{"id":"https://openalex.org/W2806412533","doi":"https://doi.org/10.1093/bib/bby040","title":"A comparison of mechanistic signaling pathway activity analysis methods","display_name":"A comparison of mechanistic signaling pathway activity analysis methods","publication_year":2018,"publication_date":"2018-05-14","ids":{"openalex":"https://openalex.org/W2806412533","doi":"https://doi.org/10.1093/bib/bby040","mag":"2806412533","pmid":"https://pubmed.ncbi.nlm.nih.gov/29868818"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bby040","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby040","pdf_url":"https://academic.oup.com/bib/article-pdf/20/5/1655/33614926/bby040.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/20/5/1655/33614926/bby040.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018017520","display_name":"Alicia Amadoz","orcid":"https://orcid.org/0000-0003-3915-0404"},"institutions":[{"id":"https://openalex.org/I4210154725","display_name":"Igenomix","ror":"https://ror.org/04mjvsy78","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210154725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alicia Amadoz","raw_affiliation_strings":["Department of Bioinformatics, Igenomix S.L., 46980 Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Igenomix S.L., 46980 Valencia, Spain","institution_ids":["https://openalex.org/I4210154725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015858475","display_name":"Marta R. Hidalgo","orcid":"https://orcid.org/0000-0002-5801-7804"},"institutions":[{"id":"https://openalex.org/I4210086910","display_name":"Fundaci\u00f3n Progreso y Salud","ror":"https://ror.org/0048t7e91","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210086910","https://openalex.org/I4210152975","https://openalex.org/I918821925"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta R Hidalgo","raw_affiliation_strings":["Clinical Bioinformatics Area, Fundaci\u00f3n Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Sevilla 41013, Spain"],"affiliations":[{"raw_affiliation_string":"Clinical Bioinformatics Area, Fundaci\u00f3n Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Sevilla 41013, Spain","institution_ids":["https://openalex.org/I4210086910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081433623","display_name":"Cankut \u00c7ubuk","orcid":"https://orcid.org/0000-0003-4646-0849"},"institutions":[{"id":"https://openalex.org/I4210086910","display_name":"Fundaci\u00f3n Progreso y Salud","ror":"https://ror.org/0048t7e91","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210086910","https://openalex.org/I4210152975","https://openalex.org/I918821925"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cankut \u00c7ubuk","raw_affiliation_strings":["Clinical Bioinformatics Area, Fundaci\u00f3n Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Sevilla 41013, Spain"],"affiliations":[{"raw_affiliation_string":"Clinical Bioinformatics Area, Fundaci\u00f3n Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Sevilla 41013, Spain","institution_ids":["https://openalex.org/I4210086910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066796940","display_name":"Jos\u00e9 Carbonell\u2010Caballero","orcid":"https://orcid.org/0000-0002-9170-0533"},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Carbonell-Caballero","raw_affiliation_strings":["Chromatin and Gene expression Lab, Gene Regulation, Stem Cells and Cancer Program, Centre de Regulaci\u00f3 Gen\u00f2mica (CRG), The Barcelona Institute of Science and Technology, PRBB, Barcelona 08003, Spain"],"affiliations":[{"raw_affiliation_string":"Chromatin and Gene expression Lab, Gene Regulation, Stem Cells and Cancer Program, Centre de Regulaci\u00f3 Gen\u00f2mica (CRG), The Barcelona Institute of Science and Technology, PRBB, Barcelona 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074140420","display_name":"Joaqu\u0131\u0301n Dopazo","orcid":"https://orcid.org/0000-0003-3318-120X"},"institutions":[{"id":"https://openalex.org/I4210086910","display_name":"Fundaci\u00f3n Progreso y Salud","ror":"https://ror.org/0048t7e91","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210086910","https://openalex.org/I4210152975","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Joaqu\u00edn Dopazo","raw_affiliation_strings":["Chromatin and Gene expression Lab, Gene Regulation, Stem Cells and Cancer Program, Centre de Regulaci\u00f3 Gen\u00f2mica (CRG), The Barcelona Institute of Science and Technology, PRBB, Barcelona 08003, Spain","Clinical Bioinformatics Area, Fundaci\u00f3n Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Sevilla 41013, Spain","Clinical Bioinformatics Area, Fundaci\u00f3n Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Sevilla 41013, Spain, Functional Genomics Node (INB), FPS, Hospital Virgen del Roc\u00edo, Sevilla 41013, Spain and Bioinformatics in Rare Diseases (BiER), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Roc\u00edo, Sevilla 41013, Spain"],"affiliations":[{"raw_affiliation_string":"Chromatin