{"id":"https://openalex.org/W2941371399","doi":"https://doi.org/10.1093/bib/bbz036","title":"Genome-wide identification and analysis of the eQTL lncRNAs in multiple sclerosis based on RNA-seq data","display_name":"Genome-wide identification and analysis of the eQTL lncRNAs in multiple sclerosis based on RNA-seq data","publication_year":2019,"publication_date":"2019-04-16","ids":{"openalex":"https://openalex.org/W2941371399","doi":"https://doi.org/10.1093/bib/bbz036","mag":"2941371399","pmid":"https://pubmed.ncbi.nlm.nih.gov/31323688"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbz036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbz036","pdf_url":"https://academic.oup.com/bib/article-pdf/21/3/1023/33227272/bbz036.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/21/3/1023/33227272/bbz036.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064979986","display_name":"Zhijie Han","orcid":"https://orcid.org/0000-0001-7693-7375"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijie Han","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China","School of Pharmaceutical Sciences and Collaborative Innovation Center for Brain Science, Chongqing University, Chongqing, China","Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences and Collaborative Innovation Center for Brain Science, Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027345342","display_name":"Weiwei Xue","orcid":"https://orcid.org/0000-0002-3285-0574"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiwei Xue","raw_affiliation_strings":["School of Pharmaceutical Sciences and Collaborative Innovation Center for Brain Science, Chongqing University, Chongqing, China"],"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences and Collaborative Innovation Center for Brain Science, Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061697130","display_name":"Lin Tao","orcid":"https://orcid.org/0000-0001-7494-4758"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Tao","raw_affiliation_strings":["Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, School of Medicine, Hangzhou Normal University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, School of Medicine, Hangzhou Normal University, Hangzhou, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020010918","display_name":"Yan Lou","orcid":"https://orcid.org/0000-0002-9126-476X"},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Lou","raw_affiliation_strings":["Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027440092","display_name":"Yunqing Qiu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunqing Qiu","raw_affiliation_strings":["Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210166576"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100755257","display_name":"Feng Zhu","orcid":"https://orcid.org/0000-0001-8069-0053"},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Zhu","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China","School of Pharmaceutical Sciences and Collaborative Innovation Center for Brain Science, Chongqing University, Chongqing, China","Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences and Collaborative Innovation Center for Brain Science, Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210166576"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5027440092","https://openalex.org/A5100755257"],"corresponding_institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210166576","https://openalex.org/I76130692"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.3008,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.76699455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"21","issue":"3","first_page":"1023","last_page":"1037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.842361569404602},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.7060801982879639},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6341170072555542},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5774262547492981},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.5132639408111572},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41581594944000244},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"Multiple sclerosis","score":0.41092780232429504},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4105875790119171},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.34485530853271484},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.335913747549057},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.17750948667526245},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12810108065605164},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.0737646222114563}],"concepts":[{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.842361569404602},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7060801982879639},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6341170072555542},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5774262547492981},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.5132639408111572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41581594944000244},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.41092780232429504},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4105875790119171},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34485530853271484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.335913747549057},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.17750948667526245},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12810108065605164},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0737646222114563},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbz036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbz036","pdf_url":"https://academic.oup.com/bib/article-pdf/21/3/1023/33227272/bbz036.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31323688","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31323688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbz036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbz036","pdf_url":"https://academic.oup.com/bib/article-pdf/21/3/1023/33227272/bbz036.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1724776241","display_name":null,"funder_award_id":"2018YFC0910500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2446395889","display_name":null,"funder_award_id":"81872798","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2941371399.pdf","grobid_xml":"https://content.openalex.org/works/W2941371399.