{"id":"https://openalex.org/W2801194071","doi":"https://doi.org/10.1093/bib/bby030","title":"Integrated use of bioinformatic resources reveals that co-targeting of histone deacetylases, IKBK and SRC inhibits epithelial-mesenchymal transition in cancer","display_name":"Integrated use of bioinformatic resources reveals that co-targeting of histone deacetylases, IKBK and SRC inhibits epithelial-mesenchymal transition in cancer","publication_year":2018,"publication_date":"2018-03-23","ids":{"openalex":"https://openalex.org/W2801194071","doi":"https://doi.org/10.1093/bib/bby030","mag":"2801194071","pmid":"https://pubmed.ncbi.nlm.nih.gov/29726962"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bby030","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bby030","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082880431","display_name":"Farnaz Barneh","orcid":"https://orcid.org/0000-0003-4715-9732"},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]},{"id":"https://openalex.org/I4210088961","display_name":"Biotechnology Research Center","ror":"https://ror.org/013t96v18","country_code":"IR","type":"facility","lineage":["https://openalex.org/I163205636","https://openalex.org/I4210088961"]},{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farnaz Barneh","raw_affiliation_strings":["Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran","Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I58048189"]},{"raw_affiliation_string":"Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061","https://openalex.org/I4210088961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046889449","display_name":"Mehdi Mirzaie","orcid":"https://orcid.org/0000-0003-4434-5118"},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehdi Mirzaie","raw_affiliation_strings":["Department of Applied Mathematics, Faculty of Mathematical Sciences, Tarbiat Modares University, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, Faculty of Mathematical Sciences, Tarbiat Modares University, Tehran, Iran","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066136575","display_name":"Payman Nickchi","orcid":"https://orcid.org/0000-0003-0477-7987"},"institutions":[{"id":"https://openalex.org/I4210088961","display_name":"Biotechnology Research Center","ror":"https://ror.org/013t96v18","country_code":"IR","type":"facility","lineage":["https://openalex.org/I163205636","https://openalex.org/I4210088961"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]},{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["CA","IR"],"is_corresponding":false,"raw_author_name":"Payman Nickchi","raw_affiliation_strings":["Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada","Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061","https://openalex.org/I4210088961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012262880","display_name":"Tuan Zea Tan","orcid":"https://orcid.org/0000-0001-6624-1593"},"institutions":[{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Tuan Zea Tan","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore, Translational Centre for Development and Research, National University Health System, MD11, #03-10, 10 Medical Drive, Singapore 117597, Singapore"],"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore, Translational Centre for Development and Research, National University Health System, MD11, #03-10, 10 Medical Drive, Singapore 117597, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039283945","display_name":"Jean Paul Thiery","orcid":"https://orcid.org/0000-0003-0478-5020"},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210127056","display_name":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes","ror":"https://ror.org/032w6q449","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210095849","https://openalex.org/I4210127056"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR","SG"],"is_corresponding":false,"raw_author_name":"Jean Paul Thiery","raw_affiliation_strings":["CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France","Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore","Institut Gustave Roussy, Inserm Unit 1186 Comprehensive Cancer Center, Villejuif, France"],"affiliations":[{"raw_affiliation_string":"CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France","institution_ids":["https://openalex.org/I4210127056","https://openalex.org/I204730241","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Institut Gustave Roussy, Inserm Unit 1186 Comprehensive Cancer Center, Villejuif, France","institution_ids":["https://openalex.org/I2801843802","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015040403","display_name":"Mehran Piran","orcid":"https://orcid.org/0000-0001-7891-728X"},"institutions":[{"id":"https://openalex.org/I4210088961","display_name":"Biotechnology Research Center","ror":"https://ror.org/013t96v18","country_code":"IR","type":"facility","lineage":["https://openalex.org/I163205636","https://openalex.org/I4210088961"]},{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehran Piran","raw_affiliation_strings":["Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061","https://openalex.org/I4210088961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068265825","display_name":"Mona