and Gene expression Lab, Gene Regulation, Stem Cells and Cancer Program, Centre de Regulaci\u00f3 Gen\u00f2mica (CRG), The Barcelona Institute of Science and Technology, PRBB, Barcelona 08003, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Clinical Bioinformatics Area, Fundaci\u00f3n Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Sevilla 41013, Spain","institution_ids":["https://openalex.org/I4210086910"]},{"raw_affiliation_string":"Clinical Bioinformatics Area, Fundaci\u00f3n Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Sevilla 41013, Spain, Functional Genomics Node (INB), FPS, Hospital Virgen del Roc\u00edo, Sevilla 41013, Spain and Bioinformatics in Rare Diseases (BiER), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Roc\u00edo, Sevilla 41013, Spain","institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210086910"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5074140420"],"corresponding_institution_ids":["https://openalex.org/I4210086910","https://openalex.org/I4210111366","https://openalex.org/I4210137962"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":3.2482,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.93096258,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"20","issue":"5","first_page":"1655","last_page":"1668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6026266813278198},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"Pathway analysis","score":0.6018008589744568},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.5798375010490417},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5382006764411926},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.4644021987915039},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.45521682500839233},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.33014634251594543},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27716296911239624},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19788533449172974},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13101613521575928},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08640149235725403}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6026266813278198},{"id":"https://openalex.org/C2779230013","wikidata":"https://www.wikidata.org/wiki/Q25303877","display_name":"Pathway analysis","level":4,"score":0.6018008589744568},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.5798375010490417},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5382006764411926},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4644021987915039},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.45521682500839233},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.33014634251594543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27716296911239624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19788533449172974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13101613521575928},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08640149235725403},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011180","descriptor_name":"Postmortem Changes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011180","descriptor_name":"Postmortem Changes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011180","descriptor_name":"Postmortem Changes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bib/bby040","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby040","pdf_url":"https://academic.oup.com/bib/article-pdf/20/5/1655/33614926/bby040.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29868818","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29868818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:repositori-api.upf.edu:10230/43928","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/43928","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:www.repositoriosalud.es:10668/12548","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917216/pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4377196114","display_name":"RISalud Institutional Health Repository of Andaluc\u00eda","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:europepmc.org:5874728","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6917216","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/57966","is_oa":true,"landing_page_url":"https://qmro.qmul.ac.uk/xmlui/handle/123456789/57966","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bib/bby040","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby040","pdf_url":"https://academic.oup.com/bib/article-pdf/20/5/1655/33614926/bby040.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2806412533.pdf","grobid_xml":"https://content.openalex.org/works/W2806412533.