2153875170","https://openalex.org/W2162408998","https://openalex.org/W2162553756","https://openalex.org/W2162955464","https://openalex.org/W2164990391","https://openalex.org/W2165276227","https://openalex.org/W2166162509","https://openalex.org/W2167320417","https://openalex.org/W2174956452","https://openalex.org/W2204023188","https://openalex.org/W2271670697","https://openalex.org/W2280404143","https://openalex.org/W2287937249","https://openalex.org/W2303883198","https://openalex.org/W2309459004","https://openalex.org/W2330028493","https://openalex.org/W2332078202","https://openalex.org/W2341574236","https://openalex.org/W2341817708","https://openalex.org/W2345568581","https://openalex.org/W2346779382","https://openalex.org/W2376236856","https://openalex.org/W2399140686","https://openalex.org/W2404901863","https://openalex.org/W2432987008","https://openalex.org/W2474277182","https://openalex.org/W2480891847","https://openalex.org/W2491787181","https://openalex.org/W2496661162","https://openalex.org/W2519872421","https://openalex.org/W2520798037","https://openalex.org/W2522331955","https://openalex.org/W2535900974","https://openalex.org/W2550447077","https://openalex.org/W2558366645","https://openalex.org/W2566727508","https://openalex.org/W2571957366","https://openalex.org/W2573818099","https://openalex.org/W2574855372","https://openalex.org/W2587939208","https://openalex.org/W2593766584","https://openalex.org/W2602482624","https://openalex.org/W2605399853","https://openalex.org/W2620241325","https://openalex.org/W2625092217","https://openalex.org/W2689318812","https://openalex.org/W2729932379","https://openalex.org/W2734475592","https://openalex.org/W2734677628","https://openalex.org/W2739432223","https://openalex.org/W2746617665","https://openalex.org/W2749328728","https://openalex.org/W2752299790","https://openalex.org/W2761829119","https://openalex.org/W2762411375","https://openalex.org/W2765795745","https://openalex.org/W2766599608","https://openalex.org/W2766745670","https://openalex.org/W2768146862","https://openalex.org/W2769997711","https://openalex.org/W2771421273","https://openalex.org/W2773309042","https://openalex.org/W2777442908","https://openalex.org/W2783674487","https://openalex.org/W2784094750","https://openalex.org/W2785301912","https://openalex.org/W2788468983","https://openalex.org/W2794138240","https://openalex.org/W2796121061","https://openalex.org/W2797768855","https://openalex.org/W2799605298","https://openalex.org/W2800030655","https://openalex.org/W2802154065","https://openalex.org/W2802397093","https://openalex.org/W2802870003","https://openalex.org/W2803332630","https://openalex.org/W2806314581","https://openalex.org/W2807593075","https://openalex.org/W2810838177","https://openalex.org/W2811443527","https://openalex.org/W2883853688","https://openalex.org/W2906311950","https://openalex.org/W2908201961","https://openalex.org/W2912867228","https://openalex.org/W2982584582","https://openalex.org/W2989597219","https://openalex.org/W4231903835","https://openalex.org/W4240902204","https://openalex.org/W6673135545","https://openalex.org/W6684052594","https://openalex.org/W6729571156","https://openalex.org/W6753656013","https://openalex.org/W6769455620","https://openalex.org/W6770451209"],"related_works":["https://openalex.org/W3215560449","https://openalex.org/W3030236844","https://openalex.org/W4249377076","https://openalex.org/W4237737355","https://openalex.org/W1520457732","https://openalex.org/W2794721326","https://openalex.org/W2832459556","https://openalex.org/W4385384888","https://openalex.org/W4210389441","https://openalex.org/W2979695286"],"abstract_inverted_index":{"Sepsis":[0],"is":[1],"a":[2,157],"series":[3],"of":[4,42,63,86,97,108,129,137