Salimi","orcid":"https://orcid.org/0000-0002-3997-7009"},"institutions":[{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mona Salimi","raw_affiliation_strings":["Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008501723","display_name":"Fatemeh Goshadrou","orcid":"https://orcid.org/0000-0001-6677-6985"},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Goshadrou","raw_affiliation_strings":["Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078858622","display_name":"Amir Reza Aref","orcid":"https://orcid.org/0000-0002-5174-0522"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amir R Aref","raw_affiliation_strings":["Department of Medical Oncology, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston 02215, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston 02215, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017969980","display_name":"Mohieddin Jafari","orcid":null},"institutions":[{"id":"https://openalex.org/I4210088961","display_name":"Biotechnology Research Center","ror":"https://ror.org/013t96v18","country_code":"IR","type":"facility","lineage":["https://openalex.org/I163205636","https://openalex.org/I4210088961"]},{"id":"https://openalex.org/I1301411061","display_name":"Pasteur Institute of Iran","ror":"https://ror.org/00wqczk30","country_code":"IR","type":"facility","lineage":["https://openalex.org/I1301411061"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohieddin Jafari","raw_affiliation_strings":["Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"],"affiliations":[{"raw_affiliation_string":"Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran","institution_ids":["https://openalex.org/I1301411061","https://openalex.org/I4210088961"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5017969980","https://openalex.org/A5078858622"],"corresponding_institution_ids":["https://openalex.org/I1301411061","https://openalex.org/I136199984","https://openalex.org/I4210088961","https://openalex.org/I4210117453"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.195,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78441077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"2","first_page":"717","last_page":"731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial\u2013mesenchymal-transition","display_name":"Epithelial\u2013mesenchymal transition","score":0.6191580295562744},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.6124133467674255},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5362924933433533},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5176568627357483},{"id":"https://openalex.org/keywords/mesenchymal-stem-cell","display_name":"Mesenchymal stem cell","score":0.5114323496818542},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46281397342681885},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.43359825015068054},{"id":"https://openalex.org/keywords/histone","display_name":"Histone","score":0.419432669878006},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40694183111190796},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37156832218170166},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.32082587480545044},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.27501052618026733},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19882246851921082},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10029348731040955}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6191580295562744},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6124133467674255},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5362924933433533},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5176568627357483},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5114323496818542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46281397342681885},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43359825015068054},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.419432669878006},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40694183111190796},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37156832218170166},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.32082587480545044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27501052618026733},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19882246851921082},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10029348731040955}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bby030","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bby030","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29726962","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29726962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:HAL:hal-04078740v1","is_oa":false,"landing_page_url":"https://cnrs.hal.science/hal-04078740","pdf_url":null,"source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in Bioinformatics, 2019, 20 (2), pp.717-731. ⟨10.1093/bib/bby030⟩","raw_type":"Journal