{"id":"https://openalex.org/W2896829849","doi":"https://doi.org/10.1093/bib/bby098","title":"MicroRNA-small molecule association identification: from experimental results to computational models","display_name":"MicroRNA-small molecule association identification: from experimental results to computational models","publication_year":2018,"publication_date":"2018-09-12","ids":{"openalex":"https://openalex.org/W2896829849","doi":"https://doi.org/10.1093/bib/bby098","mag":"2896829849","pmid":"https://pubmed.ncbi.nlm.nih.gov/30325405"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bby098","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bby098","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036210249","display_name":"Xing Chen","orcid":"https://orcid.org/0000-0001-9028-5342"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing Chen","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-9028-5342","affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053787520","display_name":"Na\u2010Na Guan","orcid":"https://orcid.org/0000-0002-3966-1709"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na-Na Guan","raw_affiliation_strings":["College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063862193","display_name":"Yazhou Sun","orcid":"https://orcid.org/0000-0003-4401-1011"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Zhou Sun","raw_affiliation_strings":["College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393871","display_name":"Jianqiang Li","orcid":"https://orcid.org/0000-0002-2208-962X"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Qiang Li","raw_affiliation_strings":["College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045990965","display_name":"Jia Qu","orcid":"https://orcid.org/0000-0002-2611-8731"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Qu","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China","institution_ids":["https://openalex.org/I25757504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036210249","https://openalex.org/A5100393871"],"corresponding_institution_ids":["https://openalex.org/I180726961","https://openalex.org/I25757504"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":6.1599,"has_fulltext":false,"cited_by_count":178,"citation_normalized_percentile":{"value":0.97994996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"47","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.8341666460037231},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7419056296348572},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6877215504646301},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.6352071762084961},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5543071627616882},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4427701532840729},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4131353795528412},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3478873372077942},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1430460512638092},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12763667106628418}],"concepts":[{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.8341666460037231},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7419056296348572},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6877215504646301},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6352071762084961},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5543071627616882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4427701532840729},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4131353795528412},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3478873372077942},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1430460512638092},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12763667106628418},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bby098","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bby098","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30325405","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30325405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4376950261","display_name":null,"funder_award_id":"61772531","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5693537545","display_name":"\u590d\u6742\u73af\u5883\u4e0b\u7a7a\u4e2d/\u5730\u9762\u591a\u5f02\u6784\u673a\u5668\u4eba\u7acb\u4f53\u534f\u540c\u7b56\u7565\u7814\u7a76","funder_award_id":"61572330","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5810767477","display_name":null,"funder_award_id":"CYZZ20160304165036893","funder_id":"https://openalex.org/F4320334944","funder_display_name":"Shenzhen Graduate School, Peking University"},{"id":"https://openalex.org/G6733505969","display_name":null,"funder_award_id":"U1713212","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7570340352","display_name":null,"funder_award_id":"61602319","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334944","display_name":"Shenzhen Graduate School, Peking University","ror":"https://ror.org/02v51f717"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W58938204","https://openalex.org/W141539550","https://openalex.org/W144423133","https://openalex.org/W883328580","https://openalex.org/W1517802390","https://openalex.org/W1889514258","https://openalex.org/W1939069213","https://openalex.org/W1971106435","https://openalex.org/W1971460830","https://openalex.org/W1971645224","https://openalex.org/W1971847988","https://openalex.org/W1975441976","https://openalex.org/W1976840283","https://openalex.org/W1978929052","https://openalex.org/W1979537657","https://openalex.org/W1979912768","https://openalex.org/W1996575556","https://openalex.org/W2002995168","https://openalex.org/W2005440577","https://openalex.org/W2006797972","https://openalex.org/W2008945738","https://openalex.org/W2011350824","https://openalex.org/W2018904785","https://openalex.org/W2026051181","https://openalex.org/W2028042343","https://openalex.org/W2028532596","https://openalex.org/W2030817376","https://openalex.org/W2037001061","https://openalex.org/W2039340234","https://openalex.org/W2040430318","https://openalex.org/W2041755933","https://openalex.org/W2042714431","https://openalex.org/W2049772720","https://openalex.org/W2052480299","