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W180513472","https://openalex.org/W893557411","https://openalex.org/W1618390401","https://openalex.org/W1848939527","https://openalex.org/W1849111649","https://openalex.org/W1968378366","https://openalex.org/W1979616603","https://openalex.org/W1982023029","https://openalex.org/W1984225101","https://openalex.org/W1986241711","https://openalex.org/W1989108446","https://openalex.org/W1989277387","https://openalex.org/W1999086631","https://openalex.org/W2001474458","https://openalex.org/W2006540875","https://openalex.org/W2011226251","https://openalex.org/W2011417152","https://openalex.org/W2015291385","https://openalex.org/W2017568254","https://openalex.org/W2018838463","https://openalex.org/W2021560851","https://openalex.org/W2023250031","https://openalex.org/W2041440766","https://openalex.org/W2043548405","https://openalex.org/W2044702943","https://openalex.org/W2049527386","https://openalex.org/W2056300490","https://openalex.org/W2059232554","https://openalex.org/W2062533676","https://openalex.org/W2068523052","https://openalex.org/W2075602427","https://openalex.org/W2080218141","https://openalex.org/W2082026429","https://openalex.org/W2085264684","https://openalex.org/W2087444873","https://openalex.org/W2096283457","https://openalex.org/W2097554668","https://openalex.org/W2100768460","https://openalex.org/W2100980426","https://openalex.org/W2103017472","https://openalex.org/W2105734437","https://openalex.org/W2107018762","https://openalex.org/W2107665951","https://openalex.org/W2110687686","https://openalex.org/W2111867681","https://openalex.org/W2116103722","https://openalex.org/W2118069309","https://openalex.org/W2118104220","https://openalex.org/W2119028181","https://openalex.org/W2119454933","https://openalex.org/W2119789108","https://openalex.org/W2119943416","https://openalex.org/W2121126239","https://openalex.org/W2121215171","https://openalex.org/W2122863959","https://openalex.org/W2124388496","https://openalex.org/W2126086567","https://openalex.org/W2126146261","https://openalex.org/W2127401140","https://openalex.org/W2128985829","https://openalex.org/W2130410032","https://openalex.org/W2130940380","https://openalex.org/W2134736660","https://openalex.org/W2139084975","https://openalex.org/W2143969914","https://openalex.org/W2144983644","https://openalex.org/W2156695919","https://openalex.org/W2157646380","https://openalex.org/W2161112598","https://openalex.org/W2163480486","https://openalex.org/W2164298117","https://openalex.org/W2165040702","https://openalex.org/W2168673205","https://openalex.org/W2180481128","https://openalex.org/W2197234859","https://openalex.org/W2201254472","https://openalex.org/W2262414037","https://openalex.org/W2263356566","https://openalex.org/W2275877493","https://openalex.org/W2282377787","https://openalex.org/W2335012284","https://openalex.org/W2346323658","https://openalex.org/W2399303024","https://openalex.org/W2555023220","https://openalex.org/W2560367415","https://openalex.org/W2566814726","https://openalex.org/W2566908806","https://openalex.org/W2767914218","https://openalex.org/W2773309042","https://openalex.org/W2787729717","https://openalex.org/W2963190765","https://openalex.org/W4237335579"],"related_works":["https://openalex.org/W2378076731","https://openalex.org/W4286888643","https://openalex.org/W3210795196","https://openalex.org/W2088988140","https://openalex.org/W2803103875","https://openalex.org/W2103019253","https://openalex.org/W2594573607","https://openalex.org/W2154972152","https://openalex.org/W2996680049","https://openalex.org/W2941424978"],"abstract_inverted_index":{"Understanding":[0],"the":[1,27,57,60,64,78,116,132],"aspects":[2],"of":[3,14,30,43,50,66,80,136],"cell":[4,101],"functionality":[5],"that":[6,55,71,93],"account":[7],"for":[8,20,128],"disease":[9],"mechanisms":[10],"or":[11],"drug":[12],"modes":[13],"action":[15],"is":[16],"a":[17,48,90,113],"main":[18],"challenge":[19],"precision":[21],"medicine.":[22],"Classical":[23],"gene-based":[24],"approaches":[25,38,127],"ignore":[26],"modular":[28],"nature":[29],"most":[31],"human":[32],"traits,":[33],"whereas":[34],"conventional":[35],"pathway":[36,85],"enrichment":[37],"produce":[39],"only":[40],"illustrative":[41],"results":[42],"limited":[44],"practical":[45],"utility.":[46],"Recently,":[47],"family":[49],"new":[51,91],"methods":[52,88,118],"has":[53],"emerged":[54],"change":[56],"focus":[58],"from":[59],"whole":[61],"pathways":[62],"to":[63,77,108,124],"definition":[65],"elementary":[67],"subpathways":[68],"within":[69],"them":[70,107],"have":[72],"any":[73],"mechanistic":[74,84],"significance":[75],"and":[76,105,120,134],"study":[79],"their":[81,122],"activities.":[82],"Thus,":[83],"activity":[86,102],"(MPA)":[87],"constitute":[89],"paradigm":[92],"allows":[94],"recoding":[95],"poorly":[96],"informative":[97],"genomic":[98],"measurements":[99],"into":[100],"quantitative":[103],"values":[104],"relate":[106],"phenotypes.":[109],"Here":[110],"we":[111],"provide":[112],"review":[114],"on":[115],"MPA":[117],"available":[119],"explain":[121],"contribution":[123],"systems":[125],"medicine":[126],"addressing":[129],"challenges":[130],"in":[131],"diagnostic":[133],"treatment":[135],"complex":[137],"diseases.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}