articles"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W942736360","https://openalex.org/W1522260031","https://openalex.org/W1601327278","https://openalex.org/W1941947567","https://openalex.org/W1963195533","https://openalex.org/W1972587504","https://openalex.org/W1973890143","https://openalex.org/W1977099733","https://openalex.org/W1987380441","https://openalex.org/W1988723336","https://openalex.org/W1992976199","https://openalex.org/W1994523772","https://openalex.org/W1996433189","https://openalex.org/W2003820252","https://openalex.org/W2011262669","https://openalex.org/W2028593825","https://openalex.org/W2032587102","https://openalex.org/W2032964150","https://openalex.org/W2038568591","https://openalex.org/W2038723641","https://openalex.org/W2044183928","https://openalex.org/W2044198666","https://openalex.org/W2056766497","https://openalex.org/W2059005938","https://openalex.org/W2062499036","https://openalex.org/W2063011414","https://openalex.org/W2073515400","https://openalex.org/W2078155300","https://openalex.org/W2079876207","https://openalex.org/W2080176093","https://openalex.org/W2096173332","https://openalex.org/W2100786079","https://openalex.org/W2103196126","https://openalex.org/W2103526670","https://openalex.org/W2106930099","https://openalex.org/W2113591602","https://openalex.org/W2114843025","https://openalex.org/W2125910575","https://openalex.org/W2130410032","https://openalex.org/W2135253885","https://openalex.org/W2139726179","https://openalex.org/W2140551998","https://openalex.org/W2141982266","https://openalex.org/W2142232788","https://openalex.org/W2149248356","https://openalex.org/W2149542744","https://openalex.org/W2154980968","https://openalex.org/W2158169216","https://openalex.org/W2160908941","https://openalex.org/W2165469857","https://openalex.org/W2167198989","https://openalex.org/W2171030481","https://openalex.org/W2172286207","https://openalex.org/W2173565120","https://openalex.org/W2176533785","https://openalex.org/W2201460708","https://openalex.org/W2211064704","https://openalex.org/W2226783953","https://openalex.org/W2258428006","https://openalex.org/W2319386045","https://openalex.org/W2333150484","https://openalex.org/W2345356016","https://openalex.org/W2410223381","https://openalex.org/W2419374830","https://openalex.org/W2430117556","https://openalex.org/W2465211533","https://openalex.org/W2489003193","https://openalex.org/W2497501816","https://openalex.org/W2517974598","https://openalex.org/W2524066112","https://openalex.org/W2618074111","https://openalex.org/W2766123339","https://openalex.org/W2952223936","https://openalex.org/W6631168456","https://openalex.org/W6685340275"],"related_works":["https://openalex.org/W3129816939","https://openalex.org/W2912862995","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867"],"abstract_inverted_index":{"With":[0],"the":[1,115,125,129,151,186,201,208,211],"advent":[2],"of":[3,13,23,41,48,57,104,128,138,145,184,193,207],"high-throughput":[4],"technologies":[5],"leading":[6],"to":[7,19,32,66,101,170],"big":[8],"data":[9],"generation,":[10],"increasing":[11],"number":[12],"gene":[14],"signatures":[15,35,88],"are":[16],"being":[17],"published":[18,83],"predict":[20],"various":[21],"features":[22],"diseases":[24],"such":[25],"as":[26,89,181],"prognosis":[27],"and":[28,62,68,78,112,191,204],"patient":[29],"survival.":[30],"However,":[31],"use":[33,40],"these":[34],"for":[36],"identifying":[37],"therapeutic":[38],"targets,":[39],"additional":[42],"bioinformatic":[43,60],"tools":[44,61],"is":[45],"indispensible":[46],"part":[47],"research.":[49],"Here,":[50],"we":[51,135,149],"have":[52],"generated":[53],"a":[54,70,90,178,182],"pipeline":[55],"comprised":[56],"nearly":[58],"15":[59],"enrichment":[63],"statistical":[64],"methods":[65],"propose":[67],"validate":[69],"drug":[71],"combination":[72,132,187,213],"strategy":[73],"from":[74,174],"already":[75],"approved":[76],"drugs":[77],"present":[79],"our":[80],"approach":[81],"using":[82,156],"pan-cancer":[84],"epithelial-mesenchymal":[85],"transition":[86],"(EMT)":[87],"case":[91],"study.":[92],"We":[93,163],"observed":[94],"that":[95,165],"histone":[96],"deacetylases":[97],"were":[98,114],"critical":[99],"targets":[100,139],"tune":[102],"expression":[103,137],"multiple":[105,120],"epithelial":[106,143],"versus":[107,142],"mesenchymal":[108,141],"genes.":[109],"Moreover,":[110],"SRC":[111],"IKBK":[113],"principal":[116],"intracellular":[117],"kinases":[118],"regulating":[119],"signaling":[121],"pathways.":[122],"To":[123],"confirm":[124],"anti-EMT":[126],"efficacy":[127],"proposed":[130,212],"target":[131],"in":[133,140,154,177,218],"silico,":[134],"validated":[136],"subtypes":[144],"ovarian":[146],"cancer.":[147],"Additionally,":[148],"inhibited":[150,189],"pinpointed":[152],"proteins":[153],"vitro":[155],"an":[157],"invasive":[158],"lung":[159],"cancer":[160,194],"cell":[161,172],"line.":[162],"found":[164],"whereas":[166],"low-dose":[167],"mono-therapy":[168],"failed":[169],"limit":[171],"dispersion":[173],"collagen":[175],"spheroids":[176],"microfluidic":[179],"device":[180],"metric":[183],"EMT,":[185],"fully":[188],"dissociation":[190],"invasion":[192],"cells":[195],"toward":[196],"cocultured":[197],"endothelial":[198],"cells.":[199],"Given":[200],"approval":[202],"status":[203],"safety":[205],"profiles":[206],"suggested":[209],"drugs,":[210],"set":[214],"can":[215],"be":[216],"considered":[217],"clinical":[219],"trials.":[220]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}