https://openalex.org/W2053490054","https://openalex.org/W2054308913","https://openalex.org/W2057093679","https://openalex.org/W2062290101","https://openalex.org/W2064222302","https://openalex.org/W2074370114","https://openalex.org/W2075317528","https://openalex.org/W2075860675","https://openalex.org/W2077475358","https://openalex.org/W2077576784","https://openalex.org/W2078849828","https://openalex.org/W2080424200","https://openalex.org/W2081386963","https://openalex.org/W2083158631","https://openalex.org/W2083364674","https://openalex.org/W2087975583","https://openalex.org/W2092113020","https://openalex.org/W2093804567","https://openalex.org/W2094097897","https://openalex.org/W2105649494","https://openalex.org/W2106210472","https://openalex.org/W2109115947","https://openalex.org/W2110666579","https://openalex.org/W2110789683","https://openalex.org/W2113072832","https://openalex.org/W2114202720","https://openalex.org/W2114605673","https://openalex.org/W2117391818","https://openalex.org/W2123602182","https://openalex.org/W2127553917","https://openalex.org/W2131596261","https://openalex.org/W2135240955","https://openalex.org/W2135314242","https://openalex.org/W2135613885","https://openalex.org/W2135906490","https://openalex.org/W2137403619","https://openalex.org/W2137649483","https://openalex.org/W2150305712","https://openalex.org/W2152970345","https://openalex.org/W2154694480","https://openalex.org/W2155669068","https://openalex.org/W2159526949","https://openalex.org/W2163169932","https://openalex.org/W2168230240","https://openalex.org/W2168494970","https://openalex.org/W2168750261","https://openalex.org/W2171201030","https://openalex.org/W2171757104","https://openalex.org/W2183717576","https://openalex.org/W2259538443","https://openalex.org/W2280254736","https://openalex.org/W2315089568","https://openalex.org/W2318932315","https://openalex.org/W2339350795","https://openalex.org/W2339718724","https://openalex.org/W2395168605","https://openalex.org/W2396649694","https://openalex.org/W2410390867","https://openalex.org/W2443187137","https://openalex.org/W2444690946","https://openalex.org/W2462108616","https://openalex.org/W2502055988","https://openalex.org/W2562083153","https://openalex.org/W2584926544","https://openalex.org/W2589703198","https://openalex.org/W2607159126","https://openalex.org/W2610603164","https://openalex.org/W2736802640","https://openalex.org/W2765760205","https://openalex.org/W2765950793","https://openalex.org/W2780777007","https://openalex.org/W2781702232","https://openalex.org/W2786578820","https://openalex.org/W2800595743","https://openalex.org/W2809893308","https://openalex.org/W2888358121","https://openalex.org/W3145571634","https://openalex.org/W3146360245","https://openalex.org/W4238545515","https://openalex.org/W6630978243","https://openalex.org/W6660748943","https://openalex.org/W6684850288","https://openalex.org/W6686420396","https://openalex.org/W6730658936","https://openalex.org/W6736394078","https://openalex.org/W6745256139","https://openalex.org/W6749595737"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W2043558654","https://openalex.org/W4225792090","https://openalex.org/W2090863707","https://openalex.org/W4385741417","https://openalex.org/W4285201319","https://openalex.org/W4283692078","https://openalex.org/W2057742104"],"abstract_inverted_index":{"Small":[0],"molecule":[1,98,167],"is":[2],"a":[3,24,28],"kind":[4],"of":[5,13,27,81,96,104,154,175,212,219,221,234,245],"low":[6],"molecular":[7],"weight":[8],"organic":[9],"compound":[10,66],"with":[11,84,111],"variety":[12],"biological":[14],"functions.":[15],"Studies":[16],"have":[17,37,120,184],"indicated":[18],"that":[19,119],"small":[20,85,97,130,160,166,192,223],"molecules":[21,131],"can":[22],"inhibit":[23],"specific":[25],"function":[26],"multifunctional":[29],"protein":[30],"or":[31,39,158],"disrupt":[32],"protein-protein":[33],"interactions":[34],"and":[35,61,94,99,140,151,181,187,237],"may":[36],"beneficial":[38],"detrimental":[40],"effect":[41],"against":[42,71],"diseases.":[43],"MicroRNAs":[44],"(miRNAs)":[45],"play":[46],"crucial":[47],"roles":[48],"in":[49,74,109,202],"cellular":[50,75],"biology,":[51],"which":[52],"makes":[53],"it":[54],"possible":[55],"to":[56,123,133,189,207],"develop":[57],"miRNA":[58,105,124],"as":[59,214,216],"diagnostics":[60],"therapeutic":[62],"targets.":[63],"Several":[64],"drug-like":[65],"libraries":[67],"were":[68,107,126,142,163],"screened":[69],"successfully":[70],"different":[72,227],"miRNAs":[73,83,136,169],"assays":[76],"further":[77,243],"demonstrating":[78],"the":[79,92,155,203,232,239],"possibility":[80],"targeting":[82,168],"molecules.":[86],"In":[87,114],"this":[88],"review,":[89],"we":[90,196,230],"summarized":[91,231],"concept":[93],"functions":[95,106],"miRNAs.":[100],"Especially,":[101],"five":[102],"aspects":[103],"exhibited":[108],"detail":[110],"individual":[112],"examples.":[113],"addition,":[115],"four":[116,134,198],"disease":[117],"states":[118],"been":[121,185],"linked":[122],"alterations":[125],"summed":[127],"up.":[128],"Then,":[129],"related":[132],"important":[135,147,173],"miR-21,":[137],"122,":[138],"4644":[139],"27":[141],"selected":[143],"for":[144,209,242],"introduction.":[145],"Some":[146],"publicly":[148],"accessible":[149],"databases":[150],"web":[152],"servers":[153],"experimentally":[156],"validated":[157],"potential":[159],"molecule-miRNA":[161,193,224],"associations":[162,225],"discussed.":[164],"Identifying":[165],"has":[170],"become":[171],"an":[172],"goal":[174],"biomedical":[176],"research.":[177],"Thus,":[178],"several":[179],"experimental":[180,199],"computational":[182,246],"models":[183,220],"developed":[186],"implemented":[188],"identify":[190],"novel":[191],"associations.":[194],"Here,":[195],"reviewed":[197],"techniques":[200],"used":[201],"past":[204],"few":[205],"years":[206],"search":[208],"small-molecule":[210],"inhibitors":[211],"miRNAs,":[213],"well":[215],"three":[217],"types":[218],"predicting":[222],"from":[226],"perspectives.":[228],"Finally,":[229],"limitations":[233],"existing":[235],"methods":[236],"discussed":[238],"future":[240],"directions":[241],"development":[244],"models.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}