{"id":"https://openalex.org/W2802891357","doi":"https://doi.org/10.1093/bib/bby035","title":"Post genome-wide association analysis: dissecting computational pathway/network-based approaches","display_name":"Post genome-wide association analysis: dissecting computational pathway/network-based approaches","publication_year":2018,"publication_date":"2018-04-09","ids":{"openalex":"https://openalex.org/W2802891357","doi":"https://doi.org/10.1093/bib/bby035","mag":"2802891357","pmid":"https://pubmed.ncbi.nlm.nih.gov/29701762"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bby035","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby035","pdf_url":"https://academic.oup.com/bib/article-pdf/20/2/690/28834094/bby035.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/20/2/690/28834094/bby035.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057943240","display_name":"Emile R. Chimusa","orcid":"https://orcid.org/0000-0001-8846-2047"},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Emile R Chimusa","raw_affiliation_strings":["Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Level 3, Wernher and Beit North, Private Bag, Rondebosch, 7700, Anzio road, Observatory Cape Town, South Africa"],"raw_orcid":"https://orcid.org/0000-0001-8846-2047","affiliations":[{"raw_affiliation_string":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Level 3, Wernher and Beit North, Private Bag, Rondebosch, 7700, Anzio road, Observatory Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033751278","display_name":"Shareefa Dalvie","orcid":"https://orcid.org/0000-0003-2333-4823"},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Shareefa Dalvie","raw_affiliation_strings":["Department of Psychiatry and Mental Health, University of Cape Town, Observatory, 7925, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Mental Health, University of Cape Town, Observatory, 7925, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047773727","display_name":"Collet Dandara","orcid":"https://orcid.org/0000-0002-5925-4895"},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Collet Dandara","raw_affiliation_strings":["Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023130040","display_name":"Ambroise Wonkam","orcid":"https://orcid.org/0000-0003-1420-9051"},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Ambroise Wonkam","raw_affiliation_strings":["Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062226758","display_name":"Gaston K. Mazandu","orcid":"https://orcid.org/0000-0002-6441-8006"},"institutions":[{"id":"https://openalex.org/I148561064","display_name":"African Institute for Mathematical Sciences","ror":"https://ror.org/02f9k5d27","country_code":"ZA","type":"education","lineage":["https://openalex.org/I148561064"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gaston K Mazandu","raw_affiliation_strings":["Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa; African Institute for Mathematical Sciences, 7945 Muizenberg, Cape Town, South Africa and Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of","African Institute for Mathematical Sciences, 7945 Muizenberg, Cape Town, South Africa and Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa; African Institute for Mathematical Sciences, 7945 Muizenberg, Cape Town, South Africa and Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of","institution_ids":["https://openalex.org/I148561064","https://openalex.org/I157614274"]},{"raw_affiliation_string":"African Institute for Mathematical Sciences, 7945 Muizenberg, Cape Town, South Africa and Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa","institution_ids":["https://openalex.org/I148561064","https://openalex.org/I157614274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5057943240"],"corresponding_institution_ids":["https://openalex.org/I157614274"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.8378,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.7222963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"20","issue":"2","first_page":"690","last_page":"700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.8988513946533203},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.6699981093406677},{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.6661948561668396},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.591533362865448},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.5714050531387329},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48932474851608276},{"id":"https://openalex.org/keywords/statistic","display_name":"Statistic","score":0.453772634267807},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40826618671417236},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25559723377227783},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.24024397134780884},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20573750138282776},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.17335474491119385},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.07937845587730408}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8988513946533203},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6699981093406677},{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.6661948561668396},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.591533362865448},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.5714050531387329},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48932474851608276},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.453772634267807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40826618671417236},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25559723377227783},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.24024397134780884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20573750138282776},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.17335474491119385},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.07937845587730408},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bby035","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby035","pdf_url":"https://academic.oup.com/bib/article-pdf/20/2/690/28834094/bby035.