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W775956452","https://openalex.org/W1533942137","https://openalex.org/W1573408349","https://openalex.org/W1578830280","https://openalex.org/W1966327575","https://openalex.org/W1969022211","https://openalex.org/W1975922601","https://openalex.org/W1981311921","https://openalex.org/W1981509058","https://openalex.org/W1986589033","https://openalex.org/W1987968685","https://openalex.org/W1989277387","https://openalex.org/W1998009421","https://openalex.org/W1998430163","https://openalex.org/W2006358633","https://openalex.org/W2017332009","https://openalex.org/W2019926860","https://openalex.org/W2021962342","https://openalex.org/W2025943989","https://openalex.org/W2027285375","https://openalex.org/W2027455260","https://openalex.org/W2031393403","https://openalex.org/W2032183472","https://openalex.org/W2035618305","https://openalex.org/W2036272952","https://openalex.org/W2048612325","https://openalex.org/W2053255069","https://openalex.org/W2056198580","https://openalex.org/W2064310798","https://openalex.org/W2065776802","https://openalex.org/W2071717527","https://openalex.org/W2076638353","https://openalex.org/W2077352904","https://openalex.org/W2085065009","https://openalex.org/W2085315239","https://openalex.org/W2092138236","https://openalex.org/W2095666175","https://openalex.org/W2096525273","https://openalex.org/W2096791516","https://openalex.org/W2100697281","https://openalex.org/W2103441770","https://openalex.org/W2107903949","https://openalex.org/W2108234281","https://openalex.org/W2110561490","https://openalex.org/W2128016314","https://openalex.org/W2132646449","https://openalex.org/W2135403800","https://openalex.org/W2144110754","https://openalex.org/W2144961623","https://openalex.org/W2146621754","https://openalex.org/W2150131459","https://openalex.org/W2151010498","https://openalex.org/W2152239989","https://openalex.org/W2154431984","https://openalex.org/W2159675211","https://openalex.org/W2166686431","https://openalex.org/W2171599819","https://openalex.org/W2183091920","https://openalex.org/W2186803051","https://openalex.org/W2195359644","https://openalex.org/W2197124664","https://openalex.org/W2199550613","https://openalex.org/W2225287204","https://openalex.org/W2285345659","https://openalex.org/W2313421525","https://openalex.org/W2323326409","https://openalex.org/W2329857651","https://openalex.org/W2332018470","https://openalex.org/W2397759082","https://openalex.org/W2511381148","https://openalex.org/W2538142187","https://openalex.org/W2559588208","https://openalex.org/W2560140067","https://openalex.org/W2565212965","https://openalex.org/W2593747486","https://openalex.org/W2604808360","https://openalex.org/W2614935527","https://openalex.org/W2739999456","https://openalex.org/W2748551035","https://openalex.org/W2749264889","https://openalex.org/W2757426058","https://openalex.org/W2767918570","https://openalex.org/W2784570320","https://openalex.org/W2787437662","https://openalex.org/W2793859699","https://openalex.org/W2884850508","https://openalex.org/W2885374590","https://openalex.org/W2910249797","https://openalex.org/W4210659358","https://openalex.org/W4211254511","https://openalex.org/W4230932396","https://openalex.org/W4233698560","https://openalex.org/W4251386234","https://openalex.org/W6757884981"],"related_works":["https://openalex.org/W2164780420","https://openalex.org/W2995716764","https://openalex.org/W2161056048","https://openalex.org/W2587589680","https://openalex.org/W2995369528","https://openalex.org/W2901416251","https://openalex.org/W2110614590","https://openalex.org/W4296579751","https://openalex.org/W3093860938","https://openalex.org/W4385842477"],"abstract_inverted_index":{"The":[0,168],"pathogenesis":[1,220],"of":[2,16,24,38,47,55,62,71,82,142,160,190,213,221,228,254,269,274],"multiple":[3],"sclerosis":[4],"(MS)":[5],"is":[6,18,32],"significantly":[7],"regulated":[8],"by":[9,21,41,146,230],"long":[10],"noncoding":[11],"RNAs":[12],"(lncRNAs),":[13],"the":[14,36,48,53,60,72,80,149,161,183,196,211,219,226,237,252,255,265,272],"expression":[15,67,97,118],"which":[17],"substantially":[19,172],"influenced":[20],"a":[22,89,224],"number":[23],"MS-associated":[25],"risk":[26],"single":[27],"nucleotide":[28],"polymorphisms":[29],"(SNPs).":[30],"It":[31],"thus":[33],"hypothesized":[34],"that":[35],"dysregulation":[37],"lncRNA":[39,66,96,165],"induced":[40],"genomic":[42],"variants":[43],"may":[44],"be":[45],"one":[46],"key":[49],"molecular":[50,77],"mechanisms":[51,78],"for":[52],"pathology":[54,81,273],"MS.":[56,194,222,248,275],"However,":[57],"due":[58],"to":[59,94,208,218,234],"lack":[61],"sufficient":[63],"data":[64,101],"on":[65,113,215],"and":[68,98,109,116,140,155,157,164,173,179,182,201,240,261],"SNP":[69,99],"genotypes":[70],"same":[73],"MS":[74,83,107],"patients,":[75],"such":[76],"underlying":[79,271],"remain":[84],"elusive.":[85],"In":[86,126],"this":[87,259],"study,":[88],"bioinformatics":[90],"strategy":[91,256],"was":[92,124,186,232],"applied":[93],"obtain":[95],"genotype":[100],"simultaneously":[102],"from":[103],"142":[104],"samples":[105],"(51":[106],"patients":[108],"91":[110],"controls)":[111],"based":[112],"RNA-seq":[114],"data,":[115],"an":[117],"quantitative":[119],"trait":[120],"loci":[121],"(eQTL)":[122],"analysis":[123],"conducted.":[125],"total,":[127],"2383":[128],"differentially":[129],"expressed":[130],"lncRNAs":[131,192,216,229],"were":[132,144,166,171,206],"identified":[133],"as":[134],"specifically":[135,174],"expressing":[136],"in":[137,176,188,193,247,258],"brain-related":[138],"tissues,":[139],"517":[141],"them":[143],"affected":[145],"SNPs.":[147],"Then,":[148],"functional":[150],"characterization,":[151],"secondary":[152,184],"structure":[153,185],"changes":[154],"tissue":[156],"disease":[158,178],"specificity":[159],"cis-eQTL":[162,169],"SNPs":[163,170,214,231],"assessed.":[167],"enriched":[175],"neurological":[177],"intergenic":[180],"region,":[181],"altered":[187],"17.6%":[189],"all":[191],"Finally,":[195],"weighted":[197],"gene":[198,202],"coexpression":[199],"network":[200],"set":[203],"enrichment":[204],"analyses":[205],"used":[207],"investigate":[209],"how":[210],"influence":[212,236],"contributed":[217],"As":[223],"result,":[225],"regulation":[227],"found":[233],"mainly":[235],"antigen":[238],"processing/presentation":[239],"mitogen-activated":[241],"protein":[242],"kinases":[243],"(MAPK)":[244],"signaling":[245],"pathway":[246],"These":[249],"results":[250],"revealed":[251],"effectiveness":[253],"proposed":[257],"study":[260],"give":[262],"insight":[263],"into":[264],"mechanism":[266],"(SNP-mediated":[267],"modulation":[268],"lncRNAs)":[270]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}