,143,160,245,264,284],"clinical":[5,15,46,246],"syndromes":[6],"caused":[7],"by":[8,183],"the":[9,43,61,83,95,106,125,164,171,260,295,319],"immunological":[10],"response":[11],"to":[12,22,31,39,162,216,219,248,276,281,309,313],"infection.":[13],"The":[14,131],"evidence":[16,226],"for":[17,57,227],"sepsis":[18,72,98,167,230,265,317],"could":[19,36],"typically":[20],"attribute":[21],"bacterial":[23,26],"infection":[24],"or":[25,34],"endotoxins,":[27],"but":[28],"infections":[29],"due":[30],"viruses,":[32],"fungi":[33],"parasites":[35],"also":[37,223],"lead":[38,275],"sepsis.":[40,64,130,221],"Regardless":[41],"etiology,":[44],"rapid":[45],"deterioration,":[47],"prolonged":[48],"stay":[49],"in":[50,71,94,149,174,297,318],"intensive":[51],"care":[52],"units":[53],"and":[54,68,91,99,119,127,135,146,152,169,194,211,234,243,251,262,266,274,288,303,315],"high":[55],"risk":[56,87],"mortality":[58],"correlate":[59],"with":[60],"incidence":[62],"Despite":[65],"its":[66,267],"prevalence":[67],"morbidity,":[69],"improvement":[70],"outcomes":[73,255,273],"has":[74],"remained":[75],"limited.":[76],"In":[77],"this":[78],"comprehensive":[79],"review,":[80],"we":[81],"summarize":[82],"current":[84],"landscape":[85],"estimation,":[88],"diagnosis,":[89],"treatment":[90,126,272],"prognosis":[92],"strategies":[93,188,312],"setting":[96],"discuss":[100],"future":[101],"challenges.":[102],"We":[103,222],"argue":[104],"that":[105,239,270],"advent":[107],"modern":[109,185],"technologies":[110],"such":[111],"as":[112,141],"in-depth":[113],"molecular":[114],"profiling,":[115],"biomedical":[116,300],"big":[117],"data":[118,139,301],"machine":[120],"intelligence":[121],"methods":[122,238],"will":[123,256],"augment":[124],"prevention":[128],"volume,":[132],"variety,":[133],"veracity":[134],"velocity":[136],"heterogeneous":[138],"generated":[140],"part":[142],"healthcare":[144],"delivery":[145],"recent":[147],"advances":[148,296],"biotechnology-driven":[150],"therapeutics":[151],"companion":[153],"diagnostics":[154],"may":[155,214,279,307],"provide":[156,224],"new":[158,229],"wave":[159],"approaches":[161,306],"identify":[163],"most":[165,285],"at-risk":[166,286],"patients":[168,175,287],"reduce":[170],"symptom":[172],"burden":[173],"within":[176],"shorter":[177],"turnaround":[178],"times.":[179],"Developing":[180],"novel":[181],"therapies":[182],"leveraging":[184,294],"drug":[186,191],"discovery":[187],"including":[189,232],"computational":[190],"repositioning,":[192],"cell":[193],"gene-therapy,":[195],"clustered":[196],"regularly":[197],"interspaced":[198],"short":[199],"palindromic":[200],"repeats":[201],"-based":[202],"genetic":[203],"editing":[204],"systems,":[205],"immunotherapy,":[206],"microbiome":[207],"restoration,":[208],"nanomaterial-based":[209],"therapy":[210,213],"phage":[212],"help":[215,280,308],"develop":[217,310],"treatments":[218],"target":[220],"empirical":[225],"potential":[228],"targets":[231],"FER":[233],"STARD3NL.":[235],"Implementing":[236],"data-driven":[237],"use":[240],"real-time":[241],"collection":[242],"analysis":[244],"variables":[247],"trace,":[249],"track":[250],"treat":[252,316],"sepsis-related":[253],"adverse":[254],"be":[257],"key.":[258],"Understanding":[259],"root":[261],"route":[263],"comorbid":[268],"conditions":[269],"complicate":[271],"organ":[277],"dysfunction":[278],"facilitate":[282],"identification":[283],"prevent":[289],"further":[290],"deterioration.":[291],"To":[292],"conclude,":[293],"precision":[298],"medicine,":[299],"science":[302],"translational":[304],"bioinformatics":[305],"better":[311],"diagnose":[314],"next":[320],"decade.":[321]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-05-13T08:25:38.343686","created_date":"2025-10-10T00:00:00"}