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29701762","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29701762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6556901","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6556901","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bby035","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby035","pdf_url":"https://academic.oup.com/bib/article-pdf/20/2/690/28834094/bby035.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4510337760","display_name":null,"funder_award_id":"H3A/18/001","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"}],"funders":[{"id":"https://openalex.org/F4320307874","display_name":"Wellcome","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334105","display_name":"Center for High Performance Computing","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2802891357.pdf","grobid_xml":"https://content.openalex.org/works/W2802891357.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W639218804","https://openalex.org/W1555797395","https://openalex.org/W1934704664","https://openalex.org/W1981970248","https://openalex.org/W1984915072","https://openalex.org/W1991160835","https://openalex.org/W1992872040","https://openalex.org/W1995329541","https://openalex.org/W2011511782","https://openalex.org/W2046125269","https://openalex.org/W2046434400","https://openalex.org/W2051616601","https://openalex.org/W2065769502","https://openalex.org/W2070064901","https://openalex.org/W2073116379","https://openalex.org/W2084974619","https://openalex.org/W2086311997","https://openalex.org/W2087467445","https://openalex.org/W2089175718","https://openalex.org/W2092194125","https://openalex.org/W2105851205","https://openalex.org/W2106419549","https://openalex.org/W2110065044","https://openalex.org/W2111842731","https://openalex.org/W2118822739","https://openalex.org/W2122630333","https://openalex.org/W2127331517","https://openalex.org/W2146653758","https://openalex.org/W2152285853","https://openalex.org/W2157339178","https://openalex.org/W2161271430","https://openalex.org/W2165198854","https://openalex.org/W2166779336","https://openalex.org/W2167785155","https://openalex.org/W2177764460","https://openalex.org/W2183091920","https://openalex.org/W2254879037","https://openalex.org/W2329715752","https://openalex.org/W2415245143","https://openalex.org/W2537679995","https://openalex.org/W2553123256","https://openalex.org/W2580418217","https://openalex.org/W2597215890","https://openalex.org/W2754562046","https://openalex.org/W3045153201","https://openalex.org/W3103071483","https://openalex.org/W4256140420","https://openalex.org/W6732990597"],"related_works":["https://openalex.org/W2140249224","https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W1486217206","https://openalex.org/W1992310781"],"abstract_inverted_index":{"Over":[0],"thousands":[1],"of":[2,26,34,37,49,53,113,132],"genetic":[3,65,121],"associations":[4],"to":[5,74,119],"diseases":[6],"have":[7],"been":[8],"identified":[9,28],"by":[10,71,110],"genome-wide":[11],"association":[12],"studies":[13],"(GWASs),":[14],"which":[15],"conceptually":[16],"is":[17,142],"a":[18,31,98,130],"single-marker-based":[19],"approach.":[20],"There":[21],"are":[22],"potentially":[23],"many":[24],"uses":[25],"these":[27],"variants,":[29],"including":[30],"better":[32],"understanding":[33],"the":[35,72],"pathogenesis":[36],"diseases,":[38],"new":[39],"leads":[40],"for":[41],"studying":[42],"underlying":[43],"risk":[44],"prediction":[45,48],"and":[46,90],"clinical":[47],"treatment.":[50],"However,":[51],"because":[52],"inadequate":[54],"power,":[55],"GWAS":[56,79,107],"might":[57],"miss":[58],"disease":[59],"genes":[60],"and/or":[61],"pathways":[62,118],"with":[63,97,124,129],"weak":[64],"or":[66,117],"strong":[67],"epistatic":[68],"effects.":[69],"Driven":[70],"need":[73],"extract":[75],"useful":[76],"information":[77],"from":[78],"summary":[80,108,139],"statistics,":[81],"post-GWAS":[82],"approaches":[83],"(PGAs)":[84],"were":[85],"introduced.":[86],"Here,":[87],"we":[88],"dissect":[89],"discuss":[91],"advances":[92],"made":[93],"in":[94],"pathway/network-based":[95],"PGAs,":[96],"particular":[99],"focus":[100],"on":[101,138],"protein-protein":[102],"interaction":[103],"networks":[104],"that":[105],"leverage":[106],"statistics":[109],"combining":[111],"effects":[112],"multiple":[114],"loci,":[115],"subnetworks":[116],"detect":[120],"signals":[122],"associated":[123],"complex":[125],"diseases.":[126],"We":[127],"conclude":[128],"discussion":[131],"research":[133],"areas":[134],"where":[135],"further":[136],"work":[137],"statistic-based":[140],"methods":[